All Stories

  1. Using rare sugars to address alcoholism

    Article • Proceedings of the National Academy of Sciences, January 2026, Proceedings of the National Academy of Sciences

    Tsutomu Sasaki

  2. Activating transcription factor 4 mediates rare sugar-induced transactivation of the fibroblast growth factor 21 promoter

    Article • Bioscience Biotechnology and Biochemistry, October 2025, Oxford University Press (OUP)

    Tsutomu Sasaki

  3. Identification of FGF21 ‐inducing rare sugars that reduces sugar appetite in male BL /6 mice

    Article • Physiological Reports, October 2025, Wiley

    Tsutomu Sasaki

  4. Defective medium-chain fatty acid β-oxidation in the liver alters the fat preference and induces hepatic steatosis and glucose intolerance

    Article • AJP Endocrinology and Metabolism, September 2025, American Physiological Society

    Tsutomu Sasaki

  5. FTO promotes weight gain via altering Kif1a splicing and axonal vesicle trafficking in AgRP neurons

    Article • The EMBO Journal, July 2025, Springer Science + Business Media

    Tsutomu Sasaki

  6. Promotion of obesity by fibroblast growth factor 21-oxytocin system dysfunction due to sugar-specific hyperphagia

    Article • AJP Endocrinology and Metabolism, July 2025, American Physiological Society

    Tsutomu Sasaki

  7. (+)-Terrein exerts anti-obesity and anti-diabetic effects by regulating the differentiation and thermogenesis of brown adipocytes in mice fed a high-fat diet

    Article • Biomedicine & Pharmacotherapy, May 2025, Elsevier

    Tsutomu Sasaki

  8. MOB1 deletion in murine mature adipocytes ameliorates obesity and diabetes

    Article • Proceedings of the National Academy of Sciences, April 2025, Proceedings of the National Academy of Sciences

    Akira Suzuki, Tsutomu Sasaki

  9. Impaired cardiac branched-chain amino acid metabolism in a novel model of diabetic cardiomyopathy

    Article • Cardiovascular Diabetology, April 2025, Springer Science + Business Media

    Tsutomu Sasaki

  10. Exposure to mouse dams to bonito broth during gestation or lactation reduces fat intake in offspring

    Article • Appetite, February 2025, Elsevier

    Tsutomu Sasaki

  11. Selective β3-adrenoceptor agonist reduces energy intake and elevates GDF15 levels in lean and diet-induced obese mice

    Article • Endocrine Journal, January 2025, Japan Endocrine Society

    Tsutomu Sasaki

  12. Adaptive gene expression of alternative splicing variants of PGC-1α regulates whole-body energy metabolism

    Article • Molecular Metabolism, August 2024, Elsevier

    Tsutomu Sasaki

  13. Medium-chain triglyceride-specific appetite is regulated by the β-oxidation of medium-chain fatty acids in the liver

    Article • AJP Endocrinology and Metabolism, May 2024, American Physiological Society

    Tsutomu Sasaki

  14. Binding Interaction Between Lauric Acid and Cluster of Differentiation 36 Underpinned by a Fluorescence- Intensifying Assay

    Article • Journal of Oleo Science, January 2024, Japan Oil Chemists' Society

    Tsutomu Sasaki

  15. Molecular and Neural Bases of Nutrition-Based Feeding Decision-Making

    Article • Journal of Nutritional Science and Vitaminology, November 2022, Center for Academic Publications Japan

    Tsutomu Sasaki

  16. Application of a novel fluorescence intensity assay: identification of distinct fatty acetates as volatile compounds that bind specifically to amino acid region 149-168 of a transmembrane receptor CD36

    Article • Bioscience Biotechnology and Biochemistry, January 2022, Taylor & Francis

    Tsutomu Sasaki

  17. The Hypothalamic Paraventricular Nucleus Is the Center of the Hypothalamic–Pituitary–Thyroid Axis for Regulating Thyroid Hormone Levels

    Article • Thyroid, December 2021, SAGE Publications

    Tsutomu Sasaki

  18. Disordered branched chain amino acid catabolism in pancreatic islets is associated with postprandial hypersecretion of glucagon in diabetic mice

    Article • The Journal of Nutritional Biochemistry, November 2021, Elsevier

    Tsutomu Sasaki

  19. Role of SIRT1 and Progesterone Resistance in Normal and Abnormal Endometrium

    Article • The Journal of Clinical Endocrinology & Metabolism, October 2021, Endocrine Society

    Steven Young, Tsutomu Sasaki

  20. Assessment of direct binding interaction between CD36 and its potential lipid ligands using a peptide mimic of the receptor labeled with a fluorophore

