All Stories

  1. Substrate Exclusion Greenlights Physical Autocatalysis of Enzyme Activity in Membraneless Proto-Organelles

    Article • Biomacromolecules, October 2025, American Chemical Society (ACS)

    Shuichi Takayama

  2. A Mimetic Assay of Neutrophil Extracellular Trap Degradation Using YOYO-1-Stained DNA-Histone Surface Webs

    Article • Cells, April 2025, MDPI AG

    Shuichi Takayama

  3. Caki-1 Spheroids as a Renal Model for Studying Free Fatty Acid-Induced Lipotoxicity

    Article • Cells, February 2025, MDPI AG

    Shuichi Takayama

  4. Bioprinted Micro‐Clots for Kinetic Analysis of Endothelial Cell‐Mediated Fibrinolysis

    Article • Advanced Healthcare Materials, January 2025, Wiley

    Shuichi Takayama

  5. Compositional Dependence of DNA Partitioning in a Poly(Ethylene Glycol)–Ficoll Aqueous Two-Phase System

    Article • Chemistry, December 2024, MDPI AG

    Shuichi Takayama

  6. Controlled Dynamic Microfluidic Culture of Murine, Bovine, and Human Embryos Improves Development: Proof-of-Concept Studies

    Article • Cells, December 2024, MDPI AG

    Shuichi Takayama

  7. Forced air oscillations – pneumatic capacitance in microfluidic oscillators produces non-linear responses and emergent behaviors

    Article • Lab on a Chip, January 2024, Royal Society of Chemistry

    Shuichi Takayama

  8. OctoShaker: A versatile robotic biomechanical agitator for cellular and organoid research

    Article • Review of Scientific Instruments, December 2023, American Institute of Physics

    Shuichi Takayama

  9. Visualization of Nuclease- and Serum-Mediated Chromatin Degradation with DNA–Histone Mesostructures

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Shuichi Takayama

  10. Super-resolution imaging of linearized chromatin in tunable nanochannels

    Article • Nanoscale Horizons, January 2023, Royal Society of Chemistry

    Shuichi Takayama

  11. Extended longevity geometrically-inverted proximal tubule organoids

    Article • Biomaterials, November 2022, Elsevier

    Shuichi Takayama

  12. A guide to the organ-on-a-chip

    Article • Nature Reviews Methods Primers, May 2022, Springer Science + Business Media

    Shuichi Takayama

  13. Nucleic Acid Partitioning in PEG-Ficoll Protocells

    Article • Journal of Chemical & Engineering Data, May 2022, American Chemical Society (ACS)

    Shuichi Takayama

  14. Protocell arrays for simultaneous detection of diverse analytes

    Article • Nature Communications, September 2021, Springer Science + Business Media

    Shuichi Takayama

  15. A High‐Throughput Distal Lung Air–Blood Barrier Model Enabled By Density‐Driven Underside Epithelium Seeding

    Article • Advanced Healthcare Materials, June 2021, Wiley

    Shuichi Takayama

  16. Protocell Arrays for Simultaneous Detection of Diverse Analytes

    Article • February 2021, Cold Spring Harbor Laboratory Press

    Shuichi Takayama

  17. Alginate Microencapsulation for Three-Dimensional In Vitro Cell Culture

    Article • ACS Biomaterials Science & Engineering, June 2020, American Chemical Society (ACS)

    Shuichi Takayama

  18. One-incubation one-hour multiplex ELISA enabled by aqueous two-phase systems

    Article • The Analyst, January 2020, Royal Society of Chemistry

    Shuichi Takayama

  19. Novel monolithic “Slightly-Open doormat” (SOD) valve enables efficient fabrication of highly-scalable microfluidic gas-on-gas multiplexer

    Article • Sensors and Actuators B Chemical, October 2019, Elsevier

    Shuichi Takayama

  20. Embracing Heterogeneity and Disorder

    Article • Israel Journal of Chemistry, February 2019, Wiley

    Shuichi Takayama

  21. Dispersible hydrogel force sensors reveal patterns of solid mechanical stress in multicellular spheroid cultures

    Article • Nature Communications, January 2019, Springer Science + Business Media

    Shuichi Takayama, Nikita Kalashnikov

  22. Determination of Aqueous Two-Phase System Binodals and Tie-Lines by Electrowetting-on-Dielectric Droplet Manipulation

    Article • ChemBioChem, January 2019, Wiley

    Shuichi Takayama

  23. Determination of Aqueous Two‐Phase System Binodals and Tie‐Lines by Electrowetting‐on‐Dielectric Droplet Manipulation

    Article • ChemBioChem, December 2018, Wiley

    Shuichi Takayama

  24. DNA-Based Biomaterials for Immunoengineering

    Article • Advanced Healthcare Materials, December 2018, Wiley

    Shuichi Takayama

  25. Budding-like division of all-aqueous emulsion droplets modulated by networks of protein nanofibrils

    Article • Nature Communications, May 2018, Springer Science + Business Media

    Shuichi Takayama

  26. Integration of sensors in gastrointestinal organoid culture for biological analysis

    Article • Cellular and Molecular Gastroenterology and Hepatology, March 2018, Elsevier

    Shuichi Takayama

  27. Dispersible oxygen microsensors map oxygen gradients in three-dimensional cell cultures

    Article • Biomaterials Science, January 2017, Royal Society of Chemistry

    Shuichi Takayama

  28. Dynamic simulations show repeated narrowing maximizes DNA linearization in elastomeric nanochannels

    Article • Biomicrofluidics, November 2016, American Institute of Physics

    Shuichi Takayama

  29. Formation and manipulation of cell spheroids using a density adjusted PEG/DEX aqueous two phase system

    Article • Scientific Reports, July 2015, Springer Science + Business Media

    Shuichi Takayama

  30. Systems for multiplexing homogeneous immunoassays

    Article • Bioanalysis, July 2015, Future Science

    Shuichi Takayama

  31. Formation of stable small cell number three-dimensional ovarian cancer spheroids using hanging drop arrays for preclinical drug sensitivity assays

