All Stories

  1. Integrating GPC3 with Other Biomarkers to Improve the Diagnosis of Early-Stage Liver Cancer

    Article • Pathogens, November 2025, MDPI AG

    Dr Wenyu Lin

  2. YAP mediates HIV-related liver fibrosis

    Article • JHEP Reports, November 2024, Elsevier

    Dr Wenyu Lin

  3. HIV coinfection exacerbates HBV-induced liver fibrogenesis through a HIF-1α- and TGF-β1-dependent pathway

    Article • Journal of Hepatology, February 2024, Elsevier

    Dr Wenyu Lin

  4. Vaccination increased host antiviral gene expression and reduced COVID-19 severity during the Omicron variant outbreak in Fuyang City, China

    Article • International Immunopharmacology, July 2023, Elsevier

    Dr Wenyu Lin

  5. LOXL-2 and TNC-C are markers of liver fibrogenesis in HCV/HIV-, HIV- and HCV-infected patients

    Article • Biomarkers in Medicine, August 2022, Future Medicine

    Dr Wenyu Lin

  6. Hepatitis B and Hepatitis C Virus Infection Promote Liver Fibrogenesis through a TGF-β1–Induced OCT4/Nanog Pathway

    Article • The Journal of Immunology, February 2022, The American Association of Immunologists

    Dr Wenyu Lin

  7. [18F]MAGL-4-11 positron emission tomography molecular imaging of monoacylglycerol lipase changes in preclinical liver fibrosis models

    Article • Acta Pharmaceutica Sinica B, January 2022, Elsevier

    Dr Wenyu Lin

  8. A New Model to Assess Hepatitis B Virus Covalently Closed Circular DNA: A Window Into a Previously Hidden Space?

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2022, Elsevier

    Dr Wenyu Lin

  9. Assessment of Non-invasive Markers for the Prediction of Esophageal Variceal Hemorrhage

    Article • Frontiers in Medicine, December 2021, Frontiers

    Dr Wenyu Lin

  10. The risk of hepatitis C virus recurrence in hepatitis C virus‐infected patients treated with direct‐acting antivirals after achieving a sustained virological response: A comprehensive analysis

    Article • Liver International, June 2021, Wiley

    Dr Wenyu Lin

  11. Differentially expressed immune response genes in COVID-19 patients based on disease severity

    Article • Aging, March 2021, Impact Journals, LLC

    Dr Wenyu Lin

  12. Inflammatory microenvironment of fibrotic liver promotes hepatocellular carcinoma growth, metastasis and sorafenib resistance through STAT3 activation

    Article • Journal of Cellular and Molecular Medicine, January 2021, Wiley

    Dr Wenyu Lin

  13. Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

    Article • Cellular and Molecular Gastroenterology and Hepatology, January 2021, Elsevier

    Dr Wenyu Lin

  14. Virus detection using nanoparticles and deep neural network–enabled smartphone system

    Article • Science Advances, December 2020, American Association for the Advancement of Science

    Dr Wenyu Lin

  15. Pyruvate Kinase M2 Tetramerization Protects against Hepatic Stellate Cell Activation and Liver Fibrosis

    Article • American Journal Of Pathology, November 2020, Elsevier

    Dr Wenyu Lin

  16. COVID-19 induced liver function abnormality associates with age

    Article • Aging, July 2020, Impact Journals, LLC

    Dr Wenyu Lin

  17. Dexmedetomidine promotes the progression of hepatocellular carcinoma through hepatic stellate cell activation

    Article • Experimental & Molecular Medicine, July 2020, Springer Science + Business Media

    Dr Wenyu Lin

  18. 2′, 5′-Oligoadenylate Synthetase 2 (OAS2) Inhibits Zika Virus Replication through Activation of Type Ι IFN Signaling Pathway

