All Stories

  1. Comprehensive assessments of pharmacokinetics and immunogenicity of farletuzumab ecteribulin, a novel antibody-drug conjugate against tumors expressing folate receptor α, in monkeys

    Article • Journal of Pharmaceutical and Biomedical Analysis, December 2025, Elsevier

    Dr. Yuji Mano

  2. An LC–MS/MS Assay of Irsenontrine, a Novel Phosphodiesterase-9 Inhibitor, in Human Plasma, Urine and Cerebrospinal Fluid for Application to Clinical Pharmacokinetic Studies

    Article • ACS Omega, August 2025, American Chemical Society (ACS)

    Dr. Yuji Mano

  3. A Simultaneous Semiquantification of Eight Immunoglobulin Isotypes in Mouse Serum by LC-MS/MS for Application of Immunogenicity Assessment of Therapeutic Antibodies

    Article • ACS Omega, May 2025, American Chemical Society (ACS)

    Dr. Yuji Mano

  4. A simple LC-MS/MS assay for the quantification of E6011, a novel anti-fractalkine monoclonal antibody, in cynomolgus monkey serum - comparison with ligand binding assay

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2025, Elsevier

    Dr. Yuji Mano

  5. Nonclinical immunogenicity assessment of E3112, a recombinant human hepatocyte growth factor, and its impact on pharmacokinetics in rats and monkeys

    Article • Journal of Pharmaceutical and Biomedical Analysis, October 2024, Elsevier

    Dr. Yuji Mano

  6. Significant increases in detection capability for assessment of organic anion transporting polypeptide-mediated drug-drug interaction in cynomolgus monkeys by modifying pretreatment of Coproporphyrin I and III, and glycochenodeoxycholate-3-sulfate in p...

    Article • Analytica Chimica Acta, September 2024, Elsevier

    Dr. Yuji Mano

  7. Pharmacokinetic profiles of methylcobalamin in rats after multiple administration routes by a simple LC-MS/MS assay with a small volume of plasma

    Article • Journal of Pharmacological and Toxicological Methods, September 2024, Elsevier

    Dr. Yuji Mano

  8. Nonclinical pharmacokinetics of E3112, a recombinant human hepatocyte growth factor, in rats and monkeys by a simple ELISA kit assay

    Article • Journal of Pharmacological and Toxicological Methods, July 2024, Elsevier

    Dr. Yuji Mano

  9. Development of the Complement C5 Assay by LC–MS/MS in Monkey Serum and Comparison with Enzyme-Linked Immunosorbent Assay

    Article • ACS Omega, January 2024, American Chemical Society (ACS)

    Dr. Yuji Mano

  10. Generic UPLC-MS/MS and Gyrolab assays with blood microsampling for pharmacokinetic assessments of therapeutic antibodies in mice

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2024, Elsevier

    Dr. Yuji Mano

  11. A sensitive assay for the determination of E7090, a novel selective inhibitor of fibroblast growth factor receptors, and its metabolite in human plasma by UPLC-MS/MS with at-column dilution

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2024, Elsevier

    Dr. Yuji Mano

  12. A Simple UPLC-MS/MS Assay of Rifampin in a Small Volume of Human Plasma

    Article • ACS Omega, September 2023, American Chemical Society (ACS)

    Dr. Yuji Mano

  13. Quantification of anti-drug antibodies against E6011, an anti-fractalkine monoclonal antibody, in monkey and human serum, by an electrochemiluminescence assay

    Article • Journal of Pharmacological and Toxicological Methods, September 2023, Elsevier

    Dr. Yuji Mano

  14. Cross-species comparison in nonclinical pharmacokinetics of lenvatinib by a simple HPLC with ultraviolet detection

    Article • Scientific Reports, May 2023, Springer Science + Business Media

    Dr. Yuji Mano

  15. A validated UPLC-MS/MS assay of E7090, a novel selective inhibitor of fibroblast growth factor receptors, in human plasma and urine

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2023, Elsevier

    Dr. Yuji Mano

  16. Liposome-encapsulated eribulin shows enhanced antitumor activity over eribulin for combination therapy with anti-PD-1 antibody

    Article • Molecular Cancer Therapeutics, January 2023, American Association for Cancer Research (AACR)

    Dr. Yuji Mano

  17. An electrochemiluminescence assay for quantification of Denileukin Diftitox and its anti-drug antibodies in rat serum

    Article • Journal of Pharmacological and Toxicological Methods, January 2023, Elsevier

    Dr. Yuji Mano

  18. A simple UPLC-MS/MS assay with a core-shell column for the determination of exemestane in human plasma for clinical application

    Article • European Journal of Mass Spectrometry, August 2022, SAGE Publications

    Dr. Yuji Mano

  19. A separate assay of released and liposomal encapsulated eribulin in dog plasma by liquid chromatography with tandem mass spectrometry for its application to a pharmacokinetic study

