All Stories

  1. MicroRNA‐210‐mediated mitochondrial reactive oxygen species contribute to Ca V 1.2 channel hyperactivity in uterine arteries of pregnant sheep acclimatized to high‐altitude hypoxia

    Article • The Journal of Physiology, April 2026, Wiley

    Xiang-Qun Hu

  2. Chronic hypoxia during gestation impairs Rad‐mediated inhibition of Ca V 1.2 channel and increases uterine vascular resistance in pregnant sheep

    Article • The Journal of Physiology, January 2026, Wiley

    Xiang-Qun Hu

  3. Fetal Hypoxia Suppresses TRPC6 and Impairs Cerebral Autoregulation in Neonatal Rats

    Article • Stroke, September 2025, Wolters Kluwer Health

    Xiang-Qun Hu

  4. The uteroplacental circulation at high altitude: adaptation and maladaptation

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, August 2025, Royal Society Publishing

    Xiang-Qun Hu

  5. MicroRNA-210 Mediates Hypoxic Pulmonary Hypertension in the Newborn Lamb

    Article • Hypertension, June 2025, Wolters Kluwer Health

    Xiang-Qun Hu

  6. Corrigendum to “Role of transient receptor potential channels in the regulation of vascular tone” [Drug Discov. Today 29(7) (2024) 104051]

    Article • Drug Discovery Today, May 2025, Elsevier

    Xiang-Qun Hu

  7. Rad‐mediated inhibition of CaV1.2 channel activity contributes to uterine artery haemodynamic adaptation to pregnancy

    Article • The Journal of Physiology, November 2024, Wiley

    Xiang-Qun Hu

  8. Long-term hypoxia modulates depolarization activation of BKCa currents in fetal sheep middle cerebral arterial myocytes

    Article • Frontiers in Physiology, November 2024, Frontiers

    Xiang-Qun Hu

  9. Role of transient receptor potential channels in the regulation of vascular tone

    Article • Drug Discovery Today, July 2024, Elsevier

    Xiang-Qun Hu

  10. TET2 confers a mechanistic link of microRNA‐210 and mtROS in hypoxia‐suppressed spontaneous transient outward currents in uterine arteries of pregnant sheep

    Article • The Journal of Physiology, March 2023, Wiley

    Xiang-Qun Hu

  11. Ca2+-Activated K+ Channels and the Regulation of the Uteroplacental Circulation

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Xiang-Qun Hu

  12. Oxidative Regulation of Vascular Cav1.2 Channels Triggers Vascular Dysfunction in Hypertension-Related Disorders

    Article • Antioxidants, December 2022, MDPI AG

    Xiang-Qun Hu

  13. MicroRNA‐210‐mediated mitochondrial reactive oxygen species confer hypoxia‐induced suppression of spontaneous transient outward currents in ovine uterine arteries

    Article • British Journal of Pharmacology, July 2022, Wiley

    Xiang-Qun Hu

  14. Mitochondrial Dysfunction in the Pathogenesis of Preeclampsia

    Article • Current Hypertension Reports, March 2022, Springer Science + Business Media

    Xiang-Qun Hu

  15. Hypoxia and the integrated stress response promote pulmonary hypertension and preeclampsia: Implications in drug development

    Article • Drug Discovery Today, November 2021, Elsevier

    Xiang-Qun Hu

  16. Uteroplacental Circulation in Normal Pregnancy and Preeclampsia: Functional Adaptation and Maladaptation

    Article • International Journal of Molecular Sciences, August 2021, MDPI AG

    Xiang-Qun Hu

  17. MicroRNA-210 Mediates Hypoxia-Induced Repression of Spontaneous Transient Outward Currents in Sheep Uterine Arteries During Gestation

    Article • Hypertension, April 2021, Wolters Kluwer Health

    Xiang-Qun Hu

  18. Hypoxia and Mitochondrial Dysfunction in Pregnancy Complications

    Article • Antioxidants, March 2021, MDPI AG

    Xiang-Qun Hu

  19. Gestational Hypoxia Inhibits Pregnancy-Induced Upregulation of Ca 2+ Sparks and Spontaneous Transient Outward Currents in Uterine Arteries Via Heightened Endoplasmic Reticulum/Oxidative Stress

    Article • Hypertension, September 2020, Wolters Kluwer Health

    Xiang-Qun Hu

  20. Ryanodine receptor subtypes regulate Ca2+ sparks/spontaneous transient outward currents and myogenic tone of uterine arteries in pregnancy

    Article • Cardiovascular Research, April 2020, Oxford University Press (OUP)

    Xiang-Qun Hu

  21. Mitochondrial MiRNA in Cardiovascular Function and Disease

    Article • Cells, November 2019, MDPI AG

    Xiang-Qun Hu

  22. MicroRNAs in Uteroplacental Vascular Dysfunction

    Article • Cells, October 2019, MDPI AG

    Xiang-Qun Hu

  23. Glucocorticoids and programming of the microenvironment in heart

    Article • Journal of Endocrinology, July 2019, Bioscientifica

    Xiang-Qun Hu

  24. Epigenetic down-regulation of BKCa channel by miR-181a contributes to the fetal and neonatal nicotine-mediated exaggerated coronary vascular tone in adult life

