All Stories

  1. Innate immune sensing of dietary alcohol ignites inflammation to drive alcohol-related disease

    Article • Science Advances, April 2026, American Association for the Advancement of Science

    Si Ming Man

  2. Multifaceted roles of the NLRC4 inflammasome in cancer: from molecular mechanisms to therapeutic implications

    Article • Journal of Molecular Biology, April 2026, Elsevier

    Si Ming Man

  3. Mitoxyperilysis: fasting-induced cell death in immunometabolism and disease

    Article • Trends in Biochemical Sciences, March 2026, Elsevier

    Si Ming Man

  4. ALPK1 agonists ignite innate immunity in anticancer therapy

    Article • Trends in Cancer, February 2026, Elsevier

    Si Ming Man

  5. Inflammation and cell death drive Monkeypox-induced viral pathogenesis

    Article • Cellular and Molecular Immunology, December 2025, Springer Science + Business Media

    Si Ming Man

  6. A potent NLRP3 inhibitor effective against both MCC950-sensitive and -resistant inflammation

    Article • Cell Chemical Biology, September 2025, Elsevier

    Si Ming Man

  7. Cardiolipin inhibits the non-canonical inflammasome by preventing LPS binding to caspase-4/11

    Article • The EMBO Journal, July 2025, Springer Science + Business Media

    Si Ming Man

  8. Ferroptosis-activating metabolite acrolein antagonizes necroptosis and anti-cancer therapeutics

    Article • Nature Communications, May 2025, Springer Science + Business Media

    Si Ming Man

  9. Protocol for the processing, cryopreservation, and biobanking of patient-derived cells and tissues

    Article • STAR Protocols, December 2024, Elsevier

    Si Ming Man

  10. Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii

    Article • Communications Biology, November 2024, Springer Science + Business Media

    Si Ming Man

  11. Cardiolipin Inhibits the Noncanonical Inflammasome by Preventing LPS Binding to Caspase 4/11 to Mitigate Endotoxemia in Vivo

    Article • October 2024, Cold Spring Harbor Laboratory Press

    Si Ming Man

  12. Inflammasome protein scaffolds the DNA damage complex during tumor development

    Article • Nature Immunology, October 2024, Springer Science + Business Media

    Si Ming Man

  13. Molecular mechanisms of emerging inflammasome complexes and their activation and signaling in inflammation and pyroptosis

    Article • Immunological Reviews, October 2024, Wiley

    Si Ming Man

  14. Author Correction: Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration

    Article • Scientific Reports, September 2024, Springer Science + Business Media

    Si Ming Man

  15. Innate immune sensing of cell death in disease and therapeutics

    Article • Nature Cell Biology, September 2024, Springer Science + Business Media

    Si Ming Man

  16. Mouse guanylate-binding proteins of the chromosome 3 cluster do not mediate antiviral activity in vitro or in mouse models of infection

    Article • Communications Biology, August 2024, Springer Science + Business Media

    Si Ming Man

  17. NLRC5 PANoptosome: Aquaman of the Dead Sea

    Article • BDJ, August 2024, Springer Science + Business Media

    Si Ming Man

  18. A TNIP1-driven systemic autoimmune disorder with elevated IgG4

    Article • Nature Immunology, July 2024, Springer Science + Business Media

    Si Ming Man

  19. NCF4 attenuates colorectal cancer progression by modulating inflammasome activation and immune surveillance

    Article • Nature Communications, June 2024, Springer Science + Business Media

    Si Ming Man

  20. Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome

    Article • The Journal of Immunology, May 2024, Oxford University Press (OUP)

    Si Ming Man

  21. Profiling the colonic mucosal response to fecal microbiota transplantation identifies a role for GBP5 in colitis in humans and mice

    Article • Nature Communications, March 2024, Springer Science + Business Media

    Si Ming Man

  22. Interferon signalling and non-canonical inflammasome activation promote host protection against multidrug-resistant Acinetobacter baumannii

    Article • January 2024, Springer Science + Business Media

    Si Ming Man

  23. Ku70 senses cytosolic DNA and assembles a tumor-suppressive signalosome

    Article • Science Advances, January 2024, American Association for the Advancement of Science

    Si Ming Man

  24. DECTIN-1: A modifier protein in CTLA-4 haploinsufficiency

    Article • Science Advances, December 2023, American Association for the Advancement of Science

