All Stories

  1. Helicobacter pylori geographic variation: a window into global differences in gastric cancer incidence

    Article • Microbiology and Molecular Biology Reviews, July 2026, ASM Journals

    Dr Timothy L Cover

  2. Contributions of conserved and species-specific CagX (VirB9) domains to the assembly and function of the Helicobacter pylori Cag type IV secretion system

    Article • Infection and Immunity, June 2026, ASM Journals

    Dr Timothy L Cover

  3. Multiple TonB-dependent transport systems in Helicobacter pylori

    Article • Infection and Immunity, June 2026, ASM Journals

    Dr Timothy L Cover

  4. Species-specific components of the Helicobacter pylori Cag type IV secretion system

    Article • Infection and Immunity, May 2025, ASM Journals

    Dr Timothy L Cover

  5. A unique Helicobacter pylori strain to study gastric cancer development

    Article • Microbiology Spectrum, January 2025, ASM Journals

    Dr Timothy L Cover

  6. Taurine modulates host cell responses to Helicobacter pylori VacA toxin

    Article • Infection and Immunity, August 2024, ASM Journals

    Dr Timothy L Cover

  7. Correction: Subdomains of theHelicobacter pyloriCag T4SS outer membrane core complex exhibit structural independence

    Article • Life Science Alliance, May 2024, Life Science Alliance, LLC

    Dr Timothy L Cover

  8. Subdomains of theHelicobacter pyloriCag T4SS outer membrane core complex exhibit structural independence

    Article • Life Science Alliance, April 2024, Life Science Alliance, LLC

    Dr Timothy L Cover

  9. The Helicobacter pylori cag pathogenicity island as a determinant of gastric cancer risk

    Article • Gut Microbes, February 2024, Taylor & Francis

    Dr Timothy L Cover

  10. Structural Analysis of Membrane-associated Forms of Helicobacter pylori VacA Toxin

    Article • Journal of Molecular Biology, February 2024, Elsevier

    Dr Timothy L Cover

  11. Role of the CagY antenna projection in Helicobacter pylori Cag type IV secretion system activity

    Article • Infection and Immunity, September 2023, ASM Journals

    Dr Timothy L Cover

  12. Identification of an Essential LolD-Like Protein in Helicobacter pylori

    Article • Journal of Bacteriology, April 2023, ASM Journals

    Dr Timothy L Cover

  13. A Positively Selected fur -R88H Mutation Enhances Helicobacter pylori Fitness in a High-Salt Environment and Alters Fur-Dependent Regulation of Gene Expression

    Article • Infection and Immunity, February 2023, ASM Journals

    Dr Timothy L Cover

  14. Regulation of Helicobacter pylori Urease and Acetone Carboxylase Genes by Nitric Oxide and the CrdRS Two-Component System

    Article • Microbiology Spectrum, February 2023, ASM Journals

    Dr Timothy L Cover

  15. Molecular architecture of bacterial type IV secretion systems

    Article • PLoS Pathogens, August 2022, PLOS

    Dr Timothy L Cover

  16. Positive Selection of Mutations in the Helicobacter pylori katA 5′ Untranslated Region in a Mongolian Gerbil Model of Gastric Disease

    Article • Infection and Immunity, July 2022, ASM Journals

    Dr Timothy L Cover

  17. An infection-induced oxidation site regulates legumain processing and tumor growth

    Article • Nature Chemical Biology, March 2022, Springer Science + Business Media

    Dr Timothy L Cover

  18. Enhanced Fitness of a Helicobacter pylori babA Mutant in a Murine Model

    Article • Infection and Immunity, September 2021, ASM Journals

    Dr Timothy L Cover

  19. Tracking bacterial effector protein delivery into host cells

    Article • Molecular Microbiology, July 2021, Wiley

    Dr Timothy L Cover

  20. Delineation of the pH-Responsive Regulon Controlled by the Helicobacter pylori ArsRS Two-Component System

    Article • Infection and Immunity, March 2021, ASM Journals

    Dr Timothy L Cover

  21. Association of Combined Sero-Positivity to Helicobacter pylori and Streptococcus gallolyticus with Risk of Colorectal Cancer

    Article • Microorganisms, October 2020, MDPI AG

    Dr Timothy L Cover

  22. Cryo-EM reveals species-specific components within the Helicobacter pylori Cag type IV secretion system core complex

    Article • eLife, September 2020, eLife

    Dr Timothy L Cover

  23. Cryo-EM reveals species-specific components within theHelicobacter pyloriCag type IV secretion system core complex

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Dr Timothy L Cover

  24. The Helicobacter pylori Cag Type IV Secretion System

    Article • Trends in Microbiology, August 2020, Elsevier

    Dr Timothy L Cover

  25. Temporal Control of the Helicobacter pylori Cag Type IV Secretion System in a Mongolian Gerbil Model of Gastric Carcinogenesis

