All Stories

  1. DNA breaks and repeat expansion diseases

    Article • Proceedings of the National Academy of Sciences, November 2024, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  2. DNA Nicks Drive Massive Expansions of (GAA)nRepeats

    Article • June 2024, Cold Spring Harbor Laboratory Press

    Professor Sergei M. Mirkin

  3. Pathogenic CANVAS (AAGGG)nrepeats stall DNA replication due to the formation of alternative DNA structures

    Article • July 2023, Cold Spring Harbor Laboratory Press

    Professor Sergei M. Mirkin

  4. Large-scale expansions of Friedreich's ataxia GAA•TTC repeats in an experimental human system: role of DNA replication and prevention by LNA-DNA oligonucleotides and PNA oligomers

    Article • Nucleic Acids Research, May 2023, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  5. Large-scale expansions and replication stalling of Friedreich’s ataxia GAA repeats in an experimental mammalian system

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Professor Sergei M. Mirkin

  6. Large-scale expansions of Friedreich’s ataxia GAA•TTC repeats in human cells are prevented by LNA-DNA oligonucleotides and PNA oligomers

    Article • July 2022, Cold Spring Harbor Laboratory Press

    Professor Sergei M. Mirkin

  7. Fleeing Russian researchers seek Western support

    Article • Nature, June 2022, Springer Science + Business Media

    Professor Sergei M. Mirkin

  8. Partners in crime: Tbf1 and Vid22 promote expansions of long human telomeric repeats at an interstitial chromosome position in yeast

    Article • PNAS Nexus, June 2022, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  9. Rad9-mediated checkpoint activation is responsible for elevated expansions of GAA repeats in CST-deficient yeast

    Article • Genetics, August 2021, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  10. At the Beginning of the End and in the Middle of the Beginning: Structure and Maintenance of Telomeric DNA Repeats and Interstitial Telomeric Sequences

    Article • Genes, February 2019, MDPI AG

    Professor Sergei M. Mirkin

  11. Mechanisms of genetic instability caused by (CGG)n repeats in an experimental mammalian system

    Article • Nature Structural & Molecular Biology, July 2018, Springer Science + Business Media

    Professor Sergei M. Mirkin

  12. Cis- and Trans-Modifiers of Repeat Expansions: Blending Model Systems with Human Genetics

    Article • Trends in Genetics, June 2018, Elsevier

    Professor Sergei M. Mirkin

  13. Nanopore sequencing of complex genomic rearrangements in yeast reveals mechanisms of repeat-mediated double-strand break repair

    Article • Genome Research, November 2017, Cold Spring Harbor Laboratory Press

    Professor Sergei M. Mirkin

  14. Quantitative Analysis of the Rates for Repeat-Mediated Genome Instability in a Yeast Experimental System

    Article • October 2017, Springer Science + Business Media

    Professor Sergei M. Mirkin

  15. A Defective mRNA Cleavage and Polyadenylation Complex Facilitates Expansions of Transcribed (GAA)n Repeats Associated with Friedreich’s Ataxia

    Article • Cell Reports, September 2017, Elsevier

    Professor Sergei M. Mirkin

  16. Precarious maintenance of simple DNA repeats in eukaryotes

    Article • BioEssays, July 2017, Wiley

    Professor Sergei M. Mirkin

  17. Phosphate steering by Flap Endonuclease 1 promotes 5′-flap specificity and incision to prevent genome instability

    Article • Nature Communications, June 2017, Springer Science + Business Media

    Professor Sergei M. Mirkin

  18. The role of break-induced replication in large-scale expansions of (CAG)n/(CTG)n repeats

    Article • Nature Structural & Molecular Biology, December 2016, Springer Science + Business Media

    Professor Sergei M. Mirkin

  19. Expansion of Interstitial Telomeric Sequences in Yeast

    Article • Cell Reports, November 2015, Elsevier

    Professor Sergei M. Mirkin

  20. Putting the Brakes on Huntington Disease in a Mouse Experimental Model

    Article • PLoS Genetics, August 2015, PLOS

    Professor Sergei M. Mirkin

  21. The hidden side of unstable DNA repeats: Mutagenesis at a distance

    Article • DNA Repair, August 2015, Elsevier

    Professor Sergei M. Mirkin

  22. Transcription blockage by stable H-DNA analogs in vitro

    Article • Nucleic Acids Research, June 2015, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  23. Coupling Transcriptional State to Large-Scale Repeat Expansions in Yeast

