All Stories

  1. Distinct gut microbiota and health outcomes in asymptomatic infection, viral nucleic acid test re‐positive, and convalescent COVID‐19 cases

    Article • mLife, June 2022, Tsinghua University Press

    Professor Yiqun Deng, jikai wen

  2. EGR1 is essential for deoxynivalenol-induced G2/M cell cycle arrest in HepG2 cells via the ATF3ΔZip2a/2b-EGR1-p21 pathway

    Article • Toxicology Letters, December 2018, Elsevier

    Professor Yiqun Deng

  3. JNK-AKT-NF-κB controls P-glycoprotein expression to attenuate the cytotoxicity of deoxynivalenol in mammalian cells

    Article • Biochemical Pharmacology, October 2018, Elsevier

    Professor Yiqun Deng

  4. The critical role of porcine cytochrome P450 3A46 in the bioactivation of aflatoxin B1

    Article • Biochemical Pharmacology, October 2018, Elsevier

    Professor Yiqun Deng

  5. Subchronic reproductive effects of 6:2 chlorinated polyfluorinated ether sulfonate (6:2 Cl-PFAES), an alternative to PFOS, on adult male mice

    Article • Journal of Hazardous Materials, September 2018, Elsevier

    Professor Yiqun Deng

  6. Sp1, Instead of AhR, Regulates the Basal Transcription of Porcine CYP1A1 at the Proximal Promoter

    Article • Frontiers in Pharmacology, August 2018, Frontiers

    Professor Yiqun Deng

  7. C9orf140, a novel Axin1-interacting protein, mediates the negative feedback loop of Wnt/β-catenin signaling

    Article • Oncogene, March 2018, Springer Science + Business Media

    Professor Yiqun Deng

  8. Detoxification of trichothecene mycotoxins by a novel bacterium, Eggerthella sp. DII-9

    Article • Food and Chemical Toxicology, February 2018, Elsevier

    Professor Yiqun Deng

  9. miR449a/SIRT1/PGC-1α Is Necessary for Mitochondrial Biogenesis Induced by T-2 Toxin

    Article • Frontiers in Pharmacology, January 2018, Frontiers

    Professor Yiqun Deng

  10. Carrier-Mediated and Energy-Dependent Uptake and Efflux of Deoxynivalenol in Mammalian Cells

    Article • Scientific Reports, July 2017, Nature

    Professor Yiqun Deng

  11. T-2 toxin induces the expression of porcine CYP3A22 via the upregulation of the transcription factor, NF-Y

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, October 2016, Elsevier

    Professor Yiqun Deng

  12. Bioactivation and Regioselectivity of Pig Cytochrome P450 3A29 towards Aflatoxin B1

    Article • Toxins, September 2016, MDPI AG

    Professor Yiqun Deng

  13. TRAIP regulates replication fork recovery and progression via PCNA

    Article • Cell Discovery, June 2016, Nature

    Professor Yiqun Deng

  14. Mycotoxins: cytotoxicity and biotransformation in animal cells

    Article • Toxicology Research, January 2016, Oxford University Press (OUP)

    Professor Yiqun Deng

  15. Role of Specificity Protein 1, Hepatocyte Nuclear Factor 1α, and Pregnane X Receptor in the Basal and Rifampicin-Induced Transcriptional Regulation of Porcine Cytochrome P450 3A46

    Article • Drug Metabolism and Disposition, July 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Yiqun Deng

  16. Transcriptional regulation of chicken cytochrome P450 2D49 basal expression by CCAAT/enhancer‐binding protein α and hepatocyte nuclear factor 4α

    Article • FEBS Journal, January 2014, Wiley

    Professor Yiqun Deng

  17. N-Oxide Reduction of Quinoxaline-1,4-Dioxides Catalyzed by Porcine Aldehyde Oxidase SsAOX1

    Article • Drug Metabolism and Disposition, January 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Yiqun Deng

  18. Trp266 determines the binding specificity of a porcine aflatoxin B1 aldehyde reductase for aflatoxin B1-dialdehyde

    Article • Biochemical Pharmacology, November 2013, Elsevier

    Professor Yiqun Deng

  19. Proteomic changes in chicken primary hepatocytes exposed to T-2 toxin are associated with oxidative stress and mitochondrial enhancement

    Article • PROTEOMICS, October 2013, Wiley

    Professor Yiqun Deng

  20. The ubiquitin specific protease USP34 promotes ubiquitin signaling at DNA double-strand breaks

    Article • Nucleic Acids Research, July 2013, Oxford University Press (OUP)

    Professor Yiqun Deng

  21. Chicken Cytochrome P450 1A5 Is the Key Enzyme for Metabolizing T-2 Toxin to 3'OH-T-2

    Article • International Journal of Molecular Sciences, May 2013, MDPI AG

    Professor Yiqun Deng

  22. Ring Finger Protein RNF169 Antagonizes the Ubiquitin-dependent Signaling Cascade at Sites of DNA Damage

    Article • Journal of Biological Chemistry, June 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yiqun Deng

  23. Functional Characterization of a First Avian Cytochrome P450 of the CYP2D Subfamily (CYP2D49)

    Article • PLoS ONE, June 2012, PLOS

    Professor Yiqun Deng

  24. Carbonyl Reduction of Mequindox by Chicken and Porcine Cytosol and Cloned Carbonyl Reductase 1

    Article • Drug Metabolism and Disposition, January 2012, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Professor Yiqun Deng

