All Stories

  1. Automated enzymatic hydrolysis of urine samples for improved systematic toxicological analysis of drug‐facilitated sexual assault cases

    Article • Drug Testing and Analysis, January 2024, Wiley

    Sys Stybe Johansen

  2. CCH attack frequency reduction after psilocybin correlates with hypothalamic functional connectivity

    Article • Headache The Journal of Head and Face Pain, January 2024, Wiley

    Sys Stybe Johansen

  3. Exploring Enzymatic Hydrolysis of Urine Samples for Investigation of Drugs Associated with Drug-Facilitated Sexual Assault

    Article • Pharmaceuticals, December 2023, MDPI AG

    Sys Stybe Johansen

  4. Uncovering forensic evidence of drug-facilitated sexual assault: Toxicological findings from Eastern Denmark from 2015–2022

    Article • Legal Medicine, November 2023, Elsevier

    Sys Stybe Johansen

  5. Detection of scopolamine in urine and hair in a drug-facilitated sexual assault

    Article • Forensic Science International, June 2023, Elsevier

    Sys Stybe Johansen

  6. Driving under the Influence of Amphetamine: Analytical Evaluation of Illegal or Prescription Drug Intake Using Chiral UHPLC–MS-MS

    Article • Journal of Analytical Toxicology, December 2022, Oxford University Press (OUP)

    Sys Stybe Johansen

  7. Improving analysis of urine samples from drug-facilitated sexual assault cases

    Article • Toxicologie Analytique et Clinique, September 2022, Elsevier

    Sys Stybe Johansen

  8. Psilocybin-induced reduction in chronic cluster headache attack frequency correlates with changes in hypothalamic functional connectivity

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Sys Stybe Johansen

  9. Concentrations of citalopram and escitalopram in postmortem hair segments

    Article • Forensic Science International, July 2022, Elsevier

    Sys Stybe Johansen

  10. A Systematic Review of Metabolite-to-Drug Ratios of Pharmaceuticals in Hair for Forensic Investigations

    Article • Metabolites, October 2021, MDPI AG

    Sys Stybe Johansen

  11. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

    Article • European Neuropsychopharmacology, September 2021, Elsevier

    Sys Stybe Johansen

  12. Hair cortisol concentrations in decedents with severe mental illness – An autopsy-based cohort study

    Article • Forensic Science International Reports, July 2021, Elsevier

    Sys Stybe Johansen

  13. Psilocybin-induced changes in brain network integrity and segregation correlate with plasma psilocin level and psychedelic experience

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Sys Stybe Johansen

  14. Effects of a single dose of psilocybin on behaviour, brain 5-HT2A receptor occupancy and gene expression in the pig

    Article • European Neuropsychopharmacology, January 2021, Elsevier

    Sys Stybe Johansen

  15. Concentrations of aripiprazole and dehydroaripiprazole in hair segments from deceased individuals with mental disorders

    Article • Forensic Science International, December 2020, Elsevier

    Sys Stybe Johansen

  16. Temporal patterns of tramadol in hair after a single dose

    Article • Forensic Science International, November 2020, Elsevier

    Sys Stybe Johansen

  17. Segmental hair analysis of olanzapine and N-desmethyl-olanzapine in postmortem hair from mentally ill patients by LC–MS/MS

    Article • Journal of Pharmaceutical and Biomedical Analysis, October 2020, Elsevier

    Sys Stybe Johansen

  18. Internal quality control samples for hair testing

    Article • Journal of Pharmaceutical and Biomedical Analysis, September 2020, Elsevier

    Sys Stybe Johansen

  19. In vitro and in vivo metabolism and detection of 3‐HO‐PCP, a synthetic phencyclidine, in human samples and pooled human hepatocytes using high resolution mass spectrometry

    Article • Drug Testing and Analysis, May 2020, Wiley

    Sys Stybe Johansen

  20. Postmortem Brain–Blood Ratios of Codeine, Fentanyl, Oxycodone and Tramadol

    Article • Journal of Analytical Toxicology, May 2020, Oxford University Press (OUP)

    Sys Stybe Johansen

  21. Ketamine analogues: Comparative toxicokinetic in vitro–in vivo extrapolation and quantification of 2-fluorodeschloroketamine in forensic blood and hair samples

    Article • Journal of Pharmaceutical and Biomedical Analysis, February 2020, Elsevier

