All Stories

  1. A Phase 2, Prospective, Multicenter, Single-Arm Trial of Transarterial Chemoembolization Therapy in Combination Strategy with Lenvatinib in Patients with Unresectable Intermediate-Stage Hepatocellular Carcinoma: TACTICS-L Trial
  2. Therapeutic Modifications without Discontinuation of Atezolizumab Plus Bevacizumab Therapy Are Associated with Favorable Overall Survival and Time to Progression in Patients with Unresectable Hepatocellular Carcinoma
  3. Safety and Effectiveness of Lenvatinib in Patients with Unresectable Hepatocellular Carcinoma in Real-World Clinical Practice: An Observational Post-Marketing Study in Japan
  4. DEB-TACE combined with hepatic artery infusion chemotherapy might be an affordable treatment option for advanced stage of HCC
  5. Clinical practice guidelines for autoimmune hepatitis
  6. Long-Term Efficacy and Safety of Rifaximin in Japanese Patients with Hepatic Encephalopathy: A Multicenter Retrospective Study
  7. Anti-nuclear antibody and a granuloma could be biomarkers for iCIs-related hepatitis by anti-PD-1 treatment
  8. DEB-TACE Combined With Hepatic Artery Infusion Chemotherapy Might Be an Affordable Treatment Option for Advanced Stage of HCC: Retrospective Study
  9. Transcriptomics Identify Thrombospondin‐2 as a Biomarker for NASH and Advanced Liver Fibrosis
  10. Identification of microRNA‐96‐5p as a postoperative, prognostic microRNA predictor in nonviral hepatocellular carcinoma
  11. Proposal of Stroop test cut‐off values as screening for neuropsychological impairments in cirrhosis: a Japanese multicenter study
  12. Establishing Efficient Systems through Electronic Medical Records to Promote Intra-hospital Referrals of Hepatitis Virus Carriers to Hepatology Specialists: A Multicenter Questionnaire-based Survey of 1,281 Healthcare Professionals
  13. Immune Checkpoint Inhibitor Can Reduce HCV-RNA without Liver Damage
  14. Pilot study of tenofovir disoproxil fumarate and pegylated interferon-alpha 2a add-on therapy in Japanese patients with chronic hepatitis B
  15. Hepatitis C virus infection suppresses hepatitis B virus replication via the RIG-I-like helicase pathway
  16. The reduction of miR146b-5p in monocytes and T cells could contribute to the immunopathogenesis of hepatitis C virus infection
  17. Hepatitis C Virus infection could affect the pathogenesis of ischemic heart diseases in northern part of Japan
  18. Selective insulin resistance with differential expressions of IRS-1 and IRS-2 in human NAFLD livers
  19. Complete Atrioventricular Block Associated with Pembrolizumab-induced Acute Myocarditis: The Need for Close Cardiac Monitoring
  20. Baseline quasispecies selection and novel mutations contribute to emerging resistance-associated substitutions in hepatitis C virus after direct-acting antiviral treatment
  21. Hepatitis C virus has a genetically determined lymphotropism through co-receptor B7.2
  22. Activation of the Hypoxia Inducible Factor 1 Alpha Subunit Pathway in Steatotic Liver Contributes to Formation of Cholesterol Gallstones
  23. Hepatitis C infected patients need vitamin D3 supplementation in the era of direct acting antivirals treatment
  24. PD-L1+MDSCs are increased in HCC patients and induced by soluble factor in the tumor microenvironment
  25. Global, cancer-specific microRNA cluster hypomethylation was functionally associated with the development of non-B non-C hepatocellular carcinoma
  26. The expression of miR-125b-5p is increased in the serum of patients with chronic hepatitis B infection and inhibits the detection of hepatitis B virus surface antigen
  27. Reactivation of resolved hepatitis B virus infection with immune escape mutations after long-term corticosteroid therapy
  28. Shifting hepatitis B virus genotypes of acute hepatitis B patients in northeast Japan
