All Stories

  1. Dual Role of 3′ UTR Length in Modulating Translation Termination Efficiency
  2. The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation
  3. The p48 isoform of the PA2G4/EBP1/ITAF45 oncoprotein is required for the encephalomyocarditis virus IRES-driven translation initiation
  4. Mechanism of read-through enhancement by aminoglycosides and mefloquine
  5. Guidelines for minimal reporting requirements, design and interpretation of experiments involving the use of eukaryotic dual gene expression reporters (MINDR)
  6. Eukaryotic initiation factors eIF4F and eIF4B promote translation termination upon closed-loop formation
  7. Forced Overexpression and Knockout Analysis of SLC30A and SLC39A Family Genes Suggests Their Involvement in Establishing Resistance to Cisplatin in Human Cancer Cells
  8. Novel Efficient Lipid-Based Delivery Systems Enable a Delayed Uptake and Sustained Expression of mRNA in Human Cells and Mouse Tissues
  9. Major Role of S-Glycoprotein in Providing Immunogenicity and Protective Immunity in mRNA Lipid Nanoparticle Vaccines Based on SARS-CoV-2 Structural Proteins
  10. Introduction of Dicistrovirus IRESs into UAS/SV40-polyA constructs results in premature polyadenylation and strong overexpression of the upstream ORF inDrosophilaanimals
  11. Multi-omic rejuvenation and life span extension on exposure to youthful circulation
  12. Monitoring integrated stress response in liveDrosophila
  13. Human Tissues Exhibit Diverse Composition of Translation Machinery
  14. Human tissues exhibit diverse composition of translation machinery
  15. Relocalization of Translation Termination and Ribosome Recycling Factors to Stress Granules Coincides with Elevated Stop-Codon Readthrough and Reinitiation Rates upon Oxidative Stress
  16. Longevity and rejuvenation effects of cell reprogramming are decoupled from loss of somatic identity
  17. Enteroviruses Manipulate the Unfolded Protein Response through Multifaceted Deregulation of the Ire1-Xbp1 Pathway
  18. Robust expression of transgenes inDrosophila melanogaster
  19. In vivo cyclic induction of the FOXM1 transcription factor delays natural and progeroid aging phenotypes and extends healthspan
  20. Ribo-Seq and RNA-Seq of TMA46 (DFRP1) and GIR2 (DFRP2) knockout yeast strains
  21. Multi-omic rejuvenation and lifespan extension upon exposure to youthful circulation
  22. Systematic identification of yeast mutants with increased rates of cell death reveals rapid stochastic necrosis associated with cell division
  23. A standard knockout procedure alters expression of adjacent loci at the translational level
  24. A standard knockout procedure alters expression of adjacent loci at the translational level
  25. Abstract P-22: Enhanced Crosslinking and Immunoprecipitation (Eclip) Data Reveal Interactions of RNA Binding Proteins with the Human Ribosome
  26. Assessing Ribosome Distribution Along Transcripts with Polarity Scores and Regression Slope Estimates
  27. Patterns of aging biomarkers, mortality, and damaging mutations illuminate the beginning of aging and causes of early-life mortality
  28. Multifaceted deregulation of gene expression and protein synthesis with age
  29. CTELS: A Cell-Free System for the Analysis of Translation Termination Rate
  30. Functional Cyclization of Eukaryotic mRNAs
  31. Multi-faceted deregulation of gene expression and protein synthesis with age
  32. Patterns of Aging Biomarkers, Mortality, and Damaging Mutations Illuminate the Beginning of Aging and Causes of Early-Life Mortality
  33. Abstract P-17: Structural and Functional Insights into Eukaryotic Translation Reinitiation and Ribosome Recycling Orchestrated by eIF2D and MCT-1/DENR
