All Stories

  1. Visualization of spatial distribution of hemoglobin with various oxygen saturations in small animals using a photoacoustic imaging scanner with a hemispherical detector array
  2. Tissue-resident macrophages are major tumor-associated macrophage resources, contributing to early TNBC development, recurrence, and metastases
  3. Unconscious Bias Surrounding Female Researchers
  4. Droplet-based valveless microfluidic system for phage-display screening against spheroids
  5. International activity of SJWS expanding through ICWES/INWES
  6. A Murine Bone Metastasis Model Using Caudal Artery Injection and Bioluminescence Imaging
  7. ROR2 regulates the survival of murine osteosarcoma cells in lung capillaries
  8. Reconstitution of an Anti‐HER2 Antibody Paratope by Grafting Dual CDR‐Derived Peptides onto a Small Protein Scaffold
  9. Abstract LB-006: In vivo imaging of HIF-active cells in tumors using transgenic mice with a HIF-dependent reporter gene
  10. Slicing Spheroids in Microfluidic Devices for Morphological and Immunohistochemical Analysis
  11. Semi-rational Design of Target-binding Small Proteins for Cancer Treatment
  12. Design Strategy to Create Antibody Mimetics Harbouring Immobilised Complementarity Determining Region Peptides for Practical Use
  13. Strategic design to create HER2-targeting proteins with target-binding peptides immobilized on a fibronectin type III domain scaffold
  14. A reliable murine model of bone metastasis by injecting cancer cells through caudal arteries
  15. Novel lymphoid enhancer-binding factor 1-cytoglobin axis promotes extravasation of osteosarcoma cells into the lungs
  16. Blockage of the mevalonate pathway overcomes the apoptotic resistance to MEK inhibitors with suppressing the activation of Akt in cancer cells
  17. Single-cell bioluminescence imaging of deep tissue in freely moving animals
  18. Novel adherent CD11b+ Gr-1+ tumor-infiltrating cells initiate an immunosuppressive tumor microenvironment
  19. Domain architecture of vasohibins required for their chaperone-dependent unconventional extracellular release
  20. A novel injectable BRET-based in vivo imaging probe for detecting the activity of hypoxia-inducible factor regulated by the ubiquitin-proteasome system
  21. Investigation of the Influence of Glucose Concentration on Cancer Cells by Using a Microfluidic Gradient Generator without the Induction of Large Shear Stress
  22. Hypoxia-inducible factor-targeting prodrug TOP3 combined with gemcitabine or TS-1 improves pancreatic cancer survival in an orthotopic model
  23. A luciferin analogue generating near-infrared bioluminescence achieves highly sensitive deep-tissue imaging
  24. Distinctive role of vasohibin-1A and its splicing variant vasohibin-1B in tumor angiogenesis
  25. Application of HaloTag® Technology to in Vivo Molecular Imaging Using Protein Probes Labeled by Metallic Radionuclides
  26. VEGF-A/NRP1 stimulates GIPC1 and Syx complex formation to promote RhoA activation and proliferation in skin cancer cells
  27. Crystal Structure of RuCO/apo-R52CFr
  28. Crystal Structure of RuCO/apo-E45C_C48AFr
  29. Crystal structure of RuCO/apo-WTFr
  30. High resolution imaging of intracellular oxygen concentration by phosphorescence lifetime
  31. The effect of triamcinolone acetonide on laser-induced choroidal neovascularization in mice using a hypoxia visualization bio-imaging probe
  32. Uniform Cell Distribution Achieved by Using Cell Deformation in a Micropillar Array
  33. Design of a CO-releasing Extracellular Scaffold Using in Vivo Protein Crystals
  34. Cell penetrating peptides improve tumor delivery of cargos through neuropilin-1-dependent extravasation
  35. Preparation of a Cross-Linked Porous Protein Crystal Containing Ru Carbonyl Complexes as a CO-Releasing Extracellular Scaffold
  36. A metal carbonyl–protein needle composite designed for intracellular CO delivery to modulate NF-κB activity
  37. Intracellular CO Release from Composite of Ferritin and Ruthenium Carbonyl Complexes
  38. A Fluorescent Protein Scaffold for Presenting Structurally Constrained Peptides Provides an Effective Screening System to Identify High Affinity Target-Binding Peptides
  39. Bone resorption facilitates osteoblastic bone metastasis by insulin‐like growth factor and hypoxia. Von Kossa staining showing aberrant bone formation due to bone metastasis of murine osteosarcoma LM8 cells.