    Si Ming Man

  25. A High-Throughput Screen Identifies New Drugs for the Treatment of Lymphoma

    Article • Blood, November 2023, American Society of Hematology

    Si Ming Man

  26. Impairing Gasdermin D-mediated pyroptosis is protective against retinal degeneration

    Article • Journal of Neuroinflammation, October 2023, Springer Science + Business Media

    Si Ming Man

  27. Guanylate-binding proteins: mechanisms of pattern recognition and antimicrobial functions

    Article • Trends in Biochemical Sciences, October 2023, Elsevier

    Si Ming Man

  28. Clostridium perfringens virulence factors are nonredundant activators of the NLRP3 inflammasome

    Article • EMBO Reports, April 2023, Springer Science + Business Media

    Si Ming Man

  29. Cell death and barrier disruption by clinically used iodine concentrations

    Article • Life Science Alliance, March 2023, Life Science Alliance, LLC

    Si Ming Man

  30. Mouse guanylate‐binding protein 1 does not mediate antiviral activity against influenza virus in vitro or in vivo

    Article • Immunology and Cell Biology, February 2023, Wiley

    Si Ming Man

  31. Immunity against Moraxella catarrhalis requires guanylate‐binding proteins and caspase‐11‐ NLRP3 inflammasomes

    Article • The EMBO Journal, February 2023, Springer Science + Business Media

    Si Ming Man

  32. Primary Intestinal Fibroblasts: Isolation, Cultivation, and Maintenance

    Article • January 2023, Springer Science + Business Media

    Si Ming Man

  33. Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

    Article • PLOS One, November 2022, PLOS

    Si Ming Man

  34. GBP1 promotes killing of multidrug-resistantAcinetobacter baumanniiand promotes host protection via interferon signalling and inflammasome activation

    Article • October 2022, Cold Spring Harbor Laboratory Press

    Si Ming Man

  35. Peer Review Week 2022: an interview with Rafal Marszalek, Si Ming Man and Guideng Li about their views on research integrity as scientists and editors

    Article • Communications Biology, September 2022, Springer Science + Business Media

    Si Ming Man

  36. Plasma cells arise from differentiation of clonal lymphocytes and secrete IgM in Waldenström macroglobulinemia

    Article • iScience, August 2022, Elsevier

    Si Ming Man

  37. Pathogen-selective killing by guanylate-binding proteins as a molecular mechanism leading to inflammasome signaling

    Article • Nature Communications, July 2022, Springer Science + Business Media

    Si Ming Man

  38. Clostridium septicum α-toxin activates the NLRP3 inflammasome by engaging GPI-anchored proteins

    Article • Science Immunology, May 2022, American Association for the Advancement of Science

    Si Ming Man

  39. Gallium–Strontium Phosphate Conversion Coatings for Promoting Infection Prevention and Biocompatibility of Magnesium for Orthopedic Applications

    Article • ACS Biomaterials Science & Engineering, May 2022, American Chemical Society (ACS)

    Si Ming Man

  40. Mpeg1 is not essential for antibacterial or antiviral immunity, but is implicated in antigen presentation

    Article • Immunology and Cell Biology, May 2022, Wiley

    Si Ming Man

  41. Differential activation of NLRP3 inflammasome by Acinetobacter baumannii strains

    Article • May 2022, Cold Spring Harbor Laboratory Press

    Si Ming Man

  42. Streptococcus makes the cut: Gasdermin A-induced pyroptosis

    Article • Cell Host & Microbe, April 2022, Elsevier

    Si Ming Man

  43. Context-dependent functions of pattern recognition receptors in cancer

    Article • Nature Reviews Drug Discovery, March 2022, Springer Science + Business Media

    Si Ming Man

  44. Interferon-γ primes macrophages for pathogen ligand-induced killing via a caspase-8 and mitochondrial cell death pathway

    Article • Immunity, March 2022, Elsevier

    Arfatur Rahman, Si Ming Man

  45. Cell biology of inflammasome activation

    Article • Trends in Cell Biology, November 2021, Elsevier

    Si Ming Man

  46. Viperin has species-specific roles in response to herpes simplex virus infection

    Article • Journal of General Virology, August 2021, Society for General Microbiology

    Si Ming Man

  47. Multi-omics of the esophageal microenvironment identifies signatures associated with progression of Barrett’s esophagus

