All Stories

  1. A new route to N-vinyl heterocycles and anilines through cine-substitution

    Article • Advanced Synthesis & Catalysis, June 2026, Wiley

    Associate Professor Tsutomu Kimura

  2. An unusual substitution reaction of fluorinated vinylmagnesium chlorides with Grignard reagents

    Article • Tetrahedron, March 2025, Elsevier

    Associate Professor Tsutomu Kimura

  3. What makes some organomagnesium compounds behave like carbenes?

    Article • Journal of Organometallic Chemistry, October 2024, Elsevier

    Associate Professor Tsutomu Kimura

  4. A practical new source of alkynyl Grignard reagents from stable sulfoxides

    Article • Tetrahedron, June 2023, Elsevier

    Associate Professor Tsutomu Kimura

  5. Fritsch–Buttenberg–Wiechell rearrangement of magnesium alkylidene carbenoids leading to the formation of alkynes

    Article • Beilstein Journal of Organic Chemistry, May 2021, Beilstein Institut

    Associate Professor Tsutomu Kimura

  6. Discovery of a multipotent chaperone, 1-(2,6-Difluorobenzylamino)-3-(1,2,3,4-tetrahydrocarbazol-9-yl)-propan-2-ol with the inhibitory effects on the proliferation of prion, cancer as well as influenza virus

    Article • Prion, January 2020, Taylor & Francis

    Associate Professor Tsutomu Kimura

  7. A designer molecular chaperone against transmissible spongiform encephalopathy slows disease progression in mice and macaques

    Article • Nature Biomedical Engineering, February 2019, Springer Science + Business Media

    Dr Takeshi Ishikawa, Associate Professor Tsutomu Kimura

  8. Oral toxicity study of an antiprion compound <i>N</i>,<i>N</i><i>’</i>-[(cyclohexylmethylene)di-4,1-phenylene]bis[2-(1-pyrrolidinyl)acetamide] in rats and cynomolgus monkeys

    Article • Fundamental Toxicological Sciences, January 2019, Japanese Society of Toxicology

    Associate Professor Tsutomu Kimura

  9. Development of Organic Reactions Utilizing Three Different Types of Reactivity of Magnesium Carbenoids

    Article • Journal of Synthetic Organic Chemistry Japan, January 2018, The Society of Synthetic Organic Chemistry, Japan

    Associate Professor Tsutomu Kimura

  10. Recent Advances in Magnesium Carbenoid Chemistry

    Article • Synthesis, September 2017, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  11. Efficient one-pot synthesis of 1-chlorovinyl p -tolyl sulfoxides from aldehydes and ketones by the Horner-Wadsworth-Emmons reaction

    Article • Heteroatom Chemistry, September 2017, Wiley

    Associate Professor Tsutomu Kimura

  12. Consecutive reaction of 1-chlorovinyl p-tolyl sulfoxides with [chloro(p-tolylsulfinyl)methyl]lithium leading to the formation of multi-functionalized methylenecyclopropanes

    Article • Tetrahedron Letters, September 2017, Elsevier

    Associate Professor Tsutomu Kimura

  13. Synthesis of 2-azabicyclo[2.1.0]pentanes by the intramolecular nucleophilic substitution of cyclopropylmagnesium carbenoids with magnesium anilide

    Article • Tetrahedron, May 2017, Elsevier

    Associate Professor Tsutomu Kimura

  14. Synthesis of 3-azabicyclo[3.1.0]hexanes by insertion of cyclopropylmagnesium carbenoids into an intramolecular C–H bond adjacent to a nitrogen atom

    Article • Tetrahedron, September 2015, Elsevier

    Associate Professor Tsutomu Kimura

  15. Mechanism of magnesium carbenoid 1,3-C-H insertion: a DFT study

    Article • Journal of Physical Organic Chemistry, April 2015, Wiley

    Associate Professor Tsutomu Kimura

  16. Synthesis of α-Halobutenolides Using the Nucleophilicity of Magnesium Alkylidene Carbenoids

    Article • Heterocycles, January 2015, Japan Institute of Heterocyclic Chemistry

    Associate Professor Tsutomu Kimura

  17. Synthesis of cyclopropane-fused α-chlorolactones utilizing the nucleophilicity of cyclopropylmagnesium carbenoids

    Article • Tetrahedron Letters, February 2014, Elsevier

    Associate Professor Tsutomu Kimura

  18. Nucleophilic substitution at the alkenyl and cyclopropyl carbon atoms of magnesium carbenoids: a DFT study

    Article • Tetrahedron Letters, September 2013, Elsevier

    Associate Professor Tsutomu Kimura

  19. Degree of vinylidene character of α-heteroatom-substituted vinylmagnesium chlorides: a DFT study to discern the role of the halogen atom in magnesium alkylidene carbenoid chemistry