    Article • Journal of Separation Science, March 2022, Wiley

    Dr. Yuji Mano

  20. Quantitative and qualitative application of a novel capillary microsampling device, Microsampling Wing™ (MSW), using antiepileptic drugs in rats

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2021, Elsevier

    Dr. Yuji Mano

  21. A sensitive bioanalytical assay for methylcobalamin, an endogenous and light-labile substance, in human plasma by liquid chromatography with tandem mass spectrometry and its application to a pharmacokinetic study

    Article • Journal of Pharmaceutical and Biomedical Analysis, November 2020, Elsevier

    Dr. Yuji Mano

  22. Establishment of a simultaneous assay for lemborexant, a novel dual orexin receptor antagonist, and its three metabolites, and its application to a clinical protein binding study

    Article • Journal of Pharmaceutical and Biomedical Analysis, August 2020, Elsevier

    Dr. Yuji Mano

  23. Minimal impact of hepatic and renal impairment on plasma protein binding of lenvatinib, and identification of its major plasma binding protein

    Article • Biopharmaceutics & Drug Disposition, September 2019, Wiley

    Dr. Yuji Mano

  24. Method validation studies and an inter-laboratory cross validation study of lenvatinib assay in human plasma using LC-MS/MS

    Article • Practical Laboratory Medicine, November 2018, Elsevier

    Dr. Yuji Mano

  25. A dried blood spot assay with UPLC–MS/MS for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human blood

    Article • Journal of Pharmaceutical and Biomedical Analysis, August 2018, Elsevier

    Dr. Yuji Mano

  26. Application of an electrochemiluminescence assay for quantification of E6011, an antifractalkine monoclonal antibody, to pharmacokinetic studies in monkeys and humans

    Article • Journal of Clinical Laboratory Analysis, July 2018, Wiley

    Dr. Yuji Mano

  27. Application of a Volumetric Absorptive Microsampling Device to a Pharmacokinetic Study of Tacrolimus in Rats: Comparison with Wet Blood and Plasma

    Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2018, Springer Science + Business Media

    Dr. Yuji Mano

  28. LC–MS-MS Determination of Oxcarbazepine and an Active Metabolite in Human Plasma for Clinical Application

    Article • Journal of Chromatographic Science, May 2018, Oxford University Press (OUP)

    Dr. Yuji Mano

  29. Application of volumetric absorptive microsampling device for quantification of tacrolimus in human blood as a model drug of high blood cell partition

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2017, Elsevier

    Dr. Yuji Mano

  30. An inter-laboratory cross-validation study for the determination of perampanel in human plasma by liquid chromatography assays

    Article • Biomedical Chromatography, June 2016, Wiley

    Dr. Yuji Mano

  31. Simultaneous Determination of Donepezil and Its Three Metabolites in Human Plasma Using LC–MS-MS

    Article • Journal of Chromatographic Science, May 2016, Oxford University Press (OUP)

    Dr. Yuji Mano

  32. A validated LC–MS/MS method of total and unbound lenvatinib quantification in human serum for protein binding studies by equilibrium dialysis

    Article • Journal of Pharmaceutical and Biomedical Analysis, October 2015, Elsevier

    Dr. Yuji Mano

  33. Hematocrit-independent recovery is a key for bioanalysis using volumetric absorptive microsampling devices, MitraTM

    Article • Bioanalysis, August 2015, Future Science

    Dr. Yuji Mano

  34. Validation of a UPLC–MS/MS method for the simultaneous determination of E6005, a phosphodiesterase 4 inhibitor, and its metabolite in human plasma

    Article • Journal of Chromatography B, August 2015, Elsevier

    Dr. Yuji Mano

  35. HPLC with fluorescence detection assay of perampanel, a novel AMPA receptor antagonist, in human plasma for clinical pharmacokinetic studies

    Article • Biomedical Chromatography, March 2015, Wiley

    Dr. Yuji Mano

  36. High-performance liquid chromatography–tandem mass spectrometry method for the determination of perampanel, a novel α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor antagonist in human plasma

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2015, Elsevier

    Dr. Yuji Mano

  37. Validation of an ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of flecainide in human plasma and its clinical application

    Article • Biomedical Chromatography, February 2015, Wiley

    Dr. Yuji Mano

  38. Validation of a hydrophilic interaction ultra-performance liquid chromatography-tandem mass spectrometry method for the determination of gemcitabine in human plasma with tetrahydrouridine

    Article • Biomedical Chromatography, February 2015, Wiley

    Dr. Yuji Mano

  39. Species Differences in Inhibition Potential of Nonsteroidal Anti-Inflammatory Drugs Against Estradiol 3β-Glucuronidation Between Rats, Dogs, and Humans

