All Stories

  1. The enduring effect of education-socioeconomic differences in disability trajectories from age 85 years in the Newcastle 85+ Study
  2. Is There an Association Between Metabolic Syndrome and Cognitive Function in Very Old Adults? The Newcastle 85+ Study
  3. A dynamic framework for the study of optimal birth intervals reveals the importance of sibling competition and mortality risks
  4. Deciphering death: a commentary on Gompertz (1825) 'On the nature of the function expressive of the law of human mortality, and on a new mode of determining the value of life contingencies'
  5. Serum osmolarity and haematocrit do not modify the association between the impedance index (Ht2/Z) and total body water in the very old: The Newcastle 85+ Study
  6. Grip Strength across the Life Course: Normative Data from Twelve British Studies
  7. Improving Retention of Very Old Participants in Longitudinal Research: Experiences from the Newcastle 85+ Study
  8. Utility of NT-proBNP as a rule-out test for left ventricular dysfunction in very old people with limiting dyspnoea: the Newcastle 85+ Study
  9. Clonal Expansion of Early to Mid-Life Mitochondrial DNA Point Mutations Drives Mitochondrial Dysfunction during Human Ageing
  10. Dynamic Modelling of Pathways to Cellular Senescence Reveals Strategies for Targeted Interventions
  11. Similar patterns of clonally expanded somatic mtDNA mutations in the colon of heterozygous mtDNA mutator mice and ageing humans
  12. Erratum to “Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?” [J. Theor. Biol. 340 (2014) 111–118]
  13. Acquisition of aberrant DNA methylation is associated with frailty in the very old: findings from the Newcastle 85+ Study
  14. Reactive Oxygen Species Production and Mitochondrial Dysfunction in White Blood Cells Are Not Valid Biomarkers of Ageing in the Very Old
  15. Biological Determinants and Malleability of Aging
  16. The Contribution of Diseases to the Male-Female Disability-Survival Paradox in the Very Old: Results from the Newcastle 85+ Study
  17. Foresight Mental Capital and Wellbeing Project
  18. Mitochondrial mutations and ageing: Can mitochondrial deletion mutants accumulate via a size based replication advantage?
  19. Frailty and mortality are not influenced by mitochondrial DNA haplotypes in the very old
  20. Shared Ageing Research Models (ShARM): a new facility to support ageing research
  21. Untangling Functional Declines in the Locomotion of Aging Worms
  22. Life-History Evolution and the Polyphenic Regulation of Somatic Maintenance and Survival
  23. Mitochondrial mutations and aging: random drift is insufficient to explain the accumulation of mitochondrial deletion mutants in short‐lived animals
  24. Malleability of Human Aging The Curious Case of Old-Age Mortality in Japan
  25. The Predictive Adaptive Response: Modeling the Life-History Evolution of the Butterfly Bicyclus anynana in Seasonal Environments
  26. Comparison of Mitochondrial Mutation Spectra in Ageing Human Colonic Epithelium and Disease: Absence of Evidence for Purifying Selection in Somatic Mitochondrial DNA Point Mutations
  27. Does Aging Stop? By Laurence D. Mueller, Casandra L. Rauser, and Michael R. Rose. Oxford and New York: Oxford University Press. $49.95. xix + 204 p.; ill.; author and subject indexes. ISBN: 978-0-19-975422-9. 2011.
  28. The place of genetics in ageing research
  29. Frailty and the role of inflammation, immunosenescence and cellular ageing in the very old: Cross-sectional findings from the Newcastle 85+ Study
  30. The free-radical theory of ageing - older, wiser and still alive
  31. The Personal and Health Service Impact of Falls in 85 Year Olds: Cross-Sectional Findings from the Newcastle 85+ Cohort Study
  32. A whole-body mathematical model of cholesterol metabolism and its age-associated dysregulation
  33. Aggregation, impaired degradation and immunization targeting of amyloid-beta dimers in Alzheimer’s disease: a stochastic modelling approach
