All Stories

  1. Targeting glucose metabolism with dichloroacetate (DCA) reduces zika virus replication in brain cortical progenitors at different stages of maturation
  2. Structural and functional characterization of nanobodies that neutralize Omicron variants of SARS-CoV-2
  3. Proactive vaccination using multiviral Quartet Nanocages to elicit broad anti-coronavirus responses
  4. Hypoxia dampens innate immune signalling at early time points and increases Zika virus RNA levels in iPSC-derived macrophages
  5. Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy
  6. Density dependent regulation of inflammatory responses in macrophages
  7. Intranasal SARS-CoV-2 spike-based immunisation adjuvanted with polyethyleneimine elicits mucosal and systemic humoral responses in mice
  8. Single-cell transcriptomics defines an improved, validated monoculture protocol for differentiation of human iPSC to microglia
  9. Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia
  10. Radical-SAM dependent nucleotide dehydratase (SAND), rectification of the names of an ancient iron-sulfur enzyme using NC-IUBMB recommendations
  11. Aberrant inflammatory responses to type I interferon in STAT2 or IRF9 deficiency
  12. SAMHD1 controls nucleoside-based cancer therapeutics, deoxyguanosine toxicity, and inflammation
  13. Zika virus-induces metabolic alterations in fetal neuronal progenitors that could influence in neurodevelopment during early pregnancy
  14. Human iPSC co-culture model to investigate the interaction between microglia and motor neurons
  15. Finding a chink in the armor: Update, limitations, and challenges toward successful antivirals against flaviviruses
  16. A rapid antibody screening haemagglutination test for predicting immunity to SARS-CoV-2 variants of concern
  17. Zika Virus Neuropathogenesis: The Different Brain Cells, Host Factors and Mechanisms Involved
  18. Divergent trajectories of antiviral memory after SARS-CoV-2 infection
  19. Host Molecules Regulating Neural Invasion of Zika Virus and Drug Repurposing Strategy
  20. Absolute quantitation of individual SARS-CoV-2 RNA molecules provides a new paradigm for infection dynamics and variant differences
  21. SARS-CoV-2 Variants, Vaccines, and Host Immunity
  22. T-cell and antibody responses to first BNT162b2 vaccine dose in previously infected and SARS-CoV-2-naive UK health-care workers: a multicentre prospective cohort study
  23. Structures and therapeutic potential of anti-RBD human monoclonal antibodies against SARS-CoV-2
  24. An immunodominant NP105–113-B*07:02 cytotoxic T cell response controls viral replication and is associated with less severe COVID-19 disease
  25. Neutralizing Antibodies to SARS‐CoV‐2 Selected from a Human Antibody Library Constructed Decades Ago
  26. Hide and Seek: The Interplay Between Zika Virus and the Host Immune Response
  27. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
  28. The use of nanobodies in a sensitive ELISA test for SARS-CoV-2 Spike 1 protein
  29. Two doses of SARS-CoV-2 vaccination induce robust immune responses to emerging SARS-CoV-2 variants of concern
  30. Correlative multi-scale cryo-imaging unveils SARS-CoV-2 assembly and egress
  31. A potent SARS-CoV-2 neutralising nanobody shows therapeutic efficacy in the Syrian golden hamster model of COVID-19
  32. Differentiation of human induced pluripotent stem cells to authentic macrophages using a defined, serum-free, open-source medium
  33. Absolute quantitation of individual SARS-CoV-2 RNA molecules: a new paradigm for infection dynamics and variant differences
  34. Evidence of escape of SARS-CoV-2 variant B.1.351 from natural and vaccine-induced sera
  35. Hypoxic and pharmacological activation of HIF inhibits SARS-CoV-2 infection of lung epithelial cells
  36. Reduced neutralization of SARS-CoV-2 B.1.1.7 variant by convalescent and vaccine sera
  37. Naturally-acquired immunity in Syrian Golden Hamsters provides protection from re-exposure to emerging heterosubtypic SARS-CoV-2 variants B.1.1.7 and B.1.351
  38. Breadth and function of antibody response to acute SARS-CoV-2 infection in humans
  39. In vitro Quantitative Imaging Assay for Phagocytosis of Dead Neuroblastoma Cells by iPSC-Macrophages
  40. Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
  41. The antigenic anatomy of SARS-CoV-2 receptor binding domain
