All Stories

  1. Targeting carboxypeptidase A/B activity with the phosphinic inhibitor C28 reduces the asthmatic response in a mouse model of house dust mite-induced asthma

    Article • Inflammation Research, May 2025, Springer Science + Business Media

    PhD Julia Lorenzo, Dr Srinivas Akula

  2. Characterization of Freshly Isolated Human Peripheral Blood B Cells, Monocytes, CD4+ and CD8+ T Cells, and Skin Mast Cells by Quantitative Transcriptomics

    Article • International Journal of Molecular Sciences, December 2024, MDPI AG

    Dr Srinivas Akula

  3. Exploring a pico-well based scRNA-seq method (HIVE) for simplified processing of equine bronchoalveolar lavage cells

    Article • November 2024, Cold Spring Harbor Laboratory Press

    Dr Srinivas Akula

  4. Monensin Suppresses Multiple Features of House Dust Mite-Induced Experimental Asthma in Mice

    Article • Inflammation, July 2024, Springer Science + Business Media

    Dr Srinivas Akula

  5. Disruption of the mast cell carboxypeptidase A3 gene does not attenuate airway inflammation and hyperresponsiveness in two mouse models of asthma

    Article • PLOS One, April 2024, PLOS

    Dr Srinivas Akula

  6. Extended Cleavage Specificity of two Hematopoietic Serine Proteases from a Ray-Finned Fish, the Spotted Gar (Lepisosteus oculatus)

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Dr Srinivas Akula

  7. Cultures of Human Skin Mast Cells, an Attractive In Vitro Model for Studies of Human Mast Cell Biology

    Article • Cells, January 2024, MDPI AG

    Dr Srinivas Akula

  8. The Extended Cleavage Specificity of Channel Catfish Granzyme-like II, A Highly Specific Elastase, Expressed by Natural Killer-like Cells

    Article • International Journal of Molecular Sciences, December 2023, MDPI AG

    Dr Srinivas Akula

  9. Identification of the Major Protein Components of Human and Cow Saliva

    Article • International Journal of Molecular Sciences, November 2023, MDPI AG

    Dr Srinivas Akula

  10. Two granzyme A/K homologs in Zebra mbuna have different specificities, one classical tryptase and one with chymase activity

    Article • Developmental & Comparative Immunology, November 2023, Elsevier

    Dr Srinivas Akula

  11. Single-cell transcriptomics delineates the immune cell landscape in equine lower airways and reveals upregulation of FKBP5 in horses with asthma

    Article • Scientific Reports, September 2023, Springer Science + Business Media

    Dr Srinivas Akula

  12. Extended cleavage specificities of human granzymes A and K, two closely related enzymes with conserved but still poorly defined functions in T and NK cell-mediated immunity

    Article • Frontiers in Immunology, July 2023, Frontiers

    Dr Srinivas Akula

  13. Nafamostat has anti-asthmatic effects associated with suppressed pro-inflammatory gene expression, eosinophil infiltration and airway hyperreactivity

    Article • Frontiers in Immunology, April 2023, Frontiers

    Dr Srinivas Akula

  14. Quantitative Transcriptome Analysis of Purified Equine Mast Cells Identifies a Dominant Mucosal Mast Cell Population with Possible Inflammatory Functions in Airways of Asthmatic Horses

    Article • International Journal of Molecular Sciences, November 2022, MDPI AG

    Dr Srinivas Akula

  15. Mast Cell and Basophil Granule Proteases - In Vivo Targets and Function

    Article • Frontiers in Immunology, July 2022, Frontiers

    Dr Srinivas Akula

  16. Quantitative Analysis of the Transcriptome of Two Commonly Used Human Monocytic Cell Lines—THP-1 and Mono Mac 6—Reveals Their Arrest during Early Monocyte/Neutrophil Differentiation

    Article • International Journal of Molecular Sciences, May 2022, MDPI AG

    Dr Srinivas Akula

  17. Chicken cathepsin G-like - A highly specific serine protease with a peculiar tryptase specificity expressed by chicken thrombocytes

    Article • Developmental & Comparative Immunology, April 2022, Elsevier

    Dr Srinivas Akula

  18. The Human Monocyte—A Circulating Sensor of Infection and a Potent and Rapid Inducer of Inflammation

    Article • International Journal of Molecular Sciences, March 2022, MDPI AG

    Dr Srinivas Akula

  19. Extended cleavage specificity of a Chinese alligator granzyme B homologue, a strict Glu-ase in contrast to the mammalian Asp-ases

    Article • Developmental & Comparative Immunology, March 2022, Elsevier

    Dr Srinivas Akula

  20. Analysis of the mast cell expressed carboxypeptidase A3 and its structural and evolutionary relationship to other vertebrate carboxypeptidases

    Article • Developmental & Comparative Immunology, February 2022, Elsevier

    Dr Srinivas Akula

  21. Quantitative In-Depth Transcriptome Analysis Implicates Peritoneal Macrophages as Important Players in the Complement and Coagulation Systems

    Article • International Journal of Molecular Sciences, January 2022, MDPI AG

    Dr Srinivas Akula

  22. Mast Cells and Basophils in the Defense against Ectoparasites: Efficient Degradation of Parasite Anticoagulants by the Connective Tissue Mast Cell Chymases

