Contact

All Stories

  1. Astrocytic glycogenolysis gates Warburg-like metabolic reprogramming that promotes neuropathic pain chronification

    Article • Progress in Neurobiology, July 2026, Elsevier

    Professor Seung Bum Park

  2. ChemInform Abstract: Privileged Structures: Efficient Chemical “Navigators” Toward Unexplored Biologically Relevant Chemical Spaces

    Article • ChemInform, February 2015, Wiley

    Professor Seung Bum Park

  3. Unique photophysical properties of 9-styryl-1,2-dihydropyrrolo[3,4-β]indolizin-3-one and its efficient synthesis via direct C–H activation

    Article • Organic & Biomolecular Chemistry, January 2015, Royal Society of Chemistry

    Professor Seung Bum Park

  4. Diverse display of non-covalent interacting elements using pyrimidine-embedded polyheterocycles

    Article • Chemical Communications, January 2015, Royal Society of Chemistry

    Professor Seung Bum Park

  5. A small molecule binding HMGB1 and HMGB2 inhibits microglia-mediated neuroinflammation

    Article • Nature Chemical Biology, October 2014, Springer Science + Business Media

    Professor Seung Bum Park

  6. Phenotypic Screening to Identify Small‐Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy

    Article • Angewandte Chemie, April 2014, Wiley

    Professor Seung Bum Park

  7. Rücktitelbild: Phenotypic Screening to Identify Small‐Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy (Angew. Chem. 20/2014)

    Article • Angewandte Chemie, April 2014, Wiley

    Professor Seung Bum Park

  8. Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy

    Article • Angewandte Chemie, March 2014, Wiley

    Professor Seung Bum Park

  9. ChemInform Abstract: Privileged Substructure‐Based Diversity‐Oriented Synthesis Pathway for Diverse Pyrimidine‐Embedded Polyheterocycles.

    Article • ChemInform, March 2014, Wiley

    Professor Seung Bum Park

  10. Rational Perturbation of the Fluorescence Quantum Yield in Emission‐Tunable and Predictable Fluorophores (Seoul‐Fluors) by a Facile Synthetic Method Involving CH Activation

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Seung Bum Park, Prof Eunha Kim

  11. Rational Perturbation of the Fluorescence Quantum Yield in Emission‐Tunable and Predictable Fluorophores (Seoul‐Fluors) by a Facile Synthetic Method Involving CH Activation

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Seung Bum Park

  12. Impact of molecular charge on GLUT-specific cellular uptake of glucose bioprobes and in vivo application of the glucose bioprobe, GB2-Cy3

    Article • Chemical Communications, January 2014, Royal Society of Chemistry

    Professor Seung Bum Park

  13. Phenotypic Screening to Identify Small-Molecule Enhancers for Glucose Uptake: Target Identification and Rational Optimization of Their Efficacy

    Article • Angewandte Chemie, January 2014, Wiley

    Professor Seung Bum Park

  14. Privileged Substructure-Based Diversity-Oriented Synthesis Pathway for Diverse Pyrimidine-Embedded Polyheterocycles

    Article • Organic Letters, October 2013, American Chemical Society (ACS)

    Professor Seung Bum Park

  15. Synthesis of Molecular Frameworks Containing Two Distinct Heterocycles Connected in a Single Molecule with Enhanced Three‐Dimensional Shape Diversity

    Article • Chemistry - A European Journal, March 2013, Wiley

    Professor Seung Bum Park

  16. Exploiting the mechanism of cellular glucose uptake to develop an image-based high-throughput screening system in living cells

    Article • Chemical Communications, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  17. Discovery of a highly selective FLT3 kinase inhibitor from phenotypic cell viability profiling

    Article • MedChemComm, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  18. Fluorescent chemosensor for biological zinc ions

    Article • Supramolecular Chemistry, January 2013, Taylor & Francis

    Professor Seung Bum Park

  19. Discovery of autophagy modulators through the construction of a high-content screening platform via monitoring of lipid droplets

