All Stories

  1. The structural pathology for hypophosphatasia caused by malfunctional tissue non-specific alkaline phosphatase

    Article • Nature Communications, July 2023, Springer Science + Business Media

    Yu Cao

  2. Pregnane X receptor agonist nomilin extends lifespan and healthspan in preclinical models through detoxification functions

    Article • Nature Communications, June 2023, Springer Science + Business Media

    Yu Cao

  3. The structural basis of the pH-homeostasis mediated by the Cl−/HCO3− exchanger, AE2

    Article • Nature Communications, March 2023, Springer Science + Business Media

    Yu Cao

  4. Sphingomyelin synthases 1 and 2 exhibit phosphatidylcholine phospholipase C activity

    Article • Journal of Biological Chemistry, December 2021, Elsevier

    Yu Cao

  5. The structural basis for the phospholipid remodeling by lysophosphatidylcholine acyltransferase 3

    Article • Nature Communications, November 2021, Springer Science + Business Media

    Yu Cao

  6. Sphingomyelin synthase related protein is a mammalian phosphatidylethanolamine phospholipase C

    Article • Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, November 2021, Elsevier

    Yu Cao

  7. The structural basis for glycerol permeation by human AQP7

    Article • Science Bulletin, August 2021, Elsevier

    Yu Cao

  8. Structure-guided engineering of adenine base editor with minimized RNA off-targeting activity

    Article • Nature Communications, April 2021, Springer Science + Business Media

    Yu Cao

  9. The cryo-EM structure of an ERAD protein channel formed by tetrameric human Derlin-1

    Article • Science Advances, March 2021, American Association for the Advancement of Science

    Yu Cao

  10. The expression and purification of human steroid hormone processing enzyme CYP7B1 and the characterization of its interactive network

    Article • Chinese Science Bulletin (Chinese Version), March 2021, Science China Press., Co. Ltd.

    Yu Cao

  11. Expression, purification and characterization of TMCO1 for structural studies

    Article • Protein Expression and Purification, March 2021, Elsevier

    Yu Cao

  12. Redox-dependent and independent effects of thioredoxin interacting protein

    Article • Biological Chemistry, October 2020, De Gruyter

    Yu Cao

  13. Upgraded adenine base editor (uABE) with minimized RNA off-targeting activity

    Article • September 2020, Research Square

    Yu Cao

  14. Crystal structure of a bacterial homolog to human lysosomal transporter, spinster

    Article • Science Bulletin, September 2019, Elsevier

    Yu Cao

  15. A novel assay for measuring recombinant human lysophosphatidylcholine acyltransferase 3 activity

    Article • FEBS Open Bio, August 2019, Wiley

    Yu Cao

  16. Pregnancy and Live Birth In Women With Pathogenic LHCGR Variants Using Their Own Oocytes

    Article • The Journal of Clinical Endocrinology & Metabolism, August 2019, Endocrine Society

    Yu Cao

  17. Miniaturization of the Whole Process of Protein Crystallographic Analysis by a Microfluidic Droplet Robot: From Nanoliter-Scale Purified Proteins to Diffraction-Quality Crystals

    Article • Analytical Chemistry, July 2019, American Chemical Society (ACS)

    Yu Cao

  18. A Historical Perspective of G Protein-Coupled Receptor Structural Biology

    Article • January 2019, Springer Science + Business Media

    Yu Cao

  19. Dermal-Epidermal Separation by Heat

    Article • January 2019, Springer Science + Business Media

    Yu Cao

  20. Discovery of 4-Benzyloxybenzo[d]isoxazole-3-amine Derivatives as Highly Selective and Orally Efficacious Human Sphingomyelin Synthase 2 Inhibitors that Reduce Chronic Inflammation in db/db Mice

    Article • Journal of Medicinal Chemistry, August 2018, American Chemical Society (ACS)

    Yu Cao

  21. Membrane As the Barrier of Life

    Article • January 2018, Springer Science + Business Media

    Yu Cao

  22. The sphingomyelin synthase family: proteins, diseases, and inhibitors

    Article • Biological Chemistry, January 2017, De Gruyter

    Yu Cao

  23. The molecular transportation across intracellular membrane system

    Article • Chinese Science Bulletin (Chinese Version), August 2016, Science China Press., Co. Ltd.

    Yu Cao

  24. CRYPTOCHROME-mediated phototransduction by modulation of the potassium ion channel β-subunit redox sensor

    Article • Proceedings of the National Academy of Sciences, February 2015, Proceedings of the National Academy of Sciences

    Yu Cao

  25. Gating of the TrkH ion channel by its associated RCK protein TrkA

    Article • Nature, April 2013, Springer Science + Business Media

    Yu Cao

  26. Structure and permeation mechanism of a mammalian urea transporter

    Article • Proceedings of the National Academy of Sciences, June 2012, Proceedings of the National Academy of Sciences

    Yu Cao

  27. Crystal structure of a phosphorylation-coupled saccharide transporter

    Article • Nature, April 2011, Springer Science + Business Media

    Yu Cao

  28. Crystal structure of a potassium ion transporter, TrkH

    Article • Nature, February 2011, Springer Science + Business Media

    Yu Cao

  29. Cortisone dissociates the Shaker family K+ channels from their β subunits

    Article • Nature Chemical Biology, September 2008, Springer Science + Business Media

    Yu Cao

  30. Functional Coupling between the Kv1.1 Channel and Aldoketoreductase Kvβ1

    Article • Journal of Biological Chemistry, March 2008, Elsevier

    Yu Cao

  31. Analyzing and modeling the inhibitory effect of phosphatidic acid on the GTP-γ-S binding activity of Goα

    Article • Proteins Structure Function and Bioinformatics, January 2008, Wiley

    Yu Cao

  32. Modulation of Voltage-dependent Shaker Family Potassium Channels by an Aldo-Keto Reductase*

    Article • Journal of Biological Chemistry, June 2006, Elsevier

    Yu Cao

  33. Palmitoylation regulates GDP/GTP exchange of G protein by affecting the GTP-binding activity of Goα

    Article • The International Journal of Biochemistry & Cell Biology, March 2005, Elsevier

    Yu Cao