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  1. Computational methods to identify bimodal gene expression and facilitate personalized treatment in cancer patients

    Article • March 2019, Elsevier

    Associate Professor Yuan-Xiang Pan

  2. Perinatal phthalate and high-fat diet exposure induce sex-specific changes in adipocyte size and DNA methylation

    Article • The Journal of Nutritional Biochemistry, March 2019, Elsevier

    Associate Professor Yuan-Xiang Pan

  3. Epigenetic regulation of carnitine palmitoyltransferase 1 (Cpt1a) by high fat diet

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, February 2019, Elsevier

    Associate Professor Yuan-Xiang Pan

  4. Methionine Supply During Late-Gestation Triggers Offspring Sex-Specific Divergent Changes in Metabolic and Epigenetic Signatures in Bovine Placenta

    Article • Journal of Nutrition, January 2019, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  5. Perinatal High-Fat Diet and Bisphenol A: Effects on Behavior and Gene Expression in the Medial Prefrontal Cortex

    Article • Developmental Neuroscience, December 2018, Karger Publishers

    Associate Professor Yuan-Xiang Pan

  6. Molecular Mechanisms Underlying the Link between Diet and DNA Methylation

    Article • International Journal of Molecular Sciences, December 2018, MDPI AG

    Associate Professor Yuan-Xiang Pan

  7. High-fat diet modifies expression of hepatic cellular senescence gene p16(INK4a) through chromatin modifications in adult male rats

    Article • Genes & Nutrition, March 2018, Springer Science + Business Media

    Associate Professor Yuan-Xiang Pan

  8. Effects of Perinatal Exposure to Phthalates and a High-Fat Diet on Maternal Behavior and Pup Development and Social Play

    Article • Endocrinology, December 2017, Endocrine Society

    Associate Professor Yuan-Xiang Pan

  9. Postnatal diet remodels hepatic DNA methylation in metabolic pathways established by a maternal high-fat diet

    Article • Epigenomics, November 2017, Future Medicine

    Associate Professor Yuan-Xiang Pan

  10. Epigenetic Regulation of Centromere Chromatin Stability by Dietary and Environmental Factors

    Article • Advances in Nutrition, November 2017, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  11. Methods and novel technology for microRNA quantification in colorectal cancer screening

    Article • Clinical Epigenetics, October 2017, Springer Science + Business Media

    Associate Professor Yuan-Xiang Pan

  12. Placentome Nutrient Transporters and Mammalian Target of Rapamycin Signaling Proteins Are Altered by the Methionine Supply during Late Gestation in Dairy Cows and Are Associated with Newborn Birth Weight

    Article • Journal of Nutrition, August 2017, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  13. Early-Life Nutritional Programming of Cognition—The Fundamental Role of Epigenetic Mechanisms in Mediating the Relation between Early-Life Environment and Learning and Memory Process

    Article • Advances in Nutrition, March 2017, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  14. Compensatory induction of Fads1 gene expression in heterozygous Fads2-null mice and by diet with a high n-6/n-3 PUFA ratio

    Article • Journal of Lipid Research, September 2016, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  15. Genistein exposure inhibits growth and alters steroidogenesis in adult mouse antral follicles

    Article • Toxicology and Applied Pharmacology, February 2016, Elsevier

    Associate Professor Yuan-Xiang Pan

  16. In utero growth restriction and catch-up adipogenesis after developmental di (2-ethylhexyl) phthalate exposure cause glucose intolerance in adult male rats following a high-fat dietary challenge

    Article • The Journal of Nutritional Biochemistry, November 2015, Elsevier

    Associate Professor Yuan-Xiang Pan

  17. High-fat diet caused widespread epigenomic differences on hepatic methylome in rat

    Article • Physiological Genomics, October 2015, American Physiological Society

    Associate Professor Yuan-Xiang Pan

  18. Induction of autophagy through the activating transcription factor 4 (ATF4)-dependent amino acid response pathway in maternal skeletal muscle may function as the molecular memory in response to gestational protein restriction to alert offspring to mate...

