All Stories

  1. Transcriptomic profiling and bioinformatics-driven statistical prioritization of CRC biomarkers: A step toward precision oncology
  2. Muscle Rev-erb controls time-dependent adaptations to chronic exercise in mice
  3. Multi‐omics delineate growth factor network underlying exercise effects in an Alzheimer's mouse model
  4. Editorial: Cell cycle modulators: regulating the basic unit of life for disease treatment and tissue regeneration
  5. Unraveling the intricate physiological processes dysregulated in CHD-affected and Dan-Lou tablet-treated individuals
  6. Multi-omics delineate growth factor network underlying exercise effects in an Alzheimer’s mouse model
  7. Decoding genetic and pathophysiological mechanisms in amyotrophic lateral sclerosis and primary lateral sclerosis: A comparative study of differentially expressed genes and implicated pathways in motor neuron disorders
  8. Exploring the effect of disease causing mutations in metal binding sites of human ARSA in metachromatic leukodystrophy
  9. Identification of Potential Inhibitors Targeting GTPase-Kirsten RAt Sarcoma Virus (K-Ras) Driven Cancers via E-Pharmacophore-Based Virtual Screening and Drug Repurposing Approach
  10. SARS-CoV-2 vaccine breakthrough infections (VBI) by Omicron variant (B.1.1.529) and consequences in structural and functional impact
  11. Biosynthesis of bioactive pigment from halotolerant Bacillus cereus for fabric – an eco-friendly initiative
  12. Effect of Biogenic Selenium Nanocomposite on Okra and Metagenomic Analysis of Bacterial Community Associated with Rhizosphere and Phyllosphere
  13. A new horizon in the phosphorylated sites of AGA: the structural impact of C163S mutation in aspartylglucosaminuria through molecular dynamics simulation
  14. Molecular dynamics simulations corroborate recombinant expression studies carried out on three αIIb β‐propeller mutations reported in Indian Glanzmann thrombasthenia patients
  15. Exome sequence analysis of rare frequency variants in Late-Onset Alzheimer Disease
  16. Gene network interaction analysis to elucidate the antimicrobial resistance mechanisms in the Clostridium difficile
  17. Integrated gene network analysis sheds light on understanding the progression of Osteosarcoma
  18. The targeted next-generation sequence revealed SMAD4, AKT1, and TP53 mutations from circulating cell-free DNA of breast cancer and its effect on protein structure – A computational approach
  19. HPV and molecular mimicry in systemic lupus erythematosus and an impact of compiling B-cell epitopes and MHC-class II binding profiles with in silico evidence
  20. Identification of dysregulated canonical pathways associated with pathogenesis and progression of Amyotrophic Lateral Sclerosis—An integrated bioinformatics approach
  21. CDK regulators—Cell cycle progression or apoptosis—Scenarios in normal cells and cancerous cells
  22. Controlling cell proliferation by targeting cyclin-dependent kinase 6 using drug repurposing approach
  23. Elucidating the mechanism of antimicrobial resistance in Mycobacterium tuberculosis using gene interaction networks
  24. Molecular characterization of circadian gene expression and its correlation with survival percentage in colorectal cancer patients
  25. Multispectroscopic, virtual and in vivo insights into the photoaging defense mediated by the natural food colorant bixin
  26. Structure-based virtual screening to identify potential lipase inhibitors to reduce lipid storage in Wolman disorder
  27. Analysis of signaling cascades from myeloma cells treated with pristimerin
  28. Effects of the pathological E200K mutation on human prion protein: A computational screening and molecular dynamics approach
  29. An integrated investigation of structural and pathway alteration caused by PIK3CA and TP53 mutations identified in cfDNA of metastatic breast cancer
  30. SARS-CoV-2 vaccine-breakthrough infections (VBIs) by Omicron (B.1.1.529) variant and consequences in structural and functional impact
  31. Whole-exome sequencing analysis of NSCLC reveals the pathogenic missense variants from cancer-associated genes
  32. Identification of potential inhibitors, conformational dynamics, and mechanistic insights into mutant Kirsten rat sarcoma virus (G13D) driven cancers
  33. Computational and structural investigation of Palmitoyl-Protein Thioesterase 1 (PPT1) protein causing Neuronal Ceroid Lipofuscinoses (NCL)
  34. Deciphering the effect of mutations in MMAA protein causing methylmalonic acidemia—A computational approach
  35. Investigation of differentially expressed genes and dysregulated pathways involved in multiple sclerosis
  36. A review of bioinformatics tools and web servers in different microarray platforms used in cancer research
