All Stories

  1. A biological-systems-based analysis using proteomic and metabolic network inference reveals mechanistic insights into hepatic steatosis

    Article • Metabolism, May 2026, Elsevier

    Dr Tarja Kokkola

  2. Elevated Serum Neurofilament Light Chain Is Associated With Systemic Inflammation in Very Preterm Infants

    Article • Acta Paediatrica, April 2026, Wiley

    Dr Tarja Kokkola

  3. The performance of plasma pTau181 and pTau217 in distinguishing Alzheimer's disease from various neurodegenerative disorders, psychiatric disorders, and cognitively unimpaired controls

    Article • Journal of Alzheimer’s Disease, March 2026, SAGE Publications

    Dr Tarja Kokkola

  4. Combining a computerized cognitive test with serum biomarkers improves detection of early-onset neurodegenerative disorders

    Article • Journal of Alzheimer’s Disease, October 2025, SAGE Publications

    Dr Tarja Kokkola

  5. Predicting Alzheimer’s Disease Phenotypes With Aging Clocks: An Exploratory Analysis

    Article • September 2025, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  6. Scalable biological-cognitive profiling for Alzheimer’s disease in the population

    Article • August 2025, openRxiv

    Dr Tarja Kokkola

  7. The influence of metformin treatment on the circulating proteome

    Article • EBioMedicine, August 2025, Elsevier

    Dr Tarja Kokkola

  8. Bayesian network imputation methods applied to multi-omics data identify putative causal relationships in a type 2 diabetes dataset containing incomplete data: An IMI DIRECT Study

    Article • PLoS Genetics, July 2025, PLOS

    Dr Tarja Kokkola

  9. The dynamics of the gut microbiota in prediabetes during a four-year follow-up among European patients—an IMI-DIRECT prospective study

    Article • Genome Medicine, July 2025, Springer Science + Business Media

    Dr Tarja Kokkola

  10. Immunometabolic profiling in menopausal women with multiple sclerosis: the role of adipokines and hormone therapy

    Article • BMJ Neurology Open, July 2025, BMJ

    Dr Tarja Kokkola

  11. A Biological-Systems-Based Analyses Using Proteomic and Metabolic Network Inference Reveals Mechanistic Insights into Hepatic Lipid Accumulation: An IMI-DIRECT Study

    Article • June 2025, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  12. Increased activity of Piezo1 channel in red blood cells is associated with Alzheimer's disease‐related dementia

    Article • Alzheimer s & Dementia, June 2025, Wiley

    Dr Tarja Kokkola

  13. Cross‐sectional study of plasma phosphorylated tau 217 in persons without dementia

    Article • Alzheimer s & Dementia Diagnosis Assessment & Disease Monitoring, April 2025, Wiley

    Dr Tarja Kokkola

  14. Effect of ventricular volume on cerebrospinal fluid Alzheimer's disease biomarkers in patients with idiopathic normal pressure hydrocephalus

    Article • Journal of Alzheimer’s Disease, March 2025, SAGE Publications

    Dr Tarja Kokkola

  15. The L-type amino acid transporter 1 enhances drug delivery to the mouse pancreatic beta cell line (MIN6)

    Article • European Journal of Pharmaceutical Sciences, December 2024, Elsevier

    Dr Tarja Kokkola

  16. Role of human plasma metabolites in prediabetes and type 2 diabetes from the IMI-DIRECT study

    Article • Diabetologia, September 2024, Springer Science + Business Media

    Dr Tarja Kokkola

  17. TWINGEN: protocol for an observational clinical biobank recall and biomarker cohort study to identify Finnish individuals with high risk of Alzheimer’s disease

    Article • BMJ Open, June 2024, BMJ

    Sari Aaltonen, Dr Tarja Kokkola

  18. Correction to: “The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study”

    Article • The Journal of Clinical Endocrinology & Metabolism, May 2024, Endocrine Society

    Dr Tarja Kokkola

  19. Cross-sectional study of plasma phosphorylated Tau 217 in persons without dementia

    Article • May 2024, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  20. The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1: An IMI DIRECT Study

    Article • The Journal of Clinical Endocrinology & Metabolism, April 2024, Endocrine Society

    Dr Tarja Kokkola

  21. TWINGEN – protocol for an observational clinical biobank recall and biomarker study to identify individuals with high risk of Alzheimer’s disease

    Article • November 2023, Cold Spring Harbor Laboratory Press

    Sari Aaltonen, Dr Tarja Kokkola

  22. Genetic analysis of blood molecular phenotypes reveals common properties in the regulatory networks affecting complex traits

