Sander Houten
Mount Sinai Medical Center
Professor, Biological Sciences
United States
My co-authors include
Professor Michael McDermott
Dr Alberto Sánchez Guijo
My Publications
Metabolic crosstalk between organelles
The FASEB Journal
December 2018
News and views
Journal of Inherited Metabolic Disease
February 2018
Deficiency of the Mitochondrial NAD Kinase Causes Stress-Induced Hepatic Steatosis in Mice
Gastroenterology
January 2018
Changes in the Metabolome in Response to Low-Dose Exposure to Environmental Chemicals U...
PLoS ONE
July 2016
In vivomouse myocardial31P MRS using three-dimensional image-selectedin vivospectroscop...
NMR in Biomedicine
August 2015
Transorgan fluxes in a porcine model reveal a central role for liver in acylcarnitine m...
AJP Endocrinology and Metabolism
August 2015
Corrigendum
Experimental Biology and Medicine
July 2015
Novel, Compound Heterozygous, Single-Nucleotide Variants inMARS2Associated with Develop...
Human Mutation
April 2015
Fiber-type-specific sensitivities and phenotypic adaptations to dietary fat overload di...
The Journal of Nutritional Biochemistry
February 2015
Cholesterol-Induced Hepatic Inflammation Does Not Underlie the Predisposition to Insuli...
Journal of Diabetes Research
January 2015
High-protein diets prevent steatosis and induce hepatic accumulation of monomethyl bran...
The Journal of Nutritional Biochemistry
December 2014
Pioglitazone treatment restoresin vivomuscle oxidative capacity in a rat model of diabetes
Diabetes Obesity and Metabolism
October 2014
SUMOylation-Dependent LRH-1/PROX1 Interaction Promotes Atherosclerosis by Decreasing He...
Cell Metabolism
October 2014
Multilayered Genetic and Omics Dissection of Mitochondrial Activity in a Mouse Referenc...
Cell
September 2014
Bile acids alter male fertility through G-protein-coupled bile acid receptor 1 signalin...
Hepatology
August 2014
A Mitochondrial Expatriate: Nuclear Pyruvate Dehydrogenase
Cell
July 2014
Plasma acylcarnitines inadequately reflect tissue acylcarnitine metabolism
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
July 2014
In vivo proton T1relaxation times of mouse myocardial metabolites at 9.4 T
Magnetic Resonance in Medicine
June 2014
Mitochondrial NADP(H) deficiency due to a mutation in NADK2 causes dienoyl-CoA reductas...
Human Molecular Genetics
May 2014
Fasting Serum Taurine-Conjugated Bile Acids Are Elevated in Type 2 Diabetes and Do Not ...
The Journal of Clinical Endocrinology & Metabolism
April 2014
Optimizing anesthetic regimen for surgery in mice through minimization of hemodynamic, ...
Experimental Biology and Medicine
March 2014
Food withdrawal lowers energy expenditure and induces inactivity in long-chain fatty ac...
The FASEB Journal
March 2014
Aberrant protein acylation is a common observation in inborn errors of acyl-CoA metabolism
Journal of Inherited Metabolic Disease
February 2014
Mitochondrial protein acetylation is driven by acetyl-CoA from fatty acid oxidation
Human Molecular Genetics
February 2014
Identification and characterization of Eci3, a murine kidney-specific 3, 2-enoyl-CoA i...
The FASEB Journal
December 2013
Muscle MRI in patients with long-chain fatty acid oxidation disorders
Journal of Inherited Metabolic Disease
December 2013
ACAD9, a complex I assembly factor with a moonlighting function in fatty acid oxidation...
Human Molecular Genetics
October 2013
Myocardial energy shortage and unmet anaplerotic needs in the fasