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  1. A hidden valve-like structure helps control sperm transport

    Article • Proceedings of the National Academy of Sciences, September 2026, Proceedings of the National Academy of Sciences

    Tsuyoshi Hirashima

  2. Geometric confinement regulates ERK signaling dynamics and collective migration

    Article • June 2026, openRxiv

    Tsuyoshi Hirashima

  3. Flow-driven lumen remodeling and valve opening in the vas deferens

    Article • March 2026, openRxiv

    Tsuyoshi Hirashima

  4. Transient contractility attenuation followed by recovery reprograms epithelial cells into a protrusion-driven state that drives tissue fluidization

    Article • March 2026, openRxiv

    Tsuyoshi Hirashima

  5. Curvature feedback for repetitive tissue morphogenesis – Bridging algorithmic principles and self-regulatory systems

    Article • Seminars in Cell and Developmental Biology, September 2025, Elsevier

    Tsuyoshi Hirashima

  6. Collective sperm movement in mammalian reproductive tracts

    Article • Seminars in Cell and Developmental Biology, February 2025, Elsevier

    Tsuyoshi Hirashima

  7. Robust tissue pattern formation by coupling morphogen signal and cell adhesion

    Article • EMBO Reports, September 2024, Springer Science + Business Media

    Tsuyoshi Hirashima

  8. Regulation of intercellular viscosity by E-cadherin-dependent phosphorylation of EGFR in collective cell migration

    Article • Proceedings of the National Academy of Sciences, September 2024, Proceedings of the National Academy of Sciences

    virgile viasnoff, Tsuyoshi Hirashima

  9. ERK-mediated curvature feedback regulates branching morphogenesis in lung epithelial tissue

    Article • Current Biology, February 2024, Elsevier

    Tsuyoshi Hirashima

  10. Tug-of-war via ERK signaling pathway for tissue organization – ERK activation to force generation

    Article • Current Opinion in Cell Biology, December 2023, Elsevier

    Tsuyoshi Hirashima

  11. Stretching the limits of extracellular signal-related kinase (ERK) signaling — Cell mechanosensing to ERK activation

    Article • Current Opinion in Cell Biology, October 2023, Elsevier

    Tsuyoshi Hirashima

  12. Interplay between Mechanochemical Patterning and Glassy Dynamics in Cellular Monolayers

    Article • PRX Life, July 2023, American Physical Society (APS)

    Tsuyoshi Hirashima

  13. Collective cell dynamics and luminal fluid flow in the epididymis: A mechanobiological perspective

    Article • Andrology, July 2023, Wiley

    Tsuyoshi Hirashima

  14. Apoptotic extracellular vesicle formation via local phosphatidylserine exposure drives efficient cell extrusion

    Article • Developmental Cell, July 2023, Elsevier

    Tsuyoshi Hirashima

  15. Interplay between mechanochemical patterning and glassy dynamics in cellular monolayers

    Article • March 2023, openRxiv

    Tsuyoshi Hirashima

  16. Editorial: Multicellularity: Views from cellular signaling and mechanics

    Article • Frontiers in Cell and Developmental Biology, March 2023, Frontiers

    Tsuyoshi Hirashima

  17. Tissue hydraulics in reproduction

    Article • Seminars in Cell and Developmental Biology, November 2022, Elsevier

    Tsuyoshi Hirashima

  18. A visualization system for erectile vascular dynamics

    Article • Frontiers in Cell and Developmental Biology, October 2022, Frontiers

    Tsuyoshi Hirashima

  19. A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration

    Article • Developmental Cell, October 2022, Elsevier

    Tsuyoshi Hirashima

  20. Functional visualization of NK cell-mediated killing of metastatic single tumor cells

    Article • eLife, February 2022, eLife

    Tsuyoshi Hirashima

  21. Three-dimensional analysis and in vivo imaging for sperm release and transport in the murine seminiferous tubule

    Article • January 2022, openRxiv

    Tsuyoshi Hirashima

  22. Live imaging approach of dynamic multicellular responses in ERK signaling during vertebrate tissue development

    Article • Biochemical Journal, January 2022, Portland Press Ltd.

    Tsuyoshi Hirashima

  23. C-type Natriuretic Peptide–induced PKA Activation Promotes Endochondral Bone Formation in Hypertrophic Chondrocytes

    Article • Endocrinology, January 2022, Endocrine Society

    Tsuyoshi Hirashima

  24. Mechanical Feedback Control for Multicellular Tissue Size Maintenance: A Minireview

    Article • Frontiers in Cell and Developmental Biology, January 2022, Frontiers

    Tsuyoshi Hirashima

  25. Stalling interkinetic nuclear migration in curved pseudostratified epithelium of developing cochlea

    Article • Royal Society Open Science, December 2021, Royal Society Publishing

    Tsuyoshi Hirashima

  26. Development of Surgical and Visualization Procedures to Analyze Vasculatures by Mouse Tail Edema Model

    Article • Biological Procedures Online, November 2021, Springer Science + Business Media

