All Stories

  1. The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells

    Article • PLOS One, October 2023, PLOS

    Thaddeus Allen

  2. In-vitro metabolism of LXY18, an orally available, potent blocker of AURKB relocation in mitosis

    Article • Journal of Pharmaceutical and Biomedical Analysis, August 2023, Elsevier

    Thaddeus Allen

  3. Orally Bioavailable 4-Phenoxy-quinoline Compound as a Potent Aurora Kinase B Relocation Blocker for Cancer Treatment

    Article • ACS Pharmacology & Translational Science, July 2023, American Chemical Society (ACS)

    Thaddeus Allen

  4. Characterization of mitotic phenotypes associated with a MYC synthetic lethal compound

    Article • April 2023, Cold Spring Harbor Laboratory Press

    Thaddeus Allen

  5. Integrating a phenotypic screening with a structural simplification strategy to identify 4-phenoxy-quinoline derivatives to potently disrupt the mitotic localization of Aurora kinase B

    Article • Bioorganic & Medicinal Chemistry, February 2023, Elsevier

    Thaddeus Allen

  6. An orally bioavailable 4-phenoxy-quinoline compound as a potent AURKB relocation blocker for cancer treatment

    Article • January 2023, Cold Spring Harbor Laboratory Press

    Thaddeus Allen

  7. 2-Phenoxy-3, 4′-bipyridine derivatives inhibit AURKB-dependent mitotic processes by disrupting its localization

    Article • European Journal of Medicinal Chemistry, January 2023, Elsevier

    Thaddeus Allen

  8. The phytochemical, corynoline, diminishes Aurora kinase B activity to induce mitotic defect and polyploidy

    Article • Biomedicine & Pharmacotherapy, March 2022, Elsevier

    Thaddeus Allen

  9. The Phytochemical Scoulerine Inhibits Aurora Kinase Activity to Induce Mitotic and Cytokinetic Defects

    Article • Journal of Natural Products, August 2021, American Chemical Society (ACS)

    Thaddeus Allen

  10. A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

    Article • PLOS One, March 2021, PLOS

    Thaddeus Allen

  11. Aberrant Activation of Notch1 Signaling in Glomerular Endothelium Induces Albuminuria

    Article • Circulation Research, March 2021, Wolters Kluwer Health

    Thaddeus Allen

  12. A high-content screen for anti-mitosis and polyploidy-induction identifies an unknown activity of two benzophenanthridine alkaloids from Corydalis longicalcarata

    Article • Phytochemistry Letters, February 2021, Elsevier

    Thaddeus Allen

  13. The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin 1/Atg6-mediated lethal autophagy in polyploid cells

    Article • Experimental Cell Research, September 2020, Elsevier

    Thaddeus Allen

  14. Purification, identification, and characterization of two benzophenanthridine alkaloids fromCorydalis longicalcaratarhizomes with anti-mitotic and polyploidy-inducing activities

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Thaddeus Allen

  15. A high-content screen identifies the vulnerability of MYC-overexpressing cells to dimethylfasudil

    Article • October 2019, Cold Spring Harbor Laboratory Press

    Thaddeus Allen

  16. The anti-apoptotic proteins Bcl-2 and Bcl-xL suppress Beclin1/Atg6-mediated lethal autophagy in polyploid cells

    Article • June 2019, Cold Spring Harbor Laboratory Press

    Thaddeus Allen

  17. Metabolic reprogramming and Notch activity distinguish between non-small cell lung cancer subtypes

    Article • British Journal of Cancer, May 2019, Springer Science + Business Media

    Thaddeus Allen

  18. Notch1 activates angiogenic regulator Netrin4 in endothelial cells

    Article • Journal of Cellular and Molecular Medicine, February 2019, Wiley

    Thaddeus Allen

  19. Dihydroartemisinin ameliorates sepsis-induced hyperpermeability of glomerular endothelium via up-regulation of occludin expression

    Article • Biomedicine & Pharmacotherapy, March 2018, Elsevier

    Thaddeus Allen

  20. GATA3-induced vWF upregulation in the lung adenocarcinoma vasculature

    Article • Oncotarget, November 2017, Impact Journals, LLC

    Thaddeus Allen

  21. Dihydroartemisinin up-regulates VE-cadherin expression in human renal glomerular endothelial cells

    Article • Journal of Cellular and Molecular Medicine, November 2017, Wiley

    Thaddeus Allen

  22. Glomerular endothelial cell IQGAP2 and filtration barrier function

    Article • Kidney International, May 2016, Elsevier

    Thaddeus Allen

  23. Plasma von Willebrand factor level is transiently elevated in a rat model of acute myocardial infarction

    Article • Experimental and Therapeutic Medicine, September 2015, Spandidos Publications

    Thaddeus Allen

  24. Trichostatin A suppresses lung adenocarcinoma development in Grg1 overexpressing transgenic mice

    Article • Biochemical and Biophysical Research Communications, August 2015, Elsevier

    Thaddeus Allen

  25. CD109 is specifically expressed in endothelial cells of cutaneous cavernous haemangioma

    Article • Histopathology, January 2015, Wiley

    Thaddeus Allen

  26. Dihydroartemisinin targets VEGFR2 via the NF-κB pathway in endothelial cells to inhibit angiogenesis

    Article • Cancer Biology & Therapy, November 2014, Taylor & Francis

    Thaddeus Allen

  27. Dihydroartemisinin inhibits vascular endothelial growth factor-induced endothelial cell migration by a p38 mitogen-activated protein kinase-independent pathway

    Article • Experimental and Therapeutic Medicine, September 2014, Spandidos Publications

    Thaddeus Allen

  28. Postnatal Notch1 activation induces T-cell malignancy in conditional and inducible mouse models

    Article • International Journal of Oncology, August 2014, Spandidos Publications

    Thaddeus Allen

  29. Cadmium induces vascular permeability via activation of the p38 MAPK pathway

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Thaddeus Allen

  30. Sox9 mediates Notch1-induced mesenchymal features in lung adenocarcinoma

    Article • Oncotarget, May 2014, Impact Journals, LLC

    Thaddeus Allen

  31. The Metabolic Profile of Tumors Depends on Both the Responsible Genetic Lesion and Tissue Type

    Article • Cell Metabolism, February 2012, Elsevier

    Prof. José M Matés, Thaddeus Allen

  32. Activated Notch1 Induces Lung Adenomas in Mice and Cooperates with Myc in the Generation of Lung Adenocarcinoma

    Article • Cancer Research, September 2011, American Association for Cancer Research (AACR)

    Thaddeus Allen

  33. Interaction between MYC and MCL1 in the Genesis and Outcome of Non–Small-Cell Lung Cancer

    Article • Cancer Research, March 2011, American Association for Cancer Research (AACR)

    Thaddeus Allen

  34. Id1 cooperates with oncogenic Ras to induce metastatic mammary carcinoma by subversion of the cellular senescence response

    Article • Proceedings of the National Academy of Sciences, April 2008, Proceedings of the National Academy of Sciences

    Thaddeus Allen

  35. Grg1 Acts as a Lung-Specific Oncogene in a Transgenic Mouse Model

    Article • Cancer Research, February 2006, American Association for Cancer Research (AACR)

    Thaddeus Allen

  36. TALE Homeoproteins as HOX11-Interacting Partners in T-cell Leukemia

    Article • Leukemia & Lymphoma, January 2000, Taylor & Francis

    Thaddeus Allen

  37. Cutaneously applied acyclovir acts systemically in the treatment of herpetic infection in the hairless mouse

    Article • Antiviral Research, August 1997, Elsevier

    Thaddeus Allen