All Stories

  1. Transcriptomics reveal stretched human pluripotent stem cell-derived cardiomyocytes as an advantageous hypertrophy model

    Article • Journal of Molecular and Cellular Cardiology Plus, December 2022, Elsevier

    Virpi Talman

  2. Protein Kinase A–Mediated Effects of Protein Kinase C Partial Agonist 5-(Hydroxymethyl)Isophthalate 1a3 in Colorectal Cancer Cells

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2022, Elsevier

    Virpi Talman

  3. Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell‐derived cardiomyocytes

    Article • The Journal of Physiology, December 2021, Wiley

    Virpi Talman

  4. In Vitro Evaluation of the Therapeutic Effects of Dual‐Drug Loaded Spermine‐Acetalated Dextran Nanoparticles Coated with Tannic Acid for Cardiac Applications

    Article • Advanced Functional Materials, October 2021, Wiley

    Prof. Hélder Santos, Virpi Talman

  5. Distinct Regulation of Cardiac Fibroblast Proliferation and Transdifferentiation by Classical and Novel Protein Kinase C Isoforms: Possible Implications for New Antifibrotic Therapies

    Article • Molecular Pharmacology, February 2021, Elsevier

    Virpi Talman

  6. Pharmacological Protein Kinase C Modulators Reveal a Pro-hypertrophic Role for Novel Protein Kinase C Isoforms in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes

    Article • Frontiers in Pharmacology, January 2021, Frontiers

    Virpi Talman

  7. Application of Human Induced Pluripotent Stem Cell Technology for Cardiovascular Regenerative Pharmacology

    Article • January 2021, Springer Science + Business Media

    Virpi Talman

  8. Rigorous Computational Study Reveals What Docking Overlooks: Double Trouble from Membrane Association in Protein Kinase C Modulators

    Article • Journal of Chemical Information and Modeling, September 2020, American Chemical Society (ACS)

    Virpi Talman

  9. GATA4-targeted compound exhibits cardioprotective actions against doxorubicin-induced toxicity in vitro and in vivo: establishment of a chronic cardiotoxicity model using human iPSC-derived cardiomyocytes

    Article • Archives of Toxicology, March 2020, Springer Science + Business Media

    Virpi Talman

  10. Dual-peptide functionalized acetalated dextran-based nanoparticles for sequential targeting of macrophages during myocardial infarction

    Article • Nanoscale, January 2020, Royal Society of Chemistry

    Virpi Talman, Prof. Hélder Santos

  11. Cell adhesion and proliferation on common 3D printing materials used in stereolithography of microfluidic devices

    Article • Lab on a Chip, January 2020, Royal Society of Chemistry

    Virpi Talman

  12. Missing Selectivity of Targeted 4β-Phorbol Prodrugs Expected to be Potential Chemotherapeutics

    Article • ACS Medicinal Chemistry Letters, December 2019, American Chemical Society (ACS)

    Virpi Talman, Professor Søren Brøgger Christensen

  13. Synthesis, Identification, and Structure–Activity Relationship Analysis of GATA4 and NKX2-5 Protein–Protein Interaction Modulators

    Article • Journal of Medicinal Chemistry, August 2019, American Chemical Society (ACS)

    Virpi Talman

  14. Abstract 924: The Role of Protein Kinase C Isoforms in Cardiomyocyte Hypertrophy

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Virpi Talman

  15. Abstract 781: Doxorubicin-Induced Cardiotoxicity and Novel GATA4-Targeted Compounds

    Article • Circulation Research, August 2019, Wolters Kluwer Health

    Virpi Talman

  16. Molecular Atlas of Postnatal Mouse Heart Development

    Article • Journal of the American Heart Association, October 2018, Wolters Kluwer Health

    Virpi Talman

  17. Protein kinase C -activating isophthalate derivatives mitigate Alzheimer's disease-related cellular alterations

    Article • Neuropharmacology, October 2018, Elsevier

    Virpi Talman

  18. Cardiomyocyte—Endothelial Cell Interactions in Cardiac Remodeling and Regeneration

    Article • Frontiers in Cardiovascular Medicine, July 2018, Frontiers

    Virpi Talman

  19. Stem cells are the most sensitive screening tool to identify toxicity of GATA4-targeted novel small-molecule compounds

    Article • Archives of Toxicology, July 2018, Springer Science + Business Media

    Virpi Talman

  20. Anticancer activity of the protein kinase C modulator HMI-1a3 in 2D and 3D cell culture models of androgen-responsive and androgen-unresponsive prostate cancer