    Article • Nature Communications, August 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  23. A FinnGen pilot clinical recall study for Alzheimer’s disease

    Article • Scientific Reports, August 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  24. Cerebrospinal Fluid Diagnostics of Alzheimer’s Disease in Patients with Idiopathic Normal Pressure Hydrocephalus

    Article • Journal of Alzheimer’s Disease, July 2023, IOS Press

    Dr Tarja Kokkola

  25. Novel cerebrospinal fluid biomarkers correlating with shunt responsiveness in patients with idiopathic normal pressure hydrocephalus

    Article • Fluids and Barriers of the CNS, June 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  26. Protective Alzheimer's disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

    Article • Neurobiology of Disease, June 2023, Elsevier

    Dr Tarja Kokkola

  27. Serum Cathepsin S Levels Do Not Show Alterations in Different Clinical, Neuropathological, or Genetic Subtypes of Frontotemporal Dementia Patients nor in Comparison to Healthy Control Individuals

    Article • Journal of Alzheimer’s Disease, May 2023, IOS Press

    Dr Tarja Kokkola

  28. Author Correction: Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

    Article • Nature Biotechnology, May 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  29. A FinnGen pilot clinical recall study for Alzheimer’s disease

    Article • February 2023, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  30. Concordance of Alzheimer’s Disease-Related Biomarkers Between Intraventricular and Lumbar Cerebrospinal Fluid in Idiopathic Normal Pressure Hydrocephalus

    Article • Journal of Alzheimer’s Disease, January 2023, IOS Press

    Dr Tarja Kokkola

  31. Discovery of drug–omics associations in type 2 diabetes with generative deep-learning models

    Article • Nature Biotechnology, January 2023, Springer Science + Business Media

    Dr Tarja Kokkola

  32. Pharmacogenomics of GLP-1 receptor agonists: a genome-wide analysis of observational data and large randomised controlled trials

    Article • The Lancet Diabetes & Endocrinology, January 2023, Elsevier

    Dr Tarja Kokkola

  33. Protective Alzheimer’s disease-associated APP A673T variant predominantly decreases sAPPβ levels in cerebrospinal fluid and 2D/3D cell culture models

    Article • December 2022, Springer Science + Business Media

    Dr Tarja Kokkola

  34. Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype

    Article • Alzheimer s Research & Therapy, October 2022, Springer Science + Business Media

    Dr Tarja Kokkola

  35. Four groups of type 2 diabetes contribute to the etiological and clinical heterogeneity in newly diagnosed individuals: An IMI DIRECT study

    Article • Cell Reports Medicine, January 2022, Elsevier

    Dr Tarja Kokkola

  36. Serum GFAP and NfL levels in benign relapsing-remitting multiple sclerosis

    Article • Multiple Sclerosis and Related Disorders, November 2021, Elsevier

    Dr Tarja Kokkola

  37. Inferring causal pathways between metabolic processes and liver fat accumulation: an IMI DIRECT study

    Article • September 2021, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  38. Profiles of Glucose Metabolism in Different Prediabetes Phenotypes, Classified by Fasting Glycemia, 2-Hour OGTT, Glycated Hemoglobin, and 1-Hour OGTT: An IMI DIRECT Study

    Article • Diabetes, July 2021, American Diabetes Association

    Dr Tarja Kokkola

  39. GFAP as a biomarker in frontotemporal dementia and primary psychiatric disorders: diagnostic and prognostic performance

    Article • Journal of Neurology Neurosurgery & Psychiatry, June 2021, BMJ

    Dr Tarja Kokkola

  40. Genetic analysis of blood molecular phenotypes reveals regulatory networks affecting complex traits: a DIRECT study

    Article • March 2021, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  41. Oxygen-18 and carbon-13 isotopes in eCO2 and erythrocytes carbonic anhydrase activity of Finnish prediabetic population

    Article • Journal of Breath Research, January 2021, Institute of Physics Publishing

    Dr Tarja Kokkola

  42. Processes Underlying Glycemic Deterioration in Type 2 Diabetes: An IMI DIRECT Study

    Article • Diabetes Care, December 2020, American Diabetes Association

    Roberto Bizzotto, Dr Tarja Kokkola

  43. Whole blood co-expression modules associate with metabolic traits and type 2 diabetes: an IMI-DIRECT study

    Article • Genome Medicine, December 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  44. Post-load glucose subgroups and associated metabolic traits in individuals with type 2 diabetes: An IMI-DIRECT study

    Article • PLOS One, November 2020, PLOS

    Dr Tarja Kokkola

  45. Correction to: The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

    Article • Diabetologia, November 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  46. A reference map of potential determinants for the human serum metabolome

