All Stories

  1. Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway

    Article • Psychopharmacology, February 2022, Springer Science + Business Media

    professor xuechu zhen

  2. Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice

    Article • Acta Pharmacologica Sinica, November 2021, Springer Science + Business Media

    professor xuechu zhen

  3. Inhibition of neuroinflammation by MIF inhibitor 3-({[4-(4-methoxyphenyl)-6-methyl-2-pyrimidinyl]thio}1methyl)benzoic acid (Z-312)

    Article • International Immunopharmacology, September 2021, Elsevier

    professor xuechu zhen

  4. Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection

    Article • Neuropharmacology, September 2021, Elsevier

    professor xuechu zhen

  5. Discovery of novel MIF inhibitors that attenuate microglial inflammatory activation by structures-based virtual screening and in vitro bioassays

    Article • Acta Pharmacologica Sinica, August 2021, Springer Science + Business Media

    professor xuechu zhen

  6. Early glycolytic reprogramming controls microglial inflammatory activation

    Article • Journal of Neuroinflammation, June 2021, Springer Science + Business Media

    professor xuechu zhen

  7. Glycoproteins as diagnostic and prognostic biomarkers for neurodegenerative diseases: A glycoproteomic approach

    Article • Journal of Neuroscience Research, February 2021, Wiley

    professor xuechu zhen

  8. Small Molecules Selectively Targeting Sigma-1 Receptor for the Treatment of Neurological Diseases

    Article • Journal of Medicinal Chemistry, October 2020, American Chemical Society (ACS)

    professor xuechu zhen

  9. PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6

    Article • Brain Behavior and Immunity, August 2020, Elsevier

    professor xuechu zhen

  10. Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

    Article • Oxidative Medicine and Cellular Longevity, July 2020, Hindawi Publishing Corporation

    professor xuechu zhen

  11. Knockdown of milk‐fat globule EGF factor‐8 suppresses glioma progression in GL261 glioma cells by repressing microglial M2 polarization

    Article • Journal of Cellular Physiology, April 2020, Wiley

    professor xuechu zhen

  12. Emerging novel approaches to drug research and diagnosis of Parkinson’s disease

    Article • Acta Pharmacologica Sinica, March 2020, Springer Science + Business Media

    professor xuechu zhen

  13. Development and characterization of an inducible Dicer conditional knockout mouse model of Parkinson’s disease: validation of the antiparkinsonian effects of a sigma-1 receptor agonist and dihydromyricetin

    Article • Acta Pharmacologica Sinica, February 2020, Springer Science + Business Media

    professor xuechu zhen

  14. C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis

    Article • Aging Cell, February 2020, Wiley

    professor xuechu zhen

  15. Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond

    Article • Frontiers in Pharmacology, January 2020, Frontiers

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  16. FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis

    Article • International Journal of Biological Sciences, January 2020, Ivyspring International Publisher

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  17. Absence of TRIM32 Leads to Reduced GABAergic Interneuron Generation and Autism-like Behaviors in Mice via Suppressing mTOR Signaling

    Article • Cerebral Cortex, December 2019, Oxford University Press (OUP)

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  18. D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice

    Article • Neuropharmacology, October 2019, Elsevier

    professor xuechu zhen

  19. The oncometabolite 2-hydroxyglutarate inhibits microglial activation via the AMPK/mTOR/NF-κB pathway

    Article • Acta Pharmacologica Sinica, April 2019, Springer Science + Business Media

    professor xuechu zhen

  20. Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

    Article • Frontiers in Cellular Neuroscience, September 2018, Frontiers

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  21. Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson’s Disease: A Recent Update and Challenge

    Article • ACS Chemical Neuroscience, September 2018, American Chemical Society (ACS)

    professor xuechu zhen

  22. Emerging and evolving concepts in the pathobiology and treatment of psychosis

    Article • CNS Neuroscience & Therapeutics, June 2018, Wiley

    professor xuechu zhen

  23. Dysregulation of miRNA and its potential therapeutic application in schizophrenia

    Article • CNS Neuroscience & Therapeutics, March 2018, Wiley

    professor xuechu zhen

  24. Macrophage migration inhibitory factor (MIF) inhibitor, Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activation

