All Stories

  1. The landscape of microbial associations in human cancer

    Article • Science Translational Medicine, September 2025, American Association for the Advancement of Science

    Tim Fenton

  2. Using a novel panel of drug-resistant triple-negative breast cancer cell lines to identify candidate therapeutic targets and biomarkers

    Article • Cancer Letters, August 2025, Elsevier

    Tim Fenton

  3. APOBEC3 Proteins: From Antiviral Immunity to Oncogenic Drivers in HPV-Positive Cancers

    Article • Viruses, March 2025, MDPI AG

    Tim Fenton

  4. Exploring targets in oropharyngeal cancer – association with immune markers and AI‐scoring of B7‐H3 expression

    Article • Clinical and Translational Medicine, March 2025, Wiley

    Tim Fenton

  5. DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma

    Article • Clinical Epigenetics, December 2024, Springer Science + Business Media

    Tim Fenton

  6. Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma

    Article • The EMBO Journal, November 2024, Springer Science + Business Media

    Dr Simak Ali, Tim Fenton

  7. Epigenetic profiling of prostate cancer reveals potential prognostic signatures

    Article • Journal of Cancer Research and Clinical Oncology, August 2024, Springer Science + Business Media

    Tim Fenton

  8. Human-likeAPOBEC3gene expression and anti-viral responses following replacement of mouseApobec3with the 7-gene humanAPOBEC3locus

    Article • July 2024, Cold Spring Harbor Laboratory Press

    Tim Fenton

  9. Differentiation signals induce APOBEC3A expression via GRHL3 in squamous epithelia and squamous cell carcinoma

    Article • March 2024, Springer Science + Business Media

    Dr Simak Ali, Tim Fenton

  10. Molecular landscape of proliferative verrucous leukoplakia: a systematic review

    Article • British Journal of Oral and Maxillofacial Surgery, February 2024, Elsevier

    Tim Fenton

  11. Resistance patterns in drug-adapted cancer cell lines reflect the complex evolution in clinical tumours

    Article • January 2024, Cold Spring Harbor Laboratory Press

    Tim Fenton

  12. Large inherent variability in data derived from highly standardised cell culture experiments

    Article • Pharmacological Research, February 2023, Elsevier

    Tim Fenton

  13. Value of p53 sequencing in the prognostication of head and neck cancer: a systematic review and meta-analysis

    Article • Scientific Reports, December 2022, Springer Science + Business Media

    Tim Fenton

  14. Integrated analysis of cervical squamous cell carcinoma cohorts from three continents reveals conserved subtypes of prognostic significance

    Article • Nature Communications, October 2022, Springer Science + Business Media

    Tim Fenton

  15. International Multicenter Study of Clinical Outcomes of Sinonasal Melanoma Shows Survival Benefit for Patients Treated with Immune Checkpoint Inhibitors and Potential Improvements to the Current TNM Staging System

    Article • Journal of Neurological Surgery Part B Skull Base, July 2022, Thieme Publishing Group

    Tim Fenton

  16. OX40 and 4-1BB delineate distinct immune profiles in sarcoma

    Article • OncoImmunology, May 2022, Taylor & Francis

    Tim Fenton

  17. Reply to ‘HPV-associated oropharyngeal cancer — discussion points’

    Article • Nature Reviews Clinical Oncology, March 2022, Springer Science + Business Media

    Tim Fenton

  18. Induction of APOBEC3-mediated genomic damage in urothelium implicates BK polyomavirus (BKPyV) as a hit-and-run driver for bladder cancer

    Article • Oncogene, February 2022, Springer Science + Business Media

    Dr Simak Ali, Tim Fenton

  19. HPV-associated oropharyngeal cancer: epidemiology, molecular biology and clinical management

    Article • Nature Reviews Clinical Oncology, February 2022, Springer Science + Business Media

    Tim Fenton

  20. Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma

    Article • European Journal of Cancer, February 2022, Elsevier

    Tim Fenton

  21. Accumulation of host cell genetic errors following high-risk HPV infection

    Article • Current Opinion in Virology, December 2021, Elsevier

    Tim Fenton

  22. DNA methylation-based prediction of response to immune checkpoint inhibition in metastatic melanoma

    Article • Journal for ImmunoTherapy of Cancer, July 2021, BMJ

    Tim Fenton

  23. Induction of APOBEC3 Exacerbates DNA Replication Stress and Chromosomal Instability in Early Breast and Lung Cancer Evolution