  34. A novel uORF-based regulatory mechanism controls translation of the human MDM2 and eIF2D mRNAs during stress
  35. Protein synthesis and quality control in aging
  36. Reversibility of irreversible aging
  37. Crystal Structure of the Human Ribosome in Complex with DENR-MCT-1
  38. Crystal Structure of the C-terminal Domain of Human eIF2D and its Implications on Eukaryotic Translation Initiation
  39. Synergistic suppression of t(8;21)-positive leukemia cell growth by combining oridonin and MAPK1/ERK2 inhibitors
  40. Insights into the mechanisms of eukaryotic translation gained with ribosome profiling
  41. Late Diagnosis of POMC Deficiency and in vitro evidence of residual translation from allele with c.-11C>A mutation
  42. Four translation initiation pathways employed by the leaderless mRNA in eukaryotes
  43. A researcher’s guide to the galaxy of IRESs
  44. Early B-cell factor 1 (EBF1) is critical for transcriptional control of SLAMF1 gene in human B cells
  45. Amicoumacin A induces cancer cell death by targeting the eukaryotic ribosome
  46. Pros and cons of pDNA and mRNA transfection to study mRNA translation in mammalian cells
  47. Does HIV-1 mRNA 5'-untranslated region bear an internal ribosome entry site?
  48. Sliding of a 43S ribosomal complex from the recognized AUG codon triggered by a delay in eIF2-bound GTP hydrolysis
  49. RNA-seq analysis of an apical meristem time series reveals a critical point in Arabidopsis thaliana flower initiation
  50. Translation of 5′ leaders is pervasive in genes resistant to eIF2 repression
  51. Upstream open reading frames regulate translation of the long isoform of SLAMF1 mRNA that encodes costimulatory receptor CD150
  52. Identification of a Mg2+-sensitive ORF in the 5'-leader of TRPM7 magnesium channel mRNA
  53. Silencing AML1-ETO gene expression leads to simultaneous activation of both pro-apoptotic and proliferation signaling
  54. Transcriptome-wide studies uncover the diversity of modes of mRNA recruitment to eukaryotic ribosomes
  55. Human-specific endogenous retroviral insert serves as an enhancer for the schizophrenia-linked gene PRODH
  56. Cap-independent translation initiation of Apaf-1 mRNA based on a scanning mechanism is determined by some features of the secondary structure of its 5′ untranslated region
  57. A novel mechanism of eukaryotic translation initiation that is neither m7G-cap-, nor IRES-dependent
  58. In vitro activity of human translation initiation factor eIF4B is not affected by phosphomimetic amino acid substitutions S422D and S422E
  59. Sense transcripts originated from an internal part of the human retrotransposon LINE-1 5′ UTR
  60. The 5′ untranslated region of Apaf-1 mRNA directs translation under apoptosis conditions via a 5′ end-dependent scanning mechanism
  61. Glycyl-tRNA synthetase specifically binds to the poliovirus IRES to activate translation initiation
  62. Archaeal Translation Initiation Factor aIF2 Can Substitute for Eukaryotic eIF2 in Ribosomal Scanning during Mammalian 48S Complex Formation
  63. Design of Targeted B Cell Killing Agents
  64. Unidirectional constant rate motion of the ribosomal scanning particle during eukaryotic translation initiation
  65. Cap- and IRES-independent scanning mechanism of translation initiation as an alternative to the concept of cellular IRESs
  66. GTP-independent tRNA Delivery to the Ribosomal P-site by a Novel Eukaryotic Translation Factor
  67. Differential contribution of the m7G-cap to the 5′ end-dependent translation initiation of mammalian mRNAs
  68. Efficient cap-dependent translation of mammalian mRNAs with long and highly structured 5′-untranslated regions in vitro and in vivo
  69. Eukaryotic translation initiation machinery can operate in a bacterial-like mode without eIF2
  70. The bacterial toxin RelE induces specific mRNA cleavage in the A site of the eukaryote ribosome
  71. Differential factor requirement to assemble translation initiation complexes at the alternative start codons of foot-and-mouth disease virus RNA
  72. Key role of the internal 5′-UTR segment in the transcription activity of the human L1 retrotransposon
  73. Efficient Translation Initiation Directed by the 900-Nucleotide-Long and GC-Rich 5′ Untranslated Region of the Human Retrotransposon LINE-1 mRNA Is Strictly Cap Dependent Rather than Internal Ribosome Entry Site Mediated
  74. Similar features in the mechanisms of mRNA translation initiation in eukaryotic and prokaryotic systems
  75. A Leaderless mRNA Can Bind to Mammalian 80S Ribosomes and Direct Polypeptide Synthesis in the Absence of Translation Initiation Factors
  76. Adequate system for studying translation initiation on the human retrotransposon L1 mRNA in vitro
  77. Analysis of point mutations of the BRCA1 gene by hybridization with hydrogel microarrays
  78. A Cross-Kingdom Internal Ribosome Entry Site Reveals a Simplified Mode of Internal Ribosome Entry
  79. Mutual Effects of Translation Initiation Factors in Binding to the IRES of the Encephalomyocarditis Virus RNA
  80. Assembly of 48S Translation Initiation Complexesfrom Purified Components with mRNAs That Have Some Base Pairingwithin Their 5′ UntranslatedRegions
  81. Distinctive Properties of the 5′-Untranslated Region of Human Hsp70 mRNA
  82. Conversion of 48S translation preinitiation complexes into 80S initiation complexes as revealed by toeprinting