    Article • International Journal of Molecular Sciences, November 2021, MDPI AG

    Dr Srinivas Akula

  23. The Evolutionary History of the Chymase Locus -a Locus Encoding Several of the Major Hematopoietic Serine Proteases

    Article • International Journal of Molecular Sciences, October 2021, MDPI AG

    Dr Srinivas Akula

  24. Duodenases are a small subfamily of ruminant intestinal serine proteases that have undergone a remarkable diversification in cleavage specificity

    Article • PLOS One, May 2021, PLOS

    Dr Srinivas Akula

  25. Marked difference in efficiency of the digestive enzymes pepsin, trypsin, chymotrypsin, and pancreatic elastase to cleave tightly folded proteins

    Article • Biological Chemistry, May 2021, De Gruyter

    Dr Srinivas Akula

  26. Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells

    Article • International Journal of Molecular Sciences, November 2020, MDPI AG

    Dr Srinivas Akula

  27. Mouse Strain-Dependent Difference Toward the Staphylococcus aureus Allergen Serine Protease-Like Protein D Reveals a Novel Regulator of IL-33

    Article • Frontiers in Immunology, September 2020, Frontiers

    Dr Srinivas Akula

  28. How Relevant Are Bone Marrow-Derived Mast Cells (BMMCs) as Models for Tissue Mast Cells? A Comparative Transcriptome Analysis of BMMCs and Peritoneal Mast Cells

    Article • Cells, September 2020, MDPI AG

    Dr Srinivas Akula

  29. Protective role of mouse mast cell tryptase Mcpt6 in melanoma

    Article • Pigment Cell & Melanoma Research, January 2020, Wiley

    Dr Srinivas Akula

  30. Potent and Broad but not Unselective Cleavage of Cytokines and Chemokines by Human Neutrophil Elastase and Proteinase 3

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Dr Srinivas Akula

  31. Quantitative In-Depth Analysis of the Mouse Mast Cell Transcriptome Reveals Organ-Specific Mast Cell Heterogeneity

    Article • Cells, January 2020, MDPI AG

    Dr Srinivas Akula

  32. Extended Cleavage Specificities of Two Mast Cell Chymase-Related Proteases and One Granzyme B-Like Protease from the Platypus, a Monotreme

    Article • International Journal of Molecular Sciences, January 2020, MDPI AG

    Dr Srinivas Akula

  33. Extended Cleavage Specificities of Rabbit and Guinea Pig Mast Cell Chymases: Two Highly Specific Leu-Ases

    Article • International Journal of Molecular Sciences, December 2019, MDPI AG

    Dr Srinivas Akula

  34. Highly Selective Cleavage of TH2-Promoting Cytokines by the Human and the Mouse Mast Cell Tryptases, Indicating a Potent Negative Feedback Loop on TH2 Immunity

    Article • International Journal of Molecular Sciences, October 2019, MDPI AG

    Dr Srinivas Akula

  35. Extended cleavage specificity of sheep mast cell protease-2: A classical chymase with preference to aromatic P1 substrate residues

    Article • Developmental & Comparative Immunology, March 2019, Elsevier

    Dr Srinivas Akula

  36. Extended cleavage specificities of mast cell proteases 1 and 2 from golden hamster: Classical chymase and an elastolytic protease comparable to rat and mouse MCP-5

    Article • PLOS One, December 2018, PLOS

    Dr Srinivas Akula

  37. Extended Cleavage Specificity of Human Neutrophil Elastase, Human Proteinase 3, and Their Distant Ortholog Clawed Frog PR3—Three Elastases With Similar Primary but Different Extended Specificities and Stability

    Article • Frontiers in Immunology, October 2018, Frontiers

    Dr Srinivas Akula

  38. Extended cleavage specificity of human neutrophil cathepsin G: A low activity protease with dual chymase and tryptase-type specificities

    Article • PLOS One, April 2018, PLOS

    Dr Srinivas Akula

  39. Tracing the Origins of IgE, Mast Cells, and Allergies by Studies of Wild Animals

    Article • Frontiers in Immunology, December 2017, Frontiers

    Dr Srinivas Akula

  40. The Appearance and Diversification of Receptors for IgM During Vertebrate Evolution

    Article • January 2017, Springer Science + Business Media

    Dr Srinivas Akula

  41. Channel catfish granzyme-like I is a highly specific serine protease with metase activity that is expressed by fish NK-like cells

    Article • Developmental & Comparative Immunology, October 2016, Elsevier

    Dr Srinivas Akula

  42. Asp-ase Activity of the Opossum Granzyme B Supports the Role of Granzyme B as Part of Anti-Viral Immunity Already during Early Mammalian Evolution

    Article • PLOS One, May 2016, PLOS

    Dr Srinivas Akula

  43. Granule Associated Serine Proteases of Hematopoietic Cells – An Analysis of Their Appearance and Diversification during Vertebrate Evolution

    Article • PLOS One, November 2015, PLOS

    Dr Srinivas Akula

  44. Fc Receptors for Immunoglobulins and Their Appearance during Vertebrate Evolution

    Article • PLOS One, May 2014, PLOS

    Dr Srinivas Akula