  40. Bone resorption facilitates osteoblastic bone metastatic colonization by cooperation of insulin‐like growth factor and hypoxia
  41. Development of a novel interferon-α2b gene construct with a repetitive hypoxia-inducible factor binding site and its suppressive effects on human renal cell carcinoma cell lines in vitro
  42. Development of an Oxygen-Sensitive Degradable Peptide Probe for the Imaging of Hypoxia-Inducible Factor-1-Active Regions in Tumors
  43. The Protective Role of the Transmembrane Thioredoxin-Related Protein TMX in Inflammatory Liver Injury
  44. Radiosynthesis and initial evaluation of 18F labeled nanocarrier composed of poly(L-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide
  45. A hypoxia-inducible factor (HIF)-3α splicing variant, HIF-3α4 impairs angiogenesis in hypervascular malignant meningiomas with epigenetically silenced HIF-3α4
  46. Importance of the physicochemical properties of fluorescent dyes for obtaining target-specific in vivo images by membrane-permeable macromolecular imaging probes
  47. In Vivo Imaging of Brain Ischemia Using an Oxygen-Dependent Degradative Fusion Protein Probe
  48. MT1-MMP plays a critical role in hematopoiesis by regulating HIF-mediated chemokine/cytokine gene transcription within niche cells
  49. 2-Nitroimidazole-Tricarbocyanine Conjugate as a Near-Infrared Fluorescent Probe for in Vivo Imaging of Tumor Hypoxia
  50. Synthesis and biological activity of furanylindazoles as inhibitors of hypoxia inducible factor (HIF)-1 transcriptional activity
  51. Development of a Hypoxia-Selective Near-Infrared Fluorescent Probe for Non-invasive Tumor Imaging
  52. In VivoVisualization of Heterogeneous Intratumoral Distribution of Hypoxia-Inducible Factor-1αActivity by the Fusion of High-Resolution SPECT...
  53. Detection of the Onset of Ischemia and Carcinogenesis by Hypoxia-Inducible Transcription Factor-Based In Vivo Bioluminescence Imaging
  54. Evaluation of [125I]IPOS as a molecular imaging probe for hypoxia‐inducible factor‐1‐active regions in a tumor: Comparison among single‐photon emission computed tomography/X‐ray computed tomography imaging, autoradiography, and immunohistoch...
  55. Pathophysiological Response to Hypoxia — From the Molecular Mechanisms of Malady to Drug Discovery: Hypoxia-Inducible Factor-1 (HIF-1)-Active Cells as a Target for Cancer Therapy
  56. In Vivo Imaging of HIF-Active Tumors by an Oxygen-Dependent Degradation Protein Probe with an Interchangeable Labeling System
  57. Early Protective Effect of Bone Marrow Mononuclear Cells Against Ischemic White Matter Damage Through Augmentation of Cerebral Blood Flow
  58. PET Imaging of Hypoxia-Inducible Factor-1-Active Tumor Cells with Pretargeted Oxygen-Dependent Degradable Streptavidin and a Novel 18F-Labeled Biotin Derivative
  59. Inactivation of chemokine (C-C motif) receptor 1 (CCR1) suppresses colon cancer liver metastasis by blocking accumulation of immature myeloid cells in a mouse model
  60. Noninvasive Tracking of Donor Cell Homing by Near-Infrared Fluorescence Imaging Shortly after Bone Marrow Transplantation
  61. Rapid detection of hypoxia-inducible factor-1-active tumours: pretargeted imaging with a protein degrading in a mechanism similar to hypoxia-inducible factor-1α
  62. Abstract 5240: Influence of cell permeable property of fluorescent dye on the POHin vivoimaging probe specific to HIF-active cancer cells
  63. Abstract 5230:In vivoimaging of tumor malignancy with near-infrared fluorescence probes specific to HIF-active cells
  65. Functional molecular imaging of ILK-mediated Akt/PKB signaling cascades and the associated role of  -parvin
  66. Persisting mild hypothermia suppresses hypoxia-inducible factor-1  protein synthesis and hypoxia-inducible factor-1-mediated gene expression
  67. Near-infrared fluorescence tumor imaging using nanocarrier composed of poly(l-lactic acid)-block-poly(sarcosine) amphiphilic polydepsipeptide
  68. Physical and Functional Interaction of Transmembrane Thioredoxin-related Protein with Major Histocompatibility Complex Class I Heavy Chain: Redox-based Protein Quality Control and Its Potential Relevance to Immune Responses
  69. Enhanced Percolation and Gene Expression in Tumor Hypoxia by PEGylated Polyplex Micelles
  70. Significance of nitroimidazole compounds and hypoxia‐inducible factor‐1 for imaging tumor hypoxia
  71. The HIF-1-active microenvironment: An environmental target for cancer therapy
  72. Imaging of HIF-1-Active Tumor Hypoxia Using a Protein Effectively Delivered to and Specifically Stabilized in HIF-1-Active Tumor Cells
  73. Selective Killing of Hypoxia-Inducible Factor-1-Active Cells Improves Survival in a Mouse Model of Invasive and Metastatic Pancreatic Cancer