    Article • Immunopharmacology and Immunotoxicology, February 2018, Taylor & Francis

    professor xuechu zhen

  25. miRNA-3473b contributes to neuroinflammation following cerebral ischemia

    Article • Cell Death and Disease, January 2018, Springer Science + Business Media

    professor xuechu zhen

  26. Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

    Article • Psychopharmacology, October 2017, Springer Science + Business Media

    professor xuechu zhen

  27. Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death

    Article • Molecular Pharmacology, October 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    professor xuechu zhen

  28. Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

    Article • British Journal of Pharmacology, August 2017, Wiley

    professor xuechu zhen

  29. Clk1-regulated aerobic glycolysis is involved in glioma chemoresistance

    Article • Journal of Neurochemistry, July 2017, Wiley

    professor xuechu zhen

  30. Prediction of chemical biodegradability using computational methods

    Article • Molecular Simulation, June 2017, Taylor & Francis

    professor xuechu zhen

  31. Dihydromyricetin protects against cerebral ischemia/reperfusion injury via suppressing microglia-mediated neuroinflammation and activation of ERK1/2-CREB signaling pathway

    Article • Journal of Functional Foods, June 2017, Elsevier

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  32. Discovery of Novel and Selective Adenosine A2A Receptor Antagonists for Treating Parkinson’s Disease through Comparative Structure-Based Virtual Screening

    Article • Journal of Chemical Information and Modeling, May 2017, American Chemical Society (ACS)

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  33. Erratum: Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

    Article • Acta Pharmacologica Sinica, May 2017, Nature

    professor xuechu zhen

  34. Design and optimization of purine derivatives as in vivo active PDE10A inhibitors

    Article • Bioorganic & Medicinal Chemistry, April 2017, Elsevier

    professor xuechu zhen

  35. Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming

    Article • Brain Behavior and Immunity, February 2017, Elsevier

    professor xuechu zhen

  36. Activation of Nur77 in microglia attenuates proinflammatory mediators production and protects dopaminergic neurons from inflammation-induced cell death

    Article • Journal of Neurochemistry, December 2016, Wiley

    professor xuechu zhen

  37. GSK-3βInteracts with Dopamine D1 Receptor to Regulate Receptor Function: Implication for Prefrontal Cortical D1 Receptor Dysfunction in Schizophrenia

    Article • CNS Neuroscience & Therapeutics, December 2016, Wiley

    professor xuechu zhen

  38. Phosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory

    Article • Neuroscience Letters, December 2016, Elsevier

    professor xuechu zhen

  39. Identification of a New Series of Potent Adenosine A2A Receptor Antagonists Based on 4-Amino-5-carbonitrile Pyrimidine Template for the Treatment of Parkinson’s Disease

    Article • ACS Chemical Neuroscience, November 2016, American Chemical Society (ACS)

    professor xuechu zhen

  40. Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia-mediated inflammatory responses

    Article • Clinical and Experimental Pharmacology and Physiology, October 2016, Wiley

    professor xuechu zhen

  41. GSK-3β inhibitors reverse cocaine-induced synaptic transmission dysfunction in the nucleus accumbens

    Article • Synapse, July 2016, Wiley

    professor xuechu zhen

  42. Dihydromyricetin protects neurons in an MPTP-induced model of Parkinson's disease by suppressing glycogen synthase kinase-3 beta activity

    Article • Acta Pharmacologica Sinica, July 2016, Springer Science + Business Media

    professor xuechu zhen

  43. Functional reversal of (−)-Stepholidine analogues by replacement of benzazepine substructure using the ring-expansion strategy

