All Stories

  1. Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  2. The influence of metformin treatment on the circulating proteome

    Article • EBioMedicine, August 2025, Elsevier

    Dr Tarja Kokkola

  3. Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study

    Article • PLoS Genetics, July 2025, PLOS

    Dr Tarja Kokkola

  4. The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study

    Article • Genome Medicine, July 2025, Springer Science + Business Media

    Dr Tarja Kokkola

  5. A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  6. Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease‐related dementia

    Article • Alzheimer s & Dementia, June 2025, Wiley

    Dr Tarja Kokkola

  7. Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, April 2025, Wiley

    Dr Tarja Kokkola

  8. Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

    Article • Journal of Alzheimer’s Disease, March 2025, SAGE Publications

    Dr Tarja Kokkola

  9. The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

    Article • European Journal of Pharmaceutical Sciences, December 2024, Elsevier

    Dr Tarja Kokkola

  10. Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study

    Article • Diabetologia, September 2024, Springer Science + Business Media

    Dr Tarja Kokkola

  11. TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease

    Article • BMJ Open, June 2024, BMJ

    Sari Aaltonen, Dr Tarja Kokkola

  12. Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  13. The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

    Article • The Journal of Clinical Endocrinology & Metabolism, April 2024, Endocrine Society

    Dr Tarja Kokkola

  14. TWINGEN – protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer’s disease

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Sari Aaltonen, Dr Tarja Kokkola

  15. Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

    Article • Nature Communications, August 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  16. A FinnGen pilot clinical recall study for Alzheimer’s disease

    Article • Scientific Reports, August 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  17. Cerebrospinal Fluid Diagnostics of Alzheimer’s Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

    Article • Journal of Alzheimer’s Disease, July 2023, IOS Press

    Dr Tarja Kokkola

  18. Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

    Article • Fluids and Barriers of the CNS, June 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  19. Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

    Article • Neurobiology of Disease, June 2023, Elsevier

    Dr Tarja Kokkola

  20. Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

    Article • Journal of Alzheimer’s Disease, May 2023, IOS Press

    Dr Tarja Kokkola

  21. Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

    Article • Nature Biotechnology, May 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  22. A FinnGen pilot clinical recall study for Alzheimer’s disease

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  23. Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

    Article • Journal of Alzheimer’s Disease, January 2023, IOS Press

    Dr Tarja Kokkola

  24. Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

    Article • Nature Biotechnology, January 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  25. Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials

    Article • The Lancet Diabetes & Endocrinology, January 2023, Elsevier

    Dr Tarja Kokkola

  26. Protective Alzheimer’s disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

    Article • December 2022, Springer Science + Business Media

    Dr Tarja Kokkola

  27. Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

    Article • Alzheimer s Research & Therapy, October 2022, Springer Science + Business Media

    Dr Tarja Kokkola

  28. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

    Article • Cell Reports Medicine, January 2022, Elsevier

    Dr Tarja Kokkola

  29. Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis

    Article • Multiple Sclerosis and Related Disorders, November 2021, Elsevier

    Dr Tarja Kokkola

  30. Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  31. Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

    Article • Diabetes, July 2021, American Diabetes Association

    Dr Tarja Kokkola

  32. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance

    Article • Journal of Neurology Neurosurgery & Psychiatry, June 2021, BMJ

    Dr Tarja Kokkola

  33. Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  34. Oxygen-18 and carbon-13 isotopes in eCO2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

    Article • Journal of Breath Research, January 2021, Institute of Physics Publishing

    Dr Tarja Kokkola

  35. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

    Article • Diabetes Care, December 2020, American Diabetes Association

    Roberto Bizzotto, Dr Tarja Kokkola

  36. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

    Article • Genome Medicine, December 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  37. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

    Article • PLOS One, November 2020, PLOS

    Dr Tarja Kokkola

  38. Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

    Article • Diabetologia, November 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  39. A reference map of potential determinants for the human serum metabolome

    Article • Nature, November 2020, Springer Science + Business Media

    Dr Cristina Menni, Dr Tarja Kokkola

  40. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

    Article • EBioMedicine, August 2020, Elsevier

    Dr Tarja Kokkola

  41. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

    Article • PLoS Medicine, June 2020, PLOS

    Dr Tarja Kokkola

  42. Impact of structurally diverse BET inhibitors on SIRT1

    Article • Gene, May 2020, Elsevier

    Dr Tarja Kokkola

  43. Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  44. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

    Article • Diabetologia, January 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  45. A scaffold replacement approach towards new sirtuin 2 inhibitors

    Article • Bioorganic & Medicinal Chemistry, January 2020, Elsevier

    Dr Tarja Kokkola

  46. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

    Article • Journal of Hepatology, September 2019, Elsevier

    Dr Tarja Kokkola

  47. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

    Article • Diabetologia, June 2019, Springer Science + Business Media

    Dr Tarja Kokkola

  48. Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study

    Article • Diabetes Care, March 2019, American Diabetes Association

    Dr Tarja Kokkola

  49. Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle

    Article • F1000Research, November 2018, Faculty of 1000, Ltd.