    Article • Gynecologic Oncology, July 2015, Elsevier

    Shuichi Takayama

  32. Multiple independent autonomous hydraulic oscillators driven by a common gravity head

    Article • Nature Communications, June 2015, Springer Science + Business Media

    Shuichi Takayama

  33. Recent microfluidic devices for studying gamete and embryo biomechanics

    Article • Journal of Biomechanics, June 2015, Elsevier

    Shuichi Takayama

  34. Shear-Triggered Crystallization and Light Emission of a Thermally Stable Organic Supercooled Liquid

    Article • ACS Central Science, May 2015, American Chemical Society (ACS)

    Shuichi Takayama

  35. Cell, Isoform, and Environment Factors Shape Gradients and Modulate Chemotaxis

    Article • PLOS One, April 2015, PLOS

    Shuichi Takayama

  36. Rapid Self-Assembly of Macroscale Tissue Constructs at Biphasic Aqueous Interfaces

    Article • Advanced Functional Materials, February 2015, Wiley

    Dr John P Frampton, Shuichi Takayama

  37. Deformable L-shaped microwell array for trapping pairs of heterogeneous cells

    Article • Journal of Micromechanics and Microengineering, February 2015, Institute of Physics Publishing

    Shuichi Takayama

  38. Surface-templated hydrogel patterns prompt matrix-dependent migration of breast cancer cells towards chemokine-secreting cells

    Article • Acta Biomaterialia, February 2015, Elsevier

    Shuichi Takayama

  39. Fracture fabrication of a multi-scale channel device that efficiently captures and linearizes DNA from dilute solutions

    Article • Lab on a Chip, January 2015, Royal Society of Chemistry

    Shuichi Takayama

  40. Media additives to promote spheroid circularity and compactness in hanging drop platform

    Article • Biomaterials Science, January 2015, Royal Society of Chemistry

    Shuichi Takayama

  41. Bioprinting Using Aqueous Two-Phase System

    Article • January 2015, Elsevier

    Shuichi Takayama

  42. Failed Candy Recipe Enables Cell Force Measurements

    Article • Lab on a Chip, January 2015, Royal Society of Chemistry

    Shuichi Takayama

  43. Band-pass processing in a GPCR signaling pathway selects for NFAT transcription factor activation

    Article • Integrative Biology, January 2015, Oxford University Press (OUP)

    Shuichi Takayama, Jennifer Linderman

  44. Microfluidics for Assisted Reproductive Technologies

    Article • December 2014, Royal Society of Chemistry

    Shuichi Takayama

  45. Predictable Duty Cycle Modulation through Coupled Pairing of Syringes with Microfluidic Oscillators

    Article • Micromachines, November 2014, MDPI AG

    Shuichi Takayama

  46. Elongation of Fibers from Highly Viscous Dextran Solutions Enables Fabrication of Rapidly Dissolving Drug Carrying Fabrics

    Article • Advanced Healthcare Materials, September 2014, Wiley

    Dr John P Frampton, Shuichi Takayama

  47. Aqueous two-phase system-mediated antibody micropatterning enables multiplexed immunostaining of cell monolayers and tissues

    Article • Biotechnology Journal, August 2014, Wiley

    Dr John P Frampton, Shuichi Takayama

  48. Lungs-on-a-Chip

    Article • July 2014, Taylor & Francis

    Shuichi Takayama

  49. Fracture-Based Fabrication of Normally Closed, Adjustable, and Fully Reversible Microscale Fluidic Channels

    Article • Small, June 2014, Wiley

    Shuichi Takayama

  50. Aqueous two-phase systems enable multiplexing of homogeneous immunoassays

    Article • TECHNOLOGY, June 2014, World Scientific Pub Co Pte Lt

    Dr John P Frampton, Professor Sophie Paczesny, Shuichi Takayama

  51. Aqueous two-phase system patterning of detection antibody solutions for cross-reaction-free multiplex ELISA

    Article • Scientific Reports, May 2014, Springer Science + Business Media

    Dr John P Frampton, Professor Sophie Paczesny, Shuichi Takayama

  52. Label-Free Direct Visual Analysis of Hydrolytic Enzyme Activity Using Aqueous Two-Phase System Droplet Phase Transitions

    Article • Analytical Chemistry, April 2014, American Chemical Society (ACS)

    Dr John P Frampton, Shuichi Takayama

  53. Selected papers from the 7th International Conference on Microtechnologies in Medicine and Biology (MMB 2013)

    Article • Journal of Micromechanics and Microengineering, February 2014, Institute of Physics Publishing

