All Stories

  1. Proteins regulate the production of acid-base balance controlling cells in kidney

    Article • Journal of the American Society of Nephrology, February 2024, Wolters Kluwer Health

    Xiangjian Zheng

  2. Deficiency of Pdcd10 causes urothelium hypertrophy and vesicle trafficking defects in ureter

    Article • FEBS Journal, December 2023, Wiley

    Xiangjian Zheng

  3. Kinases in cerebral cavernous malformations: Pathogenesis and therapeutic targets

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, August 2023, Elsevier

    Xiangjian Zheng

  4. Multi-omics profiling of cholangiocytes reveals sex-specific chromatin state dynamics during hepatic cystogenesis in polycystic liver disease

    Article • Journal of Hepatology, April 2023, Elsevier

    Xiangjian Zheng

  5. Release of STK24/25 suppression on MEKK3 signaling in endothelial cells confers cerebral cavernous malformation

    Article • JCI Insight, March 2023, American Society for Clinical Investigation

    Xiangjian Zheng

  6. Role of pericytes in the development of cerebral cavernous malformations

    Article • iScience, December 2022, Elsevier

    Xiangjian Zheng

  7. Cerebral cavernous malformation development in chronic mouse models driven by dual recombinases induced gene deletion in brain endothelial cells

    Article • Journal of Cerebral Blood Flow & Metabolism, June 2022, SAGE Publications

    Xiangjian Zheng

  8. KANK4 Promotes Arteriogenesis by Potentiating VEGFR2 Signaling in a TALIN-1–Dependent Manner

    Article • Arteriosclerosis Thrombosis and Vascular Biology, June 2022, Wolters Kluwer Health

    Xiangjian Zheng

  9. Liver Endothelial Heg Regulates Vascular/Biliary Network Patterning and Metabolic Zonation Via Wnt Signaling

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2022, Elsevier

    Xiangjian Zheng

  10. Pdcd10-Stk24/25 complex controls kidney water reabsorption by regulating Aqp2 membrane targeting

    Article • JCI Insight, June 2021, American Society for Clinical Investigation

    Xiangjian Zheng

  11. Cell Cycle Withdrawal Limit the Regenerative Potential of Neonatal Cardiomyocytes

    Article • Cardiovascular Engineering and Technology, May 2021, Springer Science + Business Media

    Xiangjian Zheng

  12. CCM2L (Cerebral Cavernous Malformation 2 Like) Deletion Aggravates Cerebral Cavernous Malformation Through Map3k3-KLF Signaling Pathway

    Article • Stroke, April 2021, Wolters Kluwer Health

    Xiangjian Zheng

  13. Cerebral cavernous malformations are driven by ADAMTS5 proteolysis of versican

    Article • The Journal of Experimental Medicine, July 2020, Rockefeller University Press

    Xiangjian Zheng

  14. Targeting miR-27a/VE-cadherin interactions rescues cerebral cavernous malformations in mice

    Article • PLoS Biology, June 2020, PLOS

    Xiangjian Zheng

  15. Generation of Cerebral Cavernous Malformation in Neonatal Mouse Models Using Inducible Cre-LoxP Strategy

    Article • January 2020, Springer Science + Business Media

    Xiangjian Zheng

  16. Distinct cellular roles for PDCD10 define a gut-brain axis in cerebral cavernous malformation

    Article • Science Translational Medicine, November 2019, American Association for the Advancement of Science

    Xiangjian Zheng

  17. Low fluid shear stress conditions contribute to activation of cerebral cavernous malformation signalling pathways

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease, November 2019, Elsevier

    Xiangjian Zheng

  18. Endothelial Foxp1 Suppresses Atherosclerosis via Modulation of Nlrp3 Inflammasome Activation

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Xiangjian Zheng

  19. Endothelial Forkhead Box Transcription Factor P1 Regulates Pathological Cardiac Remodeling Through Transforming Growth Factor-β1–Endothelin-1 Signal Pathway

    Article • Circulation, August 2019, Wolters Kluwer Health

    Xiangjian Zheng

  20. Cell-Specific Effects of GATA (GATA Zinc Finger Transcription Factor Family)-6 in Vascular Smooth Muscle and Endothelial Cells on Vascular Injury Neointimal Formation

    Article • Arteriosclerosis Thrombosis and Vascular Biology, May 2019, Wolters Kluwer Health

    Xiangjian Zheng

  21. Ponatinib (AP24534) inhibits MEKK3-KLF signaling and prevents formation and progression of cerebral cavernous malformations

    Article • Science Advances, November 2018, American Association for the Advancement of Science

    Xiangjian Zheng

  22. Elevated Expression of miR302-367 in Endothelial Cells Inhibits Developmental Angiogenesis via CDC42/CCND1 Mediated Signaling Pathways