    Article • Chemical Science, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  20. Total synthesis of eryvarin H and its derivatives and their biological activity as ERRγ inverse agonist

    Article • Organic & Biomolecular Chemistry, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  21. From noncovalent to covalent bonds: a paradigm shift in target protein identification

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  22. Optimization of Seoul-Fluor-based lipid droplet bioprobes and their application in microalgae for bio-fuel study

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  23. Focus on chemical biology in Asia

    Article • Molecular BioSystems, January 2013, Royal Society of Chemistry

    Professor Seung Bum Park

  24. Colorimetric and orange light-emitting fluorescent probe for pyrophosphate in water

    Article • Tetrahedron Letters, October 2012, Elsevier

    Professor Seung Bum Park

  25. Lentiviral Vector-Mediated shRNA against AIMP2-DX2 Suppresses Lung Cancer Cell Growth through Blocking Glucose Uptake

    Article • Molecules and Cells, June 2012, Elsevier

    Professor Seung Bum Park

  26. ChemInform Abstract: Diversity‐Oriented Synthesis of Privileged Heterocycles Using Divergent Strategy.

    Article • ChemInform, May 2012, Wiley

    Professor Seung Bum Park

  27. Titelbild: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two‐Dimensional Gel Electrophoresis (Angew. Chem. 22/2012)

    Article • Angewandte Chemie, April 2012, Wiley

    Professor Seung Bum Park

  28. Cover Picture: Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two‐Dimensional Gel Electrophoresis (Angew. Chem. Int. Ed. 22/2012)

    Article • Angewandte Chemie, April 2012, Wiley

    Professor Seung Bum Park

  29. Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two‐Dimensional Gel Electrophoresis

    Article • Angewandte Chemie, April 2012, Wiley

    Professor Seung Bum Park

  30. Discovery and Target Identification of an Antiproliferative Agent in Live Cells Using Fluorescence Difference in Two‐Dimensional Gel Electrophoresis

    Article • Angewandte Chemie, April 2012, Wiley

    Professor Seung Bum Park

  31. ChemInform Abstract: A Design Strategy for Drug‐Like Polyheterocycles with Privileged Substructures for Discovery of Specific Small‐Molecule Modulators

    Article • ChemInform, February 2012, Wiley

    Professor Seung Bum Park

  32. A Seoul-Fluor-based bioprobe for lipid droplets and its application in image-based high throughput screening

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Seung Bum Park

  33. Photochemical generation of a new, highly fluorescent compound from non-fluorescent resveratrol

    Article • Chemical Communications, January 2012, Royal Society of Chemistry

    Professor Seung Bum Park

  34. Construction of Polyheterocyclic Benzopyran Library with Diverse Core Skeletons through Diversity-Oriented Synthesis Pathway: Part II

    Article • ACS Combinatorial Science, December 2011, American Chemical Society (ACS)

    Professor Seung Bum Park

  35. Diversity‐Oriented Synthesis of Privileged Heterocycles Using Divergent Strategy

    Article • December 2011, Wiley

    Professor Seung Bum Park

  36. Regioselective Construction and Screening of 1,3-Disubstituted Tetrahydroindazolones in Enantiomerically Pure Pairs

    Article • ACS Combinatorial Science, December 2011, American Chemical Society (ACS)

    Professor Seung Bum Park

  37. Ethanol and Reactive Species Increase Basal Sequence Heterogeneity of Hepatitis C Virus and Produce Variants with Reduced Susceptibility to Antivirals

    Article • PLOS One, November 2011, PLOS

    Professor Seung Bum Park

  38. ChemInform Abstract: 9‐Aryl‐1,2‐dihydropyrrolo[3,4‐b]indolizin‐3‐one (Seoul‐Fluor) as a Smart Platform for Colorful Ratiometric Fluorescent pH Sensors