  34. Differences in the accumulation of mitochondrial defects with age in mice and humans
  35. Speed-bumps ahead for the genetics of later-life diseases
  36. Assessment of a large panel of candidate biomarkers of ageing in the Newcastle 85+ study
  37. On the Programmed/Non-Programmed Nature of Ageing within the Life History
  38. The evolution and role of mitochondrial fusion and fission in aging and disease
  39. Capability and dependency in the Newcastle 85+ cohort study. Projections of future care needs
  40. Systems biology of ageing and longevity
  41. Global aging and the brain
  42. Why Women Live Longer
  43. Why Can't We Live Forever?
  44. Age-Related Meiotic Segregation Errors in Mammalian Oocytes Are Preceded by Depletion of Cohesin and Sgo2
  45. The connections between general and reproductive senescence and the evolutionary basis of menopause
  46. Defects in multiple complexes of the respiratory chain are present in ageing human colonic crypts
  47. Selection on Alleles Affecting Human Longevity and Late-Life Disease: The Example of Apolipoprotein E
  48. Feedback between p21 and reactive oxygen production is necessary for cell senescence
  49. Age-associated mitochondrial DNA mutations lead to small but significant changes in cell proliferation and apoptosis in human colonic crypts
  50. Evolution Theory and the Mechanisms of Aging
  51. Tom Kirkwood
  52. Metabolic evolution suggests an explanation for the weakness of antioxidant defences in beta-cells
  53. A mathematical model of aging-related and cortisol induced hippocampal dysfunction
  54. Consenting older adults: research as a virtuous relationship
  55. On the Surprising Weakness of Pancreatic Beta-Cell Antioxidant Defences: An Evolutionary Perspective
  56. Healthy old age
  57. The mental wealth of nations
  58. What explains variations in the clinical use of mild cognitive impairment (MCI) as a diagnostic category?
  59. A systematic look at an old problem
  60. Grandmotherhood: The Evolutionary Significance of the Second Half of Female Life . Edited by Eckart  Voland , Athanasios  Chasiotis , and Wulf  Schiefenhövel. New Brunswick (New Jersey): Rutgers University Press . $75.00. ix + 343 p; ill.; name and su...
  61. The Newcastle 85+ study: biological, clinical and psychosocial factors associated with healthy ageing: study protocol
  62. Ten commandments for the future of ageing research in the UK: a vision for action
  63. Mitochondrial Dysfunction Accounts for the Stochastic Heterogeneity in Telomere-Dependent Senescence
  64. Mitochondria and ageing: winning and losing in the numbers game
  65. Increasing longevity: an important question, a dubious answer. The evolution of death: Why we are living longer. (2006). By Stanley Shostak. State University of New York Press, Albany 246 pp. ISBN: 07914694689
  66. Too fast by mistake
  67. LINK-AGE: Coordination and consolidation of European biogerontology: en route towards formation of a European college of biogerontology
  68. Trade-off Mediated Effects on the Genetics of Human Survival Caused by Increasingly Benign Living Conditions
  69. Caloric restriction does not enhance longevity in all species and is unlikely to do so in humans
  70. Bladder Volume Alters Cholinergic Responses of the Isolated Whole Mouse Bladder
  71. Longevity in perspective
  72. Molecular Gerontology: Bridging the Simple and the Complex
  73. Age-Related Changes in Irradiation-Induced Apoptosis and Expression of p21 and p53 in Crypt Stem Cells of Murine Intestine
  74. The Biological Science of Human Ageing
  75. The Cambridge Handbook of Age and Ageing
  76. Science fact and the SENS agenda
  77. Food restriction, evolution and ageing
  78. Live long and prosper
  79. Time of our lives
  80. Asymmetry and the origins of ageing
  81. What accounts for the wide variation in life span of genetically identical organisms reared in a constant environment?