    Article • Tetrahedron, August 2013, Elsevier

    Associate Professor Tsutomu Kimura

  20. Synthesis of an 11C‐Labeled Antiprion GN8 Derivative and Evaluation of Its Brain Uptake by Positron Emission Tomography

    Article • ChemMedChem, May 2013, Wiley

    Associate Professor Tsutomu Kimura

  21. A novel one-pot synthesis of cyclopropanols based on the reaction of magnesium carbenoids with lithium enolate of ketones

    Article • Tetrahedron Letters, May 2013, Elsevier

    Associate Professor Tsutomu Kimura

  22. Synthesis of small ring-containing conjugated dienes via the coupling reaction of cyclopropyl- and cyclobutylmagnesium carbenoids with α-sulfonylallyllithiums

    Article • Tetrahedron, May 2013, Elsevier

    Associate Professor Tsutomu Kimura

  23. Configurational Stability of Optically Active Dichloromethylp-Tolyl Sulfoxide and Its Anionic Species: Experimental and Theoretical Study

    Article • Heteroatom Chemistry, February 2013, Wiley

    Associate Professor Tsutomu Kimura

  24. A novel consecutive reaction of lithium acetylides with 2-aryl-1-chlorovinyl p-tolyl sulfoxides leading to the formation of (Z)-enediynes

    Article • Tetrahedron Letters, February 2013, Elsevier

    Associate Professor Tsutomu Kimura

  25. Efficient Synthesis of Cyclopropanecarboxylic Acid Esters Starting from the Conjugate Addition of Lithium Ester Enolates to 1-Chlorovinyl p-Tolyl ­Sulfoxides

    Article • Synlett, January 2013, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  26. Alkenylation of 1- and 2-Naphthols by Using Magnesium Alkylidene Carbenoids as Electrophilic Alkenylating Agents

    Article • Synthesis, January 2013, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  27. New Synthetic Methods by Using the Electrophilic Nature of Magnesium Carbenoids: Recent Progress and Elucidation of the Essence of the Reactivity by DFT Calculation

    Article • Journal of Synthetic Organic Chemistry Japan, January 2013, The Society of Synthetic Organic Chemistry, Japan

    Associate Professor Tsutomu Kimura

  28. Coupling Reaction of Magnesium Alkylidene Carbenoids with α-Sulfonyl­allyllithiums: An Efficient Route to Multi-Substituted Vinylallenes

    Article • Synthesis, October 2012, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  29. Quantum chemical characterization of magnesium carbenoids

    Article • Journal of Organometallic Chemistry, September 2012, Elsevier

    Associate Professor Tsutomu Kimura

  30. New synthesis of multi-substituted α-chlorocyclobutanones from 1-chloro-3-cyanoalkyl p-tolyl sulfoxides by 4-Exo-Dig nucleophilic ring closure of magnesium carbenoids to nitrile group as the key reaction

    Article • Tetrahedron Letters, June 2012, Elsevier

    Associate Professor Tsutomu Kimura

  31. Synthesis of Spiro[2.6]nonadienones and Spiro[3.6]decadienones by the Reaction of Cyclopropyl- and Cyclobutylmagnesium Carbenoids with Lithium Phenolates and Naphtholates

    Article • Synthesis, May 2012, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  32. New synthesis of multisubstituted cyanocyclopropanes by the intramolecular SN2 alkylation and 1,3-CC insertion reaction of magnesium carbenoids as the key reactions

    Article • Tetrahedron, March 2012, Elsevier

    Associate Professor Tsutomu Kimura

  33. Synthesis, including asymmetric synthesis, of 3-oxabicyclo[3.1.0]hexanes and bicyclo[3.1.0]hexanes by the 1,5-CH insertion of cyclopropylmagnesium carbenoids as the key reaction

    Article • Tetrahedron, January 2012, Elsevier

    Associate Professor Tsutomu Kimura

  34. Synthesis of 9-substituted 2,3,4,9-tetrahydro-1H-carbazole derivatives and evaluation of their anti-prion activity in TSE-infected cells