    Article • mBio, June 2020, ASM Journals

    Dr Timothy L Cover

  26. Lipoprotein Processing and Sorting in Helicobacter pylori

    Article • mBio, May 2020, ASM Journals

    Dr Timothy L Cover

  27. Functional Properties of Helicobacter pylori VacA Toxin m1 and m2 Variants

    Article • Infection and Immunity, April 2020, ASM Journals

    Dr Timothy L Cover

  28. Bacterial Energetic Requirements for Helicobacter pylori Cag Type IV Secretion System-Dependent Alterations in Gastric Epithelial Cells

    Article • Infection and Immunity, November 2019, ASM Journals

    Dr Timothy L Cover

  29. Structure of a molecular machine in a bacterium that contributes to gastric cancer

    Article • eLife, June 2019, eLife

    Dr Timothy L Cover

  30. Effect of environmental salt concentration on the Helicobacter pylori exoproteome

    Article • Journal of Proteomics, June 2019, Elsevier

    Dr Timothy L Cover

  31. In Situ Molecular Architecture of the Helicobacter pylori Cag Type IV Secretion System

    Article • mBio, May 2019, ASM Journals

    Dr Timothy L Cover

  32. Cryo-EM Analysis Reveals Structural Basis of Helicobacter pylori VacA Toxin Oligomerization

    Article • Journal of Molecular Biology, May 2019, Elsevier

    Dr Timothy L Cover

  33. Transmaternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T cells

    Article • Journal of Allergy and Clinical Immunology, April 2019, Elsevier

    Dr Timothy L Cover

  34. Helicobacter pylori VacA Targets Myeloid Cells in the Gastric Lamina Propria To Promote Peripherally Induced Regulatory T-Cell Differentiation and Persistent Infection

    Article • mBio, March 2019, ASM Journals

    Dr Timothy L Cover

  35. Intracellular Degradation of Helicobacter pylori VacA Toxin as a Determinant of Gastric Epithelial Cell Viability

    Article • Infection and Immunity, January 2019, ASM Journals

    Dr Timothy L Cover

  36. Serologic Response to Helicobacter pylori Proteins Associated With Risk of Colorectal Cancer Among Diverse Populations in the United States

    Article • Gastroenterology, January 2019, Elsevier

    Dr Timothy L Cover

  37. Role of a Stem-Loop Structure in Helicobacter pylori cagA Transcript Stability

    Article • Infection and Immunity, December 2018, ASM Journals

    Dr Timothy L Cover

  38. Carcinogenic Helicobacter pylori Strains Selectively Dysregulate the In Vivo Gastric Proteome, Which May Be Associated with Stomach Cancer Progression

    Article • Molecular & Cellular Proteomics, November 2018, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  39. Antibody Responses to Streptococcus Gallolyticus Subspecies Gallolyticus Proteins in a Large Prospective Colorectal Cancer Cohort Consortium

    Article • Cancer Epidemiology Biomarkers & Prevention, July 2018, American Association for Cancer Research (AACR)

    Dr Timothy L Cover

  40. Helicobacter pylori genetic diversification in the Mongolian gerbil model

    Article • PeerJ, May 2018, PeerJ

    Dr Timothy L Cover

  41. Determinants of Raft Partitioning of the Helicobacter pylori Pore-Forming Toxin VacA

    Article • Infection and Immunity, March 2018, ASM Journals

    Dr Timothy L Cover

  42. High-Salt Conditions Alter Transcription of Helicobacter pylori Genes Encoding Outer Membrane Proteins

    Article • Infection and Immunity, December 2017, ASM Journals

    Dr Timothy L Cover

  43. Genetic signatures for Helicobacter pylori strains of West African origin

    Article • PLOS One, November 2017, PLOS

    Dr Timothy L Cover

  44. Helicobacter pylori Vacuolating Toxin and Gastric Cancer

    Article • Toxins, October 2017, MDPI AG

    Dr Timothy L Cover

  45. Pan-genomic analyses identify key Helicobacter pylori pathogenic loci modified by carcinogenic host microenvironments

    Article • Gut, September 2017, BMJ

    Dr Timothy L Cover

  46. Helicobacter pylori and its secreted immunomodulator VacA protect against anaphylaxis in experimental models of food allergy

    Article • Clinical & Experimental Allergy, September 2017, Wiley

    Dr Timothy L Cover

  47. Magnetic Extraction of Acinetobacter baumannii Using Colistin-Functionalized γ-Fe2O3/Au Core/Shell Composite Nanoclusters

    Article • ACS Applied Materials & Interfaces, August 2017, American Chemical Society (ACS)

    Dr Timothy L Cover

  48. Oxidative Phosphorylation System in Gastric Carcinomas and Gastritis

    Article • Oxidative Medicine and Cellular Longevity, January 2017, Hindawi Publishing Corporation

    Dr Timothy L Cover

  49. Dynamic Computational Model of Symptomatic Bacteremia to Inform Bacterial Separation Treatment Requirements

    Article • PLOS One, September 2016, PLOS

    Dr Timothy L Cover

  50. Dietary Composition Influences Incidence of Helicobacter pylori-Induced Iron Deficiency Anemia and Gastric Ulceration