    Article • Nature, November 2020, Springer Science + Business Media

    Dr Cristina Menni, Dr Tarja Kokkola

  47. Dietary metabolite profiling brings new insight into the relationship between nutrition and metabolic risk: An IMI DIRECT study

    Article • EBioMedicine, August 2020, Elsevier

    Dr Tarja Kokkola

  48. Predicting and elucidating the etiology of fatty liver disease: A machine learning modeling and validation study in the IMI DIRECT cohorts

    Article • PLoS Medicine, June 2020, PLOS

    Dr Tarja Kokkola

  49. Impact of structurally diverse BET inhibitors on SIRT1

    Article • Gene, May 2020, Elsevier

    Dr Tarja Kokkola

  50. Predicting and elucidating the etiology of fatty liver disease using a machine learning-based approach: an IMI DIRECT study

    Article • February 2020, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  51. The role of physical activity in metabolic homeostasis before and after the onset of type 2 diabetes: an IMI DIRECT study

    Article • Diabetologia, January 2020, Springer Science + Business Media

    Dr Tarja Kokkola

  52. A scaffold replacement approach towards new sirtuin 2 inhibitors

    Article • Bioorganic & Medicinal Chemistry, January 2020, Elsevier

    Dr Tarja Kokkola

  53. Genetic studies of abdominal MRI data identify genes regulating hepcidin as major determinants of liver iron concentration

    Article • Journal of Hepatology, September 2019, Elsevier

    Dr Tarja Kokkola, Miss Birgitte Nilsson

  54. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: descriptive characteristics of the epidemiological studies within the IMI DIRECT Consortium

    Article • Diabetologia, June 2019, Springer Science + Business Media

    Dr Tarja Kokkola

  55. Variation in the Plasma Membrane Monoamine Transporter (PMAT) (Encoded by SLC29A4) and Organic Cation Transporter 1 (OCT1) (Encoded by SLC22A1) and Gastrointestinal Intolerance to Metformin in Type 2 Diabetes: An IMI DIRECT Study

    Article • Diabetes Care, March 2019, American Diabetes Association

    Dr Tarja Kokkola

  56. Strigolactone GR24 upregulates target genes of the cytoprotective transcription factor Nrf2 in skeletal muscle

    Article • F1000Research, November 2018, Faculty of 1000, Ltd.

    Dr Tarja Kokkola

  57. Strigolactone GR24 upregulates Nrf2 target genes and may protect against oxidative stress in skeletal muscle

    Article • F1000Research, September 2018, Faculty of 1000, Ltd.

    Dr Tarja Kokkola

  58. Structural properties for selective and efficient l-type amino acid transporter 1 (LAT1) mediated cellular uptake

    Article • International Journal of Pharmaceutics, June 2018, Elsevier

    Dr Tarja Kokkola

  59. Strigolactone GR24 and pinosylvin attenuate adipogenesis and inflammation of white adipocytes

    Article • Biochemical and Biophysical Research Communications, May 2018, Elsevier

    Dr Tarja Kokkola

  60. Discovery of biomarkers for glycaemic deterioration before and after the onset of type 2 diabetes: an overview of the data from the epidemiological studies within the IMI DIRECT Consortium

    Article • April 2018, Cold Spring Harbor Laboratory Press

    Dr Tarja Kokkola

  61. Suppressed heat shock protein response in the kidney of exercise-trained diabetic rats

    Article • Scandinavian Journal of Medicine and Science in Sports, March 2018, Wiley

    Dr Tarja Kokkola

  62. Plant-derived compounds strigolactone GR24 and pinosylvin activate SIRT1 and enhance glucose uptake in rat skeletal muscle cells

    Article • Scientific Reports, December 2017, Springer Science + Business Media

    Dr Tarja Kokkola

  63. Simvastatin induces insulin resistance in L6 skeletal muscle myotubes by suppressing insulin signaling, GLUT4 expression and GSK-3β phosphorylation

    Article • Biochemical and Biophysical Research Communications, November 2016, Elsevier

    Dr Tarja Kokkola

  64. Potent and selective N-(4-sulfamoylphenyl)thiourea-based GPR55 agonists

    Article • European Journal of Medicinal Chemistry, January 2016, Elsevier

    Dr Tarja Kokkola

  65. N-Acylethanolamines Bind to SIRT6

    Article • ChemBioChem, November 2015, Wiley

    Dr Tarja Kokkola

  66. Simvastatin Impairs Insulin Secretion by Multiple Mechanisms in MIN6 Cells

    Article • PLOS One, November 2015, PLOS

    Dr Tarja Kokkola

  67. Transcriptomic Analysis of Human Primary Bronchial Epithelial Cells after Chloropicrin Treatment

    Article • Chemical Research in Toxicology, September 2015, American Chemical Society (ACS)

