All Stories

  1. Computational Methods for Cancer Neoantigen Prediction
  2. Deciphering the Tumor Microenvironment Composition Using Bulk Transcriptomics: A Guide to Recent Advances and Open Challenges
  3. Using Epigenetic Data to Deconvolute Immune Cells in Cancer from Blood Samples
  4. Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity
  5. CAR Exosome-Based Therapeutics
  6. An expert consensus statement on biomarkers of ageing for use in intervention studies
  7. AI Promoted Virtual Screening, Structure-Based Hit Optimization, and Synthesis of Novel COVID-19 S-RBD Domain Inhibitors
  8. Profiling Plasma Extracellular Vesicle Metabotypes and miRNAs: An Unobserved Clue for Predicting Relapse in Patients with Early-Stage NSCLC
  9. Rosalind Franklin Society Proudly Announces the 2023 Award Recipient for OMICS: A Journal of Integrative Biology
  10. Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s disease
  11. Natural Compounds for Bone Remodeling: A Computational and Experimental Approach Targeting Bone Metabolism-Related Proteins
  12. Clinical implementation of preemptive pharmacogenomics in psychiatry
  13. Data-Driven Drug Repurposing in Diabetes Mellitus through an Enhanced Knowledge Graph
  14. Cloudscreen: A “one-stop-shop” Platform for Drug Repurposing
  15. A quest for the stereo-electronic requirements for selective agonism for the neurotrophin receptors TrkA and TrkB in 17-spirocyclic-dehydroepiandrosterone derivatives
  16. A Robust Machine Learning Framework Built Upon Molecular Representations Predicts CYP450 Inhibition: Toward Precision in Drug Repurposing
  17. Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s Disease.
  18. Comprehensive characterization of the neurogenic and neuroprotective action of a novel TrkB agonist using mouse and human stem cell models of Alzheimer’s Disease
  19. Bioenergetic Profiling in Glioblastoma Multiforme Patients with Different Clinical Outcomes
  20. A 12-gene pharmacogenetic panel to prevent adverse drug reactions: an open-label, multicentre, controlled, cluster-randomised crossover implementation study
  21. Development of a multigram synthesis of the bradykinin receptor 2 agonist FR‐190997 and analogs thereof
  22. Development and Comparative In Vitro and In Vivo Study of BNN27 Mucoadhesive Liposomes and Nanoemulsions for Nose-to-Brain Delivery
  23. CAR Exosome-Based Therapeutics
  24. Pharmacometabolomics-Based Translational Biomarkers: How to Navigate the Data Ocean
  25. Untargeted Metabolomics for Disease-Specific Signatures
  26. Radiotherapy in Metastatic Urothelial Carcinoma: Rationale and Clinical Applications
  27. Diagnostic and Therapeutic Challenges in a Patient with Ureteral Metastases from a Triple Negative Breast Cancer
  28. A 3-miRNA Signature Enables Risk Stratification in Glioblastoma Multiforme Patients with Different Clinical Outcomes
  29. Pharmacogenomics decision support in the U-PGx project: Results and advice from clinical implementation across seven European countries
  30. The clinical utility of polygenic risk scores in genomic medicine practices: a systematic review
  31. ENT-A010, a Novel Steroid Derivative, Displays Neuroprotective Functions and Modulates Microglial Responses
  32. Development and Biological Characterization of a Novel Selective TrkA Agonist with Neuroprotective Properties against Amyloid Toxicity
  33. Three-Dimensional Cell Metabolomics Deciphers the Anti-Angiogenic Properties of the Radioprotectant Amifostine
  34. Exploiting the Role of Hypoxia-Inducible Factor 1 and Pseudohypoxia in the Myelodysplastic Syndrome Pathophysiology
  35. Insights into intrauterine growth restriction based on maternal and umbilical cord blood metabolomics
  36. Bioenergetic Profiling of the Differentiating Human MDS Myeloid Lineage with Low and High Bone Marrow Blast Counts
  37. The Metabolomic Status of the Differentiating Myeloid Lineage in MDS with Low and High Bone Marrow Blast Counts
  38. Clinical implementation of preemptive pharmacogenomics in psychiatry: Τhe “PREPARE” study
  39. The role of microRNAs in gliomas – Therapeutic implications
  40. Documentation of clinically relevant genomic biomarker allele frequencies in the next‐generation FINDbase worldwide database
  41. Multiomics Analysis Coupled with Text Mining Identify Novel Biomarker Candidates for Recurrent Cardiovascular Events
  42. Challenges in identifying large germline structural variants for clinical use by long read sequencing
  43. VEGF-A and ICAM-1 Gene Polymorphisms as Predictors of Clinical Outcome to First-Line Bevacizumab-Based Treatment in Metastatic Colorectal Cancer
  44. 4th ESPT Conference: Pharmacogenomics and Personalized Medicine – Research Progress and Clinical Implementation
  45. Corrigendum
  46. Pharmacomicrobiomics informs clinical pharmacogenomics
  47. Genomic Variants in Members of the Krüppel-Like Factor Gene Family are Associated with Disease Severity and Hydroxyurea Treatment Efficacy in β-Hemoglobinopathies Patients
  48. A Noninvasive Ocular (Tear) Sampling Method for Genetic Ascertainment of Transgenic Mice and Research Ethics Innovation
  49. Integrating Next-Generation Sequencing in the Clinical Pharmacogenomics Workflow
  50. New molecular diagnostic trends and biomarkers for amyotrophic lateral sclerosis
  51. Cost-effectiveness analysis of pharmacogenomics-guided clopidogrel treatment in Spanish patients undergoing percutaneous coronary intervention
  52. Role of Genomic Biomarkers in Increasing Fetal Hemoglobin Levels Upon Hydroxyurea Therapy and in β-Thalassemia Intermedia: A Validation Cohort Study
  53. Implementation of Genomic Medicine
  54. Autophagy in Myelodysplastic Syndromes: The Role of HIF-1a/REDD1 Molecular Pathway
  55. How far have we come with contextual data integration in drug discovery?
  56. Variants in TPMT, ITPA, ABCC4 And ABCB1 Genes as Predictors of 6-Mercaptopurine Induced Toxicity in Children with Acute Lymphoblastic Leukemia
  57. Can VEGFA and ICAM1 polymorphisms predict response to bevacizumab?
  58. An Exploratory Study of Radiation Dermatitis in Breast Cancer Patients
  59. The New Age of -omics in Urothelial Cancer – Re-wording Its Diagnosis and Treatment
  60. Recent trends on the role of epigenomics, metabolomics and noncoding RNAs in rationalizing mood stabilizing treatment
  61. Searching for Clinically Relevant Biomarkers in Geriatric Oncology
  62. Multi-Omics for Biomarker Discovery and Target Validation in Biofluids for Amyotrophic Lateral Sclerosis Diagnosis
  63. Proteomics and Metabolomics Data Analysis for Translational Medicine
  64. A Review of Tools to Automatically Infer Chromosomal Positions From dbSNP and HGVS Genetic Variants
  65. Economic Evaluation and Cost-Effectiveness Analysis of Genomic Medicine Interventions in Developing and Emerging Countries
  66. Human Genomic Databases in Translational Medicine
  67. Translating Genomic Information to Rationalize Drug Use
  68. The Genomic Medicine Alliance: A Global Effort to Facilitate the Introduction of Genomics into Healthcare in Developing Nations
  69. Advancing Global Precision Medicine: An Overview of Genomic Testing and Counseling Services in Malaysia
  70. Genomic variants in the FTO gene are associated with sporadic amyotrophic lateral sclerosis in Greek patients
  71. Genomic Medicine Without Borders: Which Strategies Should Developing Countries Employ to Invest in Precision Medicine? A New “Fast-Second Winner” Strategy
  72. Whole transcriptome analysis of human erythropoietic cells during ontogenesis suggests a role of VEGFA gene as modulator of fetal hemoglobin and pharmacogenomic biomarker of treatment response to hydroxyurea in β-type hemoglobinopathy patients
  73. Cancer Genomics and Public Health
  74. Sensitive Monogenic Noninvasive Prenatal Diagnosis by Targeted Haplotyping
  75. Exploring public genomics data for population pharmacogenomics
  76. Pharmacometabolomics Informs Quantitative Radiomics for Glioblastoma Diagnostic Innovation
  77. Key Pharmacogenomic Considerations for Sickle Cell Disease Patients
  78. Editorial: (Pharmaco)Metabolomics in Drug Discovery and Individualisation of Treatment
  79. Correction: A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
  80. Genomic Medicine in Developing Countries and Resource-Limited Environments
  81. Genomic Databases
  82. Perspectives for Future DNA Sequencing Techniques and Applications
  83. Cancer Genomics and Public Health
  84. Application of the DruGeVar Database in Cancer Genomics and Pharmacogenomics
  85. Exosomes: A Cancer Theranostics Road Map
  86. Pharmacogenomics in Clinical Care and Drug Discovery
  87. Low- and Medium-Throughput Variant Detection Methods
  88. Pharmacogenomics education and research at the Department of Pharmacy, University of Patras, Greece
  89. Correlation of SIN3A genomic variants with β-hemoglobinopathies disease severity and hydroxyurea treatment efficacy
  90. Pharmacometabolomics Informs Viromics toward Precision Medicine
  91. Novel genetic risk variants for pediatric celiac disease
  92. Expanded national database collection and data coverage in the FINDbase worldwide database for clinically relevant genomic variation allele frequencies
  93. A European Spectrum of Pharmacogenomic Biomarkers: Implications for Clinical Pharmacogenomics
  94. ePGA: A Web-Based Information System for Translational Pharmacogenomics
  95. Development and validation of a UHPLC-UV method for the determination of a prostate secretory protein 94-derived synthetic peptide (PCK3145) in human plasma and assessment of its stability in human plasma
  96. Pharmacometabolomics-aided Pharmacogenomics in Autoimmune Disease
  97. Genomic variants in the ASS1 gene, involved in the nitric oxide biosynthesis and signaling pathway, predict hydroxyurea treatment efficacy in compound sickle cell disease/β-thalassemia patients
  98. Nutrigenomics 2.0: The Need for Ongoing andIndependentEvaluation and Synthesis of Commercial Nutrigenomics Tests' Scientific Knowledge Base for Responsible Innovation
  99. Allele and genotype frequencies of the two single nucleotide polymorphisms in the VKORC1 gene that are most important for warfarin treatment among Emiratis
  100. Computational approaches in target identification and drug discovery
  101. Pharmacometabolomics: Applications and Challenges
  102. Functional Analysis of anAγ-Globin Gene Promoter Variant (HBG1: g.-225_-222delAGCA) Underlines Its Role in Increasing Fetal Hemoglobin Levels Under Erythropoietic Stress
  103. Enabling pharmacogenomic services: Informatics and computational discovery aspects
  104. Identification of a novel homozygous SPG7 mutation by whole exome sequencing in a Greek family with a complicated form of hereditary spastic paraplegia
  105. TPMT gene expression is increased during maintenance therapy in childhood acute lymphoblastic leukemia patients in a TPMT gene promoter variable number of tandem repeat-dependent manner
  106. Drug-Induced Stevens–Johnson Syndrome and Toxic Epidermal Necrolysis Call for Optimum Patient Stratification and Theranostics via Pharmacogenomics
  107. As solid scientific evidence is lacking, available nutrigenomics tests cannot be recommended
  108. The Implications of Metabotypes for Rationalizing Therapeutics in Infants and Children
  109. Identification of cancer predisposition variants in apparently healthy individuals using a next-generation sequencing-based family genomics approach
  110. Whole genome sequencing in pharmacogenomics
  111. Nutrigenomics: A controversy
  112. Pharmacogenomics for Haemoglobinopathies Therapeutics
  113. Circulating pEGFR Is a Candidate Response Biomarker of Cetuximab Therapy in Colorectal Cancer
  114. Deciphering next-generation pharmacogenomics: an information technology perspective
  115. Enhancing the Biological Relevance of Secretome-Based Proteomics by Linking Tumor Cell Proliferation and Protein Secretion
  116. Personalized pharmacogenomics profiling using whole-genome sequencing
  117. Individualizing fetal hemoglobin augmenting therapy for β-type hemoglobinopathies patients
  118. Assessment of the Pharmacogenomics Educational Environment in Southeast Europe
  119. DruGeVar: An Online Resource Triangulating Drugs with Genes and Genomic Biomarkers for Clinical Pharmacogenomics
  120. Ovarian malignant ascites-derived lymphocytes stimulated with prothymosin α or its immunoactive decapeptide lyse autologous tumour cells in vitro and retard tumour growth in SCID mice
  121. Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: Enhanced enzymatic stability and biological properties
  122. 1077 Ovarian Malignant Ascites-derived Lymphocytes Stimulated With Prothymosin Alpha or Its Immunoactive Decapeptide Lyse Autologous Tumor Cells in Vitro and Retard Tumor Growth in SCID Mice
  123. Peptide and protein drugs: The study of their metabolism and catabolism by mass spectrometry
  124. Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer
  125. Liposomal encapsulation enhances and prolongs the anti-inflammatory effects of water-soluble dexamethasone phosphate in experimental adjuvant arthritis
  126. Simultaneous Absolute Quantification of the Glucose-Dependent Insulinotropic Polypeptides GIP1−42and GIP3−42in Mouse Plasma by LC/ESI-MS/MS: Preclinical Evaluation of DP-IV Inhibitors
  127. In vivoevaluation andin vitrometabolism of leuprolide in mice-mass spectrometry-based biomarker measurement for efficacy and toxicity
  128. Evaluation of gonadotropin-releasing hormone analogues in mice – pharmacokinetic studies and biomarker based efficacy by mass spetrometry