    Article • ChemInform, October 2011, Wiley

    Professor Seung Bum Park

  39. Highly selective fluorescence turn-on probe for glutathione

    Article • Tetrahedron Letters, July 2011, Elsevier

    Professor Seung Bum Park

  40. Solid-Phase Parallel Synthesis of a Tetrahydroindazolone Library Containing Three Unique Core Skeletons

    Article • Chemistry - An Asian Journal, May 2011, Wiley

    Professor Seung Bum Park

  41. Bioinspired Polymerization of Dopamine to Generate Melanin-Like Nanoparticles Having an Excellent Free-Radical-Scavenging Property

    Article • Biomacromolecules, February 2011, American Chemical Society (ACS)

    Professor Seung Bum Park

  42. Inside Cover: Development of Fluorescent Glucose Bioprobes and Their Application on Real‐Time and Quantitative Monitoring of Glucose Uptake in Living Cells (Chem. Eur. J. 1/2011)

    Article • Chemistry - A European Journal, January 2011, Wiley

    Professor Seung Bum Park

  43. Development of Fluorescent Glucose Bioprobes and Their Application on Real‐Time and Quantitative Monitoring of Glucose Uptake in Living Cells

    Article • Chemistry - A European Journal, January 2011, Wiley

    Professor Seung Bum Park

  44. 9-Aryl-1,2-dihydropyrrolo[3,4-b]indolizin-3-one (Seoul-Fluor) as a smart platform for colorful ratiometric fluorescent pH sensors

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Seung Bum Park

  45. Ratiometric analysis of zidovudine (ZDV) incorporation by reverse transcriptases or polymerases via bio-orthogonal click chemistry

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Seung Bum Park

  46. A design strategy for drug-like polyheterocycles with privileged substructures for discovery of specific small-molecule modulators

    Article • Chemical Communications, January 2011, Royal Society of Chemistry

    Professor Seung Bum Park

  47. Discovery of a novel benzopyranyl compound as a potent in vitro and in vivo osteogenic agent

    Article • MedChemComm, January 2011, Royal Society of Chemistry

    Professor Seung Bum Park

  48. Surface modification for small-molecule microarrays and its application to the discovery of a tyrosinase inhibitor

    Article • Molecular BioSystems, January 2011, Royal Society of Chemistry

    Professor Seung Bum Park

  49. Pharmacophore-Based Strategy for the Development of General and Specific scFv Biosensors for Abused Antibiotics

    Article • Bioconjugate Chemistry, December 2010, American Chemical Society (ACS)

    Professor Seung Bum Park

  50. Discovery of Novel Benzopyranyl Tetracycles that Act as Inhibitors of Osteoclastogenesis Induced by Receptor Activator of NF-κB Ligand

    Article • Journal of Medicinal Chemistry, November 2010, American Chemical Society (ACS)

    Professor Seung Bum Park

  51. ChemInform Abstract: Orthogonal Regioselective Synthesis of N‐Alkyl‐3‐substituted Tetrahydroindazolones.

    Article • ChemInform, November 2010, Wiley

    Professor Seung Bum Park

  52. Orthogonal Regioselective Synthesis of N-Alkyl-3-substituted Tetrahydroindazolones (Eur. J. Org. Chem. 20/2010)

    Article • European Journal of Organic Chemistry, June 2010, Wiley

    Professor Seung Bum Park

  53. Orthogonal Regioselective Synthesis of N-Alkyl-3-substituted Tetrahydroindazolones

    Article • European Journal of Organic Chemistry, June 2010, Wiley

    Professor Seung Bum Park

  54. Development of a Benzopyran‐Containing Androgen Receptor Antagonist to Treat Antiandrogen‐Resistant Prostate Cancer

    Article • ChemMedChem, March 2010, Wiley

    Professor Seung Bum Park

  55. ChemInform Abstract: An Efficient One‐Step Synthesis of Heterobiaryl Pyrazolo[3,4‐b]pyridines via Indole Ring Opening.