    Article • Infection and Immunity, September 2016, ASM Journals

    Dr Timothy L Cover

  51. Epithelial Coculture and l-Lactate Promote Growth of Helicobacter cinaedi under H2-Free Aerobic Conditions

    Article • Applied and Environmental Microbiology, September 2016, ASM Journals

    Dr Timothy L Cover

  52. Colistin-Functionalized Nanoparticles for the Rapid Capture of Acinetobacter baumannii

    Article • Journal of Biomedical Nanotechnology, September 2016, American Scientific Publishers

    Dr Timothy L Cover

  53. Structural organization of membrane-inserted hexamers formed byHelicobacter pyloriVacA toxin

    Article • Molecular Microbiology, July 2016, Wiley

    Dr Timothy L Cover

  54. A Nonoligomerizing Mutant Form of Helicobacter pylori VacA Allows Structural Analysis of the p33 Domain

    Article • Infection and Immunity, July 2016, ASM Journals

    Dr Timothy L Cover

  55. An Overview of Helicobacter pylori VacA Toxin Biology

    Article • Toxins, June 2016, MDPI AG

    Dr Timothy L Cover

  56. Peptidomimetic Small Molecules Disrupt Type IV Secretion System Activity in Diverse Bacterial Pathogens

    Article • mBio, April 2016, ASM Journals

    Dr Timothy L Cover

  57. Helicobacter pylori and stomach cancer

    Article • mBio, January 2016, ASM Journals

    Dr Timothy L Cover

  58. Type IV secretion system in Helicobacter pylori

    Article • mBio, January 2016, ASM Journals

    Dr Timothy L Cover

  59. Growth phase-dependent composition of the Helicobacter pylori exoproteome

    Article • Journal of Proteomics, January 2016, Elsevier

    Dr Timothy L Cover

  60. Supporting data for analysis of the Helicobacter pylori exoproteome

    Article • Data in Brief, December 2015, Elsevier

    Dr Timothy L Cover

  61. Helicobacter pylori AdaptationIn Vivoin Response to a High-Salt Diet

    Article • Infection and Immunity, October 2015, ASM Journals

    Dr Timothy L Cover

  62. Alteration of theHelicobacter pylorimembrane proteome in response to changes in environmental salt concentration

    Article • PROTEOMICS - CLINICAL APPLICATIONS, September 2015, Wiley

    Dr Timothy L Cover

  63. Regulation ofHelicobacter pyloriVirulence Within the Context of Iron Deficiency

    Article • The Journal of Infectious Diseases, December 2014, Oxford University Press (OUP)

    Dr Timothy L Cover

  64. The Host Protein Calprotectin Modulates the Helicobacter pylori cag Type IV Secretion System via Zinc Sequestration

    Article • PLoS Pathogens, October 2014, PLOS

    Dr Eric P Skaar, Dr Timothy L Cover

  65. Effective treatment of allergic airway inflammation with Helicobacter pylori immunomodulators requires BATF3-dependent dendritic cells and IL-10

    Article • Proceedings of the National Academy of Sciences, July 2014, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover

  66. Genes Required for Assembly of Pili Associated with the Helicobacter pylori cag Type IV Secretion System

    Article • Infection and Immunity, June 2014, ASM Journals

    Dr Timothy L Cover

  67. Helicobacter pylori outer membrane proteins

    Article • Journal of Bacteriology, April 2014, ASM Journals

    Dr Timothy L Cover

  68. Vacuolating Cytotoxin

    Article • April 2014, ASM Journals

    Dr Timothy L Cover

  69. Human and Helicobacter pylori coevolution shapes the risk of gastric disease

    Article • Proceedings of the National Academy of Sciences, January 2014, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover, Dr Carrie L Shaffer

  70. Control of gene expression in Helicobacter pylori using the Tet repressor

    Article • Journal of Microbiological Methods, December 2013, Elsevier

    Dr Timothy L Cover

  71. Diet, microbial virulence, andHelicobacter pylori-induced gastric cancer

    Article • Gut Microbes, November 2013, Taylor & Francis

    Dr Timothy L Cover

  72. Role of Connexin 43 in Helicobacter pylori VacA-Induced Cell Death

    Article • Infection and Immunity, November 2013, ASM Journals

    Dr Timothy L Cover

  73. Genome Sequences of Three hpAfrica2 Strains of Helicobacter pylori

    Article • Genome Announcements, September 2013, ASM Journals

    Dr Timothy L Cover

  74. Impaired Autophagy, Defective T Cell Homeostasis, and a Wasting Syndrome in Mice with a T Cell-Specific Deletion of Vps34

    Article • The Journal of Immunology, April 2013, The American Association of Immunologists