    Article • Theranostics, January 2018, Ivyspring International Publisher

    Xiangjian Zheng

  23. Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

    Article • Journal of Visualized Experiments, September 2017, MyJove Corporation

    Xiangjian Zheng

  24. Induction and Micro-CT Imaging of Cerebral Cavernous Malformations in Mouse Model

    Article • Journal of Visualized Experiments, September 2017, MyJove Corporation

    Xiangjian Zheng

  25. Endothelial TLR4 and the microbiome drive cerebral cavernous malformations

    Article • Nature, May 2017, Springer Science + Business Media

    Xiangjian Zheng

  26. A MicroRNA302-367-Erk1/2-Klf2-S1pr1 Pathway Prevents Tumor Growth via Restricting Angiogenesis and Improving Vascular Stability

    Article • Circulation Research, January 2017, Wolters Kluwer Health

    Xiangjian Zheng

  27. Micro-CT Imaging Reveals Mekk3 Heterozygosity Prevents Cerebral Cavernous Malformations in Ccm2-Deficient Mice

    Article • PLoS ONE, August 2016, PLOS

    Xiangjian Zheng

  28. Cerebral cavernous malformations arise from endothelial gain of MEKK3–KLF2/4 signalling

    Article • Nature, March 2016, Springer Science + Business Media

    Xiangjian Zheng

  29. The Cerebral Cavernous Malformation Pathway Controls Cardiac Development via Regulation of Endocardial MEKK3 Signaling and KLF Expression

    Article • Developmental Cell, January 2015, Elsevier

    Xiangjian Zheng

  30. Cerebral Cavernous Malformations Arise Independent of the Heart of Glass Receptor

    Article • Stroke, May 2014, Wolters Kluwer Health

    Xiangjian Zheng

  31. Dynamic Regulation of the Cerebral Cavernous Malformation Pathway Controls Vascular Stability and Growth

    Article • Developmental Cell, August 2012, Elsevier

    Xiangjian Zheng

  32. Aquaporin-3 in keratinocytes and skin: Its role and interaction with phospholipase D2

    Article • Archives of Biochemistry and Biophysics, April 2011, Elsevier

    Xiangjian Zheng

  33. CCM3 signaling through sterile 20–like kinases plays an essential role during zebrafish cardiovascular development and cerebral cavernous malformations

    Article • Journal of Clinical Investigation, August 2010, American Society for Clinical Investigation

    Xiangjian Zheng

  34. Erratum: Corrigendum: Regulation of cardiovascular development and integrity by the heart of glass– cerebral cavernous malformation protein pathway

    Article • Nature Medicine, May 2009, Springer Science + Business Media

    Xiangjian Zheng

  35. Phospholipase D1 is required for angiogenesis of intersegmental blood vessels in zebrafish

    Article • Developmental Biology, April 2009, Elsevier

    Xiangjian Zheng

  36. Regulation of cardiovascular development and integrity by the heart of glass–cerebral cavernous malformation protein pathway

    Article • Nature Medicine, January 2009, Springer Science + Business Media

    Xiangjian Zheng

  37. A Potential Role for the Phospholipase D2-Aquaporin-3 Signaling Module in Early Keratinocyte Differentiation: Production of a Phosphatidylglycerol Signaling Lipid

    Article • Journal of Investigative Dermatology, December 2007, Elsevier

    Xiangjian Zheng

  38. Enrichment of regulatory CD4+CD25+ T cells by inhibition of phospholipase D signaling

    Article • Nature Methods, July 2006, Springer Science + Business Media

    Xiangjian Zheng

  39. Phospholipase D Signaling and Extracellular Signal-Regulated Kinase-1 and -2 Phosphorylation (Activation) Are Required for Maximal Phorbol Ester-Induced Transglutaminase Activity, a Marker of Keratinocyte Differentiation

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Xiangjian Zheng

  40. Aquaporin 3 Colocates with Phospholipase D2 in Caveolin-Rich Membrane Microdomains and Is Downregulated Upon Keratinocyte Differentiation

    Article • Journal of Investigative Dermatology, December 2003, Elsevier

    Xiangjian Zheng

  41. Modulation of phospholipase D-mediated phosphatidylglycerol formation by differentiating agents in primary mouse epidermal keratinocytes

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2003, Elsevier

    Xiangjian Zheng

  42. AngII induces transient phospholipase D activity in the H295R glomerulosa cell model

    Article • Molecular and Cellular Endocrinology, August 2003, Elsevier

    Xiangjian Zheng

  43. Elevated K+ induces myristoylated alanine-rich C-kinase substrate phosphorylation and phospholipase D activation in glomerulosa cells

    Article • Molecular and Cellular Endocrinology, November 2001, Elsevier

    Xiangjian Zheng

  44. Aquaporin 3, a glycerol and water transporter, is regulated by p73 of the p53 family

    Article • FEBS Letters, January 2001, Wiley

    Xiangjian Zheng