    Article • Viruses, April 2020, MDPI AG

    Dr Wenyu Lin

  19. Microrna-130a Downregulates HCV Replication through an atg5-Dependent Autophagy Pathway

    Article • Cells, April 2019, MDPI AG

    Dr Wenyu Lin

  20. A Long Noncoding RNA Regulates Hepatitis C Virus Infection Through Interferon Alpha–Inducible Protein 6

    Article • Hepatology, February 2019, Wolters Kluwer Health

    Dr Wenyu Lin

  21. Tyrosine Kinase SYK is a Potential Therapeutic Target for Liver Fibrosis

    Article • Hepatology, March 2018, Wiley

    Dr Wenyu Lin

  22. MicroRNA 130a Regulates both Hepatitis C Virus and Hepatitis B Virus Replication through a Central Metabolic Pathway

    Article • Journal of Virology, January 2018, ASM Journals

    Professor Limin Chen, Dr Wenyu Lin

  23. Intermittent hypoxia is a proinflammatory stimulus resulting in IL-6 expression and M1 macrophage polarization

    Article • Hepatology Communications, May 2017, Wiley

    Dr Wenyu Lin

  24. HELZ2 Is an IFN Effector Mediating Suppression of Dengue Virus

    Article • Frontiers in Microbiology, February 2017, Frontiers

    Dr Wenyu Lin

  25. IQGAP2 is a novel interferon-alpha antiviral effector gene acting non-conventionally through the NF-κB pathway

    Article • Journal of Hepatology, November 2016, Elsevier

    Dr Wenyu Lin

  26. Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types

    Article • Hepatology, October 2016, Wolters Kluwer Health

    Dr Wenyu Lin

  27. HCV induces transforming growth factor β1 through activation of endoplasmic reticulum stress and the unfolded protein response

    Article • Scientific Reports, March 2016, Springer Science + Business Media

    Dr Wenyu Lin

  28. Apolipoprotein B100 is required for hepatitis C infectivity and Mipomersen inhibits hepatitis C

    Article • World Journal of Gastroenterology, January 2016, Baishideng Publishing Group Co., Limited (formerly WJG Press)

    Dr Wenyu Lin

  29. The spliceosome factor SART1 exerts its anti-HCV action through mRNA splicing

    Article • Journal of Hepatology, May 2015, Elsevier

    Dr Wenyu Lin

  30. EFTUD2 Is a Novel Innate Immune Regulator Restricting Hepatitis C Virus Infection through the RIG-I/MDA5 Pathway

    Article • Journal of Virology, April 2015, ASM Journals

    Dr Wenyu Lin

  31. TRAIL Enhances Apoptosis of Human Hepatocellular Carcinoma Cells Sensitized by Hepatitis C Virus Infection: Therapeutic Implications

    Article • PLOS One, June 2014, PLOS

    Dr Wenyu Lin

  32. Kinetic differences in the induction of interferon stimulated genes by interferon-α and interleukin 28B are altered by infection with hepatitis C virus

    Article • Hepatology, April 2014, Wolters Kluwer Health

    Dr Wenyu Lin

  33. The AMPK-related kinase SNARK regulates hepatitis C virus replication and pathogenesis through enhancement of TGF-β signaling

    Article • Journal of Hepatology, November 2013, Elsevier

    Dr Wenyu Lin

  34. A Genetic Screen Identifies Interferon-α Effector Genes Required to Suppress Hepatitis C Virus Replication

    Article • Gastroenterology, June 2013, Elsevier

    Dr Wenyu Lin, Dr Yi-Wen Huang

  35. Inhibition of HCV by the serpin antithrombin III

    Article • Virology Journal, October 2012, Springer Science + Business Media

    Dr Wenyu Lin

  36. ARF1 and GBF1 Generate a PI4P-Enriched Environment Supportive of Hepatitis C Virus Replication

    Article • PLOS One, February 2012, PLOS

    Dr Wenyu Lin

  37. A functional genomic screen reveals novel host genes that mediate interferon-alpha’s effects against hepatitis C virus