    Shuichi Takayama

  54. Control of soft machines using actuators operated by a Braille display

    Article • Lab on a Chip, January 2014, Royal Society of Chemistry

    Shuichi Takayama

  55. 3D ECM & Cells by Cracking

    Article • Lab on a Chip, January 2014, Royal Society of Chemistry

    Shuichi Takayama

  56. Fracture-based micro- and nanofabrication for biological applications

    Article • Biomaterials Science, January 2014, Royal Society of Chemistry

    Shuichi Takayama

  57. Sample Preparation and Storage

    Article • Lab on a Chip, January 2014, Royal Society of Chemistry

    Shuichi Takayama

  58. Organs-on-a-Chip

    Article • January 2014, Elsevier

    Shuichi Takayama

  59. Aqueous Two-Phase System Technology for Patterning Bacterial Communities and Biofilms

    Article • January 2014, Springer Science + Business Media

    Shuichi Takayama, Professor Robert J. Mitchell

  60. Microfluidic device capable of medium recirculation for non-adherent cell culture

    Article • Biomicrofluidics, January 2014, American Institute of Physics

    Shuichi Takayama

  61. Micro-Scale Patterning of Cells and their Environment

    Article • January 2014, Elsevier

    Shuichi Takayama

  62. Aqueous two-phase printing of cell-containing contractile collagen microgels

    Article • Biomaterials, December 2013, Elsevier

    Shuichi Takayama

  63. Flow and Sound Generation in Human Lungs: Models of Wheezes and Crackles

    Article • November 2013, Springer Science + Business Media

    Shuichi Takayama

  64. Guided fracture of films on soft substrates to create micro/nano-feature arrays with controlled periodicity

    Article • Scientific Reports, October 2013, Springer Science + Business Media

    Shuichi Takayama

  65. Pumps for microfluidic cell culture

    Article • Electrophoresis, October 2013, Wiley

    Shuichi Takayama

  66. External Mechanical Cues Trigger the Establishment of the Anterior-Posterior Axis in Early Mouse Embryos

    Article • Developmental Cell, October 2013, Elsevier

    Shuichi Takayama

  67. The control of crack arrays in thin films

    Article • Journal of Materials Science, September 2013, Springer Science + Business Media

    Shuichi Takayama

  68. Preprogrammed, Parallel On-Chip Immunoassay Using System-Level Capillarity Control

    Article • Analytical Chemistry, July 2013, American Chemical Society (ACS)

    Professor Sophie Paczesny, Shuichi Takayama

  69. Microbubbles: Aqueous Two-Phase System Patterning of Microbubbles: Localized Induction of Apoptosis in Sonoporated Cells (Adv. Funct. Mater. 27/2013)

    Article • Advanced Functional Materials, July 2013, Wiley

    Dr John P Frampton, Shuichi Takayama

  70. Micro- and nanofluidic technologies for epigenetic profiling

    Article • Biomicrofluidics, July 2013, American Institute of Physics

    Shuichi Takayama

  71. Rheology Effects on Mucus Plug Rupture

    Article • June 2013, ASME International

    Shuichi Takayama

  72. Patterning Bacterial Communities on Epithelial Cells

    Article • PLOS One, June 2013, PLOS

    Shuichi Takayama, Professor Robert J. Mitchell

  73. One-dimensional patterning of cells in silicone wells via compression-induced fracture

    Article • Journal of Biomedical Materials Research Part A, June 2013, Wiley

    Shuichi Takayama

  74. Microscale Determination of Aqueous Two Phase System Binodals by Droplet Dehydration in Oil

    Article • Analytical Chemistry, May 2013, American Chemical Society (ACS)

    Shuichi Takayama

  75. Super-Resolution Imaging of PDMS Nanochannels by Single-Molecule Micelle-Assisted Blink Microscopy

    Article • The Journal of Physical Chemistry B, April 2013, American Chemical Society (ACS)

    Shuichi Takayama

  76. Patchy Surfaces Stabilize Dextran–Polyethylene Glycol Aqueous Two-Phase System Liquid Patterns

    Article • Langmuir, April 2013, American Chemical Society (ACS)

    Shuichi Takayama

  77. Delivery of Proteases in Aqueous Two-Phase Systems Enables Direct Purification of Stem Cell Colonies from Feeder Cell Co-Cultures for Differentiation into Functional Cardiomyocytes

    Article • Advanced Healthcare Materials, April 2013, Wiley

    Dr John P Frampton, Shuichi Takayama

  78. Cell Co-culture Patterning Using Aqueous Two-phase Systems

    Article • Journal of Visualized Experiments, March 2013, MyJove Corporation

    Dr John P Frampton, Shuichi Takayama

  79. Large-Scale, Ultrapliable, and Free-Standing Nanomembranes

    Article • Advanced Materials, February 2013, Wiley

    Shuichi Takayama

  80. Localized micro-scale disruption of cells using laser-generated focused ultrasound

    Article • Journal of Biophotonics, February 2013, Wiley

    Dr John P Frampton, Shuichi Takayama

  81. Productive Chemical Interaction between a Bacterial Microcolony Couple Is Enhanced by Periodic Relocation

    Article • Journal of the American Chemical Society, February 2013, American Chemical Society (ACS)

    Shuichi Takayama, Professor Robert J. Mitchell

  82. Aqueous Two-Phase System Patterning of Microbubbles: Localized Induction of Apoptosis in Sonoporated Cells

    Article • Advanced Functional Materials, February 2013, Wiley

    Dr John P Frampton, Shuichi Takayama

  83. Microfluidic oscillators with widely tunable periods

    Article • Lab on a Chip, January 2013, Royal Society of Chemistry

    Shuichi Takayama

  84. Preprogrammed capillarity to passively control system-level sequential and parallel microfluidic flows

    Article • Lab on a Chip, January 2013, Royal Society of Chemistry

    Professor Sophie Paczesny, Shuichi Takayama

  85. On being the right size: scaling effects in designing a human-on-a-chip

    Article • Integrative Biology, January 2013, Oxford University Press (OUP)

    Shuichi Takayama

  86. Dehydrated aqueous two-phase system micro-domains retain their shape upon rehydration to allow patterned reagent delivery to cells

    Article • Journal of Materials Chemistry B, January 2013, Royal Society of Chemistry

    Shuichi Takayama

  87. Simple multi-level microchannel fabrication by pseudo-grayscale backside diffused light lithography

    Article • RSC Advances, January 2013, Royal Society of Chemistry

    Shuichi Takayama

  88. Microfluidic interrogation and mathematical modeling of multi-regime calcium signaling dynamics

    Article • Integrative Biology, January 2013, Oxford University Press (OUP)

