All Stories

  1. Emotion-Related Impulsivity is Associated with Marijuana Susceptibility and Use Among Adolescents with Congenital Heart Disease: A Cross-Sectional Study of Variable- and Person-Oriented Approaches
  2. Assessing Genetic Testing in Adult Congenital Heart Disease: Current State and Patient Perspectives
  3. Expression of Netrin-1 in the developing mouse heart
  4. Loss of Methyltransferase and Hypomethylated m6A Sarcomere Transcripts Leading to Early-Onset Dilated Cardiomyopathy
  5. Cardiovascular post-acute sequelae of SARS-CoV-2 in children and adolescents: cohort study using electronic health records
  6. Impact of genetic factors on antioxidant rescue of maternal diabetes–associated congenital heart disease
  7. Cell-Free RNA Signatures in Maternal Blood with Fetal Congenital Heart Disease
  8. Case Report: An association of left ventricular outflow tract obstruction with 5p deletions
  9. Characterization of an induced pluripotent stem cell line (NCHi013-A) from a 5-year-old male with pulmonary atresia with intact ventricular septum and a biventricular repair
  10. Generation of an induced pluripotent stem cell line (NCHi016-A) from a 5-year-old female with pulmonary atresia with intact ventricular septum and one-and-half ventricle palliation
  11. Generation of iPSC line NCHi015-A from a patient with truncus arteriosus carrying heterozygous variants in KMT2D and NOTCH1
  12. Parental experiences of congenital heart disease transition care highlight the need for family-centered approaches
  13. Endocardial HDAC3 is required for myocardial trabeculation
  14. Post-Acute Cardiovascular Outcomes of COVID-19 in Children and Adolescents: An EHR Cohort Study from the RECOVER Project
  15. Associations of Impulsivity and Risky Decision-Making with E-Cigarette-Related Outcomes Among Adolescents with Congenital Heart Disease: Variable- and Person-Oriented Approaches
  16. Abnormal Progenitor Cell Differentiation and Cardiomyocyte Proliferation in Hypoplastic Right Heart Syndrome
  17. Generation and characterization of a human induced pluripotent stem cell line heterozygous for a NOTCH1 mutation (NCHi014-A)
  18. Characterization of an induced pluripotent stem cell line NCHi011-A from a 23-year-old female with Alagille Syndrome harboring a heterozygous JAG1 pathogenic variant
  19. Rare variants in CAPN2 increase risk for isolated hypoplastic left heart syndrome
  20. A Multicenter Analysis of Abnormal Chromosomal Microarray Findings in Congenital Heart Disease
  21. Novel pathogenic GATA6 variant associated with congenital heart disease, diabetes mellitus and necrotizing enterocolitis
  22. Creation of iPSC line NCHi004-A from a patient with down syndrome and congenital heart defects
  23. Generation of an induced pluripotent stem cell line (NCHi010-A) from a 6-year-old female with Down syndrome and without congenital heart disease
  24. Generation of iPSC line NCHi012-A from a patient with Alagille syndrome and heterozygous pathogenic variant in the JAG1 gene
  25. Congenital aortic valve stenosis: from pathophysiology to molecular genetics and the need for novel therapeutics
  26. Endocardial HDAC3 is required for myocardial trabeculation
  27. The Association of Global and Disease-Related Stress With Susceptibility to and Use of E-Cigarettes and Marijuana Among Adolescents With Congenital Heart Disease
  28. Establishment of NCHi009-A, an iPSC line from a patient with hypoplastic left heart syndrome (HLHS) carrying a heterozygous NOTCH1 mutation
  29. Genetics of aortic valve disease
  30. Impaired Human Cardiac Cell Development due to NOTCH1 Deficiency
  31. A multicenter cross-sectional study in infants with congenital heart defects demonstrates high diagnostic yield of genetic testing but variable evaluation practices
  32. Single-cell RNA-sequencing analysis of aortic valve interstitial cells demonstrates the regulation of integrin signaling by nitric oxide
  33. Characterization of an iPSC line NCHi006-A from a patient with hypoplastic left heart syndrome (HLHS)
  34. Generation of an induced pluripotent stem cell line NCHi003-A from a 11-year-old male with pulmonary atresia with intact ventricular septum (PA-IVS)
  35. Patent Ductus Arteriosus: A Contemporary Perspective for the Pediatric and Adult Cardiac Care Provider
  36. Single-cell transcriptomic profiling unveils dysregulation of cardiac progenitor cells and cardiomyocytes in a mouse model of maternal hyperglycemia
  37. Loss of Jagged1 in mature endothelial cells causes vascular dysfunction with alterations in smooth muscle phenotypes
  38. Molecular genetic mechanisms of congenital heart disease
  39. Exome sequencing in multiplex families with left-sided cardiac defects has high yield for disease gene discovery