    Article • International Journal of Cardiology, April 2019, Elsevier

    Xiang-Qun Hu

  25. Pregnancy Increases Ca 2+ Sparks/Spontaneous Transient Outward Currents and Reduces Uterine Arterial Myogenic Tone

    Article • Hypertension, March 2019, Wolters Kluwer Health

    Xiang-Qun Hu

  26. Effect of Oxidative Stress on the Estrogen-NOS-NO-KCa Channel Pathway in Uteroplacental Dysfunction: Its Implication in Pregnancy Complications

    Article • Oxidative Medicine and Cellular Longevity, February 2019, Hindawi Publishing Corporation

    Xiang-Qun Hu

  27. Long-term high altitude hypoxia during gestation suppresses large conductance Ca2+ -activated K+ channel function in uterine arteries: a causal role for microRNA-210

    Article • The Journal of Physiology, July 2018, Wiley

    Xiang-Qun Hu

  28. Gestational Hypoxia and Developmental Plasticity

    Article • Physiological Reviews, July 2018, American Physiological Society

    Xiang-Qun Hu

  29. MicroRNA-210 Targets Ten-Eleven Translocation Methylcytosine Dioxygenase 1 and Suppresses Pregnancy-Mediated Adaptation of Large Conductance Ca 2+ -Activated K + Channel Expression a...

    Article • Hypertension, September 2017, Wolters Kluwer Health

    Xiang-Qun Hu

  30. Angiogenesis during pregnancy: all routes lead to MAPKs

    Article • The Journal of Physiology, June 2017, Wiley

    Xiang-Qun Hu

  31. Pregnancy Reprograms Large-Conductance Ca 2+ -Activated K + Channel in Uterine Arteries

    Article • Hypertension, June 2017, Wolters Kluwer Health

    Xiang-Qun Hu

  32. Chronic hypoxia upregulates DNA methyltransferase and represses large conductance Ca2+-activated K+ channel function in ovine uterine arteries†

    Article • Biology of Reproduction, January 2017, Oxford University Press (OUP)

    Xiang-Qun Hu

  33. Direct effect of chronic hypoxia in suppressing large conductance Ca2+‐activated K+ channel activity in ovine uterine arteries via increasing oxidative stress

    Article • The Journal of Physiology, December 2015, Wiley

    Xiang-Qun Hu

  34. Hypoxia Represses ER-α Expression and Inhibits Estrogen-Induced Regulation of Ca 2+ -Activated K + Channel Activity and Myogenic Tone in Ovine Uterine Arteries

    Article • Hypertension, July 2015, Wolters Kluwer Health

    Xiang-Qun Hu

  35. Auto-inhibition at a ligand-gated ion channel: a cross-talk between orthosteric and allosteric sites

    Article • British Journal of Pharmacology, November 2014, Wiley

    Xiang-Qun Hu

  36. Gestational Hypoxia Increases Reactive Oxygen Species and Inhibits Steroid Hormone–Mediated Upregulation of Ca 2+ -Activated K + Channel Function in Uterine Arteries

    Article • Hypertension, August 2014, Wolters Kluwer Health

    Xiang-Qun Hu

  37. Chronic Hypoxia during Gestation Enhances Uterine Arterial Myogenic Tone via Heightened Oxidative Stress

    Article • PLOS One, September 2013, PLOS

    Xiang-Qun Hu

  38. Chronic Hypoxia Inhibits Pregnancy-Induced Upregulation of SK Ca Channel Expression and Function in Uterine Arteries

    Article • Hypertension, August 2013, Wolters Kluwer Health

    Xiang-Qun Hu

  39. Function and regulation of large conductance Ca2+-activated K+ channel in vascular smooth muscle cells

    Article • Drug Discovery Today, September 2012, Elsevier

    Xiang-Qun Hu

  40. Chronic Hypoxia Suppresses Pregnancy-Induced Upregulation of Large-Conductance Ca 2+ -Activated K + Channel Activity in Uterine Arteries

    Article • Hypertension, July 2012, Wolters Kluwer Health

    Xiang-Qun Hu

  41. Pregnancy Upregulates Large-Conductance Ca 2+ -Activated K + Channel Activity and Attenuates Myogenic Tone in Uterine Arteries

    Article • Hypertension, December 2011, Wolters Kluwer Health

    Xiang-Qun Hu

  42. Differential actions of ethanol and trichloroethanol at sites in the M3 and M4 domains of the NMDA receptor GluN2A (NR2A) subunit