    Article • ChemInform, March 2010, Wiley

    Professor Seung Bum Park

  56. Computer-aided design and synthesis of tetra-aryl-substituted alkenes and their bioevaluation as a selective modulator of estrogen-related receptor γ

    Article • Molecular Diversity, February 2010, Springer Science + Business Media

    Professor Seung Bum Park

  57. ChemInform Abstract: Chemistry as a Prism: A Review of Light‐Emitting Materials Having Tunable Emission Wavelenghts

    Article • ChemInform, January 2010, Wiley

    Professor Seung Bum Park

  58. Small Molecule Microarray: Functional-Group Specific Immobilization of Small Molecules

    Article • January 2010, Springer Science + Business Media

    Professor Seung Bum Park

  59. Discovery of New Fluorescent Dyes: Targeted Synthesis or Combinatorial Approach?

    Article • January 2010, Springer Science + Business Media

    Professor Seung Bum Park

  60. Chemistry as a Prism: A Review of Light‐Emitting Materials Having Tunable Emission Wavelengths

    Article • Chemistry - An Asian Journal, October 2009, Wiley

    Professor Seung Bum Park

  61. An Efficient One-Step Synthesis of Heterobiaryl Pyrazolo[3,4-b]pyridines via Indole Ring Opening

    Article • Organic Letters, October 2009, American Chemical Society (ACS)

    Professor Seung Bum Park

  62. A Two-Photon Tracer for Glucose Uptake

    Article • Angewandte Chemie, October 2009, Wiley

    Professor Seung Bum Park

  63. A Two‐Photon Tracer for Glucose Uptake

    Article • Angewandte Chemie, October 2009, Wiley

    Professor Seung Bum Park

  64. Efficient Discovery of Selective Small Molecule Agonists of Estrogen-Related Receptor γ using Combinatorial Approach

    Article • Journal of Combinatorial Chemistry, September 2009, American Chemical Society (ACS)

    Professor Seung Bum Park

  65. Natural polyphenols antagonize the antimyeloma activity of proteasome inhibitor bortezomib by direct chemical interaction

    Article • British Journal of Haematology, August 2009, Wiley

    Professor Seung Bum Park

  66. ChemInform Abstract: Diastereoselective Synthesis of Polycyclic Acetal-Fused Pyrano[3,2-c]pyran-5(2H)-one Derivatives.

    Article • ChemInform, July 2009, Wiley

    Professor Seung Bum Park

  67. ChemInform Abstract: Efficient Parallel Synthesis of Privileged Benzopyranylpyrazoles via Regioselective Condensation of β-Keto Aldehydes with Hydrazines.

    Article • ChemInform, July 2009, Wiley

    Professor Seung Bum Park

  68. Repeated Aerosol Delivery of Carboxyl-terminal Modulator Protein Suppresses Tumor in the Lungs of K-rasLA1Mice

    Article • American Review of Respiratory Disease, June 2009, American Thoracic Society

    Professor Seung Bum Park

  69. ChemInform Abstract: Regioselective Synthesis of Tetrasubstituted Pyrroles by 1,3‐Dipolar Cycloaddition and Spontaneous Decarboxylation.

    Article • ChemInform, April 2009, Wiley

    Professor Seung Bum Park

  70. Efficient Parallel Synthesis of Privileged Benzopyranylpyrazoles via Regioselective Condensation of β-Keto Aldehydes with Hydrazines

    Article • Journal of Combinatorial Chemistry, February 2009, American Chemical Society (ACS)

    Professor Seung Bum Park

  71. Diastereoselective Synthesis of Polycyclic Acetal-Fused Pyrano[3,2-c]pyran-5(2H)-one Derivatives

    Article • The Journal of Organic Chemistry, February 2009, American Chemical Society (ACS)