    Shuichi Takayama

  89. Microfluidics for Gamete Manipulation and Embryo Culture

    Article • January 2013, Springer Science + Business Media

    Shuichi Takayama

  90. Microfluidic Approaches Toward Pulmonary Tissue Constructs

    Article • January 2013, Elsevier

    Shuichi Takayama

  91. List of Contributors

    Article • January 2013, Elsevier

    Shuichi Takayama

  92. Nanoscale Squeezing in Elastomeric Nanochannels for Single Chromatin Linearization

    Article • Nano Letters, December 2012, American Chemical Society (ACS)

    Shuichi Takayama

  93. Analyzing threshold pressure limitations in microfluidic transistors for self-regulated microfluidic circuits

    Article • Applied Physics Letters, December 2012, American Institute of Physics

    Shuichi Takayama

  94. Opportunities and challenges for use of tumor spheroids as models to test drug delivery and efficacy

    Article • Journal of Controlled Release, December 2012, Elsevier

    Shuichi Takayama

  95. Microfluidic systems: A new toolbox for pluripotent stem cells

    Article • Biotechnology Journal, November 2012, Wiley

    Dr John P Frampton, Shuichi Takayama

  96. Surface chemistry modification of PDMS elastomers with boiling water improves cellular adhesion

    Article • Sensors and Actuators B Chemical, October 2012, Elsevier

    Shuichi Takayama

  97. Aqueous Two-Phase System-Derived Biofilms for Bacterial Interaction Studies

    Article • Biomacromolecules, September 2012, American Chemical Society (ACS)

    Shuichi Takayama, Professor Robert J. Mitchell

  98. Rapid Generation of Multiplexed Cell Cocultures Using Acoustic Droplet Ejection Followed by Aqueous Two-Phase Exclusion Patterning

    Article • Tissue Engineering Part C Methods, September 2012, Mary Ann Liebert Inc

    Dr John P Frampton, Shuichi Takayama

  99. Microfluidic Automation Using Elastomeric Valves and Droplets: Reducing Reliance on External Controllers

    Article • Small, July 2012, Wiley

    Shuichi Takayama

  100. Lab-on-a-chip biophotonics: its application to assisted reproductive technologies

    Article • Journal of Biophotonics, June 2012, Wiley

    Shuichi Takayama

  101. Microfluidics in ART: Current progress and future directions

    Article • June 2012, Informa Healthcare

    Shuichi Takayama

  102. Quantitative Analysis of Molecular Absorption into PDMS Microfluidic Channels

    Article • Annals of Biomedical Engineering, April 2012, Springer Science + Business Media

    Shuichi Takayama

  103. Secreted CXCL12 (SDF-1) forms dimers under physiological conditions

    Article • Biochemical Journal, March 2012, Portland Press Ltd.

    Shuichi Takayama

  104. Constant Flow-Driven Microfluidic Oscillator for Different Duty Cycles

    Article • Analytical Chemistry, January 2012, American Chemical Society (ACS)

    Shuichi Takayama

  105. Real time culture and analysis of embryo metabolism using a microfluidic device with deformation based actuation

    Article • Lab on a Chip, January 2012, Royal Society of Chemistry

    Shuichi Takayama

  106. Microfluidics for Gamete Manipulation and Embryo Culture

    Article • January 2012, Springer Science + Business Media

    Shuichi Takayama

  107. liquid plugs mimicking mucus in lung

    Article • Journal of Fluid Mechanics, December 2011, Cambridge University Press

    Shuichi Takayama

  108. Organs-on-a-Chip: A Focus on Compartmentalized Microdevices

    Article • Annals of Biomedical Engineering, November 2011, Springer Science + Business Media

    Shuichi Takayama

  109. Micro-ring structures stabilize microdroplets to enable long term spheroid culture in 384 hanging drop array plates

    Article • Biomedical Microdevices, November 2011, Springer Science + Business Media

    Shuichi Takayama

  110. ChemInform Abstract: Flexible Fabrication and Applications of Polymer Nanochannels and Nonoslits

    Article • ChemInform, September 2011, Wiley

    Shuichi Takayama

  111. Cell-Exclusion Patterning: Rehydration of Polymeric, Aqueous, Biphasic System Facilitates High Throughput Cell Exclusion Patterning for Cell Migration Studies (Adv. Funct. Mater. 15/2011)

    Article • Advanced Functional Materials, August 2011, Wiley

    Shuichi Takayama

  112. Precisely targeted delivery of cells and biomolecules within microchannels using aqueous two-phase systems

    Article • Biomedical Microdevices, July 2011, Springer Science + Business Media

    Dr John P Frampton, Shuichi Takayama

  113. Artificial Hematopoietic Stem Cell Niche: Bioscaffolds to Microfluidics to Mathematical Simulations

    Article • Current Topics in Medicinal Chemistry, July 2011, Bentham Science Publishers

    Shuichi Takayama

  114. Transient Motion of Liquid Plugs With Yield Stress in Human Airways

    Article • June 2011, ASME International

    Shuichi Takayama

  115. Responses of endothelial cells to extremely slow flows

    Article • Biomicrofluidics, June 2011, American Institute of Physics

    Shuichi Takayama

  116. Rehydration of Polymeric, Aqueous, Biphasic System Facilitates High Throughput Cell Exclusion Patterning for Cell Migration Studies

    Article • Advanced Functional Materials, May 2011, Wiley

    Shuichi Takayama

  117. Microprinted feeder cells guide embryonic stem cell fate

    Article • Biotechnology and Bioengineering, May 2011, Wiley

    Shuichi Takayama

  118. Epithelium damage and protection during reopening of occluded airways in a physiologic microfluidic pulmonary airway model

    Article • Biomedical Microdevices, April 2011, Springer Science + Business Media

    Shuichi Takayama

  119. Aqueous biphasic microprinting approach to tissue engineering

    Article • Biomicrofluidics, March 2011, American Institute of Physics

    Shuichi Takayama

  120. MICROFLUIDIC DROPLET CONSISTENCY MONITORING AND ENCAPSULATED CELL DETECTION VIA LASER EXCITATION

    Article • Journal of Mechanics in Medicine and Biology, March 2011, World Scientific Pub Co Pte Lt