  25. Mequindox induced cellular DNA damage via generation of reactive oxygen species

    Article • Mutation Research/Genetic Toxicology and Environmental Mutagenesis, January 2012, Elsevier

    Professor Yiqun Deng

  26. The mechanism of enzymatic and non-enzymatic N-oxide reductive metabolism of cyadox in pig liver

    Article • Xenobiotica, July 2011, Taylor & Francis

    Professor Yiqun Deng

  27. Integrated Transcriptional and Proteomic Analysis withIn VitroBiochemical Assay Reveal the Important Role of CYP3A46 in T-2 Toxin Hydroxylation in Porcine Primary Hepatocytes

    Article • Molecular & Cellular Proteomics, June 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yiqun Deng

  28. Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

    Article • Journal of Biological Chemistry, May 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yiqun Deng

  29. Glu659Leu substitution of recombinant HIV fusion inhibitor C52L induces soluble expression in Escherichia coli with equivalent anti-HIV potency

    Article • Protein Engineering Design and Selection, April 2011, Oxford University Press (OUP)

    Professor Yiqun Deng

  30. CYP3As catalyze nifedipine oxidation in pig liver microsomes: Enzyme kinetics, inhibition and functional expression

    Article • Catalysis Communications, March 2011, Elsevier

    Professor Yiqun Deng

  31. Catalytic characteristics of CYP3A22-dependent mequindox detoxification

    Article • Catalysis Communications, March 2011, Elsevier

    Professor Yiqun Deng

  32. The catalytic activity of cytochrome P450 3A22 is critical for the metabolism of T-2 toxin in porcine reservoirs

    Article • Catalysis Communications, November 2010, Elsevier

    Professor Yiqun Deng

  33. Role of a Putative gp41 Dimerization Domain in Human Immunodeficiency Virus Type 1 Membrane Fusion

    Article • Journal of Virology, October 2009, ASM Journals

    Professor Yiqun Deng

  34. Detailed Mechanistic Insights into HIV-1 Sensitivity to Three Generations of Fusion Inhibitors

    Article • Journal of Biological Chemistry, July 2009, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Yiqun Deng, Dr. Alexandre M.J.J. Bonvin

  35. Structure of the HIV-1 gp41 Membrane-Proximal Ectodomain Region in a Putative Prefusion Conformation†,‡

    Article • Biochemistry, April 2009, American Chemical Society (ACS)

    Professor Yiqun Deng

  36. A Heterospecific Leucine Zipper Tetramer

    Article • Chemistry & Biology, September 2008, Elsevier

    Professor Yiqun Deng

  37. Selection of T1249-Resistant Human Immunodeficiency Virus Type 1 Variants

    Article • Journal of Virology, April 2008, ASM Journals

    Professor Yiqun Deng

  38. Conformational Specificity of theLacRepressor Coiled-Coil Tetramerization Domain†,‡

    Article • Biochemistry, December 2007, American Chemical Society (ACS)

    Professor Yiqun Deng

  39. Molecular Determinants of Antiviral Potency of Paramyxovirus Entry Inhibitors

    Article • Journal of Virology, July 2007, ASM Journals

    Professor Yiqun Deng

  40. Protein Design of a Bacterially Expressed HIV-1 gp41 Fusion Inhibitor†

    Article • Biochemistry, April 2007, American Chemical Society (ACS)

    Professor Yiqun Deng

  41. Self-assembly of coiled-coil tetramers in the 1.40 A structure of a leucine-zipper mutant

    Article • Protein Science, December 2006, Wiley

    Professor Yiqun Deng

  42. A Parallel Coiled-Coil Tetramer with Offset Helices†,‡

    Article • Biochemistry, December 2006, American Chemical Society (ACS)

    Professor Yiqun Deng

  43. Core Structure of S2 from the Human Coronavirus NL63 Spike Glycoprotein†,‡

    Article • Biochemistry, December 2006, American Chemical Society (ACS)

    Professor Yiqun Deng

  44. A seven-helix coiled coil

    Article • Proceedings of the National Academy of Sciences, October 2006, Proceedings of the National Academy of Sciences

    Professor Yiqun Deng

  45. Conformational Transition between Four and Five-stranded Phenylalanine Zippers Determined by a Local Packing Interaction

    Article • Journal of Molecular Biology, August 2006, Elsevier

    Professor Yiqun Deng

  46. Structures and Polymorphic Interactions of Two Heptad-Repeat Regions of the SARS Virus S2 Protein

    Article • Structure, May 2006, Elsevier

    Professor Yiqun Deng

  47. Antiparallel Four-Stranded Coiled Coil Specified by a 3-3-1 Hydrophobic Heptad Repeat

    Article • Structure, February 2006, Elsevier

    Professor Yiqun Deng

  48. Topology characterization of a benzodiazepine-binding β-rich domain of the GABAAreceptor α1subunit

    Article • Protein Science, October 2005, Wiley

    Professor Yiqun Deng

  49. Emergence of a Drug-Dependent Human Immunodeficiency Virus Type 1 Variant during Therapy with the T20 Fusion Inhibitor

    Article • Journal of Virology, November 2004, ASM Journals

    Professor Yiqun Deng

  50. Atomic structure of a tryptophan-zipper pentamer

    Article • Proceedings of the National Academy of Sciences, November 2004, Proceedings of the National Academy of Sciences

    Professor Yiqun Deng

  51. Structure and Protein Design of a Human Platelet Function Inhibitor

    Article • Cell, March 2004, Elsevier

    Professor Yiqun Deng