    Article • Chemical Biology & Drug Design, June 2016, Wiley

    professor xuechu zhen

  44. LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation

    Article • Journal of Pharmacological Sciences, June 2016, Elsevier

    professor xuechu zhen

  45. Morphine-induced inhibition of Ca2+ -dependent d -serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens

    Article • Addiction Biology, May 2016, Wiley

    professor xuechu zhen

  46. Accessible Method for the Development of Novel Sterol Analogues with Dipeptide-like Side Chains That Act as Neuroinflammation Inhibitors

    Article • ACS Chemical Neuroscience, March 2016, American Chemical Society (ACS)

    professor xuechu zhen

  47. Allosteric Modulation of Sigma-1 Receptors Elicits Rapid Antidepressant Activity

    Article • CNS Neuroscience & Therapeutics, February 2016, Wiley

    professor xuechu zhen

  48. Mice heterozygous for cathepsin D deficiency exhibit mania-related behavior and stress-induced depression

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, December 2015, Elsevier

    professor xuechu zhen

  49. MicroRNA let-7c-5p protects against cerebral ischemia injury via mechanisms involving the inhibition of microglia activation

    Article • Brain Behavior and Immunity, October 2015, Elsevier

    professor xuechu zhen

  50. Structure–Activity Relationships and Anti-inflammatory Activities ofN-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors

    Article • Journal of Chemical Information and Computer Sciences, September 2015, American Chemical Society (ACS)

    professor xuechu zhen

  51. Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold

    Article • Bioorganic & Medicinal Chemistry Letters, September 2015, Elsevier

    professor xuechu zhen

  52. Higher-Affinity Agonists of 5-HT1AR Discovered through Tuning the Binding-Site Flexibility

    Article • Journal of Chemical Information and Computer Sciences, August 2015, American Chemical Society (ACS)

    professor xuechu zhen

  53. Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area

    Article • Neuropharmacology, August 2015, Elsevier

    professor xuechu zhen

  54. Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1

    Article • Acta Pharmacologica Sinica, August 2015, Nature

    professor xuechu zhen

  55. Neuropharmacological Actions of Metformin in Stroke

    Article • Current Neuropharmacology, July 2015, Bentham Science Publishers

    professor xuechu zhen

  56. Allosteric modulation of sigma-1 receptors elicits anti-seizure activities

    Article • British Journal of Pharmacology, June 2015, Wiley

    professor xuechu zhen

  57. Allosteric modulation of sigma-1 receptors by SKF83959 inhibits microglia-mediated inflammation

    Article • Journal of Neurochemistry, June 2015, Wiley

    professor xuechu zhen

  58. Anti-inflammatory effects of glaucocalyxin B in microglia cells

    Article • Journal of Pharmacological Sciences, May 2015, Elsevier

    professor xuechu zhen

  59. Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors

    Article • International Immunopharmacology, April 2015, Elsevier

    professor xuechu zhen

  60. Induction of COX-2-PGE2 synthesis by activation of the MAPK/ERK pathway contributes to neuronal death triggered by TDP-43-depleted microglia

    Article • Cell Death and Disease, March 2015, Nature

    professor xuechu zhen

  61. Glial Pathology in Bipolar Disorder: Potential Therapeutic Implications

    Article • CNS Neuroscience & Therapeutics, March 2015, Wiley

    professor xuechu zhen

  62. Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV-2 Microglia

    Article • ChemMedChem, March 2015, Wiley

    professor xuechu zhen

  63. Sigma-2 Receptor Ligands: Neurobiological Effects

    Article • Current Medicinal Chemistry, February 2015, Bentham Science Publishers

    professor xuechu zhen

  64. Absorption, Distribution, Metabolism, Excretion, and Toxicity Evaluation in Drug Discovery. 14. Prediction of Human Pregnane X Receptor Activators by Using Naive Bayesian Classification Technique

    Article • Chemical Research in Toxicology, January 2015, American Chemical Society (ACS)

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  65. Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors

    Article • RSC Advances, January 2015, Royal Society of Chemistry

    professor xuechu zhen

  66. Rotenone impairs autophagic flux and lysosomal functions in Parkinson’s disease

    Article • Neuroscience, January 2015, Elsevier

    professor xuechu zhen

  67. Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress

    Article • BMC Complementary and Alternative Medicine, December 2014, Springer Science + Business Media

    professor xuechu zhen

  68. A Computational Perspective on Drug Discovery and Signal Transduction Mechanism of Dopamine and Serotonin Receptors in the Treatment of Schizophrenia

    Article • Current Pharmaceutical Biotechnology, November 2014, Bentham Science Publishers

    professor xuechu zhen

  69. Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles

    Article • Bioorganic & Medicinal Chemistry, November 2014, Elsevier

    professor xuechu zhen

  70. Assessing an Ensemble Docking-Based Virtual Screening Strategy for Kinase Targets by Considering Protein Flexibility

    Article • Journal of Chemical Information and Computer Sciences, October 2014, American Chemical Society (ACS)

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  71. CaMKKβ-Dependent Activation of AMP-Activated Protein Kinase Is Critical to Suppressive Effects of Hydrogen Sulfide on Neuroinflammation

    Article • Antioxidants & Redox Signaling, October 2014, Mary Ann Liebert Inc

    professor xuechu zhen

  72. Structural manipulation on the catecholic fragment of dopamine D1 receptor agonist 1-phenyl-N-methyl-benzazepines

    Article • European Journal of Medicinal Chemistry, October 2014, Elsevier

    professor xuechu zhen

  73. Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference

    Article • Molecular Brain, September 2014, Springer Science + Business Media

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  74. ChemInform Abstract: Topsendines A-F, New 3-Alkylpyridine Alkaloids from a Hainan Sponge Topsentia sp.

    Article • ChemInform, September 2014, Wiley

    professor xuechu zhen

  75. (6aR)-11-Amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease

    Article • Pharmacology Biochemistry and Behavior, September 2014, Elsevier

    professor xuechu zhen

  76. Optimization of 6-Heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as Potent Adenosine A2AReceptor Antagonists for the Treatment of Parkinson’s Disease

    Article • ACS Chemical Neuroscience, August 2014, American Chemical Society (ACS)

    professor xuechu zhen

  77. Improvement of functional recovery by chronic metformin treatment is associated with enhanced alternative activation of microglia/macrophages and increased angiogenesis and neurogenesis following experimental stroke

    Article • Brain Behavior and Immunity, August 2014, Elsevier

    professor xuechu zhen

  78. Effects of SKF83959 on the excitability of hippocampal CA1 pyramidal neurons: a modeling study

    Article • Acta Pharmacologica Sinica, May 2014, Nature

    professor xuechu zhen

  79. Discovery of Novel Inhibitors Targeting the Macrophage Migration Inhibitory Factor via Structure-Based Virtual Screening and Bioassays

    Article • Journal of Medicinal Chemistry, May 2014, American Chemical Society (ACS)

    professor xuechu zhen

  80. Topsendines A–F, new 3-alkylpyridine alkaloids from a Hainan sponge Topsentia sp.

    Article • Tetrahedron, May 2014, Elsevier

    professor xuechu zhen

  81. Robo3.1A suppresses Slit-mediated repulsion by triggering degradation of Robo2

    Article • Journal of Neuroscience Research, February 2014, Wiley

    professor xuechu zhen

  82. Mutation of SLC35D3 Causes Metabolic Syndrome by Impairing Dopamine Signaling in Striatal D1 Neurons

    Article • PLoS Genetics, February 2014, PLOS

    professor xuechu zhen

  83. Synthesis of 5α-cholestan-6-one derivatives and their inhibitory activities of NO production in activated microglia: Discovery of a novel neuroinflammation inhibitor

