All Stories

  1. RIPK1 is a critical modulator of both tonic and TLR-responsive inflammatory and cell death pathways in human macrophage differentiation

    Article • Cell Death and Disease, September 2018, Springer Science + Business Media

    Professor William s James

  2. Excess α-synuclein compromises phagocytosis in iPSC-derived macrophages

    Article • Scientific Reports, August 2017, Nature

    Professor William s James

  3. A Highly Efficient Human Pluripotent Stem Cell Microglia Model Displays a Neuronal-Co-culture-Specific Expression Profile and Inflammatory Response

    Article • Stem Cell Reports, June 2017, Elsevier

    Professor William s James

  4. LRRK2 in peripheral and central nervous system innate immunity: its link to Parkinson's disease

    Article • Biochemical Society Transactions, February 2017, Portland Press Ltd.

    Professor William s James

  5. Human Induced Pluripotent Stem Cell-Derived Macrophages Share Ontogeny with MYB -Independent Tissue-Resident Macrophages

    Article • Stem Cell Reports, February 2017, Elsevier

    Professor William s James

  6. The nature and nurture of cell heterogeneity: accounting for macrophage gene-environment interactions with single-cell RNA-Seq

    Article • BMC Genomics, January 2017, Springer Science + Business Media

    Professor William s James

  7. Variant U1 snRNAs are implicated in human pluripotent stem cell maintenance and neuromuscular disease

    Article • Nucleic Acids Research, August 2016, Oxford University Press (OUP)

    Professor William s James

  8. A Novel Real Time Imaging Platform to Quantify Macrophage Phagocytosis

    Article • Biochemical Pharmacology, July 2016, Elsevier

    Professor William s James

  9. ER Stress and Autophagic Perturbations Lead to Elevated Extracellular α-Synuclein in GBA-N370S Parkinson's iPSC-Derived Dopamine Neurons

    Article • Stem Cell Reports, March 2016, Elsevier

    Professor William s James

  10. CRISPR-mediated genotypic and phenotypic correction of a chronic granulomatous disease mutation in human iPS cells

    Article • Experimental Hematology, October 2015, Elsevier

    Professor William s James

  11. Physiological Characterisation of Human iPS-Derived Dopaminergic Neurons

    Article • PLoS ONE, February 2014, PLOS

    Professor William s James

  12. The Productive Entry Pathway of HIV-1 in Macrophages Is Dependent on Endocytosis through Lipid Rafts Containing CD4

    Article • PLoS ONE, January 2014, PLOS

    Professor William s James

  13. Differentially expressed, variant U1 snRNAs regulate gene expression in human cells

    Article • Genome Research, October 2012, Cold Spring Harbor Laboratory Press

    Professor William s James

  14. Derivation and Functional Analysis of Patient-Specific Induced Pluripotent Stem Cells as an In Vitro Model of Chronic Granulomatous Disease

    Article • Stem Cells, March 2012, Wiley

    Professor William s James

  15. Several Commercially Available Anti-CCR5 Monoclonal Antibodies Lack Specificity and Should Be Used with Caution

    Article • February 2012, Mary Ann Liebert Inc

    Professor William s James

  16. Transportin 3 Promotes a Nuclear Maturation Step Required for Efficient HIV-1 Integration

    Article • PLoS Pathogens, August 2011, PLOS

    Professor William s James

  17. Protein Kinase C and NF- B-Dependent CD4 Downregulation in Macrophages Induced by T Cell-Derived Soluble Factors: Consequences for HIV-1 Infection

    Article • The Journal of Immunology, June 2011, The American Association of Immunologists

    Professor William s James

  18. Functional human artificial chromosomes are generated and stably maintained in human embryonic stem cells

    Article • Human Molecular Genetics, May 2011, Oxford University Press (OUP)

    Professor William s James

  19. Proteomic-Based Identification of CD4-Interacting Proteins in Human Primary Macrophages

    Article • PLoS ONE, April 2011, PLOS

    Professor William s James

  20. Generation of neutralizing aptamers against herpes simplex virus type 2: potential components of multivalent microbicides

    Article • Journal of General Virology, April 2011, Society for General Microbiology

    Professor William s James

  21. HIV-1 infects macrophages by exploiting an endocytic route dependent on dynamin, Rac1 and Pak1

    Article • Virology, January 2011, Elsevier

    Professor William s James

  22. Episomal Transgene Expression in Pluripotent Stem Cells

    Article • January 2011, Springer Science + Business Media

    Professor William s James

  23. Protection of HIV Neutralizing Aptamers against Rectal and Vaginal Nucleases: IMPLICATIONS FOR RNA-BASED THERAPEUTICS

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  24. Derivation and characterisation of the human embryonic stem cell line, OxF1