    Sys Stybe Johansen

  22. Distribution of zopiclone and main metabolites in hair following a single dose

    Article • Forensic Science International, January 2020, Elsevier

    Sys Stybe Johansen

  23. Hair testing for cortisol by UPLC–MS/MS in a family: External cross-contamination from use of cortisol cream

    Article • Forensic Science International, December 2019, Elsevier

    Sys Stybe Johansen

  24. Brain-blood ratio of morphine in heroin and morphine autopsy cases

    Article • Forensic Science International, August 2019, Elsevier

    Sys Stybe Johansen

  25. Amitriptyline accumulation in tissues after coated activated charcoal hemoperfusion—a randomized controlled animal poisoning model

    Article • Naunyn-Schmiedeberg s Archives of Pharmacology, June 2019, Springer Science + Business Media

    Sys Stybe Johansen

  26. Identification of phenobarbital and other barbiturates in forensic drug screening using positive electrospray ionization liquid chromatography−high resolution mass spectrometry

    Article • Drug Testing and Analysis, May 2019, Wiley

    Sys Stybe Johansen

  27. Efficacy and safety of dantrolene in toxic hyperthermia: a systematic review

    Article • Journal of Toxicology Clinical Toxicology, April 2019, Taylor & Francis

    Dr Hugo Langlois, Sys Stybe Johansen

  28. Psychedelic effects of psilocybin correlate with serotonin 2A receptor occupancy and plasma psilocin levels

    Article • Neuropsychopharmacology, January 2019, Springer Science + Business Media

    Sys Stybe Johansen

  29. Postmortem Brain–Blood Ratios of Amphetamine, Cocaine, Ephedrine, MDMA and Methylphenidate

    Article • Journal of Analytical Toxicology, January 2019, Oxford University Press (OUP)

    Sys Stybe Johansen

  30. Psilocybin occupancy of brain serotonin 2A receptors correlates with psilocin levels and subjective experience: a [11C]Cimbi-36 PET study in humans

    Article • European Neuropsychopharmacology, January 2019, Elsevier

    Sys Stybe Johansen

  31. Retrospective analysis for valproate screening targets with liquid chromatography–high resolution mass spectrometry with positive electrospray ionization: An omics‐based approach

    Article • Drug Testing and Analysis, December 2018, Wiley

    Sys Stybe Johansen

  32. Fatal intoxications among non-drug addicts in Eastern Denmark over a 5-year period (2008–2012)

    Article • Research and Reports in Forensic Medical Science, December 2018, Dove Medical Press

    Sys Stybe Johansen

  33. Segmental Hair Analysis-Interpretation of the Time of Drug Intake in Two Patients Undergoing Drug Treatment

    Article • Journal of Forensic Sciences, October 2018, Wiley

    Sys Stybe Johansen

  34. Postmortem analysis of three methoxyacetylfentanyl-related deaths in Denmark and in vitro metabolite profiling in pooled human hepatocytes

    Article • Forensic Science International, September 2018, Elsevier

    Sys Stybe Johansen

  35. Segmental Analysis of Chlorprothixene and Desmethylchlorprothixene in Postmortem Hair

    Article • Journal of Analytical Toxicology, June 2018, Oxford University Press (OUP)

    Sys Stybe Johansen

  36. Reference Brain and Blood Concentrations of Olanzapine in Postmortem Cases

    Article • Journal of Analytical Toxicology, June 2018, Oxford University Press (OUP)

    Sys Stybe Johansen

  37. Definition and treatment of benzodiazepine-resistant ethanol withdrawal syndrome

    Article • Journal of Toxicology Clinical Toxicology, May 2018, Taylor & Francis

    Dr Hugo Langlois, Sys Stybe Johansen

  38. Hair analysis in toxicological investigation of drug-facilitated crimes in Denmark over a 8-year period

    Article • Forensic Science International, April 2018, Elsevier

    Sys Stybe Johansen

  39. Post-mortem quetiapine concentrations in hair segments of psychiatric patients — Correlation between hair concentration, dose and concentration in blood

    Article • Forensic Science International, April 2018, Elsevier

    Sys Stybe Johansen

  40. Validation of a fully automated solid‐phase extraction and ultra‐high‐performance liquid chromatography–tandem mass spectrometry method for quantification of 30 pharmaceuticals and metabolites in post‐mortem blood and brain samples

    Article • Drug Testing and Analysis, February 2018, Wiley

    Sys Stybe Johansen

  41. Reference Brain/Blood Concentrations of Citalopram, Duloxetine, Mirtazapine and Sertraline

    Article • Journal of Analytical Toxicology, December 2017, Oxford University Press (OUP)

