All Stories

  1. Tripodal Quinone-Cyanine G-Quadruplex Ligands as Novel Photosensitizers on Photoinduced Cancer Cell Death

    Article • Molecules, October 2024, MDPI AG

    Dr Takashi Sakamoto

  2. Near-Infrared Fluorescent Switch-On Probe for Guanine-Quadruplex Imaging with Extremely Large Stokes Shift

    Article • Analytical Chemistry, November 2023, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  3. Dual-Color Fluorescence Switch-On Probe for Imaging G-Quadruplex and Double-Stranded DNA in Living Cells

    Article • Analytical Chemistry, March 2022, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  4. Simultaneous Amino Acid Analysis Based on 19F NMR Using a Modified OPA-Derivatization Method

    Article • Analytical Chemistry, December 2019, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  5. Label‐Free in Situ Monitoring of the DNA Hybridization Chain Reaction by Using Sequence‐Selective Minor‐Groove‐Binding Fluorophores

    Article • ChemBioChem, May 2019, Wiley

    Dr Takashi Sakamoto

  6. Label-free in situ Monitoring of DNA Hybridization Chain Reaction using Sequence-selective Minor-groove Binding Fluorophores

    Article • ChemBioChem, January 2019, Wiley

    Dr Takashi Sakamoto

  7. Disassembly-driven signal turn-on probes for bimodal detection of DNA with 19F NMR and fluorescence

    Article • Organic & Biomolecular Chemistry, January 2018, Royal Society of Chemistry

    Dr Takashi Sakamoto

  8. Photo-Cross-Linkable Artificial Nucleic Acid: Synthesis and Properties of 3-Cyanovinylcarbazole-Modified Nucleic Acids and Its Photo-Induced Gene-Silencing Activity in Cells

    Article • January 2018, Springer Science + Business Media

    Dr Takashi Sakamoto

  9. Characterization of human telomere RNA G-quadruplex structures in vitro and in living cells using 19F NMR spectroscopy

    Article • Nucleic Acids Research, February 2017, Oxford University Press (OUP)

    Dr Takashi Sakamoto

  10. Effect of nucleobase change on cytosine deamination through DNA photo-cross-linking reaction via 3-cyanovinylcarbazole nucleoside

    Article • Molecular BioSystems, January 2017, Royal Society of Chemistry

    Dr Takashi Sakamoto

  11. RNA fluorescence in situ hybridization using 3-cyanovinylcarbazole modified oligodeoxyribonucleotides as photo-cross-linkable probes

    Article • Bioorganic & Medicinal Chemistry Letters, November 2016, Elsevier

    Dr Takashi Sakamoto

  12. UVA-responsive Anticancer Prodrugs Based on Photoinduced Electron Injection into Oligonucleotide Having 5-Halouracils

    Article • Chemistry Letters, September 2016, The Chemical Society of Japan

    Dr Takashi Sakamoto

  13. Simultaneous detection of single-nucleotide polymorphisms in a DNA bulge structure using a fluorine-modified bisbenzimide derivative

    Article • The Analyst, January 2016, Royal Society of Chemistry

    Dr Takashi Sakamoto

  14. Photo-Cross-Linking Reaction in Nucleic Acids: Chemistry and Applications

    Article • January 2016, Springer Science + Business Media

    Dr Takashi Sakamoto

  15. Critical Effect of Base Pairing of Target Pyrimidine on the Interstrand Photo-Cross-Linking of DNA via 3-Cyanovinylcarbazole Nucleoside

    Article • Bioconjugate Chemistry, August 2015, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  16. Changing Blue Fluorescent Protein to Green Fluorescent Protein Using Chemical RNA Editing as a Novel Strategy in Genetic Restoration

    Article • Chemical Biology & Drug Design, June 2015, Wiley

    Professor Toshifumi Tsukahara, Dr Takashi Sakamoto

  17. DNA Photo-Cross-Linking Using 3-Cyanovinylcarbazole Modified Oligonucleotide with Threoninol Linker

    Article • Organic Letters, February 2015, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  18. "takashi sakamoto"

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Dr Takashi Sakamoto

  19. Short oligonucleotide prodrug having 5-fluoro and 5-iodouracil inhibits the proliferation of cancer cells in a photo-responsive manner

    Article • Bioorganic & Medicinal Chemistry Letters, August 2014, Elsevier

    Dr Takashi Sakamoto

  20. Photo-regulation of constitutive gene expression in living cells by using ultrafast photo-cross-linking oligonucleotides

    Article • Biomaterials Science, January 2014, Royal Society of Chemistry

    Dr Takashi Sakamoto

  21. Details of the Ultrafast DNA Photo-Cross-Linking Reaction of 3-Cyanovinylcarbazole Nucleoside:Cis–TransIsomeric Effect and the Application for SNP-Based Genotyping

    Article • Journal of the American Chemical Society, October 2013, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  22. Geometric Effect on the Photocrosslinking Reaction between 3-Cyanovinylcarbazole Nucleoside and Pyrimidine Base in DNA/RNA Heteroduplex

    Article • Photochemistry and Photobiology, July 2013, Wiley

    Dr Takashi Sakamoto

  23. Quick, Selective and Reversible Photocrosslinking Reaction between 5-Methylcytosine and 3-Cyanovinylcarbazole in DNA Double Strand