    Dr Timothy L Cover

  75. Flagellar Localization of a Helicobacter pylori Autotransporter Protein

    Article • mBio, April 2013, ASM Journals

    Dr Timothy L Cover

  76. High Dietary Salt Intake Exacerbates Helicobacter pylori-Induced Gastric Carcinogenesis

    Article • Infection and Immunity, April 2013, ASM Journals

    Dr Timothy L Cover

  77. Functional Plasticity in the Type IV Secretion System of Helicobacter pylori

    Article • PLoS Pathogens, February 2013, PLOS

    Professor Jay V Solnick, Dr Timothy L Cover

  78. Structure of the vacuolating toxin VacA from Helicobacter pylori

    Article • Journal of Molecular Biology, February 2013, Elsevier

    Dr Timothy L Cover

  79. Genetic analysis of Helicobacter pylori strains from East Asia

    Article • PLOS One, January 2013, PLOS

    Dr Timothy L Cover, Dr Carrie L Shaffer

  80. Downregulated Th17 responses are associated with reduced gastritis in Helicobacter pylori–infected children

    Article • Mucosal Immunology, January 2013, Nature

    Dr Timothy L Cover, Dr Carrie L Shaffer

  81. Structural Characterization of the Helicobacter Pylori VacA Toxin by Single Particle Em and X-Ray Crystallography

    Article • Biophysical Journal, January 2013, Elsevier

    Dr Timothy L Cover

  82. Iron deficiency accelerates Helicobacter pylori–induced carcinogenesis in rodents and humans

    Article • Journal of Clinical Investigation, December 2012, American Society for Clinical Investigation

    Dr Timothy L Cover

  83. Analysis ofHelicobacter pylori cagAPromoter Elements Required for Salt-Induced Upregulation of CagA Expression

    Article • Infection and Immunity, June 2012, ASM Journals

    Dr Timothy L Cover

  84. The Intermediate Region of Helicobacter pylori VacA Is a Determinant of Toxin Potency in a Jurkat T Cell Assay

    Article • Infection and Immunity, May 2012, ASM Journals

    Dr Timothy L Cover

  85. Role ofHelicobacter pyloriCagL in modulating gastrin expression

    Article • Gut, March 2012, BMJ

    Dr Timothy L Cover

  86. Non‐invasive Genotyping of Helicobacter pylori cagA, vacA, and hopQ from Asymptomatic Children

    Article • Helicobacter, March 2012, Wiley

    Dr Timothy L Cover

  87. J-Western Forms of Helicobacter pylori cagA Constitute a Distinct Phylogenetic Group with a Widespread Geographic Distribution

    Article • Journal of Bacteriology, January 2012, ASM Journals

    Dr Timothy L Cover, Dr Carrie L Shaffer

  88. Alterations in Helicobacter pylori Triggered by Contact with Gastric Epithelial Cells

    Article • Frontiers in Cellular and Infection Microbiology, January 2012, Frontiers

    Dr Timothy L Cover

  89. An RGD Helper Sequence in CagL of Helicobacter pylori Assists in Interactions with Integrins and Injection of CagA

    Article • Frontiers in Cellular and Infection Microbiology, January 2012, Frontiers

    Dr Timothy L Cover

  90. Helicobacter pylori type IV secretion system

    Article • PLoS Pathogens, September 2011, PLOS

    Dr Timothy L Cover, Dr Carrie L Shaffer

  91. Analysis of cagA in Helicobacter pylori Strains from Colombian Populations with Contrasting Gastric Cancer Risk Reveals a Biomarker for Disease Severity

    Article • Cancer Epidemiology Biomarkers & Prevention, August 2011, American Association for Cancer Research (AACR)

    Dr Timothy L Cover, Dr Carrie L Shaffer

  92. β-Catenin and p120 Mediate PPARδ-Dependent Proliferation Induced by Helicobacter pylori in Human and Rodent Epithelia

    Article • Gastroenterology, August 2011, Elsevier

    Dr Timothy L Cover

  93. Colon-specific delivery of a probiotic-derived soluble protein ameliorates intestinal inflammation in mice through an EGFR-dependent mechanism

    Article • Journal of Clinical Investigation, June 2011, American Society for Clinical Investigation

    Dr Timothy L Cover

  94. Helicobacter pylori VacA Induces Programmed Necrosis in Gastric Epithelial Cells

    Article • Infection and Immunity, April 2011, ASM Journals

    Dr Timothy L Cover

  95. Phylogeographic origin of Helicobacter pylori is a determinant of gastric cancer risk

    Article • Gut, February 2011, BMJ

    Dr Timothy L Cover, Dr Carrie L Shaffer

  96. Molecular Evolution of the Helicobacter pylori Vacuolating Toxin Gene vacA

    Article • Journal of Bacteriology, September 2010, ASM Journals

    Dr Timothy L Cover, Dr Carrie L Shaffer

  97. Reconstitution of Helicobacter pylori VacA toxin activity from p33 and p55 domains

    Article • Biochemistry, July 2010, American Chemical Society (ACS)

    Dr Timothy L Cover

  98. Analysis of Protein Expression Regulated by the Helicobacter pylori ArsRS Two-Component Signal Transduction System

    Article • Journal of Bacteriology, February 2010, ASM Journals

    Dr Timothy L Cover

  99. Analysis of a β-helical region in the p55 domain of Helicobacter pylori vacuolating toxin

    Article • BMC Microbiology, January 2010, Springer Science + Business Media

    Dr Timothy L Cover

  100. In Helicobacter pylori auto-inducer-2, but not LuxS/MccAB catalysed reverse transsulphuration, regulates motility through modulation of flagellar gene transcription