    Professor Seung Bum Park

  72. Fluorescent probe for detection of fluoride in water and bioimaging in A549 human lung carcinoma cells

    Article • Chemical Communications, January 2009, Royal Society of Chemistry

    Professor Seung Bum Park

  73. Regioselective Synthesis of Tetrasubstituted Pyrroles by 1,3-Dipolar Cycloaddition and Spontaneous Decarboxylation

    Article • Organic Letters, December 2008, American Chemical Society (ACS)

    Professor Seung Bum Park

  74. ChemInform Abstract: An Improved Synthesis of Pyrimidine- and Pyrazole-Based Acyclo-C-nucleosides as Carbohybrids.

    Article • ChemInform, November 2008, Wiley

    Professor Seung Bum Park

  75. ChemInform Abstract: Facile and Efficient Synthesis of Carbohybrids as Stereodivergent Druglike Small Molecules.

    Article • ChemInform, August 2008, Wiley

    Professor Seung Bum Park

  76. An improved synthesis of pyrimidine- and pyrazole-based acyclo-C-nucleosides as carbohybrids

    Article • Tetrahedron Letters, August 2008, Elsevier

    Professor Seung Bum Park

  77. ChemInform Abstract: Diversity‐Oriented Synthesis of Privileged Benzopyranyl Heterocycles from s‐cis‐Enones.

    Article • ChemInform, June 2008, Wiley

    Professor Seung Bum Park

  78. Facile and Efficient Synthesis of Carbohybrids as Stereodivergent Druglike Small Molecules

    Article • The Journal of Organic Chemistry, March 2008, American Chemical Society (ACS)

    Professor Seung Bum Park

  79. Diversity-Oriented Synthesis of Privileged Benzopyranyl Heterocycles from s-cis-Enones

    Article • The Journal of Organic Chemistry, February 2008, American Chemical Society (ACS)

    Professor Seung Bum Park

  80. Lentiviral siRNA targeting human AIMP2-DX2 inhibits EGFR pathway from NSCLC through block of glucose uptake

    Article • Toxicology Letters, October 2007, Elsevier

    Professor Seung Bum Park

  81. RETRACTED: Polo-like kinase 2 gene expression is regulated by the orphan nuclear receptor estrogen receptor-related receptor gamma (ERRγ)

    Article • Biochemical and Biophysical Research Communications, October 2007, Elsevier

    Professor Seung Bum Park

  82. Practical Solid-Phase Parallel Synthesis of Δ5-2-Oxopiperazines viaN-Acyliminium Ion Cyclization

    Article • Journal of Combinatorial Chemistry, June 2007, American Chemical Society (ACS)

    Professor Seung Bum Park

  83. Synthesis and in vitro photodynamic activities of water-soluble fluorinated tetrapyridylporphyrins as tumor photosensitizers

    Article • Bioorganic & Medicinal Chemistry Letters, May 2007, Elsevier

    Professor Seung Bum Park

  84. Development of a Cy3-Labeled Glucose Bioprobe and Its Application in Bioimaging and Screening for Anticancer Agents

    Article • Angewandte Chemie, March 2007, Wiley

    Professor Seung Bum Park

  85. Development of a Cy3‐Labeled Glucose Bioprobe and Its Application in Bioimaging and Screening for Anticancer Agents

    Article • Angewandte Chemie, March 2007, Wiley

    Professor Seung Bum Park

  86. Abc Amino Acids: Design, Synthesis, and Properties of New Photoelastic Amino Acids

    Article • ChemInform, January 2007, Wiley

    Professor Seung Bum Park

  87. Novel application of Leuckart–Wallach reaction for synthesis of tetrahydro-1,4-benzodiazepin-5-ones library

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Professor Seung Bum Park

  88. A practical procedure for producing silver nanocoated fabric and its antibacterial evaluation for biomedical applications