    Article • Genome Medicine, August 2021, Springer Science + Business Media

    Si Ming Man

  48. Bacillus cereus: Epidemiology, Virulence Factors, and Host–Pathogen Interactions

    Article • Trends in Microbiology, May 2021, Elsevier

    Si Ming Man

  49. Activation mechanisms of inflammasomes by bacterial toxins

    Article • Cellular Microbiology, January 2021, Wiley

    Si Ming Man

  50. Publisher Correction: Captain GBP1: inflammasomes assemble, pyroptotic endgame

    Article • Nature Immunology, September 2020, Springer Science + Business Media

    Si Ming Man

  51. Molecular mechanisms activating the NAIP‐NLRC4 inflammasome: Implications in infectious disease, autoinflammation, and cancer

    Article • Immunological Reviews, July 2020, Wiley

    Si Ming Man

  52. Captain GBP1: inflammasomes assemble, pyroptotic endgame

    Article • Nature Immunology, July 2020, Springer Science + Business Media

    Si Ming Man

  53. MicroRNA-223 Regulates Retinal Function and Inflammation in the Healthy and Degenerating Retina

    Article • Frontiers in Cell and Developmental Biology, June 2020, Frontiers

    Si Ming Man

  54. Gasdermins deliver a deadly punch to cancer

    Article • BDJ, April 2020, Springer Science + Business Media

    Si Ming Man

  55. Caspase-1-dependent inflammasomes mediate photoreceptor cell death in photo-oxidative damage-induced retinal degeneration

    Article • Scientific Reports, February 2020, Springer Science + Business Media

    Si Ming Man

  56. Bacillus cereus non-haemolytic enterotoxin activates the NLRP3 inflammasome

    Article • Nature Communications, February 2020, Springer Science + Business Media

    Si Ming Man

  57. The Ribosomal Biogenesis Inhibitor CX-5461 Is an Anti-Cancer Therapeutic That Increases Platelet Count in Mice and in Humans

    Article • Blood, November 2019, American Society of Hematology

    Si Ming Man

  58. Emerging Activators and Regulators of Inflammasomes and Pyroptosis

    Article • Trends in Immunology, November 2019, Elsevier

    Si Ming Man

  59. DDX3X: stressing the NLRP3 inflammasome

    Article • BDJ, October 2019, Springer Science + Business Media

    Si Ming Man

  60. IL-1 Family Members Mediate Cell Death, Inflammation and Angiogenesis in Retinal Degenerative Diseases

    Article • Frontiers in Immunology, July 2019, Frontiers

    Si Ming Man

  61. A multicomponent toxin from Bacillus cereus incites inflammation and shapes host outcome via the NLRP3 inflammasome

    Article • Nature Microbiology, December 2018, Springer Science + Business Media

    Dr. Kristina Schauer, Si Ming Man

  62. The Mitochondrial Apoptotic Effectors BAX/BAK Activate Caspase-3 and -7 to Trigger NLRP3 Inflammasome and Caspase-8 Driven IL-1β Activation

    Article • Cell Reports, November 2018, Elsevier

    Si Ming Man

  63. ALPK1: innate attraction to the sweetness of bacteria

    Article • BDJ, October 2018, Springer Science + Business Media

    Si Ming Man

  64. Cytosolic Recognition of Microbes and Pathogens: Inflammasomes in Action

    Article • Microbiology and Molecular Biology Reviews, September 2018, ASM Journals

    Si Ming Man

  65. Inflammasomes in the gastrointestinal tract: infection, cancer and gut microbiota homeostasis

    Article • Nature Reviews Gastroenterology & Hepatology, September 2018, Springer Science + Business Media

    Si Ming Man

  66. Mechanisms of Gasdermin Family Members in Inflammasome Signaling and Cell Death

    Article • Journal of Molecular Biology, September 2018, Elsevier

    Si Ming Man

  67. Detrimental Type I Interferon Signaling Dominates Protective AIM2 Inflammasome Responses during Francisella novicida Infection

    Article • Cell Reports, March 2018, Elsevier

    Si Ming Man

  68. Mechanisms and functions of guanylate-binding proteins and related interferon-inducible GTPases: Roles in intracellular lysis of pathogens