    Article • European Journal of Medicinal Chemistry, November 2011, Elsevier

    Associate Professor Tsutomu Kimura

  35. Respiratory and cardiovascular toxicity studies of a novel antiprion compound, GN8, in rats and dogs

    Article • Drug and Chemical Toxicology, October 2011, Taylor & Francis

    Associate Professor Tsutomu Kimura

  36. Aryl(chloro)methyl 4-Tolyl Sulfoxides: Synthesis and Application to the Synthesis of α-Aryl Ketones

    Article • Synthesis, October 2011, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  37. Synthesis of GN8 derivatives and evaluation of their antiprion activity in TSE-infected cells

    Article • Bioorganic & Medicinal Chemistry Letters, March 2011, Elsevier

    Dr Yuji O. Kamatari, Associate Professor Tsutomu Kimura

  38. Synthesis of [2,6-Bis(2-oxazolinyl)phenyl]palladium Complexes via the Ligand Introduction Route

    Article • Organometallics, September 2008, American Chemical Society (ACS)

    Associate Professor Tsutomu Kimura

  39. Alkylative Cyclization of 1,6-Enynes in Water with an Amphiphilic Resin-Supported Palladium Catalyst

    Article • Synlett, November 2006, Thieme Publishing Group

    Associate Professor Tsutomu Kimura

  40. Syntheses and Properties of Phosphinoselenoic Chlorides, Acids, and Their Salts

    Article • Current Organic Chemistry, October 2006, Bentham Science Publishers

    Associate Professor Tsutomu Kimura

  41. PCP Pincer Palladium Complexes and Their Catalytic Properties:  Synthesis via the Electrophilic Ligand Introduction Route

    Article • Organometallics, August 2006, American Chemical Society (ACS)

    Associate Professor Tsutomu Kimura

  42. Synthesis, Structures, and Some Reactions of [(Thioacyl)thio]‐ and (Acylseleno)antimony and ‐bismuth Derivatives ((RCSS)xMR$\rm{_{{\bf 3 - }{\bf x}}^{\bf 1} }$ and (RCOSe)xMR$\rm{_{{\bf 3 - }{\bf x}}^{\bf 1} }$ with ...

    Article • Helvetica Chimica Acta, April 2006, Wiley

    Associate Professor Tsutomu Kimura

  43. Optically active P-chiral phosphinoselenoic amides: stereochemical outcome at the P-stereogenic center in the synthesis of these substances and their characterization

    Article • Tetrahedron Asymmetry, November 2005, Elsevier

    Associate Professor Tsutomu Kimura

  44. Phosphinoselenothioic Acids and Their Salts:  Synthesis, Characterization, and Reaction with Electrophiles

    Article • The Journal of Organic Chemistry, June 2005, American Chemical Society (ACS)

    Associate Professor Tsutomu Kimura

  45. P-Chiral Phosphinoselenoic Chlorides and Phosphinochalcogenoselenoic Acid Esters:  Synthesis, Characterization, and Conformational Studies

    Article • The Journal of Organic Chemistry, January 2005, American Chemical Society (ACS)

    Associate Professor Tsutomu Kimura

  46. Enantiomerically pure P-chiral phosphinoselenoic chlorides: inversion of configuration at the P-chirogenic center in the synthesis and reaction of these substances

    Article • Chemical Communications, January 2005, Royal Society of Chemistry

    Associate Professor Tsutomu Kimura

  47. Selenophilic reaction of organolithium and magnesium reagents with phosphinoselenoic chlorides

    Article • Heteroatom Chemistry, January 2005, Wiley

    Associate Professor Tsutomu Kimura

  48. P-Chiral Phosphinoselenoic Chlorides and Optically Active P-Chiral Phosphinoselenoic Amides: Synthesis and Stereospecific Interconversion with Extrusion and Addition Reactions of the Selenium Atom

    Article • Chemistry Letters, June 2004, Oxford University Press (OUP)

    Associate Professor Tsutomu Kimura

  49. Iodo-cyclization of N-Homoallyl Thioamides Leading to 2,4-Diaryl-5,6-dihydro-4H-1,3-thiazines

    Article • Chemistry Letters, March 2004, Oxford University Press (OUP)

    Associate Professor Tsutomu Kimura

  50. Selenothiophosphinic Acid Salts: Efficient Synthesis, Structure and Reactivity

    Article • Chemistry Letters, September 2002, Oxford University Press (OUP)

    Associate Professor Tsutomu Kimura

  51. Heck Reaction in Water with Amphiphilic Resin-Supported Palladium-Phosphine Complexes

    Article • Synlett, January 2002, Thieme Publishing Group

    Associate Professor Tsutomu Kimura