  74. Cytokine-mediated induction of anti-apoptotic genes that are linked to nuclear factor kappa-B (NF-κB) signalling in human islets and in a mouse beta cell line
  75. Imaging probe for tumor malignancy
  76. Intravenously administered bone marrow cells alleviates white matter lesions in a model of chronic cerebral hypoperfusion
  77. Imaging and Targeting of the Hypoxia-inducible Factor 1-active Microenvironment
  78. Medical Applications of Biointerface
  79. The Akt/mTOR Pathway Assures the Synthesis of HIF-1  Protein in a Glucose- and Reoxygenation-dependent Manner in Irradiated Tumors
  80. TS‐1 enhances the effect of radiotherapy by suppressing radiation‐induced hypoxia‐inducible factor‐1 activation and inducing endothelial cell apoptosis
  81. Biomedical applications of imidazolium cation‐modified iron oxide nanoparticles
  82. Taip2 is a novel cell death-related gene expressed in the brain during development
  83. n-Propyl gallate activates hypoxia-inducible factor 1 by modulating intracellular oxygen-sensing systems
  84. Hypoxia inducible factor‐1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions
  85. Imaging and Targeting Tumors by Fusion Proteins with ODD Domain of HIF-1α
  86. Effects of Paclitaxel on human lung cancer cell lines in vitro and in vivo
  87. Near-Infrared Fluorescent Labeled Peptosome for Application to Cancer Imaging
  88. The combination of hypoxia-response enhancers and an oxygen-dependent proteolytic motif enables real-time imaging of absolute HIF-1 activity in tumor xenografts
  89. Hypoxia inducible factor‐1 influences sensitivity to paclitaxel of human lung cancer cell lines under normoxic conditions
  90. Significance of HIF-1-active cells in angiogenesis and radioresistance
  91. Hypoxia and Hypoxia-Inducible Factor-1 Expression Enhance Osteolytic Bone Metastases of Breast Cancer
  92. Development of a novel fluorescent imaging probe for tumor hypoxia by use of a fusion protein with oxygen-dependent degradation domain of HIF-1α
  93. Mechanism of hypoxia‐specific cytotoxicity of procaspase‐3 fused with a VHL‐mediated protein destruction motif of HIF‐1α containing Pro564
  94. Thioredoxin-Binding Protein-2-Like Inducible Membrane Protein Is a Novel Vitamin D3 and Peroxisome Proliferator-Activated Receptor (PPAR)γ Ligand Target Protein that Regulates PPARγ Signaling
  95. Antitumor protein therapy; Application of the protein transduction domain to the development of a protein drug for cancer treatment
  96. Suppression of VEGF transcription in renal cell carcinoma cells by pyrrole-imidazole hairpin polyamides targeting the hypoxia responsive element
  97. Targeting hypoxic cancer cells with a protein prodrug is effective in experimental malignant ascites
  98. Induction of Hypoxia-inducible Factor 1 Activity by Muscarinic Acetylcholine Receptor Signaling
  99. Cyclic AMP Promotes cAMP-responsive Element-binding Protein-dependent Induction of Cellular Inhibitor of Apoptosis Protein-2 and Suppresses Apoptosis of Colon Cancer Cells through ERK1/2 and p38 MAPK
  100. TMX, a human transmembrane oxidoreductase of the thioredoxin family: the possible role in disulfide-linked protein folding in the endoplasmic reticulum
  101. Tumor hypoxia: A target for selective cancer therapy
  102. Nitric Oxide Induces Hypoxia-inducible Factor 1 Activation That Is Dependent on MAPK and Phosphatidylinositol 3-Kinase Signaling
  103. Inhibition of apoptosis in normal and transformed intestinal epithelial cells by cAMP through induction of inhibitor of apoptosis protein (IAP)-2
  104. c‐IAP2 is induced by ionizing radiation through NF‐κB binding sites
  105. Identification of a Novel Thioredoxin-related Transmembrane Protein
  106. Identification of a Series of Transforming Growth Factor β-Responsive Genes by Retrovirus-Mediated Gene Trap Screening
  107. Transient over-expression of NGFI-A gene suppresses NGF-induced neurite outgrowth in PC12 cells
  108. Role of TGF‐β in EGF‐induced transformation of NRK cells is sustaining high‐level EGF‐signaling1
  109. Constitutive Association of EGF Receptor with the CrkII-23 Mutant that Inhibits Transformation of NRK Cells by EGF and TGF-β
  110. CrkII signals from epidermal growth factor receptor to Ras.
  111. Raf‐1 is not a major upstream regulator of MAP kinases in rat fibroblasts
  112. Raf-1 protein kinase is an integral component of the oncogenic signal cascade shared by epidermal growth factor and platelet-derived growth factor.
  113. A cell mutant that exhibits temperature-dependent sensitivity to transformation by various oncogenes.
  114. INTERACTIONS OF VIRAL PROTEINS WITH MURINE LYMPHOCYTES11This work was supported by a National Science Foundation Grant No. PCM-8003126 and a New York State Health Research Council Grant No. 10–023.