    Article • In Vitro Cellular & Developmental Biology - Animal, March 2010, Springer Science + Business Media

    Professor William s James

  25. The roles of apoptotic pathways in the low recovery rate after cryopreservation of dissociated human embryonic stem cells

    Article • Biotechnology Progress, January 2010, Wiley

    Professor William s James

  26. Enhancement of cell recovery for dissociated human embryonic stem cells after cryopreservation

    Article • Biotechnology Progress, December 2009, Wiley

    Professor William s James

  27. The 5′ Leader of the mRNA Encoding the Marek's Disease Virus Serotype 1 pp14 Protein Contains an Intronic Internal Ribosome Entry Site with Allosteric Properties

    Article • Journal of Virology, September 2009, ASM Journals

    Professor William s James

  28. Identification of an Intercistronic Internal Ribosome Entry Site in a Marek's Disease Virus Immediate-Early Gene

    Article • Journal of Virology, March 2009, ASM Journals

    Professor William s James

  29. HIV entry in macrophages is dependent on intact lipid rafts

    Article • Virology, March 2009, Elsevier

    Professor William s James

  30. An aptamer that neutralizes R5 strains of HIV-1 binds to core residues of gp120 in the CCR5 binding site

    Article • Virology, November 2008, Elsevier

    Professor William s James

  31. Homogeneous monocytes and macrophages from human embryonic stem cells following coculture-free differentiation in M-CSF and IL-3

    Article • Experimental Hematology, September 2008, Elsevier

    Professor William s James

  32. Inter-Oligomer Interactions of the Human Prion Protein Are Modulated by the Polymorphism at Codon 129

    Article • Journal of Molecular Biology, August 2008, Elsevier

    Professor William s James

  33. Conformational pH dependence of intermediate states during oligomerization of the human prion protein

    Article • Protein Science, March 2008, Wiley

    Professor William s James

  34. Aptamers in the virologists' toolkit

    Article • Journal of General Virology, February 2007, Society for General Microbiology

    Professor William s James

  35. Oligomerization of the Human Prion Protein Proceeds via a Molten Globule Intermediate

    Article • Journal of Biological Chemistry, December 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  36. Molecular Heterosis of Prion Protein β-Oligomers

    Article • Journal of Biological Chemistry, September 2006, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  37. An Aptamer That Neutralizes R5 Strains of Human Immunodeficiency Virus Type 1 Blocks gp120-CCR5 Interaction

    Article • Journal of Virology, November 2005, ASM Journals

    Professor William s James

  38. Structural characterization of an anti-gp120 RNA aptamer that neutralizes R5 strains of HIV-1

    Article • RNA, June 2005, Cold Spring Harbor Laboratory Press

    Professor William s James

  39. The presence of valine at residue 129 in human prion protein accelerates amyloid formation

    Article • FEBS Letters, April 2005, Wiley

    Professor William s James

  40. Rapid formation of amyloid from  -monomeric recombinant human PrP in vitro

    Article • Protein Science, March 2005, Wiley

    Professor William s James

  41. Autocatalytic RNA cleavage in the human β-globin pre-mRNA promotes transcription termination

    Article • Nature, November 2004, Nature

    Professor William s James

  42. Assessing potential: the development of selection procedures for the Oxford medical course

    Article • Oxford Review of Education, June 2004, Taylor & Francis

    Professor William s James

  43. Methionine 129 Variant of Human Prion Protein Oligomerizes More Rapidly than the Valine 129 Variant: IMPLICATIONS FOR DISEASE SUSCEPTIBILITY TO CREUTZFELDT-JAKOB DISEASE

    Article • Journal of Biological Chemistry, May 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  44. Structural Determinants of Conformationally Selective, Prion-binding Aptamers

    Article • Journal of Biological Chemistry, January 2004, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  45. Neutralization of Infectivity of Diverse R5 Clinical Isolates of Human Immunodeficiency Virus Type 1 by gp120-Binding 2′F-RNA Aptamers

    Article • Journal of Virology, December 2003, ASM Journals

    Professor William s James

  46. Characterization of 2'-Fluoro-RNA Aptamers That Bind Preferentially to Disease-associated Conformations of Prion Protein and Inhibit Conversion

    Article • Journal of Biological Chemistry, August 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  47. Molecular epidemiology of dengue virus type 3 in Venezuela

    Article • Journal of General Virology, June 2003, Society for General Microbiology

    Professor William s James

  48. Competing intrachain interactions regulate the formation of beta-sheet fibrils in bovine PrP peptides

    Article • Protein Science, March 2003, Wiley

    Professor William s James

  49. High affinity nucleic acid aptamers for streptavidin incorporated into bi-specific capture ligands

    Article • Nucleic Acids Research, May 2002, Oxford University Press (OUP)