    Shuichi Takayama

  121. one of first papers on high throughput automation compatible hanging drop culture plates

    Article • The Analyst, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  122. Flexible fabrication and applications of polymer nanochannels and nanoslits

    Article • Chemical Society Reviews, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  123. Rounded multi-level microchannels with orifices made in one exposure enable aqueous two-phase system droplet microfluidics

    Article • Lab on a Chip, January 2011, Royal Society of Chemistry

    Dr John P Frampton, Shuichi Takayama

  124. Next-generation integrated microfluidic circuits

    Article • Lab on a Chip, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  125. Combination of fluid and solid mechanical stresses contribute to cell death and detachment in a microfluidic alveolar model

    Article • Lab on a Chip, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  126. High-density fabrication of normally closed microfluidic valves by patterned deactivation of oxidized polydimethylsiloxane

    Article • Lab on a Chip, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  127. Fracture of metal coated elastomers

    Article • Soft Matter, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  128. Hi-Fi transmission of periodic signals amid cell-to-cell variability

    Article • Molecular BioSystems, January 2011, Royal Society of Chemistry

    Shuichi Takayama

  129. Receptor differential activation and cooperativity better explain cellular preference for different chemoattractant gradient shapes in an EGFR system

    Article • Integrative Biology, January 2011, Oxford University Press (OUP)

    Shuichi Takayama

  130. Chapter 24. Using Microfluidics, Real-time Imaging and Mathematical Modelling to study GPCR Signalling

    Article • January 2011, Royal Society of Chemistry

    Jennifer Linderman, Shuichi Takayama

  131. Transwells with Microstamped Membranes Produce Micropatterned Two-Dimensional and Three-Dimensional Co-Cultures

    Article • Tissue Engineering Part C Methods, January 2011, Mary Ann Liebert Inc

    Shuichi Takayama

  132. Phase-Locked Signals Elucidate Circuit Architecture of an Oscillatory Pathway

    Article • PLoS Computational Biology, December 2010, PLOS

    Jennifer Linderman, Shuichi Takayama

  133. Multiplexed Spectral Signature Detection for Microfluidic Color-Coded Bioparticle Flow

    Article • Analytical Chemistry, November 2010, American Chemical Society (ACS)

    Shuichi Takayama

  134. Bioengineered Three-Dimensional Physiological Model of Colonic Longitudinal Smooth Muscle In Vitro

    Article • Tissue Engineering Part C Methods, October 2010, Mary Ann Liebert Inc

    Shuichi Takayama

  135. ChemInform Abstract: Chemoenzymatic Synthesis of Iminocyclitol Derivatives: A Useful Library Strategy for the Development of Selective Fucosyltransfer Enzymes Inhibitors.

    Article • ChemInform, June 2010, Wiley

    Shuichi Takayama

  136. Propagation of Liquid Plugs With Yield Stress in Human Airways

    Article • June 2010, ASME International

    Shuichi Takayama

  137. Guided corona generates wettability patterns that selectively direct cell attachment inside closed microchannels

    Article • Biomedical Microdevices, May 2010, Springer Science + Business Media

    Shuichi Takayama

  138. Polymeric Aqueous Biphasic Systems for Non-Contact Cell Printing on Cells: Engineering Heterocellular Embryonic Stem Cell Niches

    Article • Advanced Materials, May 2010, Wiley

    Shuichi Takayama

  139. Integrated elastomeric components for autonomous regulation of sequential and oscillatory flow switching in microfluidic devices

    Article • Nature Nanotechnology, April 2010, Springer Science + Business Media

    Shuichi Takayama

  140. Patterned Electrode-Based Amperometric Gas Sensor for Direct Nitric Oxide Detection within Microfluidic Devices

    Article • Analytical Chemistry, April 2010, American Chemical Society (ACS)

    Shuichi Takayama

  141. Fabrication of Two-Layered Channel System with Embedded Electrodes to Measure Resistance Across Epithelial and Endothelial Barriers

    Article • Analytical Chemistry, March 2010, American Chemical Society (ACS)

    Shuichi Takayama

  142. Dynamics of Liquid Plugs of Buffer and Surfactant Solutions in a Micro-Engineered Pulmonary Airway Model

    Article • Langmuir, March 2010, American Chemical Society (ACS)

    Shuichi Takayama

  143. Uniform cell seeding and generation of overlapping gradient profiles in a multiplexed microchamber device with normally-closed valves

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    Shuichi Takayama

  144. Simultaneous fabrication of PDMS through-holes for three-dimensional microfluidic applications

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    Shuichi Takayama

  145. Instantaneous fabrication of arrays of normally closed, adjustable, and reversible nanochannels by tunnel cracking

    Article • Lab on a Chip, January 2010, Royal Society of Chemistry

    Shuichi Takayama

  146. Micropatterning bacterial suspensions using aqueous two phase systems

    Article • The Analyst, January 2010, Royal Society of Chemistry

    Shuichi Takayama, Professor Robert J. Mitchell

  147. Regulating microenvironmental stimuli for stem cells and cancer cells using microsystems

    Article • Integrative Biology, January 2010, Oxford University Press (OUP)

    Shuichi Takayama

  148. Microfluidic platform for chemotaxis in gradients formed by CXCL12 source-sink cells

    Article • Integrative Biology, January 2010, Oxford University Press (OUP)

    Shuichi Takayama

  149. Ionic Liquids for Microfluidic Actuation

    Article • December 2009, American Chemical Society (ACS)