    Article • BMC Microbiology, January 2010, Springer Science + Business Media

    Dr Timothy L Cover

  101. Regulation of Gastric B Cell Recruitment Is Dependent on IL-17 Receptor A Signaling in a Model of Chronic Bacterial Infection

    Article • The Journal of Immunology, October 2009, The American Association of Immunologists

    Dr Timothy L Cover

  102. Helicobacter pylori in Health and Disease

    Article • Gastroenterology, May 2009, Elsevier

    Dr Timothy L Cover

  103. Epidermal Growth Factor Receptor Activation Protects Gastric Epithelial Cells From Helicobacter pylori-Induced Apoptosis

    Article • Gastroenterology, April 2009, Elsevier

    Dr Timothy L Cover

  104. Genome sequence analysis of Helicobacter pylori strains associated with gastric ulceration and gastric cancer

    Article • BMC Genomics, January 2009, Springer Science + Business Media

    Dr Timothy L Cover, Dr Carrie L Shaffer

  105. Structural Analysis of the DNA-binding Domain of the Helicobacter pylori Response Regulator ArsR

    Article • Journal of Biological Chemistry, December 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  106. Helicobacter pyloriHopQ outer membrane protein attenuates bacterial adherence to gastric epithelial cells

    Article • FEMS Microbiology Letters, December 2008, Oxford University Press (OUP)

    Dr Timothy L Cover

  107. Helicobacter pyloriand mitogen-activated protein kinases mediate activator protein-1 (AP-1) subcomponent protein expression and DNA-binding activity in gastric epithelial cells

    Article • FEMS Immunology & Medical Microbiology, August 2008, Oxford University Press (OUP)

    Dr Timothy L Cover

  108. Helicobacter pylori VacA Disrupts Apical Membrane-Cytoskeletal Interactions in Gastric Parietal Cells

    Article • Journal of Biological Chemistry, July 2008, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  109. Helicobacter pylori VacA Subdomain Required for Intracellular Toxin Activity and Assembly of Functional Oligomeric Complexes

    Article • Infection and Immunity, April 2008, ASM Journals

    Dr Timothy L Cover

  110. β2 Integrin Mediates Entry of a Bacterial Toxin into T Lymphocytes

    Article • Cell Host & Microbe, January 2008, Elsevier

    Dr Timothy L Cover

  111. Crystal structure of the Helicobacter pylori vacuolating toxin p55 domain

    Article • Proceedings of the National Academy of Sciences, October 2007, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover

  112. Host response to Helicobacter pylori infection before initiation of the adaptive immune response

    Article • FEMS Immunology & Medical Microbiology, October 2007, Oxford University Press (OUP)

    Dr Timothy L Cover

  113. Helicobacter pylori Vacuolating Cytotoxin Inhibits Activation-Induced Proliferation of Human T and B Lymphocyte Subsets

    Article • The Journal of Immunology, October 2007, The American Association of Immunologists

    Dr Timothy L Cover

  114. l-Arginine Availability Regulates Inducible Nitric Oxide Synthase-Dependent Host Defense against Helicobacter pylori

    Article • Infection and Immunity, June 2007, ASM Journals

    Dr Timothy L Cover

  115. Regulation of Helicobacter pylori cagA Expression in Response to Salt

    Article • Cancer Research, May 2007, American Association for Cancer Research (AACR)

    Dr Timothy L Cover

  116. Soluble Proteins Produced by Probiotic Bacteria Regulate Intestinal Epithelial Cell Survival and Growth

    Article • Gastroenterology, February 2007, Elsevier

    Dr Timothy L Cover

  117. Serological Assays for Identification of Human Gastric Colonization by Helicobacter pylori Strains Expressing VacA m1 or m2

    Article • Clinical and Vaccine Immunology, January 2007, ASM Journals

    Dr Timothy L Cover

  118. Functional Analysis of Neutralizing Antibodies against Clostridium perfringens Epsilon-Toxin

    Article • Infection and Immunity, January 2007, ASM Journals

    Dr Timothy L Cover

  119. Role ofHelicobacter pyloriOuter Membrane Proteins in Gastroduodenal Disease

    Article • The Journal of Infectious Diseases, November 2006, Oxford University Press (OUP)