    Article • British Journal Of Nutrition, July 2015, Cambridge University Press

    Associate Professor Yuan-Xiang Pan

  19. Isoflavones in soy flour diet have different effects on whole-genome expression patterns than purified isoflavone mix in human MCF-7 breast tumors in ovariectomized athymic nude mice

    Article • Molecular Nutrition & Food Research, June 2015, Wiley

    Associate Professor Yuan-Xiang Pan

  20. Early-life exposure to high-fat diet may predispose rats to gender-specific hepatic fat accumulation by programming Pepck expression

    Article • The Journal of Nutritional Biochemistry, May 2015, Elsevier

    Associate Professor Yuan-Xiang Pan

  21. Developmental bisphenol A (BPA) exposure leads to sex-specific modification of hepatic gene expression and epigenome at birth that may exacerbate high-fat diet-induced hepatic steatosis

    Article • Toxicology and Applied Pharmacology, April 2015, Elsevier

    Associate Professor Yuan-Xiang Pan

  22. Pathophysiological basis for compromised health beyond generations: role of maternal high-fat diet and low-grade chronic inflammation

    Article • The Journal of Nutritional Biochemistry, January 2015, Elsevier

    Associate Professor Yuan-Xiang Pan

  23. The regulation of hepatic Pon1 by a maternal high-fat diet is gender specific and may occur through promoter histone modifications in neonatal rats

    Article • The Journal of Nutritional Biochemistry, February 2014, Elsevier

    Associate Professor Yuan-Xiang Pan

  24. Epigenetic Mechanisms of Colon Cancer Prevention: What Can Nutrition Do?

    Article • January 2014, Springer Science + Business Media

    Associate Professor Yuan-Xiang Pan

  25. Genistein Exposure During the Early Postnatal Period Favors the Development of Obesity in Female, But Not Male Rats

    Article • Toxicological Sciences, December 2013, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  26. Protein restriction during gestation alters histone modifications at the glucose transporter 4 (GLUT4) promoter region and induces GLUT4 expression in skeletal muscle of female rat offspring

    Article • The Journal of Nutritional Biochemistry, September 2012, Elsevier

    Associate Professor Yuan-Xiang Pan

  27. In Utero Oxidative Stress Epigenetically Programs Antioxidant Defense Capacity and Adulthood Diseases

    Article • Antioxidants & Redox Signaling, July 2012, Mary Ann Liebert Inc

    Associate Professor Yuan-Xiang Pan

  28. A Decrease in DKK1, a WNT Inhibitor, Contributes to Placental Lipid Accumulation in an Obesity-Prone Rat Model1

    Article • Biology of Reproduction, March 2012, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  29. Hepatic cellular senescence pathway genes are induced through histone modifications in a diet-induced obese rat model

    Article • AJP Gastrointestinal and Liver Physiology, March 2012, American Physiological Society

    Associate Professor Yuan-Xiang Pan

  30. The Skeletal Muscle Wnt Pathway May Modulate Insulin Resistance and Muscle Development in a Diet-Induced Obese Rat Model

    Article • Obesity, February 2012, Wiley

    Associate Professor Yuan-Xiang Pan

  31. Histone deacetylase 3 (HDAC3) participates in the transcriptional repression of thep16INK4agene in mammary gland of the female rat offspring exposed to an early-life high-fat diet

    Article • Epigenetics, February 2012, Taylor & Francis

    Associate Professor Yuan-Xiang Pan

  32. A gestational low-protein diet represses p21WAF1/Cip1 expression in the mammary gland of offspring rats through promoter histone modifications

    Article • British Journal Of Nutrition, December 2011, Cambridge University Press

    Associate Professor Yuan-Xiang Pan

  33. Gestational low protein diet selectively induces the amino acid response pathway target genes in the liver of offspring rats through transcription factor binding and histone modifications

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, October 2011, Elsevier

    Associate Professor Yuan-Xiang Pan

  34. Dickkopf homolog 1, a Wnt signaling antagonist, is transcriptionally up-regulated via an ATF4-independent and MAPK/ERK-dependent pathway following amino acid deprivation

    Article • Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms, July 2011, Elsevier

    Associate Professor Yuan-Xiang Pan

  35. Gestational high fat diet programs hepatic phosphoenolpyruvate carboxykinase gene expression and histone modification in neonatal offspring rats

    Article • The Journal of Physiology, June 2011, Wiley

    Associate Professor Yuan-Xiang Pan

  36. Histone modifications, not DNA methylation, cause transcriptional repression of p16 (CDKN2A) in the mammary glands of offspring of protein-restricted rats

    Article • The Journal of Nutritional Biochemistry, June 2011, Elsevier

    Associate Professor Yuan-Xiang Pan

  37. A Maternal High-Fat Diet Represses the Expression of Antioxidant Defense Genes and Induces the Cellular Senescence Pathway in the Liver of Male Offspring Rats

    Article • Journal of Nutrition, May 2011, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  38. Maternal protein restriction during pregnancy induces CCAAT/enhancer-binding protein (C/EBPβ) expression through the regulation of histone modification at its promoter region in female offspring rat skeletal muscle

    Article • Epigenetics, February 2011, Taylor & Francis

    Associate Professor Yuan-Xiang Pan

  39. A Low-Protein Diet during Gestation in Rats Activates the Placental Mammalian Amino Acid Response Pathway and Programs the Growth Capacity of Offspring