  37. Integrative ontology and pathway-based approach identifies distinct molecular signatures in transcriptomes of esophageal squamous cell carcinoma
  38. Computational structural assessment of BReast CAncer type 1 susceptibility protein (BRCA1) and BRCA1-Associated Ring Domain protein 1 (BARD1) mutations on the protein-protein interface
  39. Mutations in G6PC2 gene with increased risk for development of type 2 diabetes: Understanding via computational approach
  40. A computational model revealing the immune-related hub genes and key pathways involved in rheumatoid arthritis (RA)
  41. Understanding the activating mechanism of the immune system against COVID-19 by Traditional Indian Medicine: Network pharmacology approach
  42. A computational overview on phylogenetic characterization, pathogenic mutations, and drug targets for Ebola virus disease
  43. Computational validation of ABCB1 gene polymorphism and its effect on tacrolimus dose concentration/levels in renal transplant individuals of South India
  44. Computational investigation to identify potent inhibitors of the GTPase-Kirsten RAt sarcoma virus (K-Ras) mutants G12C and G12D
  45. Siddha Medicine and Computer Modeling: A Treasure for SARS-CoV-2 Treatment
  46. Unraveling the versatility of CCD4: Metabolic engineering, transcriptomic and computational approaches
  47. Residue interaction networks of K-Ras protein with water molecules identifies the potential role of switch II and P-loop
  48. Comparison of potential inhibitors and targeting fat mass and obesity‐associated protein causing diabesity through docking and molecular dynamics strategies
  49. Structure-Based Virtual Screening to Identify Novel Potential Compound as an Alternative to Remdesivir to Overcome the RdRp Protein Mutations in SARS-CoV-2
  50. A review of novel coronavirus disease (COVID-19): based on genomic structure, phylogeny, current shreds of evidence, candidate vaccines, and drug repurposing
  51. Molecular dynamics, residue network analysis, and cross-correlation matrix to characterize the deleterious missense mutations in GALE causing galactosemia III
  52. A systemic approach to explore the mechanisms of drug resistance and altered signaling cascades in extensively drug-resistant tuberculosis
  53. An integrative analysis to distinguish between emphysema (EML) and alpha-1 antitrypsin deficiency-related emphysema (ADL)—A systems biology approach
  54. Investigating mutations at the hotspot position of the ERBB2 and screening for the novel lead compound to treat breast cancer – a computational approach
  55. Network analysis of transcriptomics data for the prediction and prioritization of membrane-associated biomarkers for idiopathic pulmonary fibrosis (IPF) by bioinformatics approach
  56. Deciphering the Role of Filamin B Calponin-Homology Domain in Causing the Larsen Syndrome, Boomerang Dysplasia, and Atelosteogenesis Type I Spectrum Disorders via a Computational Approach
  57. Involvement of Essential Signaling Cascades and Analysis of Gene Networks in Diabesity
  58. Mutational landscape of K-Ras substitutions at 12th position-a systematic molecular dynamics approach
  59. Analysis of Differentially Expressed Genes and Molecular Pathways in Familial Hypercholesterolemia Involved in Atherosclerosis: A Systematic and Bioinformatics Approach
  60. Kerala, India's Front Runner in Novel Coronavirus Disease (COVID-19)
  61. The Rise and Impact of COVID-19 in India
  62. Dysregulation of Signaling Pathways Due to Differentially Expressed Genes From the B-Cell Transcriptomes of Systemic Lupus Erythematosus Patients – A Bioinformatics Approach
  63. Molecular dynamics simulations to decipher the structural and functional consequences of pathogenic missense mutations in the galactosylceramidase (GALC) protein causing Krabbe’s disease
  64. An extensive computational approach to analyze and characterize the functional mutations in the galactose-1-phosphate uridyl transferase (GALT) protein responsible for classical galactosemia
  65. Comprehensive in silico screening and molecular dynamics studies of missense mutations in Sjogren-Larsson syndrome associated with the ALDH3A2 gene
  66. Computational model to analyze and characterize the functional mutations of NOD2 protein causing inflammatory disorder – Blau syndrome
  67. Identification of potential inhibitors against pathogenic missense mutations of PMM2 using a structure-based virtual screening approach
  68. Integrative Bioinformatics Approaches to Map Potential Novel Genes and Pathways Involved in Ovarian Cancer
  69. Znf76 is associated with development of the eyes, midbrain, MHB, and hindbrain in zebrafish embryos
  70. Mutations in ARSB in MPS VI patients in India
  71. Functional and structural characterization of missense mutations in PAX6 gene