  40. Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury
  41. Use of machine learning to classify high-risk variants of uncertain significance in lamin A/C cardiac disease
  42. Probing single ventricle heart defects with patient‐derived induced pluripotent stem cells and emerging technologies
  43. Calcific aortic valve disease: novel insights into nitric oxide signalling
  44. Single-Cell RNA Sequencing Reveals Novel Genes Regulated by Hypoxia in the Lung Vasculature
  45. A Randomized Clinical Trial Demonstrating Feasibility and Preliminary Efficacy of a Videoconference-Delivered Physical Activity Lifestyle Intervention Among Adolescents With a Congenital Heart Defect
  46. Inhibition of BKCa channels protects neonatal hearts against myocardial ischemia and reperfusion injury
  47. Gender Differences in Physical Activity Engagement Among Adolescents With Congenital Heart Disease
  48. Correction to: Human Stem Cell Models of SARS‑CoV‑2 Infection in the Cardiovascular System
  49. Correction: Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  50. Impact of maternal hyperglycemia on cardiac development: Insights from animal models
  51. Genetics of congenital heart disease: a narrative review of recent advances and clinical implications
  52. miR‐145transgenic mice develop cardiopulmonary complications leading to postnatal death
  53. A Multi-Omics Approach Using a Mouse Model of Cardiac Malformations for Prioritization of Human Congenital Heart Disease Contributing Genes
  54. Human Stem Cell Models of SARS-CoV-2 Infection in the Cardiovascular System
  55. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  56. Common deletion variants causing protocadherin-α deficiency contribute to the complex genetics of BAV and left-sided congenital heart disease
  57. Natian and Ryabhatta—graphical user interfaces to create, analyze and visualize single-cell transcriptomic datasets
  58. Single-cell Transcriptomic Profiling Unveils Cardiac Cell-type Specific Response to Maternal Hyperglycemia Underlying the Risk of Congenital Heart Defects
  59. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
  60. Galectin-3 and sST2 as Prognosticators for Heart Failure Requiring Extracorporeal Life Support: Jack n’ Jill
  61. Decoding Genetics of Congenital Heart Disease Using Patient-Derived Induced Pluripotent Stem Cells (iPSCs)
  62. Cardiomyocyte Proliferation and Maturation: Two Sides of the Same Coin for Heart Regeneration
  63. Nitric oxide prevents aortic valve calcification by S-nitrosylation of USP9X to activate NOTCH signaling
  64. Integrative analysis of genomic variants reveals new associations of candidate haploinsufficient genes with congenital heart disease
  65. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy
  66. Subtype-specific cardiomyocytes for precision medicine: Where are we now?
  67. In Vivo and In Vitro Genetic Models of Congenital Heart Disease
  68. Novel frameshift variant in MYL2 reveals molecular differences between dominant and recessive forms of hypertrophic cardiomyopathy
  69. Reclassification of Variants of Uncertain Significance in Children with Inherited Arrhythmia Syndromes is Predicted by Clinical Factors
  70. Developmental origins for semilunar valve stenosis identified in mice harboring congenital heart disease-associated GATA4 mutation
  71. Shaping the future heart: transgenerational outcomes of maternal metabolic syndrome
  72. Another Notch in the Genetic Puzzle of Tetralogy of Fallot
  73. Maternal hyperglycemia and fetal cardiac development: Clinical impact and underlying mechanisms
  74. Genetic Basis for Congenital Heart Disease: Revisited: A Scientific Statement From the American Heart Association
  75. Corrigendum to “Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease” [J. Mol. Cell. Cardiol. 60 (2013) 27–35]
  76. The Role of Lipoprotein(a) in Calcific Aortic Valve Disease
  77. Notch1 haploinsufficiency causes ascending aortic aneurysms in mice
  78. Epigenetic mechanisms underlying maternal diabetes-associated risk of congenital heart disease
  79. Nestin expression is dynamically regulated in cardiomyocytes during embryogenesis
  80. Abnormal Longitudinal Growth of the Aorta in Children with Familial Bicuspid Aortic Valve
  81. Assessment of large copy number variants in patients with apparently isolated congenital left-sided cardiac lesions reveals clinically relevant genomic events
  82. Genetic basis of aortic valvular disease
  83. Enhancing Literacy in Cardiovascular Genetics: A Scientific Statement From the American Heart Association
  84. Utilization of Whole Exome Sequencing to Identify Causative Mutations in Familial Congenital Heart Disease