    Dr Tarja Kokkola

  50. Strigolactone GR24 upregulates Nrf2 target genes and may protect against oxidative stress in skeletal muscle

    Article • F1000Research, September 2018, Faculty of 1000, Ltd.

    Dr Tarja Kokkola

  51. Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

    Article • International Journal of Pharmaceutics, June 2018, Elsevier

    Dr Tarja Kokkola

  52. Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes

    Article • Biochemical and Biophysical Research Communications, May 2018, Elsevier

    Dr Tarja Kokkola

  53. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  54. Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats

    Article • Scandinavian Journal of Medicine and Science in Sports, March 2018, Wiley

    Dr Tarja Kokkola

  55. Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

    Article • Scientific Reports, December 2017, Springer Science + Business Media

    Dr Tarja Kokkola

  56. Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation

    Article • Biochemical and Biophysical Research Communications, November 2016, Elsevier

    Dr Tarja Kokkola

  57. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

    Article • European Journal of Medicinal Chemistry, January 2016, Elsevier

    Dr Tarja Kokkola

  58. N-Acylethanolamines Bind to SIRT6

    Article • ChemBioChem, November 2015, Wiley

    Dr Tarja Kokkola

  59. Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

    Article • PLOS One, November 2015, PLOS

    Dr Tarja Kokkola

  60. Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment

    Article • Chemical Research in Toxicology, September 2015, American Chemical Society (ACS)

    Dr Tarja Kokkola

  61. BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

    Article • ChemBioChem, August 2015, Wiley

    Dr Tarja Kokkola

  62. Virtual screening approach of sirtuin inhibitors results in two new scaffolds

    Article • European Journal of Pharmaceutical Sciences, August 2015, Elsevier

    Dr Tarja Kokkola

  63. Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells

    Article • Journal of Medicinal Chemistry, December 2014, American Chemical Society (ACS)

    Dr Tarja Kokkola

  64. Studying SIRT6 regulation using H3K56 based substrate and small molecules

    Article • European Journal of Pharmaceutical Sciences, October 2014, Elsevier

    Dr Tarja Kokkola

  65. AROS has a context-dependent effect on SIRT1

    Article • FEBS Letters, March 2014, Wiley

    Dr Tarja Kokkola

  66. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

    Article • Redox Biology, January 2014, Elsevier

    Dr Tarja Kokkola

  67. Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

    Article • Journal of Medicinal Chemistry, August 2013, American Chemical Society (ACS)

    Dr Tarja Kokkola

  68. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

    Article • FEBS Letters, July 2011, Wiley

    Dr Tarja Kokkola

  69. Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity

    Article • Molecular and Cellular Biochemistry, January 2011, Springer Science + Business Media

    Dr Tarja Kokkola

  70. An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples

    Article • Free Radical Research, September 2010, Taylor & Francis

    Professor Fiorella Biasi, Dr Tarja Kokkola

  71. Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation

    Article • Journal of Pineal Research, October 2007, Wiley

    Dr Tarja Kokkola

  72. The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor

    Article • Journal of Pineal Research, August 2005, Wiley

    Dr Tarja Kokkola

  73. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2receptor

    Article • British Journal of Pharmacology, July 2005, Wiley

    Dr Tarja Kokkola

  74. Article • BMC Cell Biology, January 2005, Springer Science + Business Media

    Dr Tarja Kokkola

  75. Important amino acids for the function of the human MT1 melatonin receptor

    Article • Biochemical Pharmacology, May 2003, Elsevier

    Dr Tarja Kokkola

  76. Mutagenesis of Human Mel1aMelatonin Receptor Expressed in Yeast Reveals Domains Important for Receptor Function

    Article • Biochemical and Biophysical Research Communications, August 1998, Elsevier

    Dr Tarja Kokkola

  77. TCDD alters melatonin metabolism in fish hepatocytes

    Article • Pathophysiology, June 1998, Elsevier

    Dr Tarja Kokkola

  78. Melatonin receptor genes

    Article • Annals of Medicine, January 1998, Taylor & Francis

    Dr Tarja Kokkola

  79. A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor

    Article • European Journal of Pharmacology, May 1996, Elsevier

    Dr Tarja Kokkola

  80. Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat

    Article • Toxicology, February 1996, Elsevier

    Dr Tarja Kokkola

  81. Cholinergic signaling in the rat pineal gland

    Article • Cellular and Molecular Neurobiology, April 1995, Springer Science + Business Media

    Dr Tarja Kokkola