    Article • Biomedical Research, September 2021, Biomedical Research Press

    Tsutomu Sasaki

  21. Urinary FABP1 is a biomarker for impaired proximal tubular protein reabsorption and is synergistically enhanced by concurrent liver injury

    Article • The Journal of Pathology, September 2021, Wiley

    Tsutomu Sasaki

  22. microRNA-33 maintains adaptive thermogenesis via enhanced sympathetic nerve activity

    Article • Nature Communications, February 2021, Springer Science + Business Media

    Tsutomu Sasaki

  23. Blood–cerebrospinal fluid barrier: another site disrupted during experimental cerebral malaria caused by Plasmodium berghei ANKA

    Article • International Journal for Parasitology, December 2020, Elsevier

    Tsutomu Sasaki

  24. Leukotriene A4hydrolase deficiency protects mice from diet‐induced obesity by increasing energy expenditure through neuroendocrine axis

    Article • The FASEB Journal, August 2020, Wiley

    Tsutomu Sasaki

  25. The PDK1-FoxO1 signaling in adipocytes controls systemic insulin sensitivity through the 5-lipoxygenase–leukotriene B 4 axis

    Article • Proceedings of the National Academy of Sciences, May 2020, Proceedings of the National Academy of Sciences

    Tsutomu Sasaki

  26. SGLT1 in pancreatic α cells regulates glucagon secretion in mice, possibly explaining the distinct effects of SGLT2 inhibitors on plasma glucagon levels

    Article • Molecular Metabolism, January 2019, Elsevier

    Tsutomu Sasaki

  27. Neuronal SIRT1 regulates macronutrient-based diet selection through FGF21 and oxytocin signalling in mice

    Article • Nature Communications, November 2018, Springer Science + Business Media

    Tsutomu Sasaki

  28. SGLT1 in Pancreatic a Cells Regulates Glucagon Secretion in Mice, Possibly Explaining the Distinct Effects of SGLT2 Inhibitors on Plasma Glucagon Levels

    Article • Diabetes, July 2018, American Diabetes Association

    Tsutomu Sasaki

  29. Overexpression of Nmnat3 efficiently increases NAD and NGD levels and ameliorates age-associated insulin resistance

    Article • Aging Cell, June 2018, Wiley

    Takashi Nakagawa, Tsutomu Sasaki

  30. A central-acting connexin inhibitor, INI-0602, prevents high-fat diet-induced feeding pattern disturbances and obesity in mice

    Article • Molecular Brain, May 2018, Springer Science + Business Media

    Tsutomu Sasaki

  31. Intraperitoneal injection of d -serine inhibits high-fat diet intake and preference in male mice

    Article • Appetite, November 2017, Elsevier

    Tsutomu Sasaki

  32. Neural and Molecular Mechanisms Involved in Controlling the Quality of Feeding Behavior: Diet Selection and Feeding Patterns

    Article • Nutrients, October 2017, MDPI AG

    Tsutomu Sasaki

  33. Zinc transporter ZIP13 suppresses beige adipocyte biogenesis and energy expenditure by regulating C/EBP-β expression

    Article • PLoS Genetics, August 2017, PLOS

    Tsutomu Sasaki

  34. Neurosecretory protein GL stimulates food intake, de novo lipogenesis, and onset of obesity

    Article • eLife, August 2017, eLife

    Tsutomu Sasaki

  35. Expanding frontiers in weight-control research explored by young investigators

    Article • The Journal of Physiological Sciences, January 2017, Elsevier

    Tsutomu Sasaki

  36. Control of Appetite and Food Preference by NMDA Receptor and Its Co-Agonist d-Serine

    Article • International Journal of Molecular Sciences, July 2016, MDPI AG

    Tsutomu Sasaki

  37. N-methyl-d-aspartate receptor coagonistd-serine suppresses intake of high-preference food

    Article • AJP Regulatory Integrative and Comparative Physiology, September 2015, American Physiological Society

    Tsutomu Sasaki

  38. Age-Associated Weight Gain, Leptin, and SIRT1: A Possible Role for Hypothalamic SIRT1 in the Prevention of Weight Gain and Aging through Modulation of Leptin Sensitivity

    Article • Frontiers in Endocrinology, July 2015, Frontiers

    Tsutomu Sasaki

  39. Miglitol protects against age-dependent weight gain in mice: A potential role of increased UCP1 content in brown adipose tissue [Rapid Communication]