    Professor William s James

  50. Structural characterization of a 2′F-RNA aptamer that binds a HIV-1 SU glycoprotein, gp120

    Article • Biochemical and Biophysical Research Communications, May 2002, Elsevier

    Professor William s James

  51. Nucleic acid and polypeptide aptamers: a powerful approach to ligand discovery

    Article • Current Opinion in Pharmacology, October 2001, Elsevier

    Professor William s James

  52. Neurological manifestations of dengue infection

    Article • The Lancet, March 2000, Elsevier

    Professor William s James

  53. Cell-surface heparan sulfate facilitates human immunodeficiency virus Type 1 entry into some cell lines but not primary lymphocytes

    Article • Virus Research, April 1999, Elsevier

    Professor William s James

  54. Affinity and Kinetics of the Interaction between Soluble Trimeric OX40 Ligand, a Member of the Tumor Necrosis Factor Superfamily, and Its Receptor OX40 on Activated T Cells

    Article • Journal of Biological Chemistry, February 1997, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor William s James

  55. Comparison of p24 measurement by ELISA versus indicator cells for detecting residual HIV infectivity in vitro

    Article • Journal of Virological Methods, April 1996, Elsevier

    Professor William s James

  56. The bicyclams, a new class of potent human immunodeficiency virus inhibitors, block viral entry after binding

    Article • Antiviral Research, March 1996, Elsevier

    Professor William s James

  57. Poly(A) site selection in the HIV-1 provirus: inhibition of promoter-proximal polyadenylation by the downstream major splice donor site.

    Article • Genes & Development, December 1995, Cold Spring Harbor Laboratory Press

    Professor William s James

  58. RNA enzymes as tools for gene ablation

    Article • Current Opinion in Biotechnology, January 1995, Elsevier

    Professor William s James

  59. Heterokaryons Formed between a Rat Myeloma and a Mouse Fibroblast Are Permissive for Entry of HIV Type 1

    Article • AIDS Research and Human Retroviruses, December 1994, Mary Ann Liebert Inc

    Professor William s James

  60. A rodent cell line permissive for entry and reverse transcription of human immunodeficiency virus type 1 has a pre-integration block to productive infection

    Article • Journal of General Virology, October 1994, Society for General Microbiology

    Professor William s James

  61. Definition of the range and distribution of human immunodeficiency virus macrophage tropism using PCR-based infectivity measurements

    Article • Journal of General Virology, July 1994, Society for General Microbiology

    Professor William s James

  62. HIV-1 pseudotype virus containing a Cocal virus genome and an HIV envelope: construction, assay and use

    Article • Journal of Virological Methods, October 1993, Elsevier

    Professor William s James

  63. Interleukin 13 inhibits human immunodeficiency virus type 1 production in primary blood-derived human macrophages in vitro

    Article • The Journal of Experimental Medicine, August 1993, Rockefeller University Press

    Professor William s James

  64. A rat CD4 mutant containing the gp120-binding site mediates human immunodeficiency virus type 1 infection

    Article • The Journal of Experimental Medicine, April 1993, Rockefeller University Press

    Professor William s James

  65. Inhibition of HIV-1 replication by ribozymes that show poor activityin vitro

    Article • Nucleic Acids Research, January 1993, Oxford University Press (OUP)

    Professor William s James

  66. Gene Inhibition of HIV-1 Replication.

    Article • Annals of the New York Academy of Sciences, October 1992, Wiley

    Professor William s James

  67. Towards Gene-Inhibition Therapy: A Review of Progress and Prospects in the Field of Antiviral Antisense Nucleic Acids and Ribozymes

    Article • Antiviral Chemistry and Chemotherapy, August 1991, SAGE Publications

    Professor William s James

  68. Development of techniques to analyse the formation of HIV provirus in primary human macrophages

    Article • Research in Virology, January 1991, Elsevier

    Professor William s James

  69. Inhibition of human immunodeficiency virus replication in cell culture by endogenously synthesized antisense RNA

    Article • Journal of General Virology, September 1990, Society for General Microbiology

    Professor William s James

  70. PCR and the cloning of receptor subtype genes

    Article • Trends in Pharmacological Sciences, September 1989, Elsevier

    Professor William s James

  71. First Workshop of the MRC AIDS-Directed Programme

    Article • Vaccine, June 1988, Elsevier

    Professor William s James

  72. The Head-Tail Linker Protein of Bacteriophage T5: Genetic and Immunological Studies

    Article • Journal of General Virology, April 1987, Society for General Microbiology

    Professor William s James

  73. Host-adaptive Antigenic Variation in Bunyaviruses

    Article • Journal of General Virology, December 1986, Society for General Microbiology

    Professor William s James