    Article • Journal of Nutrition, October 2010, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  40. Gestational low protein diet in the rat mediatesIgf2gene expression in male offspring via altered hepatic DNA methylation

    Article • Epigenetics, October 2010, Taylor & Francis

    Associate Professor Yuan-Xiang Pan

  41. Mass spectrometric quantification of asparagine synthetase in circulating leukemia cells from acute lymphoblastic leukemia patients

    Article • Journal of Proteomics, April 2008, Elsevier

    Associate Professor Yuan-Xiang Pan

  42. Deprivation of protein or amino acid induces C/EBPβ synthesis and binding to amino acid response elements, but its action is not an absolute requirement for enhanced transcription

    Article • Biochemical Journal, March 2008, Portland Press Ltd.

    Associate Professor Yuan-Xiang Pan

  43. MEK Signaling Is Required for Phosphorylation of eIF2α following Amino Acid Limitation of HepG2 Human Hepatoma Cells

    Article • Journal of Biological Chemistry, February 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  44. Correlation between asparaginase sensitivity and asparagine synthetase protein content, but not mRNA, in acute lymphoblastic leukemia cell lines

    Article • Pediatric Blood & Cancer, February 2008, Wiley

    Associate Professor Yuan-Xiang Pan

  45. Activation of theATF3gene through a co-ordinated amino acid-sensing response programme that controls transcriptional regulation of responsive genes following amino acid limitation

    Article • Biochemical Journal, January 2007, Portland Press Ltd.

    Associate Professor Yuan-Xiang Pan

  46. An Inhibitor of Human Asparagine Synthetase Suppresses Proliferation of an L-Asparaginase-Resistant Leukemia Cell Line

    Article • Chemistry & Biology, December 2006, Elsevier

    Associate Professor Yuan-Xiang Pan

  47. Pharmacologic inhibition of epigenetic modifications, coupled with gene expression profiling, reveals novel targets of aberrant DNA methylation and histone deacetylation in lung cancer

    Article • Oncogene, October 2006, Springer Science + Business Media

    Associate Professor Yuan-Xiang Pan

  48. Characterization of the amino acid response element within the human sodium-coupled neutral amino acid transporter 2 (SNAT2) System A transporter gene

    Article • Biochemical Journal, May 2006, Portland Press Ltd.

    Associate Professor Yuan-Xiang Pan

  49. Amino-acid limitation induces transcription from the humanC/EBPβ gene via an enhancer activity located downstream of the protein coding sequence

    Article • Biochemical Journal, November 2005, Portland Press Ltd.

    Associate Professor Yuan-Xiang Pan

  50. NUTRITIONAL CONTROL OF GENE EXPRESSION: How Mammalian Cells Respond to Amino Acid Limitation

    Article • Annual Review of Nutrition, August 2005, Annual Reviews

    Associate Professor Yuan-Xiang Pan

  51. Interaction of RNA-binding Proteins HuR and AUF1 with the Human ATF3 mRNA 3′-Untranslated Region Regulates Its Amino Acid Limitation-induced Stabilization

    Article • Journal of Biological Chemistry, August 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  52. Developmental regulation of a turkey intestinal peptide transporter (PepT1)

    Article • Poultry Science, January 2005, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan

  53. Amino Acid Deprivation Induces the Transcription Rate of the Human Asparagine Synthetase Gene through a Timed Program of Expression and Promoter Binding of Nutrient-responsive Basic Region/Leucine Zipper Transcription Factors as Well as Localized Histo...

    Article • Journal of Biological Chemistry, September 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  54. Human CCAAT/Enhancer-binding Protein β Gene Expression Is Activated by Endoplasmic Reticulum Stress through an Unfolded Protein Response Element Downstream of the Protein Coding Sequence

    Article • Journal of Biological Chemistry, April 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  55. Induction of p21 and p27 expression by amino acid deprivation of HepG2 human hepatoma cells involves mRNA stabilization

    Article • Biochemical Journal, April 2004, Portland Press Ltd.

    Associate Professor Yuan-Xiang Pan

  56. Amino Acid Deprivation and Endoplasmic Reticulum Stress Induce Expression of Multiple Activating Transcription Factor-3 mRNA Species That, When Overexpressed in HepG2 Cells, Modulate Transcription by the Human Asparagine Synthetase Promoter

    Article • Journal of Biological Chemistry, July 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Associate Professor Yuan-Xiang Pan

  57. Poly(A)+ RNA from sheep omasal epithelium induces expression of a peptide transport protein(s) in Xenopus laevis oocytes.

    Article • Journal of Animal Science, January 1997, Oxford University Press (OUP)

    Associate Professor Yuan-Xiang Pan