  29. Differential Expression of CX3CL1 in Hepatitis B Virus-Replicating Hepatoma Cells Can Affect the Migration Activity of CX3CR1+Immune Cells
  30. Significant biomarkers for the management of hepatocellular carcinoma
  31. Significant Roles of Regulatory T Cells and Myeloid Derived Suppressor Cells in Hepatitis B Virus Persistent Infection and Hepatitis B Virus-Related HCCs
  32. Radiation therapy has been shown to be adaptable for various stages of hepatocellular carcinoma
  33. Monitoring Serum Levels of Sorafenib and Its N-Oxide Is Essential for Long-Term Sorafenib Treatment of Patients with Hepatocellular Carcinoma
  34. Radiation Therapy Is a Reasonable Option for Improving the Prognosis in Hepatocellular Carcinoma
  35. HCV Infection Enhances Th17 Commitment, Which Could Affect the Pathogenesis of Autoimmune Diseases
  36. Expression of EpCAM Increases in the Hepatitis B Related and the Treatment-Resistant Hepatocellular Carcinoma
  37. A Quantitative HPLC-UV Method for Determination of Serum Sorafenib and Sorafenib N-Oxide and Its Application in Hepatocarcinoma Patients
  38. Endoscopically proven case of rapid esophagogastric variceal progression and rupture as a result of portal hypertension with liver sarcoidosis
  39. Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis
  40. Plasma amino acids imbalance in cirrhotic patients disturbs the tricarboxylic acid cycle of dendritic cell
  41. Involvement of miRNA-29a in epigenetic regulation of transforming growth factor-β-induced epithelial-mesenchymal transition in hepatocellular carcinoma
  42. Sequential analysis of amino acid substitutions with hepatitis B virus in association with nucleoside/nucleotide analog treatment detected by deep sequencing
  43. Three cases of adult-onset type II citrullinemia treated with different therapies: Efficacy of sodium pyruvate and low-carbohydrate diet
  44. Distinct MicroRNAs Expression Profile in Primary Biliary Cirrhosis and Evaluation of miR 505-3p and miR197-3p as Novel Biomarkers
  45. 1(OH) Vitamin D3 Supplementation Improves the Sensitivity of the Immune-Response during Peg-IFN/RBV Therapy in Chronic Hepatitis C Patients-Case Controlled Trial
  46. Eradication of hepatitis C virus could improve immunological status and pyoderma gangrenosum-like lesions
  47. Direct effects of hepatitis C virus on the lymphoid cells
  48. Supplementation of Branched-Chain Amino Acids Maintains the Serum Albumin Level in the Course of Hepatocellular Carcinoma Recurrence
  49. PPARs and Liver Disease
  50. Hepatitis B Surface Antigen Could Contribute to the Immunopathogenesis of Hepatitis B Virus Infection
  51. A case of sarcoidosis liver caused rupture of esophageal varices due to sudden portal hypertension
  52. Double Filtration Plasmapheresis Could Induce a Favorable Immune Response for Chronic Hepatitis C Therapy
  53. Association between S21 substitution in the core protein of hepatitis B virus and fulminant hepatitis
  54. The influence of pioglitazone on the plasma amino acid profile in patients with nonalcoholic steatohepatitis (NASH)
  55. Sequential immunological analysis of HBV/HCV co-infected patients during Peg-IFN/RBV therapy
  56. Regulation of hepatitis C virus secretion by the Hrs-dependent exosomal pathway
  57. The Relationship between Renal Dysfunction and Abnormalities of the Immune System in Patients with Decompensated Cirrhosis
  58. PPAR Could Contribute to the Pathogenesis of Hepatocellular Carcinoma
  59. Biological Significance of HCV in Various Kinds of Lymphoid Cells
  60. Use of Illumina Deep Sequencing Technology To Differentiate Hepatitis C Virus Variants
  61. Rapid reduction of hepatitis C virus-Core protein in the peripheral blood improve the immunological response in chronic hepatitis C patients
  62. Enhanced Replication of Hepatitis B Virus With Frameshift in the Precore Region Found in Fulminant Hepatitis Patients
