All Stories

  1. Oxidative HNO Formation Mechanisms from NH 2 OH via Two Different Heme Proteins and Effects from Hemes, Nearby Residues, and Protein Environments

    Article • ACS Omega, October 2025, American Chemical Society (ACS)

    Professor Yong Zhang

  2. Computational Mechanistic Investigation of Biocatalytic C(sp3)–H Insertions with Monosubstituted Carbenes via Engineered Heme Proteins

    Article • ACS Omega, July 2025, American Chemical Society (ACS)

    Professor Yong Zhang

  3. Oxidative and Hydrolytic HNO Formation from a Clinical Drug Hydroxyurea Catalyzed by Horseradish Peroxidase: Basic Mechanism, Active Site Effect, and Implications for Drug Design

    Article • JACS Au, June 2025, American Chemical Society (ACS)

    Professor Yong Zhang

  4. Alternative Metal with an Alternative Mechanism for Metalloporphyrin-Enabled NO Reduction to N2O: A Combined Computational and Experimental Investigation of NO Reduction by Cr Porphyrin with Lewis Acid

    Article • Inorganic Chemistry, March 2025, American Chemical Society (ACS)

    Professor Yong Zhang

  5. A comprehensive mechanistic investigation of sustainable carbene N–H insertion catalyzed by engineered His-ligated heme proteins

    Article • Catalysis Science & Technology, January 2025, Royal Society of Chemistry

    Professor Yong Zhang

  6. Heme-based catalysis for sustainable carbene transfer chemistry: computational mechanistic investigations

    Article • Chemical Communications, January 2025, Royal Society of Chemistry

    Professor Yong Zhang

  7. Mechanistic investigation of sustainable heme-inspired biocatalytic synthesis of cyclopropanes for challenging substrates

    Article • Communications Chemistry, November 2024, Springer Science + Business Media

    Professor Yong Zhang

  8. One‐Electron NO to N2O Pathways via Heme Models and Lewis Acid: Metal Effects and Differences from the Enzymatic Reaction

    Article • Chemistry - A European Journal, November 2024, Wiley

    Professor Yong Zhang

  9. Biocatalytic Carbenoid N-H Insertions Via Engineered Myoglobins: A Systematic Reaction Mechanism Study

    Article • ECS Meeting Abstracts, August 2024, The Electrochemical Society

    Professor Yong Zhang

  10. Stereodivergent Synthesis of Pyridyl Cyclopropanes via Enzymatic Activation of Pyridotriazoles

    Article • Journal of the American Chemical Society, July 2024, American Chemical Society (ACS)

    Professor Yong Zhang

  11. Reusable HNO Sensors Derived from Cu Cyclam: A DFT Study on the Mechanistic Origin of High Reactivity and Favorable Conformation Changes and Potential Improvements

    Article • Inorganic Chemistry, February 2024, American Chemical Society (ACS)

    Professor Yong Zhang

  12. Mechanistic manifold in a hemoprotein-catalyzed cyclopropanation reaction with diazoketone

    Article • Nature Communications, December 2023, Springer Science + Business Media

    Professor Yong Zhang

  13. Generation and Application of Homoallylic α,α‐Diboryl Radicals via Diboron‐Promoted Ring‐Opening of Vinyl Cyclopropanes: cis‐Diastereoselective Borylative Cycloaddition**

    Article • Chemistry - A European Journal, November 2023, Wiley

    Professor Yong Zhang

  14. Biocatalytic Intramolecular C-H Aminations Via Engineered Heme Proteins: Full Reaction Pathways and Axial Ligand Effects

    Article • ECS Meeting Abstracts, August 2023, The Electrochemical Society

    Professor Yong Zhang

  15. Computational Mechanistic Investigations of Biocatalytic Nitrenoid C−H Functionalizations via Engineered Heme Proteins

    Article • ChemBioChem, July 2023, Wiley

    Professor Yong Zhang

  16. Liposome‐Templated Green Synthesis of Mesoporous Metal Nanostructures with Universal Composition for Biomedical Application

    Article • Small, July 2023, Wiley

    Professor Yong Zhang

  17. Mechanistic Manifold in a Hemoprotein-Catalyzed Cyclopropanation Reaction with Diazoketone

    Article • December 2022, Research Square

    Professor Yong Zhang

  18. Mechanistic Origin of Favorable Substituent Effects in Excellent Cu Cyclam Based HNO Sensors

    Article • Angewandte Chemie, September 2022, Wiley

    Professor Yong Zhang

  19. Mechanistic Origin of Favorable Substituent Effects in Excellent Cu Cyclam Based HNO Sensors

    Article • Angewandte Chemie, September 2022, Wiley

    Professor Yong Zhang

  20. Biocatalytic Intramolecular C−H aminations via Engineered Heme Proteins: Full Reaction Pathways and Axial Ligand Effects

