All Stories

  1. Coincidence of acral peeling skin syndrome and Nagashima‐type palmoplantar keratosis in a Japanese pedigree with acral skin peeling

    Article • The Journal of Dermatology, August 2024, Wiley

    Dr. Toshihide Higashino

  2. Case report: Exploring autosomal recessive woolly hair: genetic and scanning electron microscopic perspectives on a Japanese patient

    Article • Frontiers in Medicine, May 2024, Frontiers

    Dr. Toshihide Higashino

  3. A case of Hailey‐Hailey disease with novel ATP2C1 gene variant (c.G925C) showing unusual phenotype

    Article • The Journal of Dermatology, May 2024, Wiley

    Dr. Toshihide Higashino

  4. Practical forensic use of kinship determination using high-density SNP profiling based on a microarray platform, focusing on low-quantity DNA

    Article • Forensic Science International Genetics, November 2022, Elsevier

    Dr. Toshihide Higashino

  5. Hypertension-Associated Genes in the Mesenteric Artery of Three Spontaneously Hypertensive Rat Substrains Identified Using a DNA Array Method

    Article • Frontiers in Bioscience-Landmark, June 2022, IMR Press

    Dr. Toshihide Higashino

  6. Assessment of Delayed Large Local Reactions After the First Dose of the SARS-CoV-2 mRNA-1273 Vaccine in Japan

    Article • JAMA Dermatology, June 2022, American Medical Association (AMA)

    Dr. Toshihide Higashino

  7. Increase of serum uric acid levels associated with APOE ε2 haplotype: a clinico-genetic investigation and in vivo approach

    Article • Human Cell, September 2021, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  8. Thromboxane A 2 receptor antagonist (ONO‐8809) attenuates renal disorders caused by salt overload in stroke‐prone spontaneously hypertensive rats

    Article • Clinical and Experimental Pharmacology and Physiology, July 2021, Wiley

    Dr. Toshihide Higashino

  9. Porphyrin accumulation in humans with common dysfunctional variants of ABCG2, a porphyrin transporter: potential association with acquired photosensitivity

    Article • Human Cell, May 2021, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  10. Substantial anti-gout effect conferred by common and rare dysfunctional variants of URAT1/SLC22A12

    Article • Rheumatology, April 2021, Oxford University Press (OUP)

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  11. A germline mutation in the platelet‐derived growth factor receptor beta gene may be implicated in hereditary progressive mucinous histiocytosis

    Article • British Journal of Dermatology, February 2021, Wiley

    Dr. Toshihide Higashino

  12. Identification of a dysfunctional splicing mutation in the SLC22A12/URAT1 gene causing renal hypouricaemia type 1: a report on two families

    Article • Rheumatology, October 2020, Oxford University Press (OUP)

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  13. Subtype-specific gout susceptibility loci and enrichment of selection pressure on ABCG2 and ALDH2 identified by subtype genome-wide meta-analyses of clinically defined gout patients

    Article • Annals of the Rheumatic Diseases, April 2020, BMJ

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  14. A common variant of LDL receptor related protein 2 (LRP2) gene is associated with gout susceptibility: a meta-analysis in a Japanese population

    Article • Human Cell, January 2020, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  15. Dysfunctional missense variant of OAT10/SLC22A13 decreases gout risk and serum uric acid levels

    Article • Annals of the Rheumatic Diseases, November 2019, BMJ

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  16. Genotype–phenotype correlation in a large English cohort of patients with autosomal recessive ichthyosis

    Article • British Journal of Dermatology, August 2019, Wiley

    Dr. Toshihide Higashino

  17. A new approach to identifying hypertension-associated genes in the mesenteric artery of spontaneously hypertensive rats and stroke-prone spontaneously hypertensive rats

    Article • Journal of Hypertension, August 2019, Wolters Kluwer Health

    Dr. Toshihide Higashino

  18. Genome-wide association study revealed novel loci which aggravate asymptomatic hyperuricaemia into gout

    Article • Annals of the Rheumatic Diseases, July 2019, BMJ

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  19. Identification of ABCG2 as an Exporter of Uremic Toxin Indoxyl Sulfate in Mice and as a Crucial Factor Influencing CKD Progression

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  20. Common variant of BCAS3 is associated with gout risk in Japanese population: the first replication study after gout GWAS in Han Chinese

    Article • BMC Medical Genetics, June 2018, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  21. Advances in the genetic understanding of hypohidrotic ectodermal dysplasia

    Article • Expert Opinion on Orphan Drugs, November 2017, Taylor & Francis

    Dr. Toshihide Higashino

  22. A common variant of MAF/c-MAF, transcriptional factor gene in the kidney, is associated with gout susceptibility

    Article • Human Cell, October 2017, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  23. Multiple common and rare variants of ABCG2 cause gout

    Article • RMD Open, August 2017, BMJ

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  24. Independent effects of ADH1B and ALDH2 common dysfunctional variants on gout risk

    Article • Scientific Reports, May 2017, Springer Science + Business Media

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  25. Expression of a human NPT1/SLC17A1 missense variant which increases urate export

    Article • Nucleosides Nucleotides & Nucleic Acids, December 2016, Taylor & Francis

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  26. Common variant of PDZ domain containing 1 (PDZK1) gene is associated with gout susceptibility: A replication study and meta-analysis in Japanese population

    Article • Drug Metabolism and Pharmacokinetics, December 2016, Elsevier

    Prof. Akiyoshi Nakayama, Dr. Toshihide Higashino

  27. GWAS of clinically defined gout and subtypes identifies multiple susceptibility loci that include urate transporter genes

    Article • Annals of the Rheumatic Diseases, November 2016, BMJ

    Dr. Toshihide Higashino, Prof. Akiyoshi Nakayama

  28. Meta-analysis confirms an association between gout and a common variant of LRRC16A locus

    Article • Modern Rheumatology, September 2016, Taylor & Francis

    Prof. Akiyoshi Nakayama, Dr. Toshihide Higashino

  29. Hyperuricemia in acute gastroenteritis is caused by decreased urate excretion via ABCG2

    Article • Scientific Reports, August 2016, Nature

    Prof. Akiyoshi Nakayama, Dr. Toshihide Higashino

  30. The effects of URAT1/SLC22A12 nonfunctional variants,R90H and W258X, on serum uric acid levels and gout/hyperuricemia progression

    Article • Scientific Reports, January 2016, Nature

    Prof. Akiyoshi Nakayama, Dr. Toshihide Higashino

  31. Photolocalized varicella in an adult

    Article • British Journal of Dermatology, May 2014, Wiley

    Dr. Toshihide Higashino

  32. Two cases of erythema exsudativum multiforme associated with Chlamydia pneumoniae infection

    Article • The Journal of Dermatology, September 2011, Wiley

    Dr. Toshihide Higashino