  63. Plasma L-Cystine/L-Glutamate Imbalance Increases Tumor Necrosis Factor-Alpha from CD14+ Circulating Monocytes in Patients with Advanced Cirrhosis
  64. Four-year study of lamivudine and adefovir combination therapy in lamivudine-resistant hepatitis B patients: influence of hepatitis B virus genotype and resistance mutation pattern
  65. Toll-Like Receptors Signaling Contributes to Immunopathogenesis of HBV Infection
  66. The Nutritional Index ‘CONUT’ Is Useful for Predicting Long-Term Prognosis of Patients with End-Stage Liver Diseases
  67. Dysfunction of Immune Systems and Host Genetic Factors in Hepatitis C Virus Infection with Persistent Normal ALT
  68. Lymphotropic HCV strain can infect human primary naïve CD4+ cells and affect their proliferation and IFN-γ secretion activity
  69. Characterization of the epithelial cell adhesion molecule (EpCAM)+ cell population in hepatocellular carcinoma cell lines
  70. Possible involvement and the mechanisms of excess trans-fatty acid consumption in severe NAFLD in mice
  71. Exosome secretion of dendritic cells is regulated by Hrs, an ESCRT-0 protein
  72. Hepatitis B Virus Replication Could Enhance Regulatory T Cell Activity by Producing Soluble Heat Shock Protein 60 From Hepatocytes
  73. Inhibitory effect on hepatitis B virus in vitro by a peroxisome proliferator-activated receptor-γ ligand, rosiglitazone
  74. Enhanced intracellular retention of a hepatitis B virus strain associated with fulminant hepatitis
  75. Branched chain amino acids enhance the maturation and function of myeloid dendritic cells ex vivo in patients with advanced cirrhosis
  76. A novel third generation bisphosphonate, minodronate (YM529), prevented proliferation and migration of hepatocellular carcinoma cells through inhibition of mevalonate pathway
  77. Immunopathogenesis of hepatitis B persistent infection: implications for immunotherapeutic strategies
  78. Sporadic acute hepatitis E occurred constantly during the last decade in northeast Japan
  79. Hepatitis C Virus Infection of T Cells Inhibits Proliferation and Enhances Fas-Mediated Apoptosis by Down-Regulating the Expression of CD44 Splicing Variant 6
  80. Transient elastography for measurement of liver stiffness measurement can detect early significant hepatic fibrosis in Japanese patients with viral and nonviral liver diseases
  81. A case of HIV co-infected with hepatitis B virus precorecore deletion mutant treated by entecavir
  82. Hepatitis C Virus (HCV)-Induced Immunoglobulin Hypermutation Reduces the Affinity and Neutralizing Activities of Antibodies against HCV Envelope Protein
  83. Pegylated interferon plus ribavirin for genotype Ib chronic hepatitis C in Japan
  84. Hepatitis C virus infects T cells and affects interferon-γ signaling in T cell lines
  85. Dynamics of immature subsets of dendritic cells during antiviral therapy in HLA-A24–positive chronic hepatitis C patients
  86. Mechanism of T cell hyporesponsiveness to HBcAg is associated with regulatory T cells in chronic hepatitis B
  87. Interferon-gamma is produced by CD8+ T cells in response to HLA-A24-restricted hepatitis C virus epitopes after sustained virus loss
  88. Living Related Liver Transplantation for Acute Fulminant Hepatitis B: Experience from Two Possible Hyper-Acute Cases
  89. Vigorous response of cytotoxic T lymphocytes associated with systemic activation of CD8+ T lymphocytes in fulminant hepatitis B
  90. Lack of common mutation in the alfa-subunit of the mitochondrial trifunctional protein and the polymorphism of CYP2E1 in three Japanese women with acute fatty liver of pregnancy/HELLP syndrome
  91. Recovery of functional cytotoxic T lymphocytes during lamivudine therapy by acquiring multi-specificity
  92. Distribution of the HLA Class I Allele in Chronic Hepatitis C and its Association with Serum ALT Level in Chronic Hepatitis C