  82. Understanding the Odd Science of Aging
  83. Modelling the disposable soma theory of ageing
  84. Computer Modeling in the Study of Aging
  85. Modelling the actions of chaperones and their role in ageing
  86. Intrinsic ageing of gut epithelial stem cells
  87. A mathematical model of ageing in yeast
  88. Life Span: Evolutionary, Ecological, and Demographic Perspectives. Based on a workshop held in Santorini, Greece, 14–18 May 2001. Edited by James R  Carey and Shripad  Tuljapurkar. New York: Population Council . $18.00 (paper). xi + 293 p; ill.; no ...
  89. Hormonal control of the yolk precursor vitellogenin regulates immune function and longevity in honeybees
  90. Mitochondrial DNA mutations in human colonic crypt stem cells
  91. Mitochondrial DNA mutations in human colonic crypt stem cells
  92. Genes that shape the course of ageing
  93. Tips for youth
  94. Modelling cellular senescence as a result of telomere state
  95. Ageing - Future Directions for Research in the Biology of Ageing
  96. Telomere-driven replicative senescence is a stress response
  97. Towards an e-biology of ageing: integrating theory and data
  98. Age Differences in Evolutionary Selection Benefits
  99. Book review:Becoming immortal: Combining cloning and stem-cell therapy
  100. Somatic mutations and ageing in silico
  101. The breath of life and death
  102. Evolutionary Basis of Human Aging
  103. The old worm turns more slowly
  104. New science for an old problem
  105. p53 and ageing: too much of a good thing?
  106. Evolution of ageing
  107. Modelling telomere shortening and the role of oxidative stress
  108. Changing complexity in aging: a metric not an hypothesis
  109. A Stochastic Model of Cell Replicative Senescence Based on Telomere Shortening, Oxidative Stress, and Somatic Mutations in Nuclear and Mitochondrial DNA
  111. If you would live long, choose your parents well
  112. Sex and ageing
  113. Evolution of the human menopause
  114. Evolution of the human menopause
  115. Where will it all end?
  116. Sex and Longevity: Sexuality, Gender, Reproduction, Parenthood
  118. La transmission hereditaire de la longevite en lignes maternelle et paternelle
  119. Living to 100: Lessons in Living to Your Maximum Potential at Any Age Thomas T. Perls Margery Hutter Silver John F. Lauerman
  120. Evolution, stress, and longevity
  121. Biology of ageing
  123. Understanding the Biological Determinants of Longevity: New Opportunities and Challenges
  125. Accumulation of Defective Mitochondria through Delayed Degradation of Damaged Organelles and Its Possible Role in the Ageing of Post-mitotic and Dividing Cells
  126. Positive correlation between mammalian life span and cellular resistance to stress
  127. Modeling the Role of Mitochondrial Mutations in Cellular Aging
  128. Human Longevity and Reproductive Success: Response to Gavrilov and Gavrilova
  129. Book reviews
  130. 3 What is the relationship between osteoarthritis and ageing?
  131. How can we live forever?
  132. Human senescence
  133. Signs of the time
  134. Cell Maintenance and Stress Response in Ageing and Longevity
  135. Beyond the limits of culture
  136. Buy now, pay later
  137. Defective interfering particles and virus evolution
  138. Explaining fruit fly longevity
  139. Neuronal precursor cells in the rat hippocampal formation contribute to more than one cytoarchitectonic area
  140. Tales of old
  141. The Biology of Aging
  142. Book Reviews
  143. Evolution of lifespan
  144. Immortality of the Germ-Line versus Disposability of the Soma
  145. Fibronectin is expressed by astrocytes cultured from embryonic and early postnatal rat brain
  146. IQ jump or trend?
  147. Cytogerontology since 1881: A reappraisal of August Weismann and a review of modern progress
  148. Bioequivalence Testing -- A Need to Rethink
  149. Human Cells and the Finite Lifespan Theory
  150. Evolution of ageing
  151. Dr. Thomas Kirkwood
  152. The Genetics of Old Age
  153. A Biological Perspective on Aging
  154. A Biological Perspective on Aging
  155. The developmental environment: implications for ageing and life span
  156. The Biology of Ageing
  157. The Mental Wealth of Nations