    Dr Tarja Kokkola

  68. BET Inhibition Upregulates SIRT1 and Alleviates Inflammatory Responses

    Article • ChemBioChem, August 2015, Wiley

    Dr Tarja Kokkola

  69. Virtual screening approach of sirtuin inhibitors results in two new scaffolds

    Article • European Journal of Pharmaceutical Sciences, August 2015, Elsevier

    Dr Tarja Kokkola

  70. Chroman-4-one- and Chromone-Based Sirtuin 2 Inhibitors with Antiproliferative Properties in Cancer Cells

    Article • Journal of Medicinal Chemistry, December 2014, American Chemical Society (ACS)

    Dr Tarja Kokkola

  71. Studying SIRT6 regulation using H3K56 based substrate and small molecules

    Article • European Journal of Pharmaceutical Sciences, October 2014, Elsevier

    Dr Tarja Kokkola

  72. AROS has a context-dependent effect on SIRT1

    Article • FEBS Letters, March 2014, Wiley

    Dr Tarja Kokkola

  73. Natural thermal adaptation increases heat shock protein levels and decreases oxidative stress

    Article • Redox Biology, January 2014, Elsevier

    Dr Tarja Kokkola

  74. Screen of Pseudopeptidic Inhibitors of Human Sirtuins 1–3: Two Lead Compounds with Antiproliferative Effects in Cancer Cells

    Article • Journal of Medicinal Chemistry, August 2013, American Chemical Society (ACS)

    Dr Tarja Kokkola

  75. G PROTEIN-COUPLED RECEPTORS

    Article • British Journal of Pharmacology, November 2011, Wiley

    Stephen Alexander, Dr Tarja Kokkola

  76. Somatostatin receptor 5 is palmitoylated by the interacting ZDHHC5 palmitoyltransferase

    Article • FEBS Letters, July 2011, Wiley

    Dr Tarja Kokkola

  77. Treatments with sodium selenate or doxycycline offset diabetes-induced perturbations of thioredoxin-1 levels and antioxidant capacity

    Article • Molecular and Cellular Biochemistry, January 2011, Springer Science + Business Media

    Dr Tarja Kokkola

  78. An inter-laboratory validation of methods of lipid peroxidation measurement in UVA-treated human plasma samples

    Article • Free Radical Research, September 2010, Taylor & Francis

    Professor Fiorella Biasi, Dr Tarja Kokkola

  79. Inverse agonist exposure enhances ligand binding and G protein activation of the human MT1 melatonin receptor, but leads to receptor down-regulation

    Article • Journal of Pineal Research, October 2007, Wiley

    Dr Tarja Kokkola

  80. The functional role of cysteines adjacent to the NRY motif of the human MT1 melatonin receptor

    Article • Journal of Pineal Research, August 2005, Wiley

    Dr Tarja Kokkola

  81. Identification of WIN55212-3 as a competitive neutral antagonist of the human cannabinoid CB2receptor

    Article • British Journal of Pharmacology, July 2005, Wiley

    Dr Tarja Kokkola

  82. Article • BMC Cell Biology, January 2005, Springer Science + Business Media

    Dr Tarja Kokkola

  83. Important amino acids for the function of the human MT1 melatonin receptor

    Article • Biochemical Pharmacology, May 2003, Elsevier

    Dr Tarja Kokkola

  84. Mutagenesis of Human Mel1aMelatonin Receptor Expressed in Yeast Reveals Domains Important for Receptor Function

    Article • Biochemical and Biophysical Research Communications, August 1998, Elsevier

    Dr Tarja Kokkola

  85. TCDD alters melatonin metabolism in fish hepatocytes

    Article • Pathophysiology, June 1998, Elsevier

    Dr Tarja Kokkola

  86. Melatonin receptor genes

    Article • Annals of Medicine, January 1998, Taylor & Francis

    Dr Tarja Kokkola

  87. A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor

    Article • European Journal of Pharmacology, May 1996, Elsevier

    Dr Tarja Kokkola

  88. Mechanism by which 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) reduces circulating melatonin levels in the rat

    Article • Toxicology, February 1996, Elsevier

    Dr Tarja Kokkola

  89. Cholinergic signaling in the rat pineal gland

    Article • Cellular and Molecular Neurobiology, April 1995, Springer Science + Business Media

    Dr Tarja Kokkola