    Shuichi Takayama

  150. High-speed tuning of visible laser wavelength using a nanoimprinted grating optical tunable filter

    Article • Applied Physics Letters, November 2009, American Institute of Physics

    Shuichi Takayama

  151. Patterning alginate hydrogels using light-directed release of caged calcium in a microfluidic device

    Article • Biomedical Microdevices, October 2009, Springer Science + Business Media

    Shuichi Takayama

  152. Single cell trapping in larger microwells capable of supporting cell spreading and proliferation

    Article • Microfluidics and Nanofluidics, October 2009, Springer Science + Business Media

    Shuichi Takayama

  153. Micro-PIV Measurements of an Airway Closure Model

    Article • June 2009, ASME International

    Shuichi Takayama

  154. Steady State Creeping Displacement of a Semi-Infinite Gas Bubble in a 2D Channel Filled by a Bingham Liquid

    Article • June 2009, ASME International

    Shuichi Takayama

  155. Microfluidic system for formation of PC-3 prostate cancer co-culture spheroids

    Article • Biomaterials, June 2009, Elsevier

    Shuichi Takayama

  156. A Student Team in a University of Michigan Biomedical Engineering Design Course Constructs a Microfluidic Bioreactor for Studies of Zebrafish Development

    Article • Zebrafish, June 2009, Mary Ann Liebert Inc

    Shuichi Takayama

  157. Microfluidic Endothelium for Studying the Intravascular Adhesion of Metastatic Breast Cancer Cells

    Article • PLOS One, June 2009, PLOS

    Shuichi Takayama

  158. Hard Top Soft Bottom Microfluidic Devices for Cell Culture and Chemical Analysis

    Article • Analytical Chemistry, May 2009, American Chemical Society (ACS)

    Shuichi Takayama

  159. Quantitative inference of cellular parameters from microfluidic cell culture systems

    Article • Biotechnology and Bioengineering, April 2009, Wiley

    Shuichi Takayama

  160. External Compression-Induced Fracture Patterning on the Surface of Poly(dimethylsiloxane) Cubes and Microspheres

    Article • Langmuir, March 2009, American Chemical Society (ACS)

    Shuichi Takayama

  161. Timing is everything: using fluidics to understand the role of temporal dynamics in cellular systems

    Article • Microfluidics and Nanofluidics, February 2009, Springer Science + Business Media

    Shuichi Takayama

  162. Microfeature guided skeletal muscle tissue engineering for highly organized 3-dimensional free-standing constructs

    Article • Biomaterials, February 2009, Elsevier

    Shuichi Takayama

  163. Microfluidic hydrodynamic cellular patterning for systematic formation of co-culture spheroids

    Article • Integrative Biology, January 2009, Oxford University Press (OUP)

    Shuichi Takayama

  164. Microfluidic culture of single human embryonic stem cell colonies

    Article • Lab on a Chip, January 2009, Royal Society of Chemistry

    Shuichi Takayama

  165. Micro- and Nanofluidics for Cell Biology, Cell Therapy, and Cell-Based Drug Testing

    Article • January 2009, ASME International

    Shuichi Takayama

  166. Liquid and surfactant delivery into pulmonary airways

    Article • Respiratory Physiology & Neurobiology, November 2008, Elsevier

    Shuichi Takayama

  167. Electromechanical Properties of Pressure-Actuated Poly(dimethylsiloxane) Microfluidic Push-Down Valves

    Article • Analytical Chemistry, August 2008, American Chemical Society (ACS)

    Shuichi Takayama

  168. Individually programmable cell stretching microwell arrays actuated by a Braille display

    Article • Biomaterials, June 2008, Elsevier

    Shuichi Takayama, Dr. Nobuhiro Kato

  169. Unsteady propagation of a liquid plug in a liquid-lined straight tube

    Article • Physics of Fluids, June 2008, American Institute of Physics

    Shuichi Takayama

  170. Electrically Programmable Surfaces for Configurable Patterning of Cells

    Article • Advanced Materials, April 2008, Wiley

    Shuichi Takayama

  171. Reversible on-demand cell alignment using reconfigurable microtopography

    Article • Biomaterials, April 2008, Elsevier

    Shuichi Takayama

  172. DNA linearization through confinement in nanofluidic channels

    Article • Fresenius Journal of Analytical Chemistry, March 2008, Springer Science + Business Media

    Shuichi Takayama

  173. Biological Micro/Nanofluidics

    Article • January 2008, ASME International

    Shuichi Takayama

  174. The mechanical properties of a surface-modified layer on polydimethylsiloxane

    Article • Journal of Materials Research, January 2008, Cambridge University Press

    Shuichi Takayama

  175. Adjustable Nanofluidic Channels by Tunnel Cracking of a Constrained Brittle Layer

    Article • January 2008, ASME International

    Shuichi Takayama

  176. Tuneable elastomeric nanochannels for nanofluidic manipulation

    Article • Nature Materials, May 2007, Springer Science + Business Media

    Shuichi Takayama

  177. Leakage-Free Bonding of Porous Membranes into Layered Microfluidic Array Systems

    Article • Analytical Chemistry, May 2007, American Chemical Society (ACS)

    Shuichi Takayama

  178. Gravity-Driven Microfluidic Particle Sorting Device with Hydrodynamic Separation Amplification

    Article • Analytical Chemistry, February 2007, American Chemical Society (ACS)

    Shuichi Takayama

  179. Characterization and Resolution of Evaporation-Mediated Osmolality Shifts That Constrain Microfluidic Cell Culture in Poly(dimethylsiloxane) Devices

    Article • Analytical Chemistry, February 2007, American Chemical Society (ACS)

    Shuichi Takayama

  180. Multiplexed hydraulic valve actuation using ionic liquid filled soft channels and Braille displays

    Article • Applied Physics Letters, January 2007, American Institute of Physics

    Shuichi Takayama

  181. Efficient formation of uniform-sized embryoid bodies using a compartmentalized microchannel device

    Article • Lab on a Chip, January 2007, Royal Society of Chemistry

    Shuichi Takayama

  182. Small volume low mechanical stress cytometry using computer-controlled Braille display microfluidics

    Article • Lab on a Chip, January 2007, Royal Society of Chemistry

    Shuichi Takayama

  183. A Microfluidic Model of Cardiovascular Bubble Lodging

    Article • January 2007, ASME International

    Shuichi Takayama

  184. Quantitative measurement and control of oxygen levels in microfluidic poly(dimethylsiloxane) bioreactors during cell culture

    Article • Biomedical Microdevices, December 2006, Springer Science + Business Media

    Shuichi Takayama

  185. Microfluidic model of bubble lodging in microvessel bifurcations

    Article • Applied Physics Letters, December 2006, American Institute of Physics

    Shuichi Takayama

  186. The effect of continuous wavy micropatterns on silicone substrates on the alignment of skeletal muscle myoblasts and myotubes

    Article • Biomaterials, August 2006, Elsevier

    Shuichi Takayama

  187. A surface-modified sperm sorting device with long-term stability

    Article • Biomedical Microdevices, June 2006, Springer Science + Business Media

    Shuichi Takayama

  188. Bubble lodging in bifurcating microvessel networks: a microfluidic model

    Article • May 2006, Institute of Electrical & Electronics Engineers (IEEE)

    Shuichi Takayama

  189. Microbioreactors

    Article • April 2006, Wiley

    Shuichi Takayama

  190. Handheld recirculation system and customized media for microfluidic cell culture

    Article • Lab on a Chip, January 2006, Royal Society of Chemistry

    Shuichi Takayama

  191. At the Interface: Advanced Microfluidic Assays for Study of Cell Function

    Article • January 2006, Springer Science + Business Media

    Shuichi Takayama

  192. Fluorescence Lifetime Imaging Microscopy (FLIM) Measures Oxygen Gradients in Microfluidic Bioreactors

    Article • January 2006, Optical Society of America (OSA)

    Shuichi Takayama

  193. Properties of the surface-modified layer of plasma-oxidized poly(dimethylsiloxane)

    Article • MRS Proceedings, January 2006, Cambridge University Press

    Shuichi Takayama

  194. Optical imaging in microfluidic bioreactors enables oxygen monitoring for continuous cell culture

    Article • Journal of Biomedical Optics, January 2006, SPIE

    Shuichi Takayama

  195. Computer-Controlled Microcirculatory Support System for Endothelial Cell Culture and Shearing

    Article • Analytical Chemistry, July 2005, American Chemical Society (ACS)

    Shuichi Takayama

  196. Fabrication of reconfigurable protein matrices by cracking

    Article • Nature Materials, April 2005, Springer Science + Business Media

    Shuichi Takayama

  197. Microfluidics for flow cytometric analysis of cells and particles

    Article • Physiological Measurement, February 2005, Institute of Physics Publishing

    Shuichi Takayama

  198. Book Review: Microsystem Engineering of Lab-on-a-Chip Devices. Edited by Oliver Geschke, Henning Klank, and Pieter Telleman.

    Article • ChemBioChem, September 2004, Wiley

    Shuichi Takayama

  199. Arrays of horizontally-oriented mini-reservoirs generate steady microfluidic flows for continuous perfusion cell culture and gradient generation

    Article • The Analyst, January 2004, Royal Society of Chemistry

    Shuichi Takayama

  200. Reversible Switching of High-Speed Air−Liquid Two-Phase Flows Using Electrowetting-Assisted Flow-Pattern Change

    Article • Journal of the American Chemical Society, December 2003, American Chemical Society (ACS)

    Shuichi Takayama

  201. In vitro fertilization within microfluidic channels requires lower total numbers and lower concentrations of spermatozoa

    Article • Fertility and Sterility, September 2003, Elsevier

    Shuichi Takayama

  202. Passively Driven Integrated Microfluidic System for Separation of Motile Sperm

    Article • Analytical Chemistry, April 2003, American Chemical Society (ACS)

    Shuichi Takayama

  203. Selective Chemical Treatment of Cellular Microdomains Using Multiple Laminar Streams

    Article • Chemistry & Biology, February 2003, Elsevier

    Shuichi Takayama

  204. Micro- and Nanotechnologies for Studying Cellular Function

    Article • Current Topics in Medicinal Chemistry, February 2003, Bentham Science Publishers

    Shuichi Takayama

  205. Fabrication of microfluidic mixers and artificial vasculatures using a high-brightness diode-pumped Nd:YAG laser direct write method

    Article • Lab on a Chip, January 2003, Royal Society of Chemistry

    Shuichi Takayama

  206. Isolation of motile spermatozoa from semen samples using microfluidics

    Article • Reproductive BioMedicine Online, January 2003, Elsevier

    Shuichi Takayama

  207. A novel microfluidic device for separating motile sperm from nonmotile sperm via inter-streamline crossing

    Article • Fertility and Sterility, September 2002, Elsevier

    Shuichi Takayama

  208. Lateral Propagation of EGF Signaling after Local Stimulation Is Dependent on Receptor Density

    Article • Developmental Cell, August 2002, Elsevier

    Shuichi Takayama

  209. Controlling Mammalian Cell Spreading and Cytoskeletal Arrangement with Conveniently Fabricated Continuous Wavy Features on Poly(dimethylsiloxane)

    Article • Langmuir, March 2002, American Chemical Society (ACS)

    Shuichi Takayama

  210. Gravity-Driven Micropump with a Steady Flow Rate

    Article • January 2002, Springer Science + Business Media

    Shuichi Takayama

  211. A Survey of Structure−Property Relationships of Surfaces that Resist the Adsorption of Protein

    Article • Langmuir, September 2001, American Chemical Society (ACS)