    Article • Chemistry - A European Journal, August 2022, Wiley

    Professor Yong Zhang

  21. Insights into the Observed trans-Bond Length Variations upon NO Binding to Ferric and Ferrous Porphyrins with Neutral Axial Ligands

    Article • ACS Omega, September 2021, American Chemical Society (ACS)

    Professor Yong Zhang

  22. Synergistic NO Coupling By Heme and Lewis Acid

    Article • ECS Meeting Abstracts, May 2021, The Electrochemical Society

    Professor Yong Zhang

  23. HNO to NO Conversion Mechanism with Copper Zinc Superoxide Dismutase, Comparison with Heme Protein Mediated Conversions, and the Origin of Questionable Reversibility

    Article • Chemistry - A European Journal, February 2021, Wiley

    Professor Yong Zhang

  24. Insight into the preferential N-binding versus O-binding of nitrosoarenes to ferrous and ferric heme centers

    Article • Dalton Transactions, January 2021, Royal Society of Chemistry

    Professor Yong Zhang

  25. Stepwise nitrosylation of the nonheme iron site in an engineered azurin and a molecular basis for nitric oxide signaling mediated by nonheme iron proteins

    Article • Chemical Science, January 2021, Royal Society of Chemistry

    Professor Yong Zhang

  26. The oxygen reactivity of an artificial hydrogenase designed in a reengineered copper storage protein

    Article • Dalton Transactions, January 2020, Royal Society of Chemistry

    Professor Yong Zhang

  27. Not Limited to Iron: A Cobalt Heme-NO Model Facilitates N-N Coupling with External NO in the Presence of a Lewis Acid to Generate N2 O

    Article • Angewandte Chemie, October 2019, Wiley

    Professor Yong Zhang

  28. Not Limited to Iron: A Cobalt Heme–NO Model Facilitates N–N Coupling with External NO in the Presence of a Lewis Acid to Generate N 2 O

    Article • Angewandte Chemie, October 2019, Wiley

    Professor Yong Zhang

  29. Frontispiece: Computational Investigations of Heme Carbenes and Heme Carbene Transfer Reactions

    Article • Chemistry - A European Journal, October 2019, Wiley

    Professor Yong Zhang

  30. Computational Investigations of Heme Carbenes and Heme Carbene Transfer Reactions

    Article • Chemistry - A European Journal, August 2019, Wiley

    Professor Yong Zhang

  31. Biocatalytic Strategy for Highly Diastereo‐ and Enantioselective Synthesis of 2,3‐Dihydrobenzofuran‐Based Tricyclic Scaffolds

    Article • Angewandte Chemie, June 2019, Wiley

    Professor Yong Zhang

  32. Biocatalytic Strategy for Highly Diastereo- and Enantioselective Synthesis of 2,3-Dihydrobenzofuran-Based Tricyclic Scaffolds

    Article • Angewandte Chemie, June 2019, Wiley

    Professor Yong Zhang

  33. Mechanistic Investigation of Biocatalytic Heme Carbenoid Si−H Insertions

    Article • ChemCatChem, June 2019, Wiley

    Professor Yong Zhang

  34. Redesign of a Copper Storage Protein into an Artificial Hydrogenase

    Article • ACS Catalysis, May 2019, American Chemical Society (ACS)

    Professor Yong Zhang

  35. Synthesis, Characterization, and Theoretical Investigation of a Transition State Analogue for Proton Transfer during C–H Activation by a Rhodium-Pincer Complex

    Article • Organometallics, March 2019, American Chemical Society (ACS)

    Professor Yong Zhang

  36. Origin of High Stereocontrol in Olefin Cyclopropanation Catalyzed by an Engineered Carbene Transferase

    Article • ACS Catalysis, December 2018, American Chemical Society (ACS)

    Professor Yong Zhang

  37. Mechanisms of HNO Reactions with Ferric Heme Proteins

    Article • Angewandte Chemie, November 2018, Wiley

    Professor Yong Zhang

  38. Mechanisms of HNO Reactions with Ferric Heme Proteins

    Article • Angewandte Chemie, November 2018, Wiley

    Professor Yong Zhang

  39. Nitrosyl Myoglobins and Their Nitrite Precursors: Crystal Structural and Quantum Mechanics and Molecular Mechanics Theoretical Investigations of Preferred Fe–NO Ligand Orientations in Myoglobin Distal Pockets

    Article • Biochemistry, July 2018, American Chemical Society (ACS)