    Article • Journal of Pharmaceutical Sciences, July 2008, Elsevier

    Dr. Yuji Mano

  40. Substrate-Dependent Modulation of UDP-Glucuronosyltransferase 1A1 (UGT1A1) by Propofol in Recombinant Human UGT1A1 and Human Liver Microsomes

    Article • Basic & Clinical Pharmacology & Toxicology, September 2007, Wiley

    Dr. Yuji Mano

  41. The UDP-Glucuronosyltransferase 2B7 Isozyme Is Responsible for Gemfibrozil Glucuronidation in the Human Liver

    Article • Drug Metabolism and Disposition, August 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Yuji Mano

  42. Predominant Contribution of UDP-Glucuronosyltransferase 2B7 in the Glucuronidation of Racemic Flurbiprofen in the Human Liver

    Article • Drug Metabolism and Disposition, April 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Yuji Mano

  43. Comparison of Inhibition Potentials of Drugs against Zidovudine Glucuronidation in Rat Hepatocytes and Liver Microsomes

    Article • Drug Metabolism and Disposition, January 2007, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr. Yuji Mano

  44. Contribution of UDP-glucuronosyltransferases 1A9 and 2B7 to the glucuronidation of indomethacin in the human liver

    Article • European Journal of Clinical Pharmacology, January 2007, Springer Science + Business Media

    Dr. Yuji Mano

  45. Inhibitory potential of nonsteroidal anti-inflammatory drugs on UDP-glucuronosyltransferase 2B7 in human liver microsomes

    Article • European Journal of Clinical Pharmacology, January 2007, Springer Science + Business Media

    Dr. Yuji Mano

  46. Identification of Human UDP-Glucuronosyltransferase Responsible for the Glucuronidation of Niflumic Acid in Human Liver

    Article • Pharmaceutical Research, June 2006, Springer Science + Business Media

    Dr. Yuji Mano

  47. Hepatobiliary transport of YM466, a novel factor Xa inhibitor, in rats

    Article • European Journal of Drug Metabolism and Pharmacokinetics, June 2006, Springer Science + Business Media

    Dr. Yuji Mano

  48. Invitro drug interaction between diflunisal and indomethacin via glucuronidation in humans

    Article • Biopharmaceutics & Drug Disposition, January 2006, Wiley

    Dr. Yuji Mano

  49. Effects of bosentan, an endothelin receptor antagonist, on bile salt export pump and multidrug resistance–associated protein 2

    Article • Biopharmaceutics & Drug Disposition, January 2006, Wiley

    Dr. Yuji Mano

  50. In Vitro inhibitory effects of non-steroidal antiinflammatory drugs on UDP-glucuronosyltransferase 1A1-catalysed estradiol 3?-glucuronidation in human liver microsomes

    Article • Biopharmaceutics & Drug Disposition, January 2005, Wiley

    Dr. Yuji Mano

  51. In vitro inhibitory effects of non-steroidal anti-inflammatory drugs on 4-methylumbelliferone glucuronidation in recombinant human UDP-glucuronosyltransferase 1A9—potent inhibition by niflumic acid

    Article • Biopharmaceutics & Drug Disposition, January 2005, Wiley

    Dr. Yuji Mano

  52. A liquid chromatographic–tandem mass spectrometric method for the determination of YM466, a novel Factor Xa inhibitor, in rat plasma

    Article • Journal of Pharmaceutical and Biomedical Analysis, November 2004, Elsevier

    Dr. Yuji Mano

  53. Effects of?-estradiol and propofol on the 4-methylumbelliferone glucuronidation in recombinant human UGT isozymes 1A1, 1A8 and 1A9

    Article • Biopharmaceutics & Drug Disposition, October 2004, Wiley

    Dr. Yuji Mano

  54. Absorption, distribution, metabolism and excretion of YM466, a novel factor Xa inhibitor, in rats

    Article • Biopharmaceutics & Drug Disposition, August 2004, Wiley

    Dr. Yuji Mano

  55. Pharmacokinetics of YM466, a new factor Xa inhibitor, in rats and dogs

    Article • European Journal of Drug Metabolism and Pharmacokinetics, March 2004, Springer Science + Business Media

    Dr. Yuji Mano

  56. Antithrombotic effects of YM466, a synthesized direct inhibitor of factor Xa, in an arterio-venous shunt thrombosis model in squirrel monkeys

    Article • Drug Development Research, February 2003, Wiley

    Dr. Yuji Mano

  57. LC determination of YM466, a new factor Xa inhibitor, in rat and dog plasma

    Article • Journal of Pharmaceutical and Biomedical Analysis, July 2002, Elsevier

    Dr. Yuji Mano

  58. Investigation of the high partition of YM992, a novel antidepressant, in rat brain -in vitro andin vivo evidence for the high binding in brain and the high permeability at the BBB

    Article • Biopharmaceutics & Drug Disposition, January 2002, Wiley

    Dr. Yuji Mano