    Sys Stybe Johansen

  42. Application of a screening method for fentanyl and its analogues using UHPLC‐QTOF‐MS with data‐independent acquisition (DIA) in MSE mode and retrospective analysis of authentic forensic blood samples

    Article • Drug Testing and Analysis, October 2017, Wiley

    Sys Stybe Johansen

  43. Advantages of analyzing postmortem brain samples in routine forensic drug screening—Case series of three non-natural deaths tested positive for lysergic acid diethylamide (LSD)

    Article • Forensic Science International, September 2017, Elsevier

    Sys Stybe Johansen

  44. Determination of GHB and GHB-β-O-glucuronide in hair of three narcoleptic patients—Comparison between single and chronic GHB exposure

    Article • Forensic Science International, September 2017, Elsevier

    Sys Stybe Johansen

  45. Enantioselective analysis of citalopram and demethylcitalopram in human whole blood by chiral LC-MS/MS and application in forensic cases

    Article • Drug Testing and Analysis, April 2017, Wiley

    Sys Stybe Johansen

  46. Simultaneous determination of ethanol's four types of non-oxidative metabolites in human whole blood by liquid chromatography tandem mass spectrometry

    Article • Analytica Chimica Acta, April 2017, Elsevier

    Sys Stybe Johansen

  47. Postmortem concentrations of gamma-hydroxybutyrate (GHB) in peripheral blood and brain tissue — Differentiating between postmortem formation and antemortem intake

    Article • Forensic Science International, March 2017, Elsevier

    Sys Stybe Johansen

  48. In vitro studies on flubromazolam metabolism and detection of its metabolites in authentic forensic samples

    Article • Drug Testing and Analysis, February 2017, Wiley

    Sys Stybe Johansen

  49. Detection of the antipsychotic drug quetiapine in the blood, urine and hair samples of the victim of a drug-facilitated sexual assault

    Article • Forensic Science International, January 2017, Elsevier

    Sys Stybe Johansen

  50. Gamma-Hydroxybutyrate (GHB) Content in Hair Samples Correlates Negatively with Age in Succinic Semialdehyde Dehydrogenase Deficiency

    Article • JIMD Reports, January 2017, Springer Science + Business Media

    Sys Stybe Johansen

  51. The significance of sampling time in therapeutic drug monitoring of clozapine

    Article • Acta Psychiatrica Scandinavica, December 2016, Wiley

    Sys Stybe Johansen

  52. Deposition of diazepam and its metabolites in hair following a single dose of diazepam

    Article • International Journal of Legal Medicine, August 2016, Springer Science + Business Media

    Sys Stybe Johansen

  53. Postmortem Brain and Blood Reference Concentrations of Alprazolam, Bromazepam, Chlordiazepoxide, Diazepam, and their Metabolites and a Review of the Literature

    Article • Journal of Analytical Toxicology, July 2016, Oxford University Press (OUP)

    Sys Stybe Johansen

  54. Sensitive, automatic method for the determination of diazepam and its five metabolites in human oral fluid by online solid-phase extraction and liquid chromatography with tandem mass spectrometry

    Article • Journal of Separation Science, May 2016, Wiley

    Sys Stybe Johansen

  55. Drug facilitated sexual assault with lethal outcome: GHB intoxication in a six-year-old girl

    Article • Forensic Science International, February 2016, Elsevier

    Sys Stybe Johansen

  56. Targeted analysis of 116 drugs in hair by UHPLC-MS/MS and its application to forensic cases

    Article • Drug Testing and Analysis, January 2016, Wiley

    Sys Stybe Johansen

  57. Development of a UPLC–MS/MS method for determining γ-hydroxybutyric acid (GHB) and GHB glucuronide concentrations in hair and application to forensic cases

    Article • Forensic Toxicology, July 2015, Springer Science + Business Media

    Sys Stybe Johansen

  58. Postmortem Quetiapine Reference Concentrations in Brain and Blood

    Article • Journal of Analytical Toxicology, July 2015, Oxford University Press (OUP)

    Sys Stybe Johansen

  59. Evaluation of poly-drug use in methadone-related fatalities using segmental hair analysis

    Article • Forensic Science International, March 2015, Elsevier

    Sys Stybe Johansen

  60. Stability of  -Hydroxybutyrate in Blood Samples from Impaired Drivers after Storage at 4 C and Comparison of GC-FID-GBL and LC-MS-MS Methods of Analysis

    Article • Journal of Analytical Toxicology, February 2015, Oxford University Press (OUP)