    Article • Cell Reports, December 2014, Elsevier

    Professor Sergei M. Mirkin

  24. To Switch or Not to Switch: At the Origin of Repeat Expansion Disease

    Article • Molecular Cell, January 2014, Elsevier

    Professor Sergei M. Mirkin

  25. Reduced local mutation density in regulatory DNA of cancer genomes is linked to DNA repair

    Article • Nature Biotechnology, December 2013, Springer Science + Business Media

    Professor Sergei M. Mirkin

  26. Genome rearrangements caused by interstitial telomeric sequences in yeast

    Article • Proceedings of the National Academy of Sciences, November 2013, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  27. DNA Sequences That Interfere with Transcription: Implications for Genome Function and Stability

    Article • Chemical Reviews, August 2013, American Chemical Society (ACS)

    Professor Sergei M. Mirkin

  28. The balancing act of DNA repeat expansions

    Article • Current Opinion in Genetics & Development, June 2013, Elsevier

    Professor Sergei M. Mirkin

  29. Driving past four-stranded snags

    Article • Nature, May 2013, Springer Science + Business Media

    Professor Sergei M. Mirkin

  30. Transcription blockage by homopurine DNA sequences: role of sequence composition and single-strand breaks

    Article • Nucleic Acids Research, December 2012, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  31. Role of DNA Polymerases in Repeat-Mediated Genome Instability

    Article • Cell Reports, November 2012, Elsevier

    Professor Sergei M. Mirkin

  32. Genome-wide Screen Identifies Pathways that Govern GAA/TTC Repeat Fragility and Expansions in Dividing and Nondividing Yeast Cells

    Article • Molecular Cell, October 2012, Elsevier

    Professor Sergei M. Mirkin

  33. Effects of Friedreich's ataxia GAA repeats on DNA replication in mammalian cells

    Article • Nucleic Acids Research, January 2012, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  34. Overcoming natural replication barriers: differential helicase requirements

    Article • Nucleic Acids Research, October 2011, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  35. A Renaissance Man: In Memoriam of Jon Widom (1955–2011)

    Article • Journal of Biomolecular Structure and Dynamics, October 2011, Taylor & Francis

    Professor Sergei M. Mirkin

  36. Expansions, contractions, and fragility of the spinocerebellar ataxia type 10 pentanucleotide repeat in yeast

    Article • Proceedings of the National Academy of Sciences, January 2011, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  37. Friedreich's Ataxia (GAA)n•(TTC)n Repeats Strongly Stimulate Mitotic Crossovers in Saccharomyces cerevisae

    Article • PLoS Genetics, January 2011, PLOS

    Mr Zachary M Harvanek, Professor Sergei M. Mirkin

  38. Getting to the Core of Repeat Expansions by Cell Reprogramming

    Article • Cell Stem Cell, November 2010, Elsevier

    Professor Sergei M. Mirkin

  39. Mechanisms and implications of transcription blockage by guanine-rich DNA sequences

    Article • Proceedings of the National Academy of Sciences, June 2010, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  40. Large-Scale Expansions of Friedreich's Ataxia GAA Repeats in Yeast

    Article • Molecular Cell, July 2009, Elsevier

    Professor Sergei M. Mirkin

  41. Checkpoint responses to unusual structures formed by DNA repeats

    Article • Molecular Carcinogenesis, March 2009, Wiley

    Professor Sergei M. Mirkin

  42. Human mutation rate associated with DNA replication timing

    Article • Nature Genetics, March 2009, Springer Science + Business Media

    Professor Sergei M. Mirkin

  43. Replisome stalling and stabilization at CGG repeats, which are responsible for chromosomal fragility

    Article • Nature Structural & Molecular Biology, January 2009, Springer Science + Business Media

    Professor Sergei M. Mirkin

  44. Chromosome fragility at GAA tracts in yeast depends on repeat orientation and requires mismatch repair

    Article • The EMBO Journal, October 2008, Springer Science + Business Media

    Professor Sergei M. Mirkin

  45. A Tribute to Evgenii V. Ananiev, 1947–2008

    Article • PLoS Genetics, August 2008, PLOS

    Professor Sergei M. Mirkin

  46. Replication stalling at unstable inverted repeats: Interplay between DNA hairpins and fork stabilizing proteins

    Article • Proceedings of the National Academy of Sciences, July 2008, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  47. Discovery of alternative DNA structures: a heroic decade (1979-1989)