    Professor Yong Zhang

  40. Periodic Trends Manifested through Gas-Phase Generation of Anions Such as [AlH4]−, [GaH4]−, [InH4]−, [SrH3]−, [BaH3]−, [Ba(0)(η2-O2CH)1]−, [Pb(0)H]−, [Bi(I)H2]−, and Bi– from Formates

    Article • ACS Omega, March 2018, American Chemical Society (ACS)

    Professor Yong Zhang

  41. Lewis Acid Activation of the Ferrous Heme–NO Fragment toward the N–N Coupling Reaction with NO To Generate N2O

    Article • Journal of the American Chemical Society, March 2018, American Chemical Society (ACS)

    Professor Yong Zhang

  42. Cyclopropanations via Heme Carbenes: Basic Mechanism and Effects of Carbene Substituent, Protein Axial Ligand, and Porphyrin Substitution

    Article • Journal of the American Chemical Society, December 2017, American Chemical Society (ACS)

    Professor Yong Zhang

  43. Frontispiece: C−H Insertions by Iron Porphyrin Carbene: Basic Mechanism and Origin of Substrate Selectivity

    Article • Chemistry - A European Journal, December 2017, Wiley

    Professor Yong Zhang

  44. C−H Insertions by Iron Porphyrin Carbene: Basic Mechanism and Origin of Substrate Selectivity

    Article • Chemistry - A European Journal, November 2017, Wiley

    Professor Yong Zhang

  45. Manganese and Cobalt in the Nonheme-Metal-Binding Site of a Biosynthetic Model of Heme-Copper Oxidase Superfamily Confer Oxidase Activity through Redox-Inactive Mechanism

    Article • Journal of the American Chemical Society, August 2017, American Chemical Society (ACS)

    Professor Yong Zhang

  46. Why copper is preferred over iron for oxygen activation and reduction in haem-copper oxidases

    Article • Nature Chemistry, November 2016, Springer Science + Business Media

    Professor Yong Zhang

  47. HNO-Binding in Heme Proteins: Effects of Iron Oxidation State, Axial Ligand, and Protein Environment

    Article • Angewandte Chemie, October 2016, Wiley

    Professor Yong Zhang

  48. HNO-Binding in Heme Proteins: Effects of Iron Oxidation State, Axial Ligand, and Protein Environment

    Article • Angewandte Chemie, October 2016, Wiley

    Professor Yong Zhang

  49. Competitive homolytic and heterolytic decomposition pathways of gas-phase negative ions generated from aminobenzoate esters

    Article • Journal of Mass Spectrometry, March 2016, Wiley

    Professor Yong Zhang

  50. Hydride Attack on a Coordinated Ferric Nitrosyl: Experimental and DFT Evidence for the Formation of a Heme Model–HNO Derivative

    Article • Journal of the American Chemical Society, December 2015, American Chemical Society (ACS)

    Professor Yong Zhang

  51. Ambulation of Incipient Proton during Gas-Phase Dissociation of Protonated Alkyl Dihydrocinnamates

    Article • The Journal of Organic Chemistry, September 2015, American Chemical Society (ACS)

    Professor Yong Zhang

  52. Toward Relatively General and Accurate Quantum Chemical Predictions of Solid-State 17O NMR Chemical Shifts in Various Biologically Relevant Oxygen-Containing Compounds

    Article • The Journal of Physical Chemistry, August 2015, American Chemical Society (ACS)

    Professor Yong Zhang

  53. Catalytic and Biocatalytic Iron Porphyrin Carbene Formation: Effects of Binding Mode, Carbene Substituent, Porphyrin Substituent, and Protein Axial Ligand

    Article • Journal of the American Chemical Society, June 2015, American Chemical Society (ACS)

    Professor Yong Zhang

  54. 77Se Chemical Shift Tensor of l-Selenocystine: Experimental NMR Measurements and Quantum Chemical Investigations of Structural Effects

    Article • The Journal of Physical Chemistry, February 2015, American Chemical Society (ACS)

    Professor Yong Zhang

  55. Solid-State17O NMR Spectroscopy of Paramagnetic Coordination Compounds

    Article • Angewandte Chemie, February 2015, Wiley

    Professor Yong Zhang

  56. The fluorescence regulation mechanism of the paramagnetic metal in a biological HNO sensor

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    xuebo chen, Professor Yong Zhang

  57. A Distonic Radical-Ion for Detection of Traces of Adventitious Molecular Oxygen (O2) in Collision Gases Used in Tandem Mass Spectrometers

    Article • Journal of the American Society for Mass Spectrometry, July 2014, Springer Science + Business Media

    Professor Yong Zhang

  58. Selectivity of gas-phase ion/molecule reaction of carbon dioxide with phenide ions

    Article • Journal of Mass Spectrometry, July 2014, Wiley

    Professor Yong Zhang

  59. Exploring Bis(cyclometalated) Ruthenium(II) Complexes as Active Catalyst Precursors: Room-Temperature Alkene-Alkyne Coupling for 1,3-Diene Synthesis