    Article • Chemical Communications, January 2007, Royal Society of Chemistry

    Professor Seung Bum Park

  89. Concise and Diversity‐Oriented Synthesis of Novel Scaffolds Embedded with Privileged Benzopyran Motif.

    Article • ChemInform, November 2006, Wiley

    Professor Seung Bum Park

  90. Abc Amino Acids:  Design, Synthesis, and Properties of New Photoelastic Amino Acids

    Article • The Journal of Organic Chemistry, September 2006, American Chemical Society (ACS)

    Professor Seung Bum Park

  91. Preparation of pilot library with tetrahydro-β-carboline alkaloid core skeleton using tandem intramolecular Pictet–Spengler cyclization

    Article • Tetrahedron Letters, September 2006, Elsevier

    Professor Seung Bum Park

  92. A Robust Small-Molecule Microarray Platform for Screening Cell Lysates

    Article • Chemistry & Biology, May 2006, Elsevier

    Professor Seung Bum Park

  93. Concise and diversity-oriented synthesis of novel scaffolds embedded with privileged benzopyran motif

    Article • Chemical Communications, January 2006, Royal Society of Chemistry

    Professor Seung Bum Park

  94. Solid-Phase Parallel Synthesis of Natural Product-Like Diaza-Bridged Heterocycles through Pictet−Spengler Intramolecular Cyclization

    Article • Journal of Combinatorial Chemistry, November 2005, American Chemical Society (ACS)

    Professor Seung Bum Park

  95. Simple Mimetics of a Nuclear Localization Signal (NLS)

    Article • Organic Letters, June 2003, American Chemical Society (ACS)

    Professor Seung Bum Park

  96. Expanding the Functional Group Compatibility of Small‐Molecule Microarrays: Discovery of Novel Calmodulin Ligands

    Article • Angewandte Chemie, May 2003, Wiley

    Professor Seung Bum Park

  97. Titelbild: Expanding the Functional Group Compatibility of Small‐Molecule Microarrays: Discovery of Novel Calmodulin Ligands (Angew. Chem. 21/2003)

    Article • Angewandte Chemie, May 2003, Wiley

    Professor Seung Bum Park

  98. Skeletal Diversity via a Branched Pathway:  Efficient Synthesis of 29 400 Discrete, Polycyclic Compounds and Their Arraying into Stock Solutions

    Article • Journal of the American Chemical Society, October 2002, American Chemical Society (ACS)

    Professor Seung Bum Park

  99. Study of the characteristics of three high-energy intermediates generated in peroxyoxalate chemiluminescence (PO-CL) reactions

    Article • Journal of the Chemical Society Perkin Transactions 2, March 2002, Royal Society of Chemistry

    Professor Seung Bum Park

  100. A photoregulated ligand for the nuclear import receptor karyopherin α

    Article • Bioorganic & Medicinal Chemistry, December 2001, Elsevier

    Professor Seung Bum Park

  101. A simple, solid-phase binding assay for the nuclear import receptor karyopherin α. Part 2: competitive binding

    Article • Bioorganic & Medicinal Chemistry Letters, May 2000, Elsevier

    Professor Seung Bum Park

  102. A simple, solid-phase binding assay for the nuclear import receptor karyopherin α. Part 1: direct binding

    Article • Bioorganic & Medicinal Chemistry Letters, May 2000, Elsevier

    Professor Seung Bum Park

  103. ChemInform Abstract: α,α‐Difluorophosphonomethyl Azobenzene Derivatives as Photo‐Regulated Phosphoamino Acid Analogues. Part 1. Design and Synthesis.

    Article • ChemInform, December 1999, Wiley

    Professor Seung Bum Park

  104. α,α-Difluorophosphonomethyl azobenzene derivatives as photo-regulated phosphoamino acid analogs. 1. Design and synthesis

    Article • Tetrahedron Letters, September 1999, Elsevier

    Professor Seung Bum Park