    Article • Frontiers in Bioscience, January 2008, IMR Press

    Professor Sergei M. Mirkin

  48. Expandable DNA repeats and human disease

    Article • Nature, June 2007, Springer Science + Business Media

    Professor Sergei M. Mirkin

  49. Replication Fork Stalling at Natural Impediments

    Article • Microbiology and Molecular Biology Reviews, March 2007, ASM Journals

    Professor Sergei M. Mirkin

  50. Effects of Friedreich's ataxia (GAA)n{middle dot}(TTC)n repeats on RNA synthesis and stability

    Article • Nucleic Acids Research, January 2007, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  51. DNA structures, repeat expansions and human hereditary disorders

    Article • Current Opinion in Structural Biology, June 2006, Elsevier

    Professor Sergei M. Mirkin

  52. Transcription regulatory elements are punctuation marks for DNA replication

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  53. Toward a unified theory for repeat expansions

    Article • Nature Structural & Molecular Biology, August 2005, Springer Science + Business Media

    Professor Sergei M. Mirkin

  54. Mechanisms of Transcription-Replication Collisions in Bacteria

    Article • Molecular and Cellular Biology, February 2005, ASM Journals

    Professor Sergei M. Mirkin

  55. Replication Stalling at Friedreich's Ataxia (GAA)n Repeats In Vivo

    Article • Molecular and Cellular Biology, March 2004, ASM Journals

    Professor Sergei M. Mirkin

  56. Schizosaccharomyces pombe Ddb1 Is functionally Linked to the Replication Checkpoint Pathway

    Article • Journal of Biological Chemistry, September 2003, Elsevier

    Professor Sergei M. Mirkin

  57. Replication and Expansion of Trinucleotide Repeats in Yeast

    Article • Molecular and Cellular Biology, February 2003, ASM Journals

    Professor Sergei M. Mirkin

  58. Positioned to expand

    Article • Nature Genetics, May 2002, Springer Science + Business Media

    Professor Sergei M. Mirkin

  59. Article • Molecular Biology, January 2002, Springer Science + Business Media

    Professor Sergei M. Mirkin

  60. A new trick for an old dog: TraY binding to a homopurine-homopyrimidine run attenuates DNA replication

    Article • Journal of Molecular Biology, October 2001, Elsevier

    Professor Sergei M. Mirkin

  61. Article • Molecular Biology, January 2001, Springer Science + Business Media

    Professor Sergei M. Mirkin

  62. Large-scale effects of transcriptional DNA supercoiling in Vivo 1 1Edited by I. Tinoco

    Article • Journal of Molecular Biology, October 1999, Elsevier

    Professor Sergei M. Mirkin

  63. Transcription through a simple DNA repeat blocks replication elongation

    Article • The EMBO Journal, September 1998, Springer Science + Business Media

    Professor Sergei M. Mirkin

  64. Trinucleotide repeats affect DNA replication in vivo

    Article • Nature Genetics, November 1997, Springer Science + Business Media

    Professor Sergei M. Mirkin

  65. Characteristic enrichment of DNA repeats in different genomes

    Article • Proceedings of the National Academy of Sciences, May 1997, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  66. Mechanisms of triplex-caused polymerization arrest

    Article • Nucleic Acids Research, April 1997, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  67. TRIPLEX DNA STRUCTURES

    Article • Annual Review of Biochemistry, June 1995, Annual Reviews

    Professor Sergei M. Mirkin

  68. Trapping DNA polymerases using triplex-forming oligodeoxyribonucleotides

    Article • Gene, November 1994, Elsevier

    Professor Sergei M. Mirkin

  69. H-DNA and Related Structures

    Article • Annual Review of Biophysics and Biomolecular Structure, June 1994, Annual Reviews

    Professor Sergei M. Mirkin

  70. Transcriptional activity of the homopurine-homopyrimidine repeat of the c-Ki-raspromoter is independent of its H-forming potential

    Article • Nucleic Acids Research, January 1994, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  71. Intramolecular DNA triplexes: unusual sequence requirements and influence on DNA polymerization.