    Article • Cancer Discovery, May 2021, American Association for Cancer Research (AACR)

    Tim Fenton

  24. Data variability in standardised cell culture experiments

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Tim Fenton

  25. Somatostatin receptor 2 expression in nasopharyngeal cancer is induced by Epstein Barr virus infection: impact on prognosis, imaging and therapy

    Article • Nature Communications, January 2021, Springer Science + Business Media

    Tim Fenton

  26. SAMHD1 is a key regulator of the lineage-specific response of acute lymphoblastic leukaemias to nelarabine

    Article • Communications Biology, June 2020, Springer Science + Business Media

    Tim Fenton

  27. NOX4 Inhibition Potentiates Immunotherapy by Overcoming Cancer-Associated Fibroblast-Mediated CD8 T-cell Exclusion from Tumors

    Article • Cancer Research, May 2020, American Association for Cancer Research (AACR)

    Tim Fenton

  28. The APOBEC3 genes and their role in cancer: insights from human papillomavirus

    Article • Journal of Molecular Endocrinology, May 2019, Bioscientifica

    Tim Fenton

  29. Inhibition of Nuclear PTEN Tyrosine Phosphorylation Enhances Glioma Radiation Sensitivity through Attenuated DNA Repair

    Article • Cancer Cell, March 2019, Elsevier

    Tim Fenton

  30. Author Correction: Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

    Article • Scientific Reports, August 2018, Springer Science + Business Media

    Tim Fenton

  31. Pan-cancer deconvolution of tumour composition using DNA methylation

    Article • Nature Communications, August 2018, Springer Science + Business Media

    Tim Fenton

  32. Frequent HPV-independent p16/INK4A overexpression in head and neck cancer

    Article • Oral Oncology, August 2018, Elsevier

    Tim Fenton

  33. Chemosensitivity profiling of osteosarcoma tumour cell lines identifies a model of BRCAness

    Article • Scientific Reports, July 2018, Springer Science + Business Media

    Tim Fenton

  34. A cross-sectional survey of awareness of human papillomavirus-associated oropharyngeal cancers among general practitioners in the UK

    Article • BMJ Open, July 2018, BMJ

    Tim Fenton

  35. Meeting Abstracts of the BACR conference: response and resistance in cancer therapy

    Article • January 2018, OAE Publishing

    Tim Fenton

  36. What really matters - response and resistance in cancer therapy

    Article • January 2018, OAE Publishing

    Tim Fenton

  37. p53 controls expression of the DNA deaminase APOBEC3B to limit its potential mutagenic activity in cancer cells

    Article • Nucleic Acids Research, August 2017, Oxford University Press (OUP)

    Dr Simak Ali, Tim Fenton

  38. Human Papillomavirus Drives Tumor Development Throughout the Head and Neck: Improved Prognosis Is Associated With an Immune Response Largely Restricted to the Oropharynx

    Article • Journal of Clinical Oncology, December 2016, American Society of Clinical Oncology (ASCO)

    Tim Fenton

  39. CD8 + T cell response to human papillomavirus 16 E7 is able to predict survival outcome in oropharyngeal cancer

    Article • European Journal of Cancer, November 2016, Elsevier

    Tim Fenton

  40. CSN1 Somatic Mutations in Penile Squamous Cell Carcinoma

    Article • Cancer Research, June 2016, American Association for Cancer Research (AACR)

    Tim Fenton

  41. Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines

    Article • Cell Reports, March 2016, Elsevier

    Tim Fenton

  42. The Genomics, Epigenomics, and Transcriptomics of HPV-Associated Oropharyngeal Cancer—Understanding the Basis of a Rapidly Evolving Disease

    Article • January 2016, Elsevier

    Tim Fenton

  43. APOBEC3 genes: retroviral restriction factors to cancer drivers

    Article • Trends in Molecular Medicine, May 2015, Elsevier

    Tim Fenton

  44. APOBEC-Mediated Cytosine Deamination Links PIK3CA Helical Domain Mutations to Human Papillomavirus-Driven Tumor Development

    Article • Cell Reports, June 2014, Elsevier

    Tim Fenton

  45. Using high-density DNA methylation arrays to profile copy number alterations

    Article • Genome Biology, January 2014, Springer Science + Business Media

    Tim Fenton

  46. When defense turns into attack

    Article • Molecular & Cellular Oncology, January 2014, Taylor & Francis

    Tim Fenton

  47. Integrated virus-host methylome analysis in head and neck squamous cell carcinoma

    Article • Epigenetics, September 2013, Taylor & Francis

    Tim Fenton

  48. A Kinome-Wide RNAi Screen in Drosophila Glia Reveals That the RIO Kinases Mediate Cell Proliferation and Survival through TORC2-Akt Signaling in Glioblastoma