    Dr Timothy L Cover

  120. Resistance of Primary Murine CD4+ T Cells to Helicobacter pylori Vacuolating Cytotoxin

    Article • Infection and Immunity, October 2006, ASM Journals

    Dr Timothy L Cover

  121. Helicobacter pylori Persistence: an Overview of Interactions between H. pylori and Host Immune Defenses

    Article • Clinical Microbiology Reviews, October 2006, ASM Journals

    Dr Timothy L Cover

  122. Helicobacter pylori VacA Toxin Inhibits Human Immunodeficiency Virus Infection of Primary Human T Cells

    Article • Journal of Virology, September 2006, ASM Journals

    Dr Timothy L Cover

  123. Random Mutagenesis of Helicobacter pylori vacA To Identify Amino Acids Essential for Vacuolating Cytotoxic Activity

    Article • Infection and Immunity, September 2006, ASM Journals

    Dr Timothy L Cover

  124. Quantitative Effect of luxS Gene Inactivation on the Fitness of Helicobacter pylori

    Article • Applied and Environmental Microbiology, August 2006, ASM Journals

    Dr Timothy L Cover

  125. Protein-Protein Interactions among Helicobacter pylori Cag Proteins

    Article • Journal of Bacteriology, July 2006, ASM Journals

    Dr Timothy L Cover

  126. Multiple Chromosomal Loci for the babA Gene in Helicobacter pylori

    Article • Infection and Immunity, May 2006, ASM Journals

    Dr Timothy L Cover

  127. Requirement of Histidine Kinases HP0165 and HP1364 for Acid Resistance in Helicobacter pylori

    Article • Infection and Immunity, May 2006, ASM Journals

    Dr Timothy L Cover

  128. Mapping of a Domain Required for Protein-Protein Interactions and Inhibitory Activity of a Helicobacter pylori Dominant-Negative VacA Mutant Protein

    Article • Infection and Immunity, April 2006, ASM Journals

    Dr Timothy L Cover

  129. Helicobacter pylori vacuolating toxin

    Article • January 2006, Elsevier

    Dr Timothy L Cover

  130. Mimicry of a Host Anion Channel by a Helicobacter pylori Pore-Forming Toxin

    Article • Biophysical Journal, November 2005, Elsevier

    Dr Timothy L Cover

  131. Analysis ofhopQalleles in East Asian and Western strains ofHelicobacter pylori

    Article • FEMS Microbiology Letters, October 2005, Oxford University Press (OUP)

    Dr Timothy L Cover

  132. The Oxysterol-binding Protein Homologue ORP1L Interacts with Rab7 and Alters Functional Properties of Late Endocytic Compartments

    Article • Molecular Biology of the Cell, September 2005, American Society for Cell Biology (ASCB)

    Dr Timothy L Cover

  133. High resolution structural analysis of Helicobacter pylori VacA toxin oligomers by cryo-negative staining electron microscopy

    Article • Journal of Structural Biology, September 2005, Elsevier

    Dr Timothy L Cover

  134. Genomic Comparison of cag Pathogenicity Island (PAI)-Positive and -Negative Helicobacter pylori Strains: Identification of Novel Markers for cag PAI-Positive Strains

    Article • Infection and Immunity, June 2005, ASM Journals

    Dr Timothy L Cover, Dr George Liechti

  135. Functional Properties of the p33 and p55 Domains of the Helicobacter pylori Vacuolating Cytotoxin

    Article • Journal of Biological Chemistry, April 2005, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  136. Helicobacter pylori VacA, a paradigm for toxin multifunctionality

    Article • Nature Reviews Microbiology, March 2005, Springer Science + Business Media

    Dr Timothy L Cover

  137. Growth Phase Regulation of flaA Expression in Helicobacter pylori Is luxS Dependent

    Article • Infection and Immunity, September 2004, ASM Journals

    Dr Timothy L Cover

  138. Targeting of Helicobacter pylori vacuolating toxin to lipid raft membrane domains analysed by atomic force microscopy

    Article • Biochemical Journal, August 2004, Portland Press Ltd.

    Dr Timothy L Cover

  139. Heterogeneity among Helicobacter pylori Strains in Expression of the Outer Membrane Protein BabA

    Article • Infection and Immunity, June 2004, ASM Journals

    Dr Timothy L Cover

  140. Inhibition of primary human T cell proliferation byHelicobacter pylorivacuolating toxin (VacA) is independent of VacA effects on IL-2 secretion

    Article • Proceedings of the National Academy of Sciences, May 2004, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover

  141. Clustering and Redistribution of Late Endocytic Compartments in Response to Helicobacter pylori Vacuolating Toxin

    Article • Molecular Biology of the Cell, January 2004, American Society for Cell Biology (ASCB)

    Dr Timothy L Cover

  142. Characterization of the MHC class I cross-presentation pathway for cell-associated antigens by human dendritic cells

    Article • Blood, December 2003, American Society of Hematology

    Dr Timothy L Cover, Dr Jean-Francois Fonteneau

  143. Interactions between p-33 and p-55 Domains of the Helicobacter pylori Vacuolating Cytotoxin (VacA)

    Article • Journal of Biological Chemistry, October 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  144. Cellular Vacuolation and Mitochondrial Cytochrome c Release Are Independent Outcomes of Helicobacter pylori Vacuolating Cytotoxin Activity That Are Each Dependent on Membrane Channel Formation

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  145. Promoter analysis of Helicobacter pylori genes with enhanced expression at low pH

    Article • Molecular Microbiology, May 2003, Wiley

    Dr Timothy L Cover

  146. Expression of Helicobacter pylori Vacuolating Toxin in Escherichia coli

    Article • Infection and Immunity, April 2003, ASM Journals

    Dr Timothy L Cover

  147. Effects ofHelicobacter pylorion intracellular Ca2+signaling in normal human gastric mucous epithelial cells

    Article • AJP Gastrointestinal and Liver Physiology, February 2003, American Physiological Society