    Article • Bioorganic & Medicinal Chemistry Letters, February 2014, Elsevier

    professor xuechu zhen

  84. Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference

    Article • Molecular Brain, January 2014, Springer Science + Business Media

    professor xuechu zhen

  85. Antiinflammatory Effects of Orientin-2″-O-Galactopyranoside on Lipopolysaccharide-Stimulated Microglia

    Article • Biological and Pharmaceutical Bulletin, January 2014, Pharmaceutical Society of Japan

    professor xuechu zhen

  86. 1-O-Tigloyl-1-O-deacetyl-nimbolinin B Inhibits LPS-Stimulated Inflammatory Responses by Suppressing NF-κB and JNK Activation in Microglia Cells

    Article • Journal of Pharmacological Sciences, January 2014, Japanese Pharmacological Society

    professor xuechu zhen

  87. Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, January 2014, Elsevier

    professor xuechu zhen

  88. Molecular Modeling of the 3D Structure of 5-HT1AR: Discovery of Novel 5-HT1AR Agonists via Dynamic Pharmacophore-Based Virtual Screening

    Article • Journal of Chemical Information and Computer Sciences, December 2013, American Chemical Society (ACS)

    professor xuechu zhen

  89. Postischemic Administration of a Potent PTEN Inhibitor Reduces Spontaneous Lung Infection Following Experimental Stroke

    Article • CNS Neuroscience & Therapeutics, October 2013, Wiley

    professor xuechu zhen

  90. Synthesis, preliminary pharmacological evaluation and receptor docking studies of 10-amino-3-methoxy-6,8,12,12a-tetrahydro-5H-thiazolo[4',5':4,5]pyrido[2,1-a]isoquinolin-2-ols as novel dopamine D1 receptor inhibitors

    Article • Vedic Research International Biological Medicinal Chemistry, October 2013, Vedic Research International

    professor xuechu zhen

  91. Design, Synthesis, and Evaluation of Indolebutylamines as a Novel Class of Selective Dopamine D3 Receptor Ligands

    Article • Chemical Biology & Drug Design, August 2013, Wiley

    professor xuechu zhen

  92. SKF83959 is a novel triple reuptake inhibitor that elicits anti-depressant activity

    Article • Acta Pharmacologica Sinica, July 2013, Nature

    professor xuechu zhen

  93. Current developments of macrophage migration inhibitory factor (MIF) inhibitors

    Article • Drug Discovery Today, June 2013, Elsevier

    professor xuechu zhen

  94. Differential mechanisms underlying neuroprotection of hydrogen sulfide donors against oxidative stress

    Article • Neurochemistry International, June 2013, Elsevier

    professor xuechu zhen

  95. Update 1 of: Recent Progress in Development of Dopamine Receptor Subtype-Selective Agents: Potential Therapeutics for Neurological and Psychiatric Disorders

    Article • Chemical Reviews, May 2013, American Chemical Society (ACS)

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  96. Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D1, D2 and serotonin 5-HT1A multi-action profile

    Article • Bioorganic & Medicinal Chemistry, February 2013, Elsevier

    professor xuechu zhen

  97. Delayed administration of a PTEN inhibitor BPV improves functional recovery after experimental stroke

    Article • Neuroscience, February 2013, Elsevier

    professor xuechu zhen

  98. CMYA5: a new potential substrate of Kcna3 in human heart

    Article • Acta Biochimica et Biophysica Sinica, January 2013, China Science Publishing & Media Ltd.

    professor xuechu zhen

  99. SKF83959 Is a Potent Allosteric Modulator of Sigma-1 Receptor

    Article • Molecular Pharmacology, January 2013, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    professor xuechu zhen

  100. Methylphenidate Enhances NMDA-Receptor Response in Medial Prefrontal Cortex via Sigma-1 Receptor: A Novel Mechanism for Methylphenidate Action

    Article • PLoS ONE, December 2012, PLOS

    professor xuechu zhen

  101. GABA Neurons in the Ventral Tegmental Area Responding to Peripheral Sensory Input

    Article • PLoS ONE, December 2012, PLOS

    professor xuechu zhen

  102. Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: Selective inhibitors of dopamine D1 receptor

