All Stories

  1. Dysregulation of SIRT1, polyamines and miRNA editing in cancer and aging

    Article • Amino Acids, March 2026, Springer Science + Business Media

    Dr. Sen Liu

  2. The Role of Metabolites in Cell–Cell Communication: A Review of Databases and Computational Tools

    Article • Cells, December 2025, MDPI AG

    Dr. Sen Liu

  3. Prophage Activation: An In Silico Platform for Identifying Prophage Regulatory Elements to Inform Phage Engineering Against Drug-Resistant Bacteria

    Article • Life, September 2025, MDPI AG

    Dr. Sen Liu

  4. High-Efficiency Discovery and Structure–Activity-Relationship Analysis of Nonsubstrate-Based Covalent Inhibitors of S-Adenosylmethionine Decarboxylase

    Article • Journal of Medicinal Chemistry, July 2025, American Chemical Society (ACS)

    Dr. Sen Liu

  5. Biological Significance and Therapeutic Promise of Programmed Ribosomal Frameshifting

    Article • International Journal of Molecular Sciences, February 2025, MDPI AG

    Dr. Sen Liu

  6. Subtype‐Specific Transcription Factors Affect Polyamine Metabolism and the Tumor Microenvironment in Breast Cancer

    Article • Cancer Innovation, December 2024, Tsinghua University Press

    Dr. Sen Liu

  7. High-efficiency discovery and structure-activity-relationship analysis of non-substrate-based covalent inhibitors of S-adenosylmethionine decarboxylase

    Article • September 2024, Cold Spring Harbor Laboratory Press

    Dr. Sen Liu

  8. Structural Insights into the Mechanisms Underlying Polyaminopathies

    Article • International Journal of Molecular Sciences, June 2024, MDPI AG

    Dr. Sen Liu

  9. SCARdock: A Web Server and Manually Curated Resource for Discovering Covalent Ligands

    Article • ACS Omega, March 2023, American Chemical Society (ACS)

    Dr. Sen Liu

  10. The computational models of AlphaFold2 and RoseTTAfold carry protein foldability information

    Article • January 2022, Cold Spring Harbor Laboratory Press

    Dr. Sen Liu

  11. Protein-DNA complex structure modeling based on structural template

    Article • Biochemical and Biophysical Research Communications, November 2021, Elsevier

    Dr. Sen Liu

  12. The rational discovery of multipurpose inhibitors of the ornithine decarboxylase

    Article • The FASEB Journal, August 2020, Wiley

    Dr. Sen Liu

  13. Potential covalent drugs targeting the main protease of the SARS-CoV-2 coronavirus

    Article • Bioinformatics, April 2020, Oxford University Press (OUP)

    Dr. Sen Liu

  14. Potential clinical drugs as covalent inhibitors of the priming proteases of the spike protein of SARS-CoV-2

    Article • Computational and Structural Biotechnology Journal, January 2020, Elsevier

    Dr. Sen Liu

  15. Electrostatic interactions in molecular recognition of intrinsically disordered proteins

    Article • Journal of Biomolecular Structure and Dynamics, November 2019, Taylor & Francis

    Dr. Sen Liu

  16. Polyamines Disrupt the KaiABC Oscillator by Inducing Protein Denaturation

    Article • Molecules, September 2019, MDPI AG

    Dr. Sen Liu

  17. Structure-based reconstruction of a Mycobacterium hypothetical protein into an active Δ5–3-ketosteroid isomerase

    Article • Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, September 2019, Elsevier

    Dr. Sen Liu

  18. Intrinsically Disordered Transactivation Domains Bind to TAZ1 Domain of CBP via Diverse Mechanisms

    Article • Biophysical Journal, August 2019, Elsevier

    Dr. Sen Liu

  19. Recombinant Butelase-Mediated Cyclization of the p53-Binding Domain of the Oncoprotein MdmX-Stabilized Protein Conformation as a Promising Model for Structural Investigation

    Article • Biochemistry, June 2019, American Chemical Society (ACS)