    Article • Cellular Microbiology, October 2017, Wiley

    Si Ming Man

  69. Molecular mechanisms of inflammasome signaling

    Article • Journal of Leukocyte Biology, August 2017, Wiley

    Si Ming Man

  70. NLRP9b: a novel RNA-sensing inflammasome complex

    Article • BDJ, July 2017, Springer Science + Business Media

    Si Ming Man

  71. Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases

    Article • Immunological Reviews, April 2017, Wiley

    Si Ming Man

  72. Differential roles of caspase-1 and caspase-11 in infection and inflammation

    Article • Scientific Reports, March 2017, Springer Science + Business Media

    Si Ming Man

  73. Inflammasomes and Cancer

    Article • Cancer Immunology Research, January 2017, American Association for Cancer Research (AACR)

    Si Ming Man

  74. NLRC3 is an inhibitory sensor of PI3K–mTOR pathways in cancer

    Article • Nature, December 2016, Springer Science + Business Media

    Si Ming Man

  75. Regulation of lysosomal dynamics and autophagy by CTSB/cathepsin B

    Article • Autophagy, October 2016, Taylor & Francis

    Si Ming Man

  76. IRGB10 Liberates Bacterial Ligands for Sensing by the AIM2 and Caspase-11-NLRP3 Inflammasomes

    Article • Cell, October 2016, Elsevier

    Si Ming Man

  77. Cathepsin B modulates lysosomal biogenesis and host defense against Francisella novicida infection

    Article • Journal of Experimental Medicine, August 2016, Rockefeller University Press

    Si Ming Man

  78. ZBP1/DAI is an innate sensor of influenza virus triggering the NLRP3 inflammasome and programmed cell death pathways

    Article • Science Immunology, August 2016, American Association for the Advancement of Science

    Dr Peter Vogel, Si Ming Man

  79. Interferon-inducible guanylate-binding proteins at the interface of cell-autonomous immunity and inflammasome activation

    Article • Journal of Leukocyte Biology, July 2016, Wiley

    Si Ming Man

  80. DOCK2 confers immunity and intestinal colonization resistance to Citrobacter rodentium infection

    Article • Scientific Reports, June 2016, Springer Science + Business Media

    Si Ming Man

  81. DNA-sensing inflammasomes: regulation of bacterial host defense and the gut microbiota

    Article • Pathogens and Disease, April 2016, Oxford University Press (OUP)

    Si Ming Man

  82. Type I Interferon Keeps IL-1β in Check

    Article • Cell Host & Microbe, March 2016, Elsevier

    Si Ming Man

  83. AIM2 inflammasome in infection, cancer, and autoimmunity: Role in DNA sensing, inflammation, and innate immunity

    Article • European Journal of Immunology, December 2015, Wiley

    Si Ming Man

  84. Converging roles of caspases in inflammasome activation, cell death and innate immunity

    Article • Nature Reviews Immunology, December 2015, Springer Science + Business Media

    Si Ming Man

  85. Gasdermin D: the long-awaited executioner of pyroptosis

    Article • BDJ, October 2015, Springer Science + Business Media

    Si Ming Man

  86. Is Campylobacter to esophageal adenocarcinoma as Helicobacter is to gastric adenocarcinoma?

    Article • Trends in Microbiology, August 2015, Elsevier

    Si Ming Man

  87. Critical Role for the DNA Sensor AIM2 in Stem Cell Proliferation and Cancer

    Article • Cell, July 2015, Elsevier

    Ankit Malik, Si Ming Man

  88. Global Epidemiology of Campylobacter Infection

    Article • Clinical Microbiology Reviews, June 2015, ASM Journals

    Si Ming Man

  89. A20 is a regulator of necroptosis

    Article • Nature Immunology, June 2015, Springer Science + Business Media

    Si Ming Man

  90. Regulation of inflammasome activation

    Article • Immunological Reviews, April 2015, Wiley

    Si Ming Man

  91. The transcription factor IRF1 and guanylate-binding proteins target activation of the AIM2 inflammasome by Francisella infection

    Article • Nature Immunology, March 2015, Springer Science + Business Media

    Si Ming Man

  92. Concerted Activation of the AIM2 and NLRP3 Inflammasomes Orchestrates Host Protection against Aspergillus Infection

    Article • Cell Host & Microbe, March 2015, Elsevier

    Si Ming Man

  93. Campylobacter

    Article • January 2015, Elsevier

    Si Ming Man

  94. Transcriptomic and Proteomic Analyses Reveal Key Innate Immune Signatures in the Host Response to the Gastrointestinal Pathogen Campylobacter concisus