    Article • Bioorganic & Medicinal Chemistry, August 2012, Elsevier

    professor xuechu zhen

  103. Synthesis and antidepressant activity of arylalkanol-piperidine derivatives as triple reuptake inhibitors

    Article • European Journal of Medicinal Chemistry, August 2012, Elsevier

    professor xuechu zhen

  104. Generation and characterization of hD5 and C-terminal Mutant hD5m transgenic rats

    Article • Brain Research, April 2012, Elsevier

    professor xuechu zhen

  105. L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

    Article • Molecular Neurodegeneration, January 2012, Springer Science + Business Media

    professor xuechu zhen

  106. PSD-95 Interacts with Dopamine D1-Receptor: Functional Implication

    Article • American Journal of Biomedical Sciences, October 2011, New World Publishing International, Inc.

    professor xuechu zhen

  107. Identification ofN-Propylnoraporphin-11-yl 5-(1,2-Dithiolan-3-yl)pentanoate as a New Anti-Parkinson's Agent Possessing a Dopamine D2and Serotonin 5-HT1ADual-Agonist Profile

    Article • Journal of Medicinal Chemistry, July 2011, American Chemical Society (ACS)

    professor xuechu zhen

  108. SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor-independent mechanism

    Article • Journal of Neuroscience Research, May 2011, Wiley

    professor xuechu zhen

  109. The Retardation of Myometrial Infiltration, Reduction of Uterine Contractility, and Alleviation of Generalized Hyperalgesia in Mice With Induced Adenomyosis by Levo-Tetrahydropalmatine (l-THP) and Andrographolide

    Article • Reproductive Sciences, April 2011, SAGE Publications

    professor xuechu zhen

  110. Further SAR study on 11-O-substituted aporphine analogues: Identification of highly potent dopamine D3 receptor ligands

    Article • Bioorganic & Medicinal Chemistry, March 2011, Elsevier

    professor xuechu zhen

  111. Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats

    Article • Reproductive Sciences, January 2011, SAGE Publications

    professor xuechu zhen

  112. Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta

    Article • Neuropharmacology, December 2010, Elsevier

    professor xuechu zhen

  113. Electrophysiological Effects of SKF83959 on Hippocampal CA1 Pyramidal Neurons: Potential Mechanisms for the Drug's Neuroprotective Effects

    Article • PLoS ONE, October 2010, PLOS

    professor xuechu zhen

  114. l-Stepholidine-induced excitation of dopamine neurons in rat ventral tegmental area is associated with its 5-HT1A receptor partial agonistic activity

    Article • Synapse, September 2010, Wiley

    professor xuechu zhen

  115. Hyperpolarization-activated, cyclic nucleotide-gated (HCN) channels in the regulation of midbrain dopamine systems

    Article • Acta Pharmacologica Sinica, August 2010, Nature

    professor xuechu zhen

  116. Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro

    Article • Brain Research, July 2010, Elsevier

    professor xuechu zhen

  117. l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

    Article • Neurobiology of Aging, June 2010, Elsevier

    professor xuechu zhen

  118. Synthesis of Dihydrofuroaporphine Derivatives: Identification of a Potent and Selective Serotonin 5-HT1AReceptor Agonist

    Article • Journal of Medicinal Chemistry, February 2010, American Chemical Society (ACS)

    professor xuechu zhen

  119. Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand

    Article • Schizophrenia Research, November 2009, Elsevier

    professor xuechu zhen

  120. ‘Click’ D1 receptor agonists with a 5-HT1A receptor pharmacophore producing D2 receptor activity

    Article • Bioorganic & Medicinal Chemistry, July 2009, Elsevier

    professor xuechu zhen

  121. Activation of Phosphatidylinositol-Linked D1-Like Receptor Modulates FGF-2 Expression in Astrocytes via IP3-Dependent Ca2+ Signaling