    Shuichi Takayama

  212. Soft Lithography in Biology and Biochemistry

    Article • Annual Review of Biomedical Engineering, August 2001, Annual Reviews

    Shuichi Takayama

  213. Subcellular positioning of small molecules

    Article • Nature, June 2001, Springer Science + Business Media

    Shuichi Takayama

  214. Zwitterionic SAMs that Resist Nonspecific Adsorption of Protein from Aqueous Buffer

    Article • Langmuir, May 2001, American Chemical Society (ACS)

    Shuichi Takayama

  215. ChemInform Abstract: Fabrication Inside Microchannels Using Fluid Flow

    Article • ChemInform, March 2001, Wiley

    Shuichi Takayama

  216. Fabrication inside Microchannels Using Fluid Flow

    Article • Accounts of Chemical Research, December 2000, American Chemical Society (ACS)

    Shuichi Takayama

  217. Surveying for Surfaces that Resist the Adsorption of Proteins

    Article • Journal of the American Chemical Society, August 2000, American Chemical Society (ACS)

    Shuichi Takayama

  218. PATTERNING OF CELLS AND THEIR ENVIRONMENT

    Article • January 2000, Elsevier

    Shuichi Takayama

  219. ChemInform Abstract: Designing Enzymatic Resolution of Amines.

    Article • ChemInform, May 1999, Wiley

    Shuichi Takayama

  220. ChemInform Abstract: Acceptor Substrate‐Based Selective Inhibition of Galactosyltransferases.

    Article • ChemInform, March 1999, Wiley

    Shuichi Takayama

  221. Selective inhibition of β-1,4- and α-1,3-galactosyltransferases: donor sugar-nucleotide based approach

    Article • Bioorganic & Medicinal Chemistry, February 1999, Elsevier

    Shuichi Takayama

  222. Designing enzymatic resolution of amines

    Article • Chemical Communications, January 1999, Royal Society of Chemistry

    Shuichi Takayama

  223. Patterning proteins and cells using soft lithography

    Article • January 1999, Elsevier

    Shuichi Takayama

  224. Chemoenzymatic synthesis of iminocyclitol derivatives: A useful library strategy for the development of selective fucosyltransfer enzymes inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, December 1998, Elsevier

    Shuichi Takayama

  225. Acceptor substrate-based selective inhibition of galactosyltransferases

    Article • Bioorganic & Medicinal Chemistry Letters, December 1998, Elsevier

    Shuichi Takayama

  226. Ligand Recognition by E- and P-Selectin:  Chemoenzymatic Synthesis and Inhibitory Activity of Bivalent Sialyl Lewis x Derivatives and Sialyl Lewis x Carboxylic Acids

    Article • The Journal of Organic Chemistry, July 1998, American Chemical Society (ACS)

    Shuichi Takayama

  227. MICROBIAL ALDOLASES AND TRANSKETOLASES:New Biocatalytic Approaches to Simple and Complex Sugars

    Article • Annual Review of Microbiology, October 1997, Annual Reviews

    Shuichi Takayama

  228. Quantitative electrospray mass spectrometry for the rapid assay of enzyme inhibitors

    Article • Chemistry & Biology, September 1997, Elsevier

    Shuichi Takayama

  229. Chemoenzymatic Preparation of Novel Cyclic Imine Sugars and Rapid Biological Activity Evaluation Using Electrospray Mass Spectrometry and Kinetic Analysis

    Article • Journal of the American Chemical Society, September 1997, American Chemical Society (ACS)

    Shuichi Takayama

  230. Enzymes in organic synthesis: recent developments in aldol reactions and glycosylations

    Article • Chemical Society Reviews, January 1997, Royal Society of Chemistry

    Shuichi Takayama

  231. Synthesis of the melanoma-associated ganglioside 9-O-acetyl GD3 through regioselective enzymatic acetylation of GD3 using subtilisin

    Article • Tetrahedron Letters, December 1996, Elsevier

    Shuichi Takayama

  232. A Practical Method for the Synthesis ofN-Acetyl-D-lactosamine Derivatives by the Tandem Use of Galactose Oxidase andβ-Galactosidase

    Article • Angewandte Chemie International Edition in English, November 1996, Wiley

    Shuichi Takayama

  233. Eine praktikable Synthese vonN-Acetyl-D-lactosamin mit Galactose-Oxidase und β-Galactosidase

    Article • Angewandte Chemie, October 1996, Wiley

    Shuichi Takayama

  234. Enzymatic resolution of amines and amino alcohols using pent-4-enoyl derivatives

    Article • Tetrahedron Letters, August 1996, Elsevier

    Shuichi Takayama

  235. Synthesis of lactosamine derivatives using β-d-galactosidase from Bacillus circulans

    Article • Bioorganic & Medicinal Chemistry Letters, May 1996, Elsevier

    Shuichi Takayama

  236. Mechanism and Specificity of Human α-1,3-Fucosyltransferase V

    Article • Biochemistry, January 1996, American Chemical Society (ACS)

    Shuichi Takayama

  237. Reduction of bicyclo[3.3.1]nonane-2,8-diones with baker's yeast

    Article • Bioorganic & Medicinal Chemistry, June 1994, Elsevier

    Shuichi Takayama

  238. Preparative Bioorganic Chemistry, XVII. – Reduction of a Prochiral Diketone, 9-Methyl-trans-decalin-1,8-dione, with Baker's Yeast

    Article • European Journal of Organic Chemistry, January 1993, Wiley

    Shuichi Takayama

  239. Microscale Integrated Sperm Sorter

    Article • Springer Science + Business Media

    Shuichi Takayama

  240. Microfluidic Pulmonary System for Experimental Investigation of Cellular Injury due to Fluid Mechanical Stresses during Airway Reopening

    Article • Springer Science + Business Media

    Shuichi Takayama