All Stories

  1. SOX10 and microRNAs: decoding their interplay in regulating melanoma plasticity

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Dr. Xin Lai

  2. ENQUIRE RECONSTRUCTS AND EXPANDS CONTEXT-SPECIFIC CO-OCCURRENCE NETWORKS FROM BIOMEDICAL LITERATURE

    Article • September 2023, Cold Spring Harbor Laboratory Press

    Dr. Xin Lai

  3. A network medicine approach for identifying diagnostic and prognostic biomarkers and exploring drug repurposing in human cancer

    Article • Computational and Structural Biotechnology Journal, January 2023, Elsevier

    Dr. Xin Lai

  4. Integration of transcriptomics data into agent-based models of solid tumor metastasis

    Article • Computational and Structural Biotechnology Journal, January 2023, Elsevier

    Dr. Xin Lai

  5. Editorial: Macrophage immunity and metabolism in cancer: Novel diagnostic and therapeutic strategies

    Article • Frontiers in Immunology, December 2022, Frontiers

    Dr. Xin Lai

  6. Melanoma 2.0. Skin cancer as a paradigm for emerging diagnostic technologies, computational modelling and artificial intelligence

    Article • Briefings in Bioinformatics, October 2022, Oxford University Press (OUP)

    Dr. Xin Lai

  7. Artificial intelligence in cancer target identification and drug discovery

    Article • Signal Transduction and Targeted Therapy, May 2022, Springer Science + Business Media

    Dr. Xin Lai

  8. Multi-Level Computational Modeling of Anti-Cancer Dendritic Cell Vaccination Utilized to Select Molecular Targets for Therapy Optimization

    Article • Frontiers in Cell and Developmental Biology, February 2022, Frontiers

    Dr. Xin Lai

  9. The Role of MicroRNAs in Cancer Biology and Therapy from a Systems Biology Perspective

    Article • January 2022, Springer Science + Business Media

    Dr. Xin Lai

  10. A disease network‐based deep learning approach for characterizing melanoma

    Article • International Journal of Cancer, November 2021, Wiley

    Dr. Xin Lai

  11. Mathematical Modelling in Biomedicine: A Primer for the Curious and the Skeptic

    Article • International Journal of Molecular Sciences, January 2021, MDPI AG

    Dr. Xin Lai

  12. Network- and systems-based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy

    Article • Theranostics, January 2021, Ivyspring International Publisher

    Dr. Xin Lai

  13. Sepsis and Autoimmune Disease: Pathology, Systems Medicine, and Artificial Intelligence

    Article • January 2021, Elsevier

    Dr. Xin Lai

  14. Network and systems based re-engineering of dendritic cells with non-coding RNAs for cancer immunotherapy

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr. Xin Lai

  15. RNA Sequencing of Collecting Duct Renal Cell Carcinoma Suggests an Interaction between miRNA and Target Genes and a Predominance of Deregulated Solute Carrier Genes

    Article • Cancers, December 2019, MDPI AG

    Dr. Xin Lai

  16. Systems biology-based investigation of cooperating microRNAs as monotherapy or adjuvant therapy in cancer

    Article • Nucleic Acids Research, July 2019, Oxford University Press (OUP)

    Dr. Xin Lai

  17. Innate extracellular vesicles from melanoma patients suppress β-catenin in tumor cells by miRNA-34a

    Article • Life Science Alliance, March 2019, Life Science Alliance, LLC

    Dr. Xin Lai

  18. A gene regulatory architecture that controls region‐independent dynamics of oligodendrocyte differentiation

    Article • Glia, February 2019, Wiley

    Dr. Xin Lai

  19. Exosomal lncRNAs and cancer: connecting the missing links

    Article • Bioinformatics, July 2018, Oxford University Press (OUP)

    Dr. Xin Lai

  20. Bacterial Adherence and Dwelling Probability: Two Drivers of Early Alveolar Infection by Streptococcus pneumoniae Identified in Multi-Level Mathematical Modeling

    Article • Frontiers in Cellular and Infection Microbiology, May 2018, Frontiers

    Dr. Xin Lai

  21. Makrophagen induzieren eine epitheliale Hyporesponsivität gegen Legionella pneumophila – eine systembiologische Studie

    Article • Pneumologie, February 2018, Thieme Publishing Group

    Dr. Xin Lai

  22. MiR-205-5p and miR-342-3p cooperate in the repression of the E2F1 transcription factor in the context of anticancer chemotherapy resistance

    Article • Theranostics, January 2018, Ivyspring International Publisher

    Dr. Xin Lai

  23. Serum levels of miR-320 family members are associated with clinical parameters and diagnosis in prostate cancer patients

    Article • Oncotarget, December 2017, Impact Journals, LLC

    Dr. Xin Lai

  24. Corrigendum: Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection

    Article • Frontiers in Physiology, October 2017, Frontiers

    Dr. Xin Lai

  25. THP-1-derived macrophages render lung epithelial cells hypo-responsive to Legionella pneumophila – a systems biology study

    Article • Scientific Reports, September 2017, Nature

    Dr. Xin Lai

  26. Multiplicity of Mathematical Modeling Strategies to Search for Molecular and Cellular Insights into Bacteria Lung Infection