    Tsuyoshi Hirashima

  27. ERK-mediated Curvature Feedback Regulates Branching Morphogenesis in Lung Epithelial Tissue

    Article • July 2021, openRxiv

    Tsuyoshi Hirashima

  28. Retrograde ERK activation waves drive base-to-apex multicellular flow in murine cochlear duct morphogenesis

    Article • eLife, March 2021, eLife

    Tsuyoshi Hirashima

  29. Dynamic erectile responses of a novel penile organ model utilizing TPEM†

    Article • Biology of Reproduction, January 2021, Oxford University Press (OUP)

    Tsuyoshi Hirashima

  30. Metastatic Single Tumor Cells Evade NK Cell-mediated Killing by Thrombin-mediated Loss of the Activating Ligand CD155/PVR/Necl-5

    Article • January 2021, openRxiv

    Tsuyoshi Hirashima

  31. Theory of mechanochemical patterning and optimal migration in cell monolayers

    Article • Nature Physics, September 2020, Springer Science + Business Media

    Tsuyoshi Hirashima

  32. Interplay between medial nuclear stalling and lateral cellular flow underlies cochlear duct spiral morphogenesis

    Article • July 2020, openRxiv

    Tsuyoshi Hirashima

  33. Incoherent feedforward regulation via Sox9 and Erk underpins mouse tracheal cartilage development

    Article • July 2020, openRxiv

    Tsuyoshi Hirashima

  34. ERK-Mediated Mechanochemical Waves Direct Collective Cell Polarization

    Article • Developmental Cell, June 2020, Elsevier

    Tsuyoshi Hirashima

  35. Theory of mechano-chemical patterning and optimal migration in cell monolayers

    Article • May 2020, openRxiv

    Tsuyoshi Hirashima

  36. Mechanical Tissue Compression and Whole-mount Imaging at Single Cell Resolution for Developing Murine Epididymal Tubules

    Article • BIO-PROTOCOL, January 2020, Bio-Protocol, LLC

    Tsuyoshi Hirashima

  37. ERK-mediated mechanochemical waves direct collective cell polarization

    Article • December 2019, openRxiv

    Tsuyoshi Hirashima

  38. Three-dimensional live imaging of Atoh1 reveals the dynamics of hair cell induction and organization in the developing cochlea

    Article • Development, November 2019, The Company of Biologists

    Tsuyoshi Hirashima

  39. Polarized cellular mechanoresponse system for maintaining radial size in developing epithelial tubes

    Article • Development, January 2019, The Company of Biologists

    Tsuyoshi Hirashima

  40. Dynamic MAPK/ERK Activity Sustains Nephron Progenitors through Niche Regulation and Primes Precursors for Differentiation

    Article • Stem Cell Reports, October 2018, Elsevier

    Tsuyoshi Hirashima

  41. In vitro tubulogenesis of Madin–Darby canine kidney (MDCK) spheroids occurs depending on constituent cell number and scaffold gel concentration

    Article • Journal of Theoretical Biology, December 2017, Elsevier

    Tsuyoshi Hirashima

  42. Anisotropic Cellular Mechanoresponse for Radial Size Maintenance of Developing Epithelial Tubes

    Article • August 2017, openRxiv

    Tsuyoshi Hirashima

  43. Cellular Potts modeling of complex multicellular behaviors in tissue morphogenesis

    Article • Development Growth & Differentiation, June 2017, Wiley

    Tsuyoshi Hirashima

  44. Mathematical study on robust tissue pattern formation in growing epididymal tubule

    Article • Journal of Theoretical Biology, October 2016, Elsevier

    Tsuyoshi Hirashima

  45. Procedures for the Quantification of Whole-Tissue Immunofluorescence Images Obtained at Single-Cell Resolution during Murine Tubular Organ Development

    Article • PLOS One, August 2015, PLOS

    Tsuyoshi Hirashima

  46. Pattern Formation of an Epithelial Tubule by Mechanical Instability during Epididymal Development

    Article • Cell Reports, November 2014, Elsevier

    Tsuyoshi Hirashima

  47. Mathematical Study of the Role of Delta/Notch Lateral Inhibition during Primary Branching of Drosophila Trachea Development

    Article • Biophysical Journal, December 2012, Elsevier

    Tsuyoshi Hirashima

  48. A kinetic model of ERK cyclic pathway on substrate control

    Article • Mathematical Biosciences, October 2012, Elsevier

    Tsuyoshi Hirashima

  49. Mechanisms for split localization of Fgf10 expression in early lung development

    Article • Developmental Dynamics, October 2009, Wiley

    Tsuyoshi Hirashima

  50. Dynamic modeling of branching morphogenesis of ureteric bud in early kidney development

    Article • Journal of Theoretical Biology, July 2009, Elsevier

    Tsuyoshi Hirashima

  51. Distance between AER and ZPA Is Defined by Feed-Forward Loop and Is Stabilized by their Feedback Loop in Vertebrate Limb Bud

    Article • The Bulletin of Mathematical Biophysics, November 2007, Springer Science + Business Media

    Tsuyoshi Hirashima