    Sys Stybe Johansen

  61. Postmortem Femoral Blood Reference Concentrations of Aripiprazole, Chlorprothixene, and Quetiapine

    Article • Journal of Analytical Toxicology, October 2014, Oxford University Press (OUP)

    Sys Stybe Johansen

  62. O6: Intoxications detected by hair analysis of bleached and non-bleached hair

    Article • Toxicologie Analytique et Clinique, June 2014, Elsevier

    Sys Stybe Johansen

  63. Pre-analytical and analytical variation of drug determination in segmented hair using ultra-performance liquid chromatography–tandem mass spectrometry

    Article • Forensic Science International, January 2014, Elsevier

    Sys Stybe Johansen

  64. Validation of a method for the targeted analysis of 96 drugs in hair by UPLC–MS/MS

    Article • Journal of Pharmaceutical and Biomedical Analysis, January 2014, Elsevier

    Sys Stybe Johansen

  65. Screening of Danish traffic cases for synthetic cannabinoids in whole blood by LC-MS/MS

    Article • Scandinavian Journal of Forensic Science, December 2013, De Gruyter

    Sys Stybe Johansen

  66. Postmortem Femoral Blood Concentrations of Risperidone

    Article • Journal of Analytical Toxicology, December 2013, Oxford University Press (OUP)

    Sys Stybe Johansen

  67. Evaluation of metabolite/drug ratios in blood and urine as a tool for confirmation of a reduced tolerance in methadone-related deaths in Denmark

    Article • Drug and Alcohol Dependence, December 2013, Elsevier

    Sys Stybe Johansen

  68. Screening for illicit and medicinal drugs in whole blood using fully automated SPE and ultra‐high‐performance liquid chromatography with TOF‐MS with data‐independent acquisition

    Article • Journal of Separation Science, June 2013, Wiley

    Sys Stybe Johansen

  69. Severe Methylphenidate Intoxication-Charcoal Hemoperfusion as an Aid in Treating the Patient

    Article • Journal of Clinical Toxicology, January 2013, OMICS Publishing Group

    Sys Stybe Johansen

  70. Simultaneous Determination of 25 Common Pharmaceuticals in Whole Blood Using Ultra-Performance Liquid Chromatography-Tandem Mass Spectrometry

    Article • Journal of Analytical Toxicology, June 2012, Oxford University Press (OUP)

    Sys Stybe Johansen

  71. Fatal intoxications among non-drug addicts in Eastern Denmark over a five-year period (2003–2007)

    Article • Research and Reports in Forensic Medical Science, June 2012, Taylor & Francis

    Sys Stybe Johansen

  72. In vitro metabolism studies on mephedrone and analysis of forensic cases

    Article • Drug Testing and Analysis, May 2012, Wiley

    Sys Stybe Johansen

  73. Isomers of fluoroamphetamines detected in forensic cases in Denmark

    Article • International Journal of Legal Medicine, January 2012, Springer Science + Business Media

    Sys Stybe Johansen

  74. Distribution Patterns, Dermatomal Anesthesia, and Ropivacaine Serum Concentrations After Bilateral Dual Transversus Abdominis Plane Block

    Article • Regional Anesthesia & Pain Medicine, January 2012, BMJ

    Sys Stybe Johansen

  75. A drug rape case involving triazolam detected in hair and urine

    Article • International Journal of Legal Medicine, December 2011, Springer Science + Business Media

    Sys Stybe Johansen

  76. In Vivo Imaging of Cerebral Serotonin Transporter and Serotonin2A Receptor Binding in 3,4-Methylenedioxymethamphetamine (MDMA or “Ecstasy”) and Hallucinogen Users

    Article • Archives of General Psychiatry, June 2011, American Medical Association (AMA)

    Sys Stybe Johansen

  77. Postmortem Femoral Blood Concentrations of Amlodipine

    Article • Journal of Analytical Toxicology, May 2011, Oxford University Press (OUP)

    Sys Stybe Johansen

  78. Simultaneous Determination of γ-Hydroxybutyrate (GHB) and its Analogues (GBL, 1.4-BD, GVL) in Whole Blood and Urine by Liquid Chromatography Coupled to Tandem Mass Spectrometry

    Article • Journal of Analytical Toxicology, January 2011, Oxford University Press (OUP)

    Sys Stybe Johansen

  79. Postmortem Blood Concentrations of R‐ and S‐Enantiomers of Methadone and EDDP in Drug Users: Influence of Co‐Medication and P‐glycoprotein Genotype

