All Stories

  1. CNVPipe: An enhanced pipeline for accurate analysis of copy number variation from whole-genome sequencing
  2. Single-cell transcriptomics reveals a compartmentalized antiviral interferon response in the nasal epithelium of mice
  3. Unveiling two distinct osteolineage cell populations linked to age-related osteoporosis in adult mice through integrative single-cell analyses
  4. Single-cell transcriptomic analysis of chondrocytes in cartilage and pathogenesis of osteoarthritis
  5. Graph-based Contrastive Learning Enables Unified Integration and Niche Transfer Across Single-Cell and Spatial Multi-Omics
  6. Protocol for mapping T cell activation using single-cell RNA-seq
  7. A catalog of gene editing sites and genetic variations in editing sites in model organisms
  8. scMMO-atlas: a single cell multimodal omics atlas and portal for exploring fine cell heterogeneity and cell dynamics
  9. Decreased GATA3 levels cause changed mouse cutaneous innate lymphoid cell fate, facilitating hair follicle recycling
  10. Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones
  11. The chromatin accessibility dynamics during cell fate specifications in zebrafish early embryogenesis
  12. Sirpα on tumor-associated myeloid cells restrains antitumor immunity in colorectal cancer independent of its interaction with CD47
  13. The bone–liver interaction modulates immune and hematopoietic function through Pinch-Cxcl12-Mbl2 pathway
  14. Proline uptake promotes activation of lymphoid tissue inducer cells to maintain gut homeostasis
  15. The chromatin accessibility dynamics during cell fate specifications in zebrafish early embryogenesis
  16. Differentiation and migration of hematopoietic stem and progenitor cells cross multiple tissues
  17. Exploring the dynamics and influencing factors of CD4 T cell activation using single-cell RNA-seq
  18. A fast and globally optimal solution for RNA-seq quantification
  19. Progress in single-cell multimodal sequencing and multi-omics data integration
  20. Glucose-induced CRL4COP1-p53 axis amplifies glycometabolism to drive tumorigenesis
  21. Single cell analyses of cancer cells identified two regulatorily and functionally distinct categories in differentially expressed genes among tumor subclones
  22. Anti-PD-1 therapy achieves favorable outcomes in HBV-positive non-liver cancer
  23. Mapping of alternative polyadenylation site usage at single-cell resolution
  24. Dissecting Complex Traits Using Omics Data: A Review on the Linear Mixed Models and Their Application in GWAS
  25. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells
  26. Sensitive, flexible and modular single-cell multi-omics profiling with ISSAAC-seq
  27. Dynamics, signals and influencing factors of CD4 T cell activation revealed by single cell RNA-seq
  28. Anti-PD1 therapy achieved better outcomes in non-liver cancer patients with HBV infection
  29. Single-Cell RNA Sequencing Unravels Upregulation of Immune Cell Crosstalk in Relapsed Pediatric Ependymoma
  30. Single-cell RNA Sequencing of Pediatric Ependymoma Unravels Subclonal Heterogeneity Associated with Patient Survival
  31. ISSAAC-seq enables sensitive and flexible multimodal profiling of chromatin accessibility and gene expression in single cells
  32. Cross-Tissue Characterization of Heterogeneities of Mesenchymal Stem Cells and Their Differentiation Potentials
  33. Reinvestigation of Classic T Cell Subsets and Identification of Novel Cell Subpopulations by Single-Cell RNA Sequencing
  34. Comprehensive mapping of the alternative polyadenylation site usage and its dynamics at single cell resolution
  35. A Comprehensive Characterization of Monoallelic Expression During Hematopoiesis and Leukemogenesis via Single-Cell RNA-Sequencing
  36. A topology-preserving dimensionality reduction method for single-cell RNA-seq data using graph autoencoder
  37. The Tyrosine Kinase-Driven Networks of Novel Long Non-coding RNAs and Their Molecular Targets in Myeloproliferative Neoplasms
  38. A plate-based single-cell ATAC-seq workflow for fast and robust profiling of chromatin accessibility
  39. Mesenchymal stem cell subpopulations and their heterogeneity of response to inductions revealed by single-cell RNA-seq
  40. Kssd: sequence dimensionality reduction by k-mer substring space sampling enables real-time large-scale datasets analysis
  41. scGAE: topology-preserving dimensionality reduction for single-cell RNA-seq data using graph autoencoder