    Article • Frontiers in Physiology, August 2017, Frontiers

    Dr. Xin Lai

  27. A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines

    Article • Oncotarget, January 2017, Impact Journals, LLC

    Dr. Xin Lai

  28. Macrophages render alveolar epithelial cells hypo-responsive to Legionella pneumophila

    Article • Pneumologie, July 2016, Thieme Publishing Group

    Dr. Xin Lai

  29. Abstract 1089: Cardiac glycosides affect miRNA expression profiles in renal cell carcinoma cell lines

    Article • Cancer Research, July 2016, American Association for Cancer Research (AACR)

    Dr. Xin Lai

  30. Understanding microRNA-mediated gene regulatory networks through mathematical modelling

    Article • Nucleic Acids Research, June 2016, Oxford University Press (OUP)

    Dr. Xin Lai

  31. Model-based genotype-phenotype mapping used to investigate gene signatures of immune sensitivity and resistance in melanoma micrometastasis

    Article • Scientific Reports, April 2016, Nature

    Dr. Xin Lai

  32. Third-Kind Encounters in Biomedicine: Immunology Meets Mathematics and Informatics to Become Quantitative and Predictive

    Article • January 2016, Springer Science + Business Media

    Dr. Xin Lai

  33. Systems Medicine for Lung Diseases: Phenotypes and Precision Medicine in Cancer, Infection, and Allergy

    Article • January 2016, Springer Science + Business Media

    Dr. Xin Lai

  34. Cooperative gene regulation by microRNA pairs and their identification using a computational workflow

    Article • Nucleic Acids Research, May 2014, Oxford University Press (OUP)

    Dr. Xin Lai

  35. The role of microRNA regulation in the early inflammatory response: miR-146a and NF-κB signaling in lung inflammation

    Article • Pneumologie, February 2014, Thieme Publishing Group

    Dr. Xin Lai

  36. Kinetic Modeling-Based Detection of Genetic Signatures That Provide Chemoresistance via the E2F1-p73/DNp73-miR-205 Network

    Article • Cancer Research, February 2013, American Association for Cancer Research (AACR)

    Dr. Xin Lai

  37. The role of microRNA regulation in the early inflammatory response: miR-146a and NF-κB signaling in lung inflammation

    Article • Pneumologie, February 2013, Thieme Publishing Group

    Dr. Xin Lai

  38. Asthma phenotyping, therapy, and prevention: what can we learn from systems biology?

    Article • Pediatric Research, January 2013, Nature

    Dr. Xin Lai

  39. A Systems’ Biology Approach to Study MicroRNA-Mediated Gene Regulatory Networks

    Article • BioMed Research International, January 2013, Hindawi Publishing Corporation

    Dr. Xin Lai

  40. MicroRNA Clusters

    Article • January 2013, Springer Science + Business Media

    Dr. Xin Lai

  41. Target Hub

    Article • January 2013, Springer Science + Business Media

    Dr. Xin Lai

  42. MicroRNA Regulation, Feed-Forward Loops

    Article • January 2013, Springer Science + Business Media

    Dr. Xin Lai

  43. MicroRNA Regulation, Time Delay

    Article • January 2013, Springer Science + Business Media

    Dr. Xin Lai

  44. Nonlinear Dynamics, miRNA Circuits

    Article • January 2013, Springer Science + Business Media

    Dr. Xin Lai

  45. MicroRNA-Regulated Networks: The Perfect Storm for Classical Molecular Biology, the Ideal Scenario for Systems Biology

    Article • December 2012, Springer Science + Business Media

    Dr. Xin Lai

  46. Computational analysis of target hub gene repression regulated by multiple and cooperative miRNAs

    Article • Nucleic Acids Research, July 2012, Oxford University Press (OUP)

    Dr. Xin Lai

  47. Modeling miRNA Regulation in Cancer Signaling Systems: miR-34a Regulation of the p53/Sirt1 Signaling Module

    Article • January 2012, Springer Science + Business Media

    Dr. Xin Lai

  48. Analyse von microRNA-Regelkreisen in der Legionella pneumophila-Infektion

    Article • Pneumologie, December 2011, Thieme Publishing Group

    Dr. Xin Lai

  49. Model-based investigation of the transcriptional activity of p53 and its feedback loop regulation via 14-3-3σ

    Article • IET Systems Biology, September 2011, the Institution of Engineering and Technology (the IET)

    Dr. Xin Lai

  50. Computational analysis and modeling the effectiveness of ‘Zanamivir’ targeting neuraminidase protein in pandemic H1N1 strains

    Article • Infection Genetics and Evolution, July 2011, Elsevier

    Dr. Xin Lai

  51. Systembiologische Analyse der Legionella pneumophila-induzierten microRNA-Expression in humanem Alveolarepithel

    Article • Pneumologie, March 2011, Thieme Publishing Group

    Dr. Xin Lai

  52. Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/Sirt1 module

    Article • Nature Reports Climate Change, October 2010, Nature

    Dr. Xin Lai

  53. Modeling miRNA regulation in signaling networks: miR-34a regulation of the p53/Sirt1 module

    Article • Nature Reports Climate Change, October 2010, Nature

    Dr. Xin Lai

  54. Integration of sensitivity and bifurcation analysis to detect critical processes in a model combining signalling and cell population dynamics

    Article • International Journal of Systems Science, January 2010, Taylor & Francis

    Dr. Xin Lai

  55. A multi-level model accounting for the effects of JAK2-STAT5 signal modulation in erythropoiesis

    Article • Computational Biology and Chemistry, August 2009, Elsevier

    Dr. Xin Lai