    Article • Journal of Forensic Sciences, March 2010, Wiley

    Sys Stybe Johansen

  80. Simultaneous screening and quantification of 52 common pharmaceuticals and drugs of abuse in hair using UPLC–TOF-MS

    Article • Forensic Science International, March 2010, Elsevier

    Sys Stybe Johansen

  81. Determination of Olanzapine in Whole Blood Using Simple Protein Precipitation and Liquid Chromatography-Tandem Mass Spectrometry

    Article • Journal of Analytical Toxicology, May 2009, Oxford University Press (OUP)

    Sys Stybe Johansen

  82. Determination of amphetamine, methamphetamine, MDA and MDMA in human hair by GC‐EI‐MS after derivatization with perfluorooctanoyl chloride

    Article • Scandinavian Journal of Clinical and Laboratory Investigation, January 2009, Taylor & Francis

    Sys Stybe Johansen

  83. Chiral Analysis of Methadone and its Main Metabolite EDDP in Postmortem Blood by Liquid Chromatography-Mass Spectrometry

    Article • Journal of Analytical Toxicology, September 2008, Oxford University Press (OUP)

    Sys Stybe Johansen

  84. Dominance of pre-analytical over analytical variation for measurement of methadone and its main metabolite in postmortem femoral blood

    Article • Forensic Science International, July 2008, Elsevier

    Sys Stybe Johansen

  85. Quantitative analysis of cocaine and its metabolites in whole blood and urine by high-performance liquid chromatography coupled with tandem mass spectrometry

    Article • Journal of Chromatography B, June 2007, Elsevier

    Sys Stybe Johansen

  86. Chiral separation and quantification of R/S-amphetamine, R/S-methamphetamine, R/S-MDA, R/S-MDMA, and R/S-MDEA in whole blood by GC-EI-MS

    Article • Journal of Chromatography B, October 2006, Elsevier

    Sys Stybe Johansen

  87. Liquid chromatography–tandem mass spectrometry determination of LSD, ISO-LSD, and the main metabolite 2-oxo-3-hydroxy-LSD in forensic samples and application in a forensic case

    Article • Journal of Chromatography B, October 2005, Elsevier

    Sys Stybe Johansen

  88. Drugs in injured drivers in Denmark

    Article • Forensic Science International, June 2005, Elsevier

    Sys Stybe Johansen

  89. AMP kinase expression and activity in human skeletal muscle: effects of immobilization, retraining, and creatine supplementation

    Article • Journal of Applied Physiology, April 2005, American Physiological Society

    Sys Stybe Johansen

  90. Liquid chromatography?tandem mass spectrometry determination of loperamide and its main metabolite desmethylloperamide in biological specimens and application to forensic cases

    Article • Journal of Chromatography B, November 2004, Elsevier

    Sys Stybe Johansen

  91. A fatal overdose of the ergot derivative cabergoline

    Article • Forensic Science International, November 2004, Elsevier

    Sys Stybe Johansen

  92. A fatal case of amlodipine poisoning

    Article • Journal of Clinical Forensic Medicine, September 2003, Elsevier

    Sys Stybe Johansen

  93. Fatal overdose of the herbicide bentazone

    Article • Forensic Science International, August 2003, Elsevier

    Sys Stybe Johansen

  94. Three Fatal Cases of PMA and PMMA Poisoning in Denmark

    Article • Journal of Analytical Toxicology, May 2003, Oxford University Press (OUP)

    Sys Stybe Johansen

  95. Metabolic pathways of quinoline, indole and their methylated analogs by Desulfobacterium indolicum (DSM 3383)

    Article • Applied Microbiology and Biotechnology, March 1997, Springer Science + Business Media

    Sys Stybe Johansen

  96. Transformation of indole and quinoline by Desulfobacterium indolicum (DSM 3383)

    Article • Applied Microbiology and Biotechnology, February 1997, Springer Science + Business Media

    Sys Stybe Johansen

  97. DEGRADATION PATHWAY OF QUINOLINES IN A BIOFILM SYSTEM UNDER DENITRIFYING CONDITIONS

    Article • Environmental Toxicology and Chemistry, January 1997, Wiley

    Sys Stybe Johansen

  98. Method development for trace analysis of heteroaromatic compounds in contaminated groundwater

    Article • Journal of Chromatography A, July 1996, Elsevier

    Sys Stybe Johansen

  99. Comparison of high-performance liquid chromatographic methods for the determination of 1,2-dibromo-2,4-dicyanobutane in cosmetic products

    Article • Journal of Chromatography A, February 1995, Elsevier

    Sys Stybe Johansen