  42. Tissue-resident macrophages regulate lymphatic vessel growth and patterning in the developing heart
  43. T-Cell and Antibody Responses to First BNT162b2 Vaccine Dose in Previously SARS-CoV-2-Infected and Infection-Naive UK Healthcare Workers: A Multicentre, Prospective, Observational Cohort Study
  44. Honing the Double-Edged Sword: Improving Human iPSC-Microglia Models
  45. Interferon‐stimulated gene products as regulators of central carbon metabolism
  46. TREM2 Alzheimer’s variant R47H causes similar transcriptional dysregulation to knockout, yet only subtle functional phenotypes in human iPSC-derived macrophages
  47. Author Correction: Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
  48. SARS-CoV-2 RNA detected in blood products from patients with COVID-19 is not associated with infectious virus
  49. Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication
  50. Safety and immunogenicity of the ChAdOx1 nCoV-19 vaccine against SARS-CoV-2: a preliminary report of a phase 1/2, single-blind, randomised controlled trial
  51. Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
  52. Neutralizing nanobodies bind SARS-CoV-2 spike RBD and block interaction with ACE2
  53. Structural basis for the neutralization of SARS-CoV-2 by an antibody from a convalescent patient
  54. SARS-CoV-2 RNA detected in blood samples from patients with COVID-19 is not associated with infectious virus
  55. LRRK2 Is Recruited to Phagosomes and Co-recruits RAB8 and RAB10 in Human Pluripotent Stem Cell-Derived Macrophages
  56. ddhCTP produced by the radical‐SAM activity of RSAD2 (viperin) inhibits the NAD+‐dependent activity of enzymes to modulate metabolism
  57. Pharmacological activation of the circadian component REV-ERB inhibits HIV-1 replication
  58. Viperin, through its radical‐SAM activity, depletes cellular nucleotide pools and interferes with mitochondrial metabolism to inhibit viral replication
  59. Mechanism of Diol Dehydration by a Promiscuous Radical‐SAM Enzyme Homologue of the Antiviral Enzyme Viperin (RSAD2)
  60. A novel biparatopic hybrid antibody-ACE2 fusion that blocks SARS-CoV-2 infection: implications for therapy
  61. Hypoxic and Pharmacological Activation of HIF Inhibits SARS-CoV-2 Infection of Lung Epithelial Cells
  62. SARS-CoV-2 Assembly and Egress Pathway Revealed by Correlative Multi-Modal Multi-Scale Cryo-Imaging
  63. The potential contribution of impaired brain glucose metabolism to congenital Zika syndrome
  64. RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation
  65. Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages
  66. A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response
  67. LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease
  68. Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB -Independent Tissue-Resident Macrophages
  69. The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq
  70. Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease
  71. A Novel Real Time Imaging Platform to Quantify Macrophage Phagocytosis
  72. ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons
  73. CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells
  74. Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons
  75. The Productive Entry Pathway of HIV-1 in Macrophages Is Dependent on Endocytosis through Lipid Rafts Containing CD4
  76. Differentially expressed, variant U1 snRNAs regulate gene expression in human cells
  77. Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease
  78. Several Commercially Available Anti-CCR5 Monoclonal Antibodies Lack Specificity and Should Be Used with Caution
  79. Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration
  80. Protein Kinase C and NF- B-Dependent CD4 Downregulation in Macrophages Induced by T Cell-Derived Soluble Factors: Consequences for HIV-1 Infection
  81. Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells
  82. Proteomic-Based Identification of CD4-Interacting Proteins in Human Primary Macrophages
  83. Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides
  84. HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1
  85. Episomal Transgene Expression in Pluripotent Stem Cells
  86. Protection of HIV Neutralizing Aptamers against Rectal and Vaginal Nucleases: IMPLICATIONS FOR RNA-BASED THERAPEUTICS
  87. Derivation and characterisation of the human embryonic stem cell line, OxF1