    Article • Journal of Neuroscience, June 2009, Society for Neuroscience

    professor xuechu zhen

  122. Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects

    Article • PLoS ONE, June 2009, PLOS

    professor xuechu zhen

  123. ChemInform Abstract: Dopamine D1Receptor Ligands: Where Are We Now and Where Are We Going

    Article • ChemInform, May 2009, Wiley

    professor xuechu zhen

  124. PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation

    Article • Cell Research, May 2009, Nature

    professor xuechu zhen

  125. Dopamine D1receptor ligands: Where are we now and where are we going

    Article • Medicinal Research Reviews, March 2009, Wiley

    professor xuechu zhen

  126. Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons

    Article • The Journal of Physiology, January 2009, Wiley

    professor xuechu zhen

  127. Limonoids from the Twigs and Leaves ofChukrasia tabularis

    Article • Helvetica Chimica Acta, December 2008, Wiley

    professor xuechu zhen

  128. Dysbindin deficiency in sandy mice causes reduction of snapin and displays behaviors related to schizophrenia

    Article • Schizophrenia Research, December 2008, Elsevier

    professor xuechu zhen

  129. Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D1 receptor activities

    Article • Bioorganic & Medicinal Chemistry, November 2008, Elsevier

    professor xuechu zhen

  130. Single Dose of Morphine Produced a Prolonged Effect on Dopamine Neuron Activities

    Article • Molecular Pain, September 2008, SAGE Publications

    professor xuechu zhen

  131. N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D2 and serotonin 5-HT1A receptor dual ligands

    Article • Bioorganic & Medicinal Chemistry, September 2008, Elsevier

    professor xuechu zhen

  132. Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines

    Article • Bioorganic & Medicinal Chemistry, July 2008, Elsevier

    professor xuechu zhen

  133. The effectiveness of carbamazepine in unipolar depression: A double-blind, randomized, placebo-controlled study

    Article • Journal of Affective Disorders, July 2008, Elsevier

    professor xuechu zhen

  134. Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine

    Article • Psychopharmacology, June 2008, Springer Science + Business Media

    professor xuechu zhen

  135. Neuroprotective effects of atypical D1receptor agonist SKF83959 are mediated via D1receptor-dependent inhibition of glycogen synthase kinase-3β and a receptor-independent anti-oxidative action

    Article • Journal of Neurochemistry, February 2008, Wiley

    professor xuechu zhen

  136. Recent Developments in Studies of l-Stepholidine and its Analogs: Chemistry, Pharmacology and Clinical Implications

    Article • Current Medicinal Chemistry, December 2007, Bentham Science Publishers

    professor xuechu zhen

  137. Differential effects of classical and atypical antipsychotic drugs on rotenone-induced neurotoxicity in PC12 cells

    Article • European Neuropsychopharmacology, December 2007, Elsevier

    professor xuechu zhen

  138. Recent Development in Studies of Tetrahydroprotoberberines: Mechanism in Antinociception and Drug Addiction

    Article • Cellular and Molecular Neurobiology, August 2007, Springer Science + Business Media

    professor xuechu zhen

  139. Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

    Article • Neuropharmacology, July 2007, Elsevier

    professor xuechu zhen

  140. Effects of (-)-stepholidine on NMDA receptors: comparison with haloperidol and clozapine

    Article • Acta Pharmacologica Sinica, July 2007, Nature

    professor xuechu zhen

  141. Requirement of PSD-95 for dopamine D1receptor modulating glutamate NR1a/NR2B receptor function

    Article • Acta Pharmacologica Sinica, June 2007, Nature

    professor xuechu zhen

  142. l-Stepholidine increases the frequency of sEPSC via the activation of D1dopamine signaling pathway in rat prelimbic cortical neurons

    Article • Acta Pharmacologica Sinica, May 2007, Nature

    professor xuechu zhen

  143. Estrogen-modulated frontal cortical CaMKII activity and behavioral supersensitization induced by prolonged cocaine treatment in female rats