    Article • International Journal of Molecular Sciences, March 2013, MDPI AG

    Dr Takashi Sakamoto

  24. Diamine Derivatives Accelerate Photochemical C → U Transition in DNA Double Strand

    Article • Chemistry Letters, March 2013, The Chemical Society of Japan

    Dr Takashi Sakamoto

  25. Quick and reversible photocrosslinking reaction of 3-cyanovinylcarbazole nucleoside in a DNA triplex

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Dr Takashi Sakamoto

  26. 5-Methylcytosine Selective Photoligation Using Photoresponsive Oligonucleotides Containing Various 5-Vinyl-2′-deoxyuridines Having an Aromatic Group

    Article • Chemistry Letters, January 2012, The Chemical Society of Japan

    Dr Takashi Sakamoto

  27. Quick regulation of mRNA functions by a few seconds of photoirradiation

    Article • Organic & Biomolecular Chemistry, January 2012, Royal Society of Chemistry

    Dr Takashi Sakamoto

  28. Specific and reversible photochemical labeling of plasmid DNA using photoresponsive oligonucleotides containing 3-cyanovinylcarbazole

    Article • Molecular BioSystems, January 2012, Royal Society of Chemistry

    Dr Takashi Sakamoto

  29. Development of a Potassium Ion Sensor for19F Magnetic Resonance Chemical Shift Imaging Based on Fluorine-labeled Thrombin Aptamer

    Article • Chemistry Letters, July 2011, The Chemical Society of Japan

    Dr Takashi Sakamoto

  30. Signal turn-on probe for nucleic acid detection based on 19F nuclear magnetic resonance

    Article • Bioorganic & Medicinal Chemistry Letters, January 2011, Elsevier

    Dr Takashi Sakamoto

  31. Site-Specific Cytosine to Uracil Transition by Using Reversible DNA Photo-crosslinking

    Article • ChemBioChem, July 2010, Wiley

    Dr Takashi Sakamoto

  32. Site-specific photochemical RNA editing

    Article • Chemical Communications, January 2010, Royal Society of Chemistry

    Dr Takashi Sakamoto

  33. Self-assembling nanoprobes that display off/on 19F nuclear magnetic resonance signals for protein detection and imaging

    Article • Nature Chemistry, September 2009, Springer Science + Business Media

    Dr Takashi Sakamoto

  34. Real-time fluorescence monitoring of GSK3β-catalyzed phosphoryation by use of a BODIPY-based Zn(II)–Dpa chemosensor

    Article • Bioorganic & Medicinal Chemistry Letters, August 2009, Elsevier

    Dr Takashi Sakamoto

  35. Fluorescent BODIPY-Based Zn(II) Complex as a Molecular Probe for Selective Detection of Neurofibrillary Tangles in the Brains of Alzheimer’s Disease Patients

    Article • Journal of the American Chemical Society, May 2009, American Chemical Society (ACS)

    Dr Takashi Sakamoto

  36. ChemInform Abstract: Molecular Recognition, Fluorescence Sensing, and Biological Assay of Phosphate Anion Derivatives Using Artificial Zn(II)-Dpa Complexes

    Article • ChemInform, April 2009, Wiley

    Dr Takashi Sakamoto

  37. Molecular recognition, fluorescence sensing, and biological assay of phosphate anion derivatives using artificial Zn(ii)–Dpa complexes

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Dr Takashi Sakamoto

  38. Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe

    Article • Bioorganic & Medicinal Chemistry Letters, April 2008, Elsevier

    Dr Takashi Sakamoto

  39. Homogeneous Fluorescence Assays for RNA Diagnosis by Pyrene-Conjugated 2′-O-Methyloligoribonucleotides

    Article • Nucleosides Nucleotides & Nucleic Acids, November 2007, Taylor & Francis

    Dr Takashi Sakamoto

  40. Transcriptome analysis device based on liquid phase detection by fluorescently labeled nucleic acid probes

    Article • Biomedical Microdevices, June 2007, Springer Science + Business Media

    Dr Takashi Sakamoto

  41. Real-time monitoring of antibody secretion from B-cells on a microchip stimulated with a minute amount of mitogen

    Article • The Analyst, January 2007, Royal Society of Chemistry

    Dr Takashi Sakamoto

  42. Monitoring Cellular Events in Living Mast Cells Stimulated with an Extremely Small Amount of Fluid on a Microchip

    Article • Japanese Journal of Applied Physics, June 2006, Japan Society of Applied Physics

    Dr Takashi Sakamoto

  43. Real-time monitoring of antibody secretion from hybridomas on a microchip by time-resolved luminescence anisotropy analysis

    Article • Analytical Biochemistry, June 2006, Elsevier

    Dr Takashi Sakamoto

  44. Evaluation of Dynamic Features of Escherichia coli 16S Ribosomal RNA in Homogeneous Physiological Solution

    Article • Biophysical Journal, December 2005, Elsevier

    Dr Takashi Sakamoto

  45. Analytical method for estimation of kinetics of oligonucleotide/RNA hybridization using fluorescence depolarization spectroscopy

    Article • Analytical Biochemistry, May 2005, Elsevier

    Dr Takashi Sakamoto

  46. Time-resolved luminescence anisotropy-based detection of immunoglobulin G using long-lifetime Ru(II) complex-labeled protein A

    Article • Analytical Biochemistry, June 2004, Elsevier

    Dr Takashi Sakamoto

  47. Detection of acceptor sites for antisense oligonucleotides on native folded RNA by fluorescence spectroscopy

    Article • Bioorganic & Medicinal Chemistry, July 2003, Elsevier

    Dr Takashi Sakamoto

  48. Bispyrene-Conjugated 2′-O-Methyloligonucleotide as a Highly Specific RNA-Recognition Probe

    Article • Angewandte Chemie, October 2002, Wiley

    Dr Takashi Sakamoto