  88. The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells
  89. Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation
  90. The 5′ Leader of the mRNA Encoding the Marek's Disease Virus Serotype 1 pp14 Protein Contains an Intronic Internal Ribosome Entry Site with Allosteric Properties
  91. Identification of an Intercistronic Internal Ribosome Entry Site in a Marek's Disease Virus Immediate-Early Gene
  92. HIV entry in macrophages is dependent on intact lipid rafts
  93. An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site
  94. Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3
  95. Inter-Oligomer Interactions of the Human Prion Protein Are Modulated by the Polymorphism at Codon 129
  96. Conformational pH dependence of intermediate states during oligomerization of the human prion protein
  97. Aptamers in the virologists' toolkit
  98. Oligomerization of the Human Prion Protein Proceeds via a Molten Globule Intermediate
  99. Molecular Heterosis of Prion Protein β-Oligomers
  100. An Aptamer That Neutralizes R5 Strains of Human Immunodeficiency Virus Type 1 Blocks gp120-CCR5 Interaction
  101. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1
  102. The presence of valine at residue 129 in human prion protein accelerates amyloid formation
  103. Rapid formation of amyloid from  -monomeric recombinant human PrP in vitro
  104. Autocatalytic RNA cleavage in the human β-globin pre-mRNA promotes transcription termination
  105. Assessing potential: the development of selection procedures for the Oxford medical course
  106. Methionine 129 Variant of Human Prion Protein Oligomerizes More Rapidly than the Valine 129 Variant: IMPLICATIONS FOR DISEASE SUSCEPTIBILITY TO CREUTZFELDT-JAKOB DISEASE
  107. Structural Determinants of Conformationally Selective, Prion-binding Aptamers
  108. Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers
  109. Characterization of 2'-Fluoro-RNA Aptamers That Bind Preferentially to Disease-associated Conformations of Prion Protein and Inhibit Conversion
  110. Molecular epidemiology of dengue virus type 3 in Venezuela
  111. Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides
  112. High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands
  113. Structural characterization of a 2′F-RNA aptamer that binds a HIV-1 SU glycoprotein, gp120
  114. Nucleic acid and polypeptide aptamers: a powerful approach to ligand discovery
  115. Neurological manifestations of dengue infection
  116. Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes
  117. Affinity and Kinetics of the Interaction between Soluble Trimeric OX40 Ligand, a Member of the Tumor Necrosis Factor Superfamily, and Its Receptor OX40 on Activated T Cells
  118. Comparison of p24 measurement by ELISA versus indicator cells for detecting residual HIV infectivity in vitro
  119. The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding
  120. The Receptor for HIV: Dissection of CD4 and Studies on Putative Accessory Factors
  121. Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.
  122. RNA enzymes as tools for gene ablation
  123. Heterokaryons Formed between a Rat Myeloma and a Mouse Fibroblast Are Permissive for Entry of HIV Type 1
  124. A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection
  125. Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurements
  126. HIV-1 pseudotype virus containing a Cocal virus genome and an HIV envelope: construction, assay and use
  127. Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro
  128. A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection
  129. Inhibition of HIV-1 replication by ribozymes that show poor activityin vitro
  130. Gene Inhibition of HIV-1 Replication.
  131. Towards Gene-Inhibition Therapy: A Review of Progress and Prospects in the Field of Antiviral Antisense Nucleic Acids and Ribozymes
  132. Development of techniques to analyse the formation of HIV provirus in primary human macrophages
  133. Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA
  134. PCR and the cloning of receptor subtype genes
  135. The cytochrome oxidases ofBacillus subtilis: mapping of a gene affecting cytochromeaa3and its replacement by cytochromeoin a mutant strain
  136. First Workshop of the MRC AIDS-Directed Programme
  137. The Head-Tail Linker Protein of Bacteriophage T5: Genetic and Immunological Studies
  138. Host-adaptive Antigenic Variation in Bunyaviruses