    Article • Proceedings of the National Academy of Sciences, December 1992, Proceedings of the National Academy of Sciences

    Professor Sergei M. Mirkin

  72. Transcriptionally driven cruciform formationin vivo

    Article • Nucleic Acids Research, January 1992, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  73. Formation of (dA-dT)n cruciforms in Escherichia coli cells under different environmental conditions

    Article • Journal of Bacteriology, April 1991, ASM Journals

    Professor Sergei M. Mirkin

  74. H-DNA and Z-DNA in the mouse c-Ki-raspromoter

    Article • Nucleic Acids Research, January 1991, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  75. Formation of intramolecular triplex in homopurine-homopyrimidine mirror repeats with point substitutions

    Article • Nucleic Acids Research, January 1990, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  76. An unusual DMA structure detected in a telomeric sequence under superhelical stress and at low pH

    Article • Nature, June 1989, Springer Science + Business Media

    Professor Sergei M. Mirkin

  77. Energetics of the B–H transition in supercoiled DNA carrying d(CT)x.d(AG)xand d(C)n.d(G)ninserts

    Article • Nucleic Acids Research, January 1989, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  78. Chemical probing of the homopurine·homopyrimidine tract in supercoiled DNA at single‐nucleotide resolution

    Article • FEBS Letters, July 1988, Wiley

    Professor Sergei M. Mirkin

  79. Chemical probing of homopurine-homopyrimidine mirror repeats in supercoiled DNA

    Article • Nature, June 1988, Springer Science + Business Media

    Professor Sergei M. Mirkin

  80. A stable complex between homopyrimidine oligomers and the homologous regions of duplex DNAs

    Article • Nucleic Acids Research, January 1988, Oxford University Press (OUP)

    Professor Sergei M. Mirkin

  81. DNA H form requires a homopurine–homopyrimidine mirror repeat

    Article • Nature, December 1987, Springer Science + Business Media

    Professor Sergei M. Mirkin

  82. Structure of (dG)n· (dC)nUnder Superhelical Stress and Acid pH

    Article • Journal of Biomolecular Structure and Dynamics, October 1987, Taylor & Francis

    Professor Sergei M. Mirkin

  83. The Energetics of the B-Z Transition in DNA

    Article • Journal of Biomolecular Structure and Dynamics, August 1987, Taylor & Francis

    Professor Sergei M. Mirkin

  84. The Ionic Strength Dependence of the Cooperativity Factor for DNA Melting

    Article • Journal of Biomolecular Structure and Dynamics, August 1987, Taylor & Francis

    Professor Sergei M. Mirkin

  85. Structures of Homopurine-homopyrimidine Tract in Superhelical DNA

    Article • Journal of Biomolecular Structure and Dynamics, February 1986, Taylor & Francis

    Professor Sergei M. Mirkin

  86. A pH-dependent Structural Transition in the Homopurine-homopyrimidine Tract in Superhelical DNA

    Article • Journal of Biomolecular Structure and Dynamics, October 1985, Taylor & Francis

    Professor Sergei M. Mirkin

  87. A Structural Transition in d(AT)n·d(AT)nInserts within Superhelical DNA

    Article • Journal of Biomolecular Structure and Dynamics, June 1985, Taylor & Francis

    Professor Sergei M. Mirkin

  88. The Absence of Cruciform Structures from pA03 Plasmid DNAIn vivo

    Article • Journal of Biomolecular Structure and Dynamics, October 1984, Taylor & Francis

    Professor Sergei M. Mirkin

  89. Native supercoiling of DNA: The effects of DNA gyrase and ω protein in E. coli

    Article • MGG Molecular & General Genetics, September 1984, Springer Science + Business Media

    Professor Sergei M. Mirkin

  90. DNA replication and transcription in a temperature-sensitive mutant of E. coli with a defective DNA gyrase B subunit

    Article • MGG Molecular & General Genetics, November 1982, Springer Science + Business Media

    Professor Sergei M. Mirkin

  91. Changed properties of the A subunit in DNA gyrase with a B subunit mutation

    Article • MGG Molecular & General Genetics, August 1982, Springer Science + Business Media

    Professor Sergei M. Mirkin

  92. DNA Supercoiling and transcription in Escherichia coli: Influence of RNA polymerase mutations

    Article • MGG Molecular & General Genetics, December 1979, Springer Science + Business Media

    Professor Sergei M. Mirkin