    Article • PLoS Genetics, February 2013, PLOS

    Tim Fenton

  49. Identification and functional validation of HPV-mediated hypermethylation in head and neck squamous cell carcinoma

    Article • Genome Medicine, January 2013, Springer Science + Business Media

    Tim Fenton

  50. Targeted next-generation sequencing of head and neck squamous cell carcinoma identifies novel genetic alterations in HPV+ and HPV- tumors

    Article • Genome Medicine, January 2013, Springer Science + Business Media

    Tim Fenton

  51. Resistance to EGF receptor inhibitors in glioblastoma mediated by phosphorylation of the PTEN tumor suppressor at tyrosine 240

    Article • Proceedings of the National Academy of Sciences, August 2012, Proceedings of the National Academy of Sciences

    Tim Fenton

  52. Phosphorylation of dedicator of cytokinesis 1 (Dock180) at tyrosine residue Y722 by Src family kinases mediates EGFRvIII-driven glioblastoma tumorigenesis

    Article • Proceedings of the National Academy of Sciences, February 2012, Proceedings of the National Academy of Sciences

    Tim Fenton

  53. Reliability of Cycling Gross Efficiency Using the Douglas Bag Method

    Article • Medicine & Science in Sports & Exercise, February 2012, Wolters Kluwer Health

    Tim Fenton

  54. Activation of Rac1 by Src-dependent phosphorylation of Dock180Y1811 mediates PDGFRα-stimulated glioma tumorigenesis in mice and humans

    Article • Journal of Clinical Investigation, December 2011, American Society for Clinical Investigation

    Tim Fenton

  55. Therapeutic targeting of epidermal growth factor receptor in human cancer: successes and limitations

    Article • Chinese Journal of Cancer, January 2011, Editorial Office of Chinese Journal of Cancer

    Tim Fenton

  56. Functions and regulation of the 70kDa ribosomal S6 kinases

    Article • The International Journal of Biochemistry & Cell Biology, January 2011, Elsevier

    Tim Fenton

  57. S6K1 is acetylated at lysine 516 in response to growth factor stimulation

    Article • Biochemical and Biophysical Research Communications, July 2010, Elsevier

    Tim Fenton

  58. Histone acetyltransferases interact with and acetylate p70 ribosomal S6 kinases in vitro and in vivo

    Article • The International Journal of Biochemistry & Cell Biology, February 2010, Elsevier

    Tim Fenton

  59. Regulation of ribosomal protein S6 kinases by ubiquitination

    Article • Biochemical and Biophysical Research Communications, May 2008, Elsevier

    Tim Fenton

  60. Malignant astrocytic glioma: genetics, biology, and paths to treatment

    Article • Genes & Development, November 2007, Cold Spring Harbor Laboratory Press

    Tim Fenton

  61. The PTEN and INK4A/ARF tumor suppressors maintain myelolymphoid homeostasis and cooperate to constrain histiocytic sarcoma development in humans

    Article • Cancer Cell, May 2006, Elsevier

    Tim Fenton

  62. Receptor association and tyrosine phosphorylation of S6 kinases

    Article • European Journal of Biochemistry, April 2006, Wiley

    Tim Fenton

  63. Subcellular Localization and Regulation of Coenzyme A Synthase

    Article • Journal of Biological Chemistry, September 2003, American Society for Biochemistry & Molecular Biology (ASBMB)

    Tim Fenton

  64. Protein Kinase C Phosphorylates Ribosomal Protein S6 Kinase βII and Regulates Its Subcellular Localization

    Article • Molecular and Cellular Biology, February 2003, ASM Journals

    Tim Fenton

  65. Molecular Cloning of CoA Synthase

    Article • Journal of Biological Chemistry, April 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Tim Fenton

  66. A novel higher plant protein tyrosine phosphatase interacts with SNF1-related protein kinases via a KIS (kinase interaction sequence) domain

    Article • The Plant Journal, March 2002, Wiley

    Tim Fenton

  67. Oligomerization of G-protein-coupled Receptors Shown by Selective Co-immunoprecipitation

    Article • Journal of Biological Chemistry, February 2002, American Society for Biochemistry & Molecular Biology (ASBMB)

    Tim Fenton