    Dr. Sen Liu

  20. The influence of intrinsic folding mechanism of an unfolded protein on the coupled folding-binding process during target recognition

    Article • Proteins Structure Function and Bioinformatics, December 2018, Wiley

    Dr. Sen Liu

  21. The influence of KaiA mutations on its function in the KaiABC circadian clock system

    Article • Data in Brief, March 2018, Elsevier

    Dr. Sen Liu

  22. Kallikrein-related peptidase 7 is a potential target for the treatment of pancreatic cancer

    Article • Oncotarget, January 2018, Impact Journals, LLC

    Dr. Sen Liu

  23. The reversible function switching of the circadian clock protein KaiA is encoded in its structure

    Article • Biochimica et Biophysica Acta (BBA) - General Subjects, August 2017, Elsevier

    Dr. Sen Liu

  24. 3D-quantitative structure-activity relationship and docking studies of coumarin derivatives as tissue kallikrein 7 inhibitors

    Article • Journal of Pharmacy and Pharmacology, May 2017, Wiley

    Dr. Sen Liu

  25. Expression and Purification of Cyanobacterial Circadian Clock Protein KaiC and Determination of Its Auto-phosphatase Activity

    Article • BIO-PROTOCOL, January 2017, Bio-Protocol, LLC

    Dr. Sen Liu

  26. Discovery of Covalent Ligands via Noncovalent Docking by Dissecting Covalent Docking Based on a “Steric-Clashes Alleviating Receptor (SCAR)” Strategy

    Article • Journal of Chemical Information and Modeling, July 2016, American Chemical Society (ACS)

    Dr. Sen Liu

  27. A dynamic interaction process between KaiA and KaiC is critical to the cyanobacterial circadian oscillator

    Article • Scientific Reports, April 2016, Nature

    Dr. Sen Liu

  28. Two Sensitive Fluorescent BOPIM Probes with Tunable TICT Character for Low-Level Water Detection in Organic Solvents

    Article • Journal of Fluorescence, November 2015, Springer Science + Business Media

    Dr. Sen Liu

  29. Discovery of novel inhibitors of human S-adenosylmethionine decarboxylase based on in silico high-throughput screening and a non-radioactive enzymatic assay

    Article • Scientific Reports, June 2015, Nature

    Dr. Sen Liu

  30. Reliable cell cycle commitment in budding yeast is ensured by signal integration

    Article • eLife, January 2015, eLife

    Dr Xili Liu, Mr Xin Wang, Dr. Sen Liu

  31. The P2/P2′ sites affect the substrate cleavage of TNF-α converting enzyme (TACE)

    Article • Molecular Immunology, November 2014, Elsevier

    Dr. Sen Liu

  32. Analysis of the Sequence Conservation of the Circadian Clock Protein KaiC

    Article • Advanced Materials Research, May 2013, Trans Tech Publications

    Dr. Sen Liu

  33. Advances in the Molecular Mechanism of the Core Circadian Oscillator of Cyanobacteria

    Article • ACTA BIOPHYSICA SINICA, January 2013, China Science Publishing & Media Ltd.

    Dr. Sen Liu

  34. Evolution Analysis of the Circadian Clock Protein KaiB

    Article • Advanced Materials Research, January 2013, Trans Tech Publications

    Dr. Sen Liu

  35. Control of protein signaling using a computationally designed GTPase/GEF orthogonal pair

    Article • Proceedings of the National Academy of Sciences, March 2012, Proceedings of the National Academy of Sciences

    Dr. Sen Liu

  36. Nonnatural protein–protein interaction-pair design by key residues grafting

    Article • Proceedings of the National Academy of Sciences, March 2007, Proceedings of the National Academy of Sciences

    Dr. Sen Liu

  37. Expression, purification, crystallization and preliminary crystallographic study of a potential metal-dependent hydrolase with cyclase activity fromThermoanaerobacter tengcongensis

    Article • Acta Crystallographica Section F Structural Biology and Crystallization Communications, December 2004, International Union of Crystallography

    Dr. Sen Liu