    Article • Journal of Hepatology, February 2012, Elsevier

    Dr Wenyu Lin

  38. Naringenin inhibits the assembly and long-term production of infectious hepatitis C virus particles through a PPAR-mediated mechanism

    Article • Journal of Hepatology, November 2011, Elsevier

    Dr Wenyu Lin

  39. IL28B inhibits hepatitis C virus replication through the JAK–STAT pathway

    Article • Journal of Hepatology, August 2011, Elsevier

    Dr Wenyu Lin

  40. HIV infection increases HCV-induced hepatocyte apoptosis

    Article • Journal of Hepatology, April 2011, Elsevier

    Dr Mark A Brockman, Dr Wenyu Lin

  41. HIV and HCV Cooperatively Promote Hepatic Fibrogenesis via Induction of Reactive Oxygen Species and NFκB

    Article • Journal of Biological Chemistry, November 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Mark A Brockman, Dr Wenyu Lin

  42. Hepatitis B screening, prophylaxis and re-activation in the era of rituximab-based chemotherapy

    Article • Liver International, August 2010, Wiley

    Dr Wenyu Lin

  43. Hepatitis C Virus Regulates Transforming Growth Factor β1 Production Through the Generation of Reactive Oxygen Species in a Nuclear Factor κB–Dependent Manner

    Article • Gastroenterology, June 2010, Elsevier

    Dr Wenyu Lin

  44. Reduction of Insulin Resistance With Effective Clearance of Hepatitis C Infection: Results From the HALT-C Trial

    Article • Clinical Gastroenterology and Hepatology, May 2010, Elsevier

    Dr Wenyu Lin

  45. Hepatic SOCS3 expression is strongly associated with non-response to therapy and race in HCV and HCV/HIV infection

    Article • Journal of Hepatology, April 2009, Elsevier

    Dr Wenyu Lin

  46. HIV Increases HCV Replication in a TGF-β1–Dependent Manner

    Article • Gastroenterology, March 2008, Elsevier

    Dr Mark A Brockman, Dr Wenyu Lin

  47. Serum Apoptosis Markers in Acute Liver Failure: A Pilot Study

    Article • Clinical Gastroenterology and Hepatology, December 2007, Elsevier

    Dr Wenyu Lin, Dr. Linda S Hynan

  48. Viral Factors Associated with Cytokine Expression During HCV/HIV Co-Infection

    Article • Journal of Interferon & Cytokine Research, April 2007, Mary Ann Liebert Inc

    Dr Wenyu Lin

  49. A Cell-Based, High-Throughput Screen for Small Molecule Regulators of Hepatitis C Virus Replication

    Article • Gastroenterology, January 2007, Elsevier

    Dr Wenyu Lin

  50. Hepatitis C Virus Core Protein Blocks Interferon Signaling by Interaction with the STAT1 SH2 Domain

    Article • Journal of Virology, September 2006, ASM Journals

    Dr Wenyu Lin

  51. GB Virus C (GBV‐C) Infection in Hepatitis C Virus (HCV)/HIV–Coinfected Patients Receiving HCV Treatment: Importance of the GBV‐C Genotype

    Article • The Journal of Infectious Diseases, August 2006, Oxford University Press (OUP)

    Dr Wenyu Lin

  52. Cell-based models of sustained, interferon-sensitive hepatitis C virus genotype 1 replication

    Article • Journal of Virological Methods, March 2006, Elsevier

    Dr Wenyu Lin

  53. Hepatitis C virus expression suppresses interferon signaling by degrading STAT1

    Article • Gastroenterology, April 2005, Elsevier

    Dr Wenyu Lin

  54. Hepatitis C virus acts as a tumor accelerator by blocking apoptosis in a mouse model of hepatocarcinogenesis

    Article • Hepatology, January 2005, Wiley

    Dr Wenyu Lin