All Stories

  1. Calcium-dependent regulation of physiological vs pathological cardiomyocyte hypertrophy

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, December 2025, Elsevier

    Vijay Rajagopal

  2. Cardiac myofibril networks induce shear stress

    Article • November 2025, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  3. A cross-scale analysis for the determinants of bonding dynamics on the distributions of rolling velocities of cells in microvessels

    Article • Biophysical Journal, November 2025, Elsevier

    Vijay Rajagopal

  4. The Human Cardiac “Age‐OME”: Age‐Specific Changes in Myocardial Molecular Expression

    Article • Aging Cell, September 2025, Wiley

    Vijay Rajagopal

  5. Energy-based modelling of single actin filament polymerization using bond graphs

    Article • Journal of The Royal Society Interface, January 2025, Royal Society Publishing

    Vijay Rajagopal

  6. Energy-based Modelling of Single Actin Filament Polymerisation Using Bond Graphs

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  7. Genome-wide identification of replication fork stalling/pausing sites and the interplay between RNA Pol II transcription and DNA replication progression

    Article • Genome Biology, May 2024, Springer Science + Business Media

    Vijay Rajagopal

  8. Optimizing coupling layer and superstrate thickness in attachable acoustofluidic devices

    Article • Ultrasonics, February 2024, Elsevier

    Vijay Rajagopal

  9. Critical review of single-cell mechanotyping approaches for biomedical applications

    Article • Lab on a Chip, January 2024, Royal Society of Chemistry

    Vijay Rajagopal

  10. BondGraphs.jl: composable energy-based modelling in systems biology

    Article • Bioinformatics, September 2023, Oxford University Press (OUP)

    Vijay Rajagopal

  11. InsP3R-RyR channel crosstalk augments sarcoplasmic reticulum Ca2+ release and arrhythmogenic activity in post-MI pig cardiomyocytes

    Article • Journal of Molecular and Cellular Cardiology, June 2023, Elsevier

    Vijay Rajagopal

  12. Frontiers of Mathematical Biology: A workshop honouring Professor Edmund Crampin

    Article • Mathematical Biosciences, May 2023, Elsevier

    Vijay Rajagopal

  13. BondGraphs.jl: Composable energy-based modelling in systems biology

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  14. Energy dependence of signalling dynamics and robustness in bacterial two component systems

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  15. IP3R activity increases propensity of RyR-mediated sparks by elevating dyadic [Ca2＋]

    Article • Mathematical Biosciences, January 2023, Elsevier

    Vijay Rajagopal

  16. Sub-wavelength acoustic stencil for tailored micropatterning

    Article • Lab on a Chip, January 2023, Royal Society of Chemistry

    Vijay Rajagopal

  17. CardioVinci: building blocks for virtual cardiac cells using deep learning

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, October 2022, Royal Society Publishing

    Vijay Rajagopal

  18. Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy: an in silico study

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, October 2022, Royal Society Publishing

    Vijay Rajagopal

  19. New revelations on the interplay between cardiomyocyte architecture and cardiomyocyte function in growth, health, and disease: a brief introduction

    Article • Philosophical Transactions of the Royal Society B Biological Sciences, October 2022, Royal Society Publishing

    Vijay Rajagopal

  20. The Cell Physiome: What Do We Need in a Computational Physiology Framework for Predicting Single-Cell Biology?

    Article • Annual Review of Biomedical Data Science, August 2022, Annual Reviews

    Vijay Rajagopal

  21. Role of actin filaments and cis binding in cadherin clustering and patterning

    Article • PLoS Computational Biology, July 2022, PLOS

    Vijay Rajagopal

  22. Effects of altered cellular ultrastructure on energy metabolism in diabetic cardiomyopathy – an in-silico study

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  23. Cortical tension initiates the positive feedback loop between cadherin and F-actin

    Article • Biophysical Journal, February 2022, Elsevier

    Vijay Rajagopal

  24. Paradoxes of Hymenoptera flight muscles, extreme machines

    Article • Biophysical Reviews, February 2022, Springer Science + Business Media

    Vijay Rajagopal

  25. Multimodal imaging reveals membrane skeleton reorganisation during reticulocyte maturation and differences in dimple and rim regions of mature erythrocytes

    Article • Journal of Structural Biology X, January 2022, Elsevier

    Vijay Rajagopal

  26. Improving student outcomes through transdisciplinary curriculum design in biomedical engineering

    Article • January 2022, Curran Associates, Inc.

    Vijay Rajagopal

  27. Periodic Rayleigh streaming vortices and Eckart flow arising from traveling-wave-based diffractive acoustic fields

    Article • Physical Review E, October 2021, American Physical Society (APS)

    Vijay Rajagopal

  28. Respiration mask waveguide optimisation for maximised speech intelligibility

    Article • The Journal of the Acoustical Society of America, September 2021, Acoustical Society of America (ASA)

    Vijay Rajagopal

  29. CardioVinci: building blocks for virtual cardiac cells using deep learning

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  30. A toolbox for generating scalable mitral valve morphometric models

    Article • Computers in Biology and Medicine, August 2021, Elsevier

    Vijay Rajagopal

  31. EGFRvIII Promotes Cell Survival during Endoplasmic Reticulum Stress through a Reticulocalbin 1-Dependent Mechanism

    Article • Cancers, March 2021, MDPI AG

    Vijay Rajagopal

  32. Cortical Tension Initiates the Positive Feedback Loop Between E-cadherin and F-actin

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  33. EM-net: Deep learning for electron microscopy image segmentation

    Article • January 2021, Institute of Electrical & Electronics Engineers (IEEE)

    Vijay Rajagopal

  34. EM-stellar: benchmarking deep learning for electron microscopy image segmentation

    Article • Bioinformatics, January 2021, Oxford University Press (OUP)

    Vijay Rajagopal

  35. Unconventional acoustic approaches for localized and designed micromanipulation

    Article • Lab on a Chip, January 2021, Royal Society of Chemistry

    Vijay Rajagopal

  36. Modelling cardiomyocyte energetics

    Article • December 2020, Institute of Physics Publishing

    Vijay Rajagopal

  37. Surface area‐to‐volume ratio, not cellular viscoelasticity, is the major determinant of red blood cell traversal through small channels

    Article • Cellular Microbiology, October 2020, Wiley

    Vijay Rajagopal

  38. Membrane Tension Can Enhance Adaptation to Maintain Polarity of Migrating Cells

    Article • Biophysical Journal, October 2020, Elsevier

    Vijay Rajagopal

  39. An in-silico study to determine whether changes to mitochondria organization through engineered mitochondrial dynamics can enhance bioenergetics in cardiomyocytes

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  40. Ca2+ Release via IP3 Receptors Shapes the Cardiac Ca2+ Transient for Hypertrophic Signaling

    Article • Biophysical Journal, September 2020, Elsevier

    Vijay Rajagopal

  41. IP3R activity increases frequency of RyR-mediated sparks by elevating dyadic Ca2+

    Article • August 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  42. EM-stellar: benchmarking deep learning for electron microscopy image segmentation

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  43. Surface area-to-volume ratio, not cellular rigidity, determines red blood cell traversal through small capillaries

    Article • July 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  44. Membrane tension can enhance adaptation to maintain polarity of migrating cells

    Article • April 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  45. EM-net: Deep learning for electron microscopy image segmentation

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  46. Efficient estimation of load‐free left ventricular geometry and passive myocardial properties using principal component analysis.

    Article • International Journal for Numerical Methods in Biomedical Engineering, January 2020, Wiley

    Vijay Rajagopal

  47. Automated segmentation of cardiomyocyte Z-disks from high-throughput scanning electron microscopy data

    Article • BMC Medical Informatics and Decision Making, December 2019, Springer Science + Business Media

    Vijay Rajagopal

  48. Assessing Cardiomyocyte Excitation-Contraction Coupling Site Detection From Live Cell Imaging Using a Structurally-Realistic Computational Model of Calcium Release

    Article • Frontiers in Physiology, October 2019, Frontiers

    Vijay Rajagopal

  49. How Does the Internal Structure of Cardiac Muscle Cells Regulate Cellular Metabolism?

    Article • Microscopy and Microanalysis, August 2019, Oxford University Press (OUP)

    Vijay Rajagopal

  50. Detecting RyR clusters with CaCLEAN: influence of spatial distribution and structural heterogeneity

    Article • February 2019, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  51. Multimodal analysis ofPlasmodium knowlesi‐infected erythrocytes reveals large invaginations, swelling of the host cell, and rheological defects

    Article • Cellular Microbiology, February 2019, Wiley

    Vijay Rajagopal

  52. Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

    Article • PLoS Computational Biology, December 2018, PLOS

    Vijay Rajagopal

  53. Automated framework to reconstruct 3D model of cardiac Z-disk: an image processing approach

    Article • December 2018, Institute of Electrical & Electronics Engineers (IEEE)

    Vijay Rajagopal

  54. Assessment of single beat end-systolic elastance methods for quantifying ventricular contractility

    Article • Heart and Vessels, November 2018, Springer Science + Business Media

    Vijay Rajagopal

  55. An automated workflow for segmenting single adult cardiac cells from large-volume serial block-face scanning electron microscopy data

    Article • Journal of Structural Biology, June 2018, Elsevier

    Vijay Rajagopal

  56. Insights on the impact of mitochondrial organisation on bioenergetics in high-resolution computational models of cardiac cell architecture

    Article • May 2018, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  57. Creating a Structurally Realistic Finite Element Geometric Model of a Cardiomyocyte to Study the Role of Cellular Architecture in Cardiomyocyte Systems Biology

    Article • Journal of Visualized Experiments, April 2018, MyJove Corporation

    Vijay Rajagopal

  58. An Automated Workflow for Segmenting Single Adult Cardiac Cells from Large-Volume Serial Block-Face Scanning Electron Microscopy Data

    Article • January 2018, Cold Spring Harbor Laboratory Press

    Vijay Rajagopal

  59. Erythrocyte β spectrin can be genetically targeted to protect mice from malaria

    Article • Blood Advances, December 2017, American Society of Hematology

    Vijay Rajagopal

  60. Computational modeling of single-cell mechanics and cytoskeletal mechanobiology

    Article • WIREs Systems Biology and Medicine, November 2017, Wiley

    Vijay Rajagopal

  61. A Semi-Automated Workflow for Segmenting Contents of Single Cardiac Cells from Serial-Block-Face Scanning Electron Microscopy Data

    Article • Microscopy and Microanalysis, July 2017, Cambridge University Press

    Vijay Rajagopal

  62. A computational study of the role of mitochondrial organization on cardiac bioenergetics

    Article • July 2017, Institute of Electrical & Electronics Engineers (IEEE)

    Vijay Rajagopal

  63. Changes in mitochondrial morphology and organization can enhance energy supply from mitochondrial oxidative phosphorylation in diabetic cardiomyopathy

    Article • AJP Cell Physiology, February 2017, American Physiological Society

    Vijay Rajagopal

  64. Examination of the Effects of Heterogeneous Organization of RyR Clusters, Myofibrils and Mitochondria on Ca2+ Release Patterns in Cardiomyocytes

    Article • PLoS Computational Biology, September 2015, PLOS

    Vijay Rajagopal

  65. Super-resolution fluorescence imaging to study cardiac biophysics: α-actinin distribution and Z-disk topologies in optically thick cardiac tissue slices

    Article • Progress in Biophysics and Molecular Biology, August 2014, Elsevier

    Vijay Rajagopal

  66. Breast lesion co-localisation between X-ray and MR images using finite element modelling

    Article • Medical Image Analysis, December 2013, Elsevier

    Vijay Rajagopal

  67. Modelling Prone to Supine Breast Deformation Under Gravity Loading Using Heterogeneous Finite Element Models

    Article • January 2012, Springer Science + Business Media

    Vijay Rajagopal

  68. OpenCMISS: A multi-physics & multi-scale computational infrastructure for the VPH/Physiome project

    Article • Progress in Biophysics and Molecular Biology, October 2011, Elsevier

    Dr Soroush Safaei, David P Nickerson, Vijay Rajagopal, Prof Alejandro F Frangi

  69. Identification of mechanical properties of heterogeneous soft bodies using gravity loading

    Article • International Journal for Numerical Methods in Biomedical Engineering, March 2011, Wiley

    Vijay Rajagopal

  70. Identification of mechanical properties of heterogeneous soft bodies using gravity loading

    Article • International Journal for Numerical Methods in Biomedical Engineering, February 2011, Wiley

    Vijay Rajagopal

  71. Patient-Specific Modeling of Breast Biomechanics with Applications to Breast Cancer Detection and Treatment

    Article • January 2011, Springer Science + Business Media

    Vijay Rajagopal

  72. Mapping Breast Cancer Between Clinical X-Ray and MR Images

    Article • January 2011, Springer Science + Business Media

    Vijay Rajagopal

  73. Stochastic modelling of cardiac cell structure

    Article • August 2010, Institute of Electrical & Electronics Engineers (IEEE)

    Dr Michael J O'Sullivan, Vijay Rajagopal

  74. Breast Image Registration by Combining Finite Elements and Free-Form Deformations

    Article • January 2010, Springer Science + Business Media

    Vijay Rajagopal

  75. Mapping Microcalcifications Between 2D Mammograms and 3D MRI Using a Biomechanical Model of the Breast

    Article • January 2010, Springer Science + Business Media

    Vijay Rajagopal

  76. Method for Validating Breast Compression Models Using Normalised Cross-Correlation

    Article • January 2010, Springer Science + Business Media

    Vijay Rajagopal

  77. Modeling breast biomechanics for multi-modal image analysis-successes and challenges

    Article • WIREs Systems Biology and Medicine, October 2009, Wiley

    Vijay Rajagopal

  78. Modeling of the mechanical function of the human gastroesophageal junction using an anatomically realistic three-dimensional model

    Article • Journal of Biomechanics, August 2009, Elsevier

    Vijay Rajagopal

  79. Correlation of breast image alignment using biomechanical modelling

    Article • February 2009, SPIE

    Vijay Rajagopal

  80. Creating Individual-specific Biomechanical Models of the Breast for Medical Image Analysis

    Article • Academic Radiology, November 2008, Elsevier

    Vijay Rajagopal

  81. Biomechanical modelling for breast image registration

    Article • March 2008, SPIE

    Vijay Rajagopal

  82. Frictional contact mechanics methods for soft materials: Application to tracking breast cancers

    Article • Journal of Biomechanics, January 2008, Elsevier

    Vijay Rajagopal

  83. Modelling Mammographic Compression of the Breast

    Article • January 2008, Springer Science + Business Media

    Vijay Rajagopal

  84. A biomechanical model of mammographic compressions

    Article • Biomechanics and Modeling in Mechanobiology, January 2007, Springer Science + Business Media

    Vijay Rajagopal

  85. Determining the finite elasticity reference state from a loaded configuration

    Article • International Journal for Numerical Methods in Engineering, January 2007, Wiley

    Vijay Rajagopal

  86. Finite Element Modelling of Breast Biomechanics: Directly Calculating the Reference State

    Article • August 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Vijay Rajagopal

  87. Computational modeling of the breast during mammography for tumor tracking

    Article • April 2005, SPIE

    Vijay Rajagopal

  88. The Breast Biomechanics Reference State for Multi-modal Image Analysis

    Article • Springer Science + Business Media

    Vijay Rajagopal

  89. Towards Tracking Breast Cancer Across Medical Images Using Subject-Specific Biomechanical Models

    Article • Springer Science + Business Media

    Vijay Rajagopal