    Article • Endocrine Journal, January 2015, Japan Endocrine Society

    Tsutomu Sasaki

  40. Overexpression of insulin receptor partially improves obese and diabetic phenotypes in <i>db/db</i> mice

    Article • Endocrine Journal, January 2015, Japan Endocrine Society

    Tsutomu Sasaki

  41. Dnmt3a in Sim1 Neurons Is Necessary for Normal Energy Homeostasis

    Article • Journal of Neuroscience, November 2014, Society for Neuroscience

    Tsutomu Sasaki

  42. Protection Against High-Fat Diet-Induced Obesity inHelz2-Deficient Male Mice Due to Enhanced Expression of Hepatic Leptin Receptor

    Article • Endocrinology, September 2014, Endocrine Society

    Tsutomu Sasaki

  43. Sirt1 rescues the obesity induced by insulin‐resistant constitutively‐nuclear FoxO1 in POMC neurons of male mice

    Article • Obesity, July 2014, Wiley

    Tsutomu Sasaki

  44. Elevated mitochondrial biogenesis in skeletal muscle is associated with testosterone‐induced body weight loss in male mice

    Article • FEBS Letters, April 2014, Wiley

    Tsutomu Sasaki

  45. ATF3 expression is induced by low glucose in pancreatic α and β cells and regulates glucagon but not insulin gene transcription

    Article • Endocrine Journal, January 2014, Japan Endocrine Society

    Tsutomu Sasaki

  46. Hypothalamic SIRT1 prevents age-associated weight gain by improving leptin sensitivity in mice

    Article • Diabetologia, December 2013, Springer Science + Business Media

    Tsutomu Sasaki

  47. A Critical Role of Fatty Acid Binding Protein 4 and 5 (FABP4/5) in the Systemic Response to Fasting

    Article • PLOS One, November 2013, PLOS

    Tsutomu Sasaki

  48. Hypothalamic ATF3 is involved in regulating glucose and energy metabolism in mice

    Article • Diabetologia, March 2013, Springer Science + Business Media

    Tsutomu Sasaki

  49. A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells

    Article • PLOS One, January 2013, PLOS

    Tsutomu Sasaki

  50. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates

    Article • Endocrine Journal, January 2013, Japan Endocrine Society

    Tsutomu Sasaki

  51. Hepatic FoxO1 Integrates Glucose Utilization and Lipid Synthesis through Regulation of Chrebp O-Glycosylation

    Article • PLOS One, October 2012, PLOS

    Tsutomu Sasaki

  52. Hypothalamic Sirt1 and regulation of food intake

    Article • Diabetology International, August 2012, Springer Science + Business Media

    Tsutomu Sasaki

  53. Necdin Controls Foxo1 Acetylation in Hypothalamic Arcuate Neurons to Modulate the Thyroid Axis

    Article • Journal of Neuroscience, April 2012, Society for Neuroscience

    Tsutomu Sasaki

  54. FoxO1 as a double-edged sword in the pancreas: analysis of pancreas- and β-cell-specific FoxO1 knockout mice

    Article • AJP Endocrinology and Metabolism, March 2012, American Physiological Society

    Tsutomu Sasaki

  55. FoxO1 Gain of Function in the Pancreas Causes Glucose Intolerance, Polycystic Pancreas, and Islet Hypervascularization

    Article • PLOS One, February 2012, PLOS

    Tsutomu Sasaki

  56. Overexpression of FoxO1 in the Hypothalamus and Pancreas Causes Obesity and Glucose Intolerance

    Article • Endocrinology, February 2012, Endocrine Society

    Tsutomu Sasaki

  57. Induction of Sirt1 expression in the murine hypothalamic AgRP and Pomc neurons leads to lean phenotype due to decreased food intake and increased energy expenditure

    Article • Neuroscience Research, September 2011, Elsevier

    Tsutomu Sasaki

  58. Genetic Defect in Phospholipase Cδ1 Protects Mice From Obesity by Regulating Thermogenesis and Adipogenesis

    Article • Diabetes, June 2011, American Diabetes Association

    Tsutomu Sasaki

  59. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via Agouti-Related Peptide

    Article • Endocrinology, June 2010, Endocrine Society

    Tsutomu Sasaki

  60. Induction of Hypothalamic Sirt1 Leads to Cessation of Feeding via AgRP

    Article • Neuroscience Research, January 2010, Elsevier

    Tsutomu Sasaki

  61. Roles of FoxO1 and Sirt1 in the central regulation of food intake

    Article • Endocrine Journal, January 2010, Japan Endocrine Society

    Tsutomu Sasaki

  62. Regulation of Pancreatic Juxtaductal Endocrine Cell Formation by FoxO1

    Article • Molecular and Cellular Biology, June 2009, ASM Journals

    Tsutomu Sasaki

  63. The roles of FoxO1 and Sirt1 in the regulation of food intake

    Article • Neuroscience Research, January 2009, Elsevier

    Tsutomu Sasaki