  85. Endothelial Notch1 Is Required for Proper Development of the Semilunar Valves and Cardiac Outflow Tract
  86. A genome-wide association study of congenital cardiovascular left-sided lesions shows association with a locus on chromosome 20
  87. Percutaneous Patent Ductus Arteriosus (PDA) Closure in Very Preterm Infants: Feasibility and Complications
  88. Dynamic Heterogeneity of the Heart Valve Interstitial Cell Population in Mitral Valve Health and Disease
  89. Early versus delayed umbilical cord clamping in infants with congenital heart disease: a pilot, randomized, controlled trial
  90. Measuring genetic knowledge: a brief survey instrument for adolescents and adults
  91. Rationale for the Cytogenomics of Cardiovascular Malformations Consortium: A Phenotype Intensive Registry Based Approach
  92. Lifetime Prevalence of Sexual Intercourse and Contraception Use at Last Sex Among Adolescents and Young Adults With Congenital Heart Disease
  93. Evidence of Aortopathy in Mice with Haploinsufficiency of Notch1 in Nos3-Null Background
  94. Pharmacological Inhibitor of Notch Signaling Stabilizes the Progression of Small Abdominal Aortic Aneurysm in a Mouse Model
  95. MicroRNA miR145 Regulates TGFBR2 Expression and Matrix Synthesis in Vascular Smooth Muscle Cells
  96. A unified test of linkage analysis and rare-variant association for analysis of pedigree sequence data
  97. Disruption of myocardial Gata4 and Tbx5 results in defects in cardiomyocyte proliferation and atrioventricular septation
  98. Rare GATA5 sequence variants identified in individuals with bicuspid aortic valve
  99. Genetics of Valvular Heart Disease
  100. Use of a targeted, combinatorial next-generation sequencing approach for the study of bicuspid aortic valve
  101. Etiology of Valvular Heart Disease
  102. Beyond genetics: focusing on maternal environment for congenital heart disease prevention
  103. Genetic Abnormalities inFOXP1Are Associated with Congenital Heart Defects
  104. Endothelial nitric oxide signaling regulates Notch1 in aortic valve disease
  105. The Congenital Heart Disease Genetic Network Study: Rationale, Design, and Early Results
  106. Compacting the heart with Notch
  107. Inhibition of Notch1 Signaling Reduces Abdominal Aortic Aneurysm in Mice by Attenuating Macrophage-Mediated Inflammation
  108. Congenital Heart Disease–Causing Gata4 Mutation Displays Functional Deficits In Vivo
  109. Submicroscopic Chromosomal Copy Number Variations Identified in Children With Hypoplastic Left Heart Syndrome
  110. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development
  111. Inhibitory Role of Notch1 in Calcific Aortic Valve Disease
  112. Chromosomal Haplotypes by Genetic Phasing of Human Families
  113. Heredity of bicuspid aortic valve: is family screening indicated?
  114. Human balanced translocation and mouse gene inactivation implicate Basonuclin 2 in distal urethral development
  115. Fetal and postnatal lung defects reveal a novel and required role for Fgf8 in lung development
  116. Impact of Mendelian inheritance in cardiovascular disease
  117. Identification of GATA6 Sequence Variants in Patients With Congenital Heart Defects
  118. Genetics of Congenital Heart Disease
  119. ABSENCE OF ABDOMINAL ANEURYSM IN ADULTS WITH COARCTATION AND/OR BICUSPID AORTIC VALVE - IS THIS REALLY AN “AORTOPATHY”?
  120. A novel mutation in LAMIN A/C is associated with isolated early-onset atrial fibrillation and progressive atrioventricular block followed by cardiomyopathy and sudden cardiac death
  121. EXPRESSION PATTERNS OF BASONUCLIN 2 IN PENILE TISSUE
  122. Interaction of Gata4 and Gata6 with Tbx5 is critical for normal cardiac development
  123. A Rare Human Sequence Variant Reveals Myocardin Autoinhibition
  124. Cryptic Chromosomal Abnormalities Identified in Children With Congenital Heart Disease
  125. Spectrum of heart disease associated with murine and human GATA4 mutation
  126. GATA4 sequence variants in patients with congenital heart disease
  127. Screening and biochemical analysis ofGATA4sequence variations identified in patients with congenital heart disease
  128. Molecular genetics of aortic valve disease
  129. Insights into the genetic basis of congenital heart disease
  130. Mutations in NOTCH1 cause aortic valve disease
  131. GATA4 mutations cause human congenital heart defects and reveal an interaction with TBX5
  132. A common cis-acting sequence in the DiGeorge critical region regulates bi-directional transcription of UFD1L and CDC45L
  133. Tbx1, a DiGeorge Syndrome Candidate Gene, Is Regulated by Sonic Hedgehog during Pharyngeal Arch Development
  134. A Molecular Pathway Revealing a Genetic Basis for Human Cardiac and Craniofacial Defects