    Article • Infection and Immunity, December 2014, ASM Journals

    Si Ming Man

  95. Actin polymerization as a key innate immune effector mechanism to control Salmonella infection

    Article • Proceedings of the National Academy of Sciences, November 2014, Proceedings of the National Academy of Sciences

    Si Ming Man

  96. Role of Emerging Campylobacter Species in Inflammatory Bowel Diseases

    Article • Inflammatory Bowel Diseases, November 2014, Oxford University Press (OUP)

    Si Ming Man

  97. Cutting Edge: STING Mediates Protection against Colorectal Tumorigenesis by Governing the Magnitude of Intestinal Inflammation

    Article • The Journal of Immunology, October 2014, The American Association of Immunologists

    Dr Peter Vogel, Si Ming Man

  98. Inflammasome activation causes dual recruitment of NLRC4 and NLRP3 to the same macromolecular complex

    Article • Proceedings of the National Academy of Sciences, May 2014, Proceedings of the National Academy of Sciences

    Si Ming Man

  99. Salmonella exploits NLRP12-dependent innate immune signaling to suppress host defenses during infection

    Article • Proceedings of the National Academy of Sciences, December 2013, Proceedings of the National Academy of Sciences

    Si Ming Man

  100. Salmonella Infection Induces Recruitment of Caspase-8 to the Inflammasome To Modulate IL-1  Production

    Article • The Journal of Immunology, October 2013, The American Association of Immunologists

    Si Ming Man

  101. Functional relationship between Campylobacter concisus and the stomach ecosystem in health and disease

    Article • The ISME Journal, July 2013, Springer Science + Business Media

    Si Ming Man

  102. Bacterial infection of macrophages induces decrease in refractive index

    Article • Journal of Biophotonics, August 2012, Wiley

    Si Ming Man

  103. The clinical importance of emerging Campylobacter species

    Article • Nature Reviews Gastroenterology & Hepatology, October 2011, Springer Science + Business Media

    Si Ming Man

  104. Stats for papers let authors track impact

    Article • Nature, August 2011, Springer Science + Business Media

    Si Ming Man

  105. Correction: The role of bacteria and pattern-recognition receptors in Crohn's disease

    Article • Nature Reviews Gastroenterology & Hepatology, May 2011, Springer Science + Business Media

    Si Ming Man

  106. The role of bacteria and pattern-recognition receptors in Crohn's disease

    Article • Nature Reviews Gastroenterology & Hepatology, February 2011, Springer Science + Business Media

    Si Ming Man

  107. Host Attachment, Invasion, and Stimulation of Proinflammatory Cytokines by Campylobacter concisus and Other Non– Campylobacter jejuni Campylobacter Species

    Article • The Journal of Infectious Diseases, December 2010, Oxford University Press (OUP)

    Professor Andrew S Day, Si Ming Man

  108. Detection of Helicobacteraceae in Intestinal Biopsies of Children with Crohn’s Disease

    Article • Helicobacter, November 2010, Wiley

    Professor Andrew S Day, Si Ming Man

  109. Campylobacter concisus and other Campylobacter species in children with newly diagnosed Crohnʼs disease

    Article • Inflammatory Bowel Diseases, June 2010, Oxford University Press (OUP)

    Professor Andrew S Day, Si Ming Man

  110. The Internal Transcribed Spacer Region, a New Tool for Use in Species Differentiation and Delineation of Systematic Relationships within the Campylobacter Genus

    Article • Applied and Environmental Microbiology, March 2010, ASM Journals

    Si Ming Man

  111. The secretome of Campylobacter concisus

    Article • European Journal of Biochemistry, February 2010, Wiley

    Si Ming Man

  112. Campylobacter concisus: a New Character in the Crohn's Disease Story?

    Article • Journal of Clinical Microbiology, April 2009, ASM Journals

    Si Ming Man

  113. Detection and Isolation of Campylobacter Species Other than C. jejuni from Children with Crohn's Disease

    Article • Journal of Clinical Microbiology, December 2008, ASM Journals

    Si Ming Man

  114. Detection of Enterohepatic and Gastric Helicobacter Species in Fecal Specimens of Children with Crohn's Disease

    Article • Helicobacter, July 2008, Wiley

    Professor Andrew S Day, Si Ming Man