  42. Re-investigation of classic T cell subsets and identification of novel cell subpopulations by single-cell RNA sequencing
  43. Integrated decoding hematopoiesis and leukemogenesis using single-cell sequencing and its medical implication
  44. Kindlin-2 regulates skeletal homeostasis by modulating PTH1R in mice
  45. Reclassification of classic T cell subsets and identification of novel cell types by single-cell RNA sequencing
  46. Single-Cell Transcriptome Analysis Reveals Six Subpopulations Reflecting Distinct Cellular Fates in Senescent Mouse Embryonic Fibroblasts
  47. Diploid genome architecture revealed by multi-omic data of hybrid mice
  48. Inhibition of Glycolysis in Pathogenic TH17 Cells through Targeting a miR -21–Peli1–c-Rel Pathway Prevents Autoimmunity
  49. The MicroRNA miR-22 Represses Th17 Cell Pathogenicity by Targeting PTEN-Regulated Pathways
  50. Integrated decoding hematopoiesis and leukemogenesis at single-cell resolution and its clinical implication
  51. Focal adhesion protein Kindlin-2 regulates bone homeostasis in mice
  52. H4K20me3 methyltransferase SUV420H2 shapes the chromatin landscape of pluripotent embryonic stem cells
  53. Visualization of Single Cell RNA-Seq Data Using t-SNE in R
  54. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  55. Exploring the changing landscape of cell-to-cell variation after CTCF knockdown via single cell RNA-seq
  56. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  57. Exploring the Changing Landscape of Cell-to-Cell Variation After CTCF Knockdown via Single Cell RNA-seq
  58. Principles of 3D Nucleus Organization and Epigenetic Regulation in Diploid Genome Revealed by Multi-omic Data from Hybrid Mouse
  59. Accumulated degeneration of transcriptional regulation contributes to disease development and detrimental clinical outcomes of Alzheimer’s disease
  60. Sequences Dimensionality-Reduction by K-mer Substring Space Sampling Enables Effective Resemblance- and Containment-Analysis for Large-Scale omics-data
  61. Publisher Correction: Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing
  62. Principles of nucleosome organization revealed by single-cell micrococcal nuclease sequencing
  63. Trac-looping measures genome structure and chromatin accessibility
  64. Transformation of Accessible Chromatin and 3D Nucleome Underlies Lineage Commitment of Early T Cells
  65. Deregulation of TGF-β1 signaling induces glycolysis by chromatin remodeling in pathogenic TH17 cells
  66. CTCF-Mediated Enhancer-Promoter Interaction Is a Critical Regulator of Cell-to-Cell Variation of Gene Expression
  67. Genome-wide identification of histone H2A and histone variant H2A.Z-interacting proteins by bPPI-seq
  68. Erratum to: Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
  69. Genome-wide detection of DNase I hypersensitive sites in single cells and FFPE tissue samples
  70. Evaluating information content of SNPs for sample-tagging in re-sequencing projects
  71. A genome wide pattern of population structure and admixture in peninsular Malaysia Malays
  72. Y Chromosomes of 40% Chinese Descend from Three Neolithic Super-Grandfathers
  73. Copy number variations and genetic admixtures in three Xinjiang ethnic minority groups
  74. Distribution of ancestral chromosomal segments in admixed genomes and its implications for inferring population history and admixture mapping
  75. Association of Two Variants in SMAD7 with the Risk of Congenital Heart Disease in the Han Chinese Population
  76. A panel of ancestry informative markers to estimate and correct potential effects of population stratification in Han Chinese
  77. Genome-wide incorporation dynamics reveal distinct categories of turnover for the histone variant H3.3
  78. Exploring Population Admixture Dynamics via Empirical and Simulated Genome-wide Distribution of Ancestral Chromosomal Segments
  79. A systematic characterization of genes underlying both complex and Mendelian diseases
  80. Genome-wide detection of natural selection in African Americans pre- and post-admixture
  81. A Map of Copy Number Variations in Chinese Populations
  82. A Genome-Wide Search for Signals of High-Altitude Adaptation in Tibetans
  83. Genomic Dissection of Population Substructure of Han Chinese and Its Implication in Association Studies
  84. Haplotype-Sharing Analysis Showing Uyghurs Are Unlikely Genetic Donors