    Article • British Journal of Pharmacology, October 2009, Wiley

    Xiang-Qun Hu

  43. Effect of cGMP on Pharmacomechanical Coupling in the Uterine Artery of Near-Term Pregnant Sheep

    Article • Journal of Pharmacology and Experimental Therapeutics, November 2008, Elsevier

    Xiang-Qun Hu

  44. The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole

    Article • Neuropharmacology, June 2008, Elsevier

    Xiang-Qun Hu

  45. Arginine 246 of the Pretransmembrane Domain 1 Region Alters 2,2,2-Trichloroethanol Action in the 5-Hydroxytryptamine3A Receptor

    Article • Journal of Pharmacology and Experimental Therapeutics, March 2008, Elsevier

    Xiang-Qun Hu

  46. The 5-HT3B Subunit Confers Spontaneous Channel Opening and Altered Ligand Properties of the 5-HT3 Receptor

    Article • Journal of Biological Chemistry, March 2008, Elsevier

    Xiang-Qun Hu

  47. Modulation of 5‐HT3 receptor desensitization by the light chain of microtubule‐associated protein 1B expressed in HEK 293 cells

    Article • The Journal of Physiology, February 2008, Wiley

    Xiang-Qun Hu

  48. An Interaction Involving an Arginine Residue in the Cytoplasmic Domain of the 5-HT3A Receptor Contributes to Receptor Desensitization Mechanism

    Article • Journal of Biological Chemistry, August 2006, Elsevier

    Xiang-Qun Hu

  49. Mutations of L293 in transmembrane two of the mouse 5‐hydroxytryptamine3A receptor alter gating and alcohol modulatory actions

    Article • British Journal of Pharmacology, May 2006, Wiley

    Xiang-Qun Hu

  50. Effects of Ethanol on Adenosine 5'-Triphosphate-Gated Purinergic and 5-Hydroxytryptamine3 Receptors

    Article • Alcoholism Clinical and Experimental Research, February 2006, Wiley

    Daryl L Davies, Xiang-Qun Hu

  51. Role of aspartate 298 in mouse 5‐HT3A receptor gating and modulation by extracellular Ca2+

    Article • The Journal of Physiology, October 2005, Wiley

    Xiang-Qun Hu

  52. The mechanism by which ethanol inhibits rat P2X4 receptors is altered by mutation of histidine 241

    Article • British Journal of Pharmacology, July 2005, Wiley

    Xiang-Qun Hu

  53. Role of extracellular histidines in agonist sensitivity of the rat P2X4 receptor

    Article • Neuroscience Letters, July 2004, Elsevier

    Xiang-Qun Hu

  54. Arginine 222 in the Pre-transmembrane Domain 1 of 5-HT3A Receptors Links Agonist Binding to Channel Gating

    Article • Journal of Biological Chemistry, November 2003, Elsevier

    Xiang-Qun Hu

  55. Effect of Chronic Hypoxia on Alpha-1 Adrenoceptor-Mediated Inositol 1,4,5-Trisphosphate Signaling in Ovine Uterine Artery

    Article • Journal of Pharmacology and Experimental Therapeutics, March 1999, Elsevier

    Xiang-Qun Hu

  56. Effect of chronic hypoxia on adrenoceptor responses of ovine foetal umbilical vessels

    Article • British Journal of Pharmacology, September 1998, Wiley

    Xiang-Qun Hu

  57. Endothelium-dependent potentiation by cocaine of serotonin-induced contractions in sheep fetal umbilical artery

    Article • Journal of the Society for Gynecologic Investigation, March 1998, Springer Science + Business Media

    Xiang-Qun Hu

  58. Modulation of Voltage-dependent Ca2+Channels in Rabbit Colonic Smooth Muscle Cells by c-Src and Focal Adhesion Kinase

    Article • Journal of Biological Chemistry, February 1998, Elsevier

    Xiang-Qun Hu

  59. Heterogeneity and complexity of α1-adrenoceptors in the ovine uterine artery and umbilical vein

    Article • European Journal of Pharmacology, April 1997, Elsevier

    Xiang-Qun Hu

  60. 5-Hydroxytryptamine stimulates phosphoinositide hydrolysis and contraction in the ovine umbilical artery

    Article • European Journal of Pharmacology, March 1997, Elsevier

    Xiang-Qun Hu

  61. Chronic hypoxia suppresses pharmacomechanical coupling of the uterine artery in near‐term pregnant sheep.

    Article • The Journal of Physiology, March 1997, Wiley

    Xiang-Qun Hu

  62. Effects of long-term high-altitude hypoxemia on alpha 1-adrenergic receptors in the ovine uterine artery

    Article • AJP Heart and Circulatory Physiology, March 1996, American Physiological Society

    Xiang-Qun Hu

  63. Serotonin stimulates rapid increase of inositol 1,4,5-trisphosphate in ovine uterine artery: correlation with contractile state.

    Article • Journal of Pharmacology and Experimental Therapeutics, November 1995, Elsevier

    Xiang-Qun Hu