    Article • Psychopharmacology, December 2006, Springer Science + Business Media

    Dr Maya Frankfurt, professor xuechu zhen

  144. Modulation of Ca2+ signals by phosphatidylinositol-linked novel D1 dopamine receptor in hippocampal neurons

    Article • Journal of Neurochemistry, August 2006, Wiley

    professor xuechu zhen

  145. The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm

    Article • Neuroscience Letters, July 2005, Elsevier

    professor xuechu zhen

  146. The role of the phosphatidyinositol-linked D dopamine receptor in the pharmacology of SKF83959

    Article • Pharmacology Biochemistry and Behavior, April 2005, Elsevier

    professor xuechu zhen

  147. Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain

    Article • Molecular Pharmacology, July 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    professor xuechu zhen

  148. Prenatal cocaine exposure alters glycogen synthase kinase-3β (GSK3β) pathway in select rabbit brain areas

    Article • Neuroscience Letters, October 2003, Elsevier

    professor xuechu zhen

  149. SKF83959 selectively regulates phosphatidylinositol-linked D1 dopamine receptors in rat brain

    Article • Journal of Neurochemistry, April 2003, Wiley

    professor xuechu zhen

  150. Inhibition of Protein Tyrosine/Mitogen-Activated Protein Kinase Phosphatase Activity Is Associated with D2 Dopamine Receptor Supersensitivity in a Rat Model of Parkinson's Disease

    Article • Molecular Pharmacology, December 2002, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    professor xuechu zhen

  151. Lithium regulates protein tyrosine phosphatase activity in vitro and in vivo

    Article • Psychopharmacology, June 2002, Springer Science + Business Media

    professor xuechu zhen

  152. Prenatal Exposure to Cocaine Disrupts D1ADopamine Receptor Function Via Selective Inhibition of Protein Phosphatase 1 Pathway in Rabbit Frontal Cortex

    Article • Journal of Neuroscience, December 2001, Society for Neuroscience

    professor xuechu zhen

  153. The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits

    Article • Journal of Neuroscience, August 2001, Society for Neuroscience

    professor xuechu zhen

  154. Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3-E1 Osteoblasts

    Article • Journal of Biological Chemistry, January 2001, American Society for Biochemistry & Molecular Biology (ASBMB)

    professor xuechu zhen

  155. Mitogen-activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone

    Article • Journal of Biological Chemistry, November 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    professor xuechu zhen

  156. Activation of Extracellular Signal-Regulated Protein Kinases Is Associated with a Sensitized Locomotor Response to D2Dopamine Receptor Stimulation in Unilateral 6-Hydroxydopamine-Lesioned Rats

    Article • Journal of Neuroscience, March 2000, Society for Neuroscience

    professor xuechu zhen

  157. Age-Associated Impairment in Brain MAPK Signal Pathways and the Effect of Caloric Restriction in Fischer 344 Rats

    Article • The Journals of Gerontology Series A, December 1999, Oxford University Press (OUP)

    professor xuechu zhen

  158. D1Dopamine Receptor Agonists Mediate Activation of p38 Mitogen-Activated Protein Kinase and c-Jun Amino-Terminal Kinase by a Protein Kinase A-Dependent Mechanism in SK-N-MC Human Neuroblastoma Cells

    Article • Molecular Pharmacology, September 1998, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    professor xuechu zhen

  159. Platelet-Derived Growth Factor Stimulates Sodium-Dependent Pi Transport in Osteoblastic Cells via Phospholipase Cγ and Phosphatidylinositol 3′-Kinase

    Article • Journal of Bone and Mineral Research, January 1997, Wiley

    professor xuechu zhen

  160. Aluminum potentiates P(i) transport stimulation induced by fluoride in osteoblast-like cells

    Article • AJP Endocrinology and Metabolism, October 1996, American Physiological Society

    professor xuechu zhen