    Article • Angewandte Chemie, June 2014, Wiley

    Professor Yong Zhang

  60. Iron Porphyrin Carbenes as Catalytic Intermediates: Structures, Mössbauer and NMR Spectroscopic Properties, and Bonding

    Article • Angewandte Chemie, June 2014, Wiley

    Professor Yong Zhang

  61. Insights into the Binding of Pyridines to the Iron–Sulfur Enzyme IspH

    Article • Journal of the American Chemical Society, May 2014, American Chemical Society (ACS)

    Professor Yong Zhang

  62. HNO/NO Conversion Mechanisms of Cu-Based HNO Probes with Implications for Cu,Zn-SOD

    Article • The Journal of Physical Chemistry Letters, March 2014, American Chemical Society (ACS)

    Professor Yong Zhang

  63. Spectroscopic and Computational Study of a Nonheme Iron Nitrosyl Center in a Biosynthetic Model of Nitric Oxide Reductase

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Yong Zhang

  64. Direct Detection of Solid Inorganic Mercury Salts at Ambient Pressure by Electron-Capture and Reaction-Assisted HePI Mass Spectrometry

    Article • Journal of the American Society for Mass Spectrometry, October 2013, Springer Science + Business Media

    Professor Yong Zhang

  65. Isoprenoid Biosynthesis: Ferraoxetane or Allyl Anion Mechanism for IspH Catalysis?

    Article • Angewandte Chemie, May 2013, Wiley

    Professor Yong Zhang

  66. Photo-induced isomerization of ethylene-bridged azobenzene explored by ab initio based non-adiabatic dynamics simulation: A comparative investigation of the isomerization in the gas and solution phases

    Article • The Journal of Chemical Physics, April 2013, American Institute of Physics

    Professor Yong Zhang

  67. Computational investigations of HNO in biology

    Article • Journal of Inorganic Biochemistry, January 2013, Elsevier

    Professor Yong Zhang

  68. Iron Binding Site in a Global Regulator in Bacteria–Ferric Uptake Regulator (Fur) Protein: Structure, Mössbauer Properties, and Functional Implication

    Article • The Journal of Physical Chemistry Letters, November 2012, American Chemical Society (ACS)

    Professor Yong Zhang

  69. Structure, function and inhibition of the two- and three-domain 4Fe-4S IspG proteins

    Article • Proceedings of the National Academy of Sciences, May 2012, Proceedings of the National Academy of Sciences

    Professor Yong Zhang

  70. Differential SERS Activity of Gold and Silver Nanostructures Enabled by Adsorbed Poly(vinylpyrrolidone)

    Article • Langmuir, January 2012, American Chemical Society (ACS)

    Professor Yong Zhang

  71. Metal centre effects on HNO binding in porphyrins and the electronic origin: metal's electronic configuration, position in the periodic table, and oxidation state

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Yong Zhang

  72. Design, Synthesis, and X-ray Crystallographic Analysis of a Novel Class of HIV-1 Protease Inhibitors

    Article • Journal of Medicinal Chemistry, October 2011, American Chemical Society (ACS)

    Professor Yong Zhang

  73. Probing Highly Efficient Photoisomerization of a Bridged Azobenzene by a Combination of CASPT2//CASSCF Calculation with Semiclassical Dynamics Simulation

    Article • The Journal of Physical Chemistry A, September 2011, American Chemical Society (ACS)

    Professor Yong Zhang

  74. HNO Binding in a Heme Protein: Structures, Spectroscopic Properties, and Stabilities

    Article • Journal of the American Chemical Society, September 2011, American Chemical Society (ACS)

    Professor Yong Zhang

  75. Enzyme Reactivation by Hydrogen Peroxide in Heme-based Tryptophan Dioxygenase

    Article • Journal of Biological Chemistry, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yong Zhang

  76. Metallic nitride azafullerenes: A novel class of fullerenes with interesting electronic properties

    Article • Chemical Physics Letters, May 2011, Elsevier

    Professor Yong Zhang

  77. Structural, EPR Superhyperfine, and NMR Hyperfine Properties of the Cu−Octarepeat Binding Site in the Prion Protein

    Article • The Journal of Physical Chemistry, March 2011, American Chemical Society (ACS)

    Professor Yong Zhang

  78. Conformational and configurational analysis of an N,N carbonyl dipyrrinone-derived oximate and nitrone by NMR and quantum chemical calculations

    Article • Magnetic Resonance in Chemistry, March 2011, Wiley

    Professor Yong Zhang