    Article • FEBS Open Bio, April 2018, Wiley

    Virpi Talman

  21. Scaffold hopping from (5-hydroxymethyl) isophthalates to multisubstituted pyrimidines diminishes binding affinity to the C1 domain of protein kinase C

    Article • PLOS One, April 2018, PLOS

    Virpi Talman

  22. P85Combined transcriptomics, proteomics and metabolomics analysis identifies metabolic pathways associated with the loss of cardiac regeneration

    Article • Cardiovascular Research, April 2018, Oxford University Press (OUP)

    Virpi Talman

  23. 8Identification of cardiomyocyte-specific lncRNAs as potential regulators of cardiac regeneration

    Article • Cardiovascular Research, April 2018, Oxford University Press (OUP)

    Virpi Talman

  24. P293Toxicity profiling of cardiac transcription factor-targeted compounds in various cardiac and stem cell types reveals cell type- and compound-dependent toxicity

    Article • Cardiovascular Research, April 2018, Oxford University Press (OUP)

    Virpi Talman

  25. Dual-Drug Delivery Using Dextran-Functionalized Nanoparticles Targeting Cardiac Fibroblasts for Cellular Reprogramming

    Article • Advanced Functional Materials, January 2018, Wiley

    Virpi Talman, Prof. Hélder Santos

  26. Drug Delivery: Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling (Small 33/2017)

    Article • Small, September 2017, Wiley

    Virpi Talman

  27. Discovery of Small Molecules Targeting the Synergy of Cardiac Transcription Factors GATA4 and NKX2-5

    Article • Journal of Medicinal Chemistry, August 2017, American Chemical Society (ACS)

    Virpi Talman

  28. Drug-Loaded Multifunctional Nanoparticles Targeted to the Endocardial Layer of the Injured Heart Modulate Hypertrophic Signaling

    Article • Small, July 2017, Wiley

    Prof. Hélder Santos, Virpi Talman

  29. Cardiac fibrosis in myocardial infarction—from repair and remodeling to regeneration

    Article • Cell and Tissue Research, June 2016, Springer Science + Business Media

    Virpi Talman

  30. Protein Kinase C Activation as a Potential Therapeutic Strategy in Alzheimer's Disease: Is there a Role for Embryonic Lethal Abnormal Vision-like Proteins?

    Article • Basic & Clinical Pharmacology & Toxicology, April 2016, Wiley

    Virpi Talman

  31. Beyond the affinity for protein kinase C: exploring 2-phenyl-3-hydroxypropyl pivalate analogues as C1 domain-targeting ligands

    Article • MedChemComm, January 2015, Royal Society of Chemistry

    Virpi Talman

  32. C1 domain-targeted isophthalates as protein kinase C modulators: structure-based design, structure–activity relationships and biological activities

    Article • Biochemical Society Transactions, November 2014, Portland Press Ltd.

    Virpi Talman

  33. Evidence for a role of MRCK in mediating HeLa cell elongation induced by the C1 domain ligand HMI-1a3

    Article • European Journal of Pharmaceutical Sciences, May 2014, Elsevier

    Virpi Talman

  34. The C1 domain-targeted isophthalate derivative HMI-1b11 promotes neurite outgrowth and GAP-43 expression through PKCα activation in SH-SY5Y cells

    Article • Pharmacological Research, July 2013, Elsevier

    Dr Cecilia Osera, Virpi Talman

  35. Stereoselective synthesis of (3-aminodecahydro-1,4-methanonaphthalen-2-yl)methanols targeted to the C1 domain of protein kinase C

    Article • Tetrahedron, November 2011, Elsevier

    Virpi Talman

  36. Correction: C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

    Article • PLOS One, June 2011, PLOS

    Virpi Talman

  37. Current Status and Future Prospects of C1 Domain Ligands as Drug Candidates

    Article • Current Topics in Medicinal Chemistry, June 2011, Bentham Science Publishers

    Virpi Talman

  38. C1 Domain-Targeted Isophthalate Derivatives Induce Cell Elongation and Cell Cycle Arrest in HeLa Cells

    Article • PLOS One, May 2011, PLOS

    Virpi Talman

  39. Design, Synthesis, and Biological Activity of Isophthalic Acid Derivatives Targeted to the C1 Domain of Protein Kinase C

    Article • Journal of Medicinal Chemistry, July 2009, American Chemical Society (ACS)

    Virpi Talman

  40. Screening of natural compounds and their derivatives as potential protein kinase C inhibitors

    Article • Drug Development Research, October 2004, Wiley

    Virpi Talman