    Dr Timothy L Cover

  148. Essential Role of a GXXXG Motif for Membrane Channel Formation by Helicobacter pylori Vacuolating Toxin

    Article • Journal of Biological Chemistry, January 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  149. Recovery from lactacidosis-induced glial cell swelling with the aid of exogenous anion channels

    Article • Glia, January 2003, Wiley

    Dr Timothy L Cover

  150. Two Different Families of hopQ Alleles in Helicobacter pylori

    Article • Journal of Clinical Microbiology, December 2002, ASM Journals

    Dr Timothy L Cover

  151. Global analysis of Helicobacter pylori gene expression in human gastric mucosa

    Article • Gastroenterology, November 2002, Elsevier

    Dr Timothy L Cover

  152. PIKfyve Kinase and SKD1 AAA ATPase Define Distinct Endocytic Compartments. ONLY PIKfyve EXPRESSION INHIBITS THE CELL-VACUOLATING ACTIVITY OF HELICOBACTER PYLORI VacA TOXIN

    Article • Journal of Biological Chemistry, September 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  153. Genome-Wide Transcriptional Profiling in a Histidine Kinase Mutant of Helicobacter pylori Identifies Members of a Regulon

    Article • Journal of Bacteriology, August 2002, ASM Journals

    Dr Timothy L Cover

  154. Association of Helicobacter pylori Vacuolating Toxin (VacA) with Lipid Rafts

    Article • Journal of Biological Chemistry, July 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  155. Multiple Oligomeric States of the Helicobacter pylori Vacuolating Toxin Demonstrated by Cryo-electron Microscopy

    Article • Journal of Molecular Biology, April 2002, Elsevier

    Dr Timothy L Cover

  156. A 12-Amino-Acid Segment, Present in Type s2 but Not Type s1 Helicobacter pylori VacA Proteins, Abolishes Cytotoxin Activity and Alters Membrane Channel Formation

    Article • Journal of Bacteriology, November 2001, ASM Journals

    Dr Timothy L Cover

  157. In search of the Helicobacter pylori VacA mechanism of action

    Article • Toxicon, November 2001, Elsevier

    Dr Timothy L Cover

  158. Antigenic Diversity among Helicobacter pyloriVacuolating Toxins

    Article • Infection and Immunity, July 2001, ASM Journals

    Dr Timothy L Cover

  159. Helicobacter pylori genotypes, host factors, and gastric mucosal histopathology in peptic ulcer disease

    Article • Human Pathology, March 2001, Elsevier

    Dr Timothy L Cover

  160. Amino-Terminal Hydrophobic Region ofHelicobacter pylori Vacuolating Cytotoxin (VacA) Mediates Transmembrane Protein Dimerization

    Article • Infection and Immunity, February 2001, ASM Journals

    Dr Timothy L Cover

  161. Carboxy-Terminal Proteolytic Processing ofHelicobacter pylori Vacuolating Toxin

    Article • Infection and Immunity, January 2001, ASM Journals

    Dr Timothy L Cover

  162. Acid activation of Helicobacter pylori vacuolating cytotoxin (VacA) results in toxin internalization by eukaryotic cells

    Article • Molecular Microbiology, July 2000, Wiley

    Dr Timothy L Cover

  163. Intercellular Communication in Helicobacter pylori: luxS Is Essential for the Production of an Extracellular Signaling Molecule

    Article • Infection and Immunity, June 2000, ASM Journals

    Dr Timothy L Cover

  164. Cell Vacuolation Induced by the VacA Cytotoxin of Helicobacter pylori Is Regulated by the Rac1 GTPase

    Article • Journal of Biological Chemistry, March 2000, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  165. A Dominant Negative Mutant of Helicobacter pyloriVacuolating Toxin (VacA) Inhibits VacA-induced Cell Vacuolation

    Article • Journal of Biological Chemistry, December 1999, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  166. Vacuolating Cytotoxin ( vacA ) Alleles of Helicobacter pylori Comprise Two Geographically Widespread Types, m1 and m2, and Have Evolved Through Limited Recombination

    Article • Current Microbiology, October 1999, Springer Science + Business Media

    Dr Timothy L Cover

  167. Helicobacter pylori Vacuolating Cytotoxin (VacA) Disorganizes the Cytoskeletal Architecture of Gastric Epithelial Cells

    Article • Biochemical and Biophysical Research Communications, August 1999, Elsevier

    Dr Timothy L Cover

  168. Helicobacter pylori factors associated with disease

    Article • Gastroenterology, July 1999, Elsevier

    Dr Timothy L Cover

  169. Release ofHelicobacter pylori vacuolating cytotoxin by both a specific secretion pathway and budding of outer membrane vesicles. Uptake of released toxin and vesicles by gastric epithelium

    Article • The Journal of Pathology, June 1999, Wiley

    Dr Timothy L Cover

  170. VacA fromHelicobacter pylori: a hexameric chloride channel

    Article • FEBS Letters, April 1999, Wiley

    Dr Timothy L Cover

  171. The vacuolating toxin from Helicobacter pylori forms hexameric pores in lipid bilayers at low pH

    Article • Proceedings of the National Academy of Sciences, March 1999, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover

  172. Acid-induced expression of an LPS-associated gene inHelicobacter pylori

    Article • Molecular Microbiology, October 1998, Wiley

    Dr Timothy L Cover

  173. The m2 form of the Helicobacter pylori cytotoxin has cell type-specific vacuolating activity

    Article • Proceedings of the National Academy of Sciences, August 1998, Proceedings of the National Academy of Sciences

    Dr Timothy L Cover

  174. Helicobacter pylori upregulates expression of epidermal growth factor-related peptides, but inhibits their proliferative effect in MKN 28 gastric mucosal cells.

    Article • Journal of Clinical Investigation, April 1998, American Society for Clinical Investigation

    Dr Timothy L Cover

  175. An intracellular target for Helicobacter pylori vacuolating toxin

    Article • Trends in Microbiology, April 1998, Elsevier

    Dr Timothy L Cover

  176. Acid-induced Dissociation of VacA, theHelicobacter pyloriVacuolating Cytotoxin, Reveals Its Pattern of Assembly

    Article • Journal of Cell Biology, August 1997, Rockefeller University Press

    Dr Timothy L Cover

  177. Clinical and pathological importance of heterogeneity in vacA, the vacuolating cytotoxin gene of Helicobacter pylori

    Article • Gastroenterology, January 1997, Elsevier

    Dr Timothy L Cover

  178. High-level genetic diversity in the vapD chromosomal region of Helicobacter pylori.

    Article • Journal of Bacteriology, January 1997, ASM Journals

    Dr Timothy L Cover

  179. Effects of Helicobacter pylori vacuolating cytotoxin on primary cultures of human gastric epithelial cells.

    Article • Gut, December 1996, BMJ

    Dr Timothy L Cover

  180. Density of Helicobacter pylori Infection In Vivo as Assessed by Quantitative Culture and Histology

    Article • The Journal of Infectious Diseases, September 1996, Oxford University Press (OUP)

    Dr Timothy L Cover

  181. The gastrin-histamine sequence

    Article • Gastroenterology, September 1996, Elsevier

    Dr Timothy L Cover

  182. The vacuolating cytotoxin of Helicobacter pylori

    Article • Molecular Microbiology, April 1996, Wiley

    Dr Timothy L Cover

  183. Helicobacter pylori and gastric acid: Biological and therapeutic implications

    Article • Gastroenterology, March 1996, Elsevier

    Dr Timothy L Cover

  184. Mosaicism in Vacuolating Cytotoxin Alleles of Helicobacter pylori

    Article • Journal of Biological Chemistry, July 1995, American Society for Biochemistry & Molecular Biology (ASBMB)

    Dr Timothy L Cover

  185. Analysis of Genetic Diversity in Cytotoxin-Producing and Non-Cytotoxin Producing Helicobacter pylori Strains

    Article • The Journal of Infectious Diseases, July 1995, Oxford University Press (OUP)

    Dr Timothy L Cover

  186. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism

    Article • Gastroenterology, November 1994, Elsevier

    Dr Timothy L Cover

  187. The proton pump inhibitor omeprazole inhibits acid survival of Helicobacter pylori by a urease-independent mechanism

    Article • Gastroenterology, September 1994, Elsevier

    Dr Timothy L Cover

  188. Helicobacter pylori infection in japanese patients with adenocarcinoma of the stomach

    Article • International Journal of Cancer, November 1993, Wiley

    Dr Timothy L Cover

  189. Potentiation of Helicobacter pylori Vacuolating Toxin Activity by Nicotine and Other Weak Bases

    Article • The Journal of Infectious Diseases, November 1992, Oxford University Press (OUP)

    Dr Timothy L Cover

  190. Characterization of Hela cell vacuoles induced by Helicobacter pylori broth culture supernatant

    Article • Human Pathology, September 1992, Elsevier

    Dr Timothy L Cover

  191. Serum neutralizing antibody response to the vacuolating cytotoxin of Helicobacter pylori.

    Article • Journal of Clinical Investigation, September 1992, American Society for Clinical Investigation

    Dr Timothy L Cover

  192. Helicobacter Pylori and Gastroduodenal Disease

    Article • Annual Review of Medicine, February 1992, Annual Reviews

    Dr Timothy L Cover

  193. Evaluation of cytotoxic activity in fecal filtrates from patients with or enteritis

    Article • FEMS Microbiology Letters, August 1990, Oxford University Press (OUP)

    Dr Timothy L Cover

  194. Yersinia Enterocolitica

    Article • The New England Journal of Medicine and Surgery and the Collateral Branches of Science, July 1989, New England Journal of Medicine (NEJM/MMS)

    Dr Timothy L Cover

  195. The Pathobiology of Campylobacter Infections in Humans

    Article • Annual Review of Medicine, February 1989, Annual Reviews

    Dr Timothy L Cover

  196. Pseudomonas paucimobilis Empyema After Cardiac Transplantation

    Article • Southern Medical Journal, June 1988, Southern Medical Association

    Dr Timothy L Cover