All Stories

  1. Expression of Netrin-1 in the developing mouse heart
  2. Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy
  3. Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records
  4. Impact of genetic factors on antioxidant rescue of maternal diabetes–associated congenital heart disease
  5. Cell-Free RNA Signatures in Maternal Blood with Fetal Congenital Heart Disease
  6. Case Report: An association of left ventricular outflow tract obstruction with 5p deletions
  7. Characterization of an induced pluripotent stem cell line (NCHi013-A) from a 5-year-old male with pulmonary atresia with intact ventricular septum and a biventricular repair
  8. Generation of an induced pluripotent stem cell line (NCHi016-A) from a 5-year-old female with pulmonary atresia with intact ventricular septum and one-and-half ventricle palliation
  9. Generation of iPSC line NCHi015-A from a patient with truncus arteriosus carrying heterozygous variants in KMT2D and NOTCH1
  10. Parental experiences of congenital heart disease transition care highlight the need for family-centered approaches
  11. Endocardial HDAC3 is required for myocardial trabeculation
  12. Post-Acute Cardiovascular Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Project
  13. Associations of Impulsivity and Risky Decision-Making with E-Cigarette-Related Outcomes Among Adolescents with Congenital Heart Disease: Variable- and Person-Oriented Approaches
  14. Abnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome
  15. Generation and characterization of a human induced pluripotent stem cell line heterozygous for a NOTCH1 mutation (NCHi014-A)
  16. Characterization of an induced pluripotent stem cell line NCHi011-A from a 23-year-old female with Alagille Syndrome harboring a heterozygous JAG1 pathogenic variant
  17. Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome
  18. A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease
  19. Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis
  20. Creation of iPSC line NCHi004-A from a patient with down syndrome and congenital heart defects
  21. Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
  22. Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene
  23. Congenital aortic valve stenosis: from pathophysiology to molecular genetics and the need for novel therapeutics
  24. Endocardial HDAC3 is required for myocardial trabeculation
  25. The Association of Global and Disease-Related Stress With Susceptibility to and Use of E-Cigarettes and Marijuana Among Adolescents With Congenital Heart Disease
  26. Establishment of NCHi009-A, an iPSC line from a patient with hypoplastic left heart syndrome (HLHS) carrying a heterozygous NOTCH1 mutation
  27. Genetics of aortic valve disease
  28. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
  29. A multicenter cross-sectional study in infants with congenital heart defects demonstrates high diagnostic yield of genetic testing but variable evaluation practices
  30. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide
  31. Characterization of an iPSC line NCHi006-A from a patient with hypoplastic left heart syndrome (HLHS)
  32. Generation of an induced pluripotent stem cell line NCHi003-A from a 11-year-old male with pulmonary atresia with intact ventricular septum (PA-IVS)
  33. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider
  34. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia
  35. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes
  36. Molecular genetic mechanisms of congenital heart disease
  37. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery
  38. Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury
  39. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease
  40. Probing single ventricle heart defects with patient‐derived induced pluripotent stem cells and emerging technologies
  41. Calcific aortic valve disease: novel insights into nitric oxide signalling
  42. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature
  43. A Randomized Clinical Trial Demonstrating Feasibility and Preliminary Efficacy of a Videoconference-Delivered Physical Activity Lifestyle Intervention Among Adolescents With a Congenital Heart Defect
  44. Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury
  45. Gender Differences in Physical Activity Engagement Among Adolescents With Congenital Heart Disease
  46. Correction to: Human Stem Cell Models of SARS‑CoV‑2 Infection in the Cardiovascular System
  47. Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  48. Impact of maternal hyperglycemia on cardiac development: Insights from animal models
  49. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications
  50. miR‐145transgenic mice develop cardiopulmonary complications leading to postnatal death
  51. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes
  52. Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System
  53. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  54. Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease
  55. Natian and Ryabhatta—graphical user interfaces to create, analyze and visualize single-cell transcriptomic datasets
  56. Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects
  57. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
  58. Galectin-3 and sST2 as Prognosticators for Heart Failure Requiring Extracorporeal Life Support: Jack n’ Jill
  59. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
  60. Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration
  61. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
  62. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  63. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy
  64. Subtype-specific cardiomyocytes for precision medicine: Where are we now?
  65. In Vivo and In Vitro Genetic Models of Congenital Heart Disease
  66. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy
  67. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors
  68. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation
  69. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome
  70. Another Notch in the Genetic Puzzle of Tetralogy of Fallot
  71. Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms
  72. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association
  73. Corrigendum to “Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease” [J. Mol. Cell. Cardiol. 60 (2013) 27–35]
  74. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease
  75. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice
  76. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
  77. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis
  78. Abnormal Longitudinal Growth of the Aorta in Children with Familial Bicuspid Aortic Valve
  79. Assessment of large copy number variants in patients with apparently isolated congenital left-sided cardiac lesions reveals clinically relevant genomic events
  80. Genetic basis of aortic valvular disease
  81. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association
  82. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease
  83. Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract
  84. A genome-wide association study of congenital cardiovascular left-sided lesions shows association with a locus on chromosome 20
  85. Percutaneous Patent Ductus Arteriosus (PDA) Closure in Very Preterm Infants: Feasibility and Complications
  86. Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease
  87. Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial
  88. Measuring genetic knowledge: a brief survey instrument for adolescents and adults
  89. Rationale for the Cytogenomics of Cardiovascular Malformations Consortium: A Phenotype Intensive Registry Based Approach
  90. Lifetime Prevalence of Sexual Intercourse and Contraception Use at Last Sex Among Adolescents and Young Adults With Congenital Heart Disease
  91. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
  92. Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model
  93. MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells
  94. A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data
  95. Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation
  96. Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve
  97. Genetics of Valvular Heart Disease
  98. Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve
  99. Etiology of Valvular Heart Disease
  100. Beyond genetics: focusing on maternal environment for congenital heart disease prevention
  101. Genetic Abnormalities inFOXP1Are Associated with Congenital Heart Defects
  102. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease
  103. The Congenital Heart Disease Genetic Network Study: Rationale, Design, and Early Results
  104. Compacting the heart with Notch
  105. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation
  106. Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo
  107. Submicroscopic Chromosomal Copy Number Variations Identified in Children With Hypoplastic Left Heart Syndrome
  108. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development
  109. Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
  110. Chromosomal Haplotypes by Genetic Phasing of Human Families
  111. Heredity of bicuspid aortic valve: is family screening indicated?
  112. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development
  113. Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development
  114. Impact of Mendelian inheritance in cardiovascular disease
  115. Identification of GATA6 Sequence Variants in Patients With Congenital Heart Defects
  116. Genetics of Congenital Heart Disease
  117. ABSENCE OF ABDOMINAL ANEURYSM IN ADULTS WITH COARCTATION AND/OR BICUSPID AORTIC VALVE - IS THIS REALLY AN “AORTOPATHY”?
  118. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death
  119. EXPRESSION PATTERNS OF BASONUCLIN 2 IN PENILE TISSUE
  120. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development
  121. A Rare Human Sequence Variant Reveals Myocardin Autoinhibition
  122. Cryptic Chromosomal Abnormalities Identified in Children With Congenital Heart Disease
  123. Spectrum of heart disease associated with murine and human GATA4 mutation
  124. GATA4 sequence variants in patients with congenital heart disease
  125. Screening and biochemical analysis ofGATA4sequence variations identified in patients with congenital heart disease
  126. Molecular genetics of aortic valve disease
  127. Insights into the genetic basis of congenital heart disease
  128. Mutations in NOTCH1 cause aortic valve disease
  129. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
  130. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L
  131. Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch Development
  132. A Molecular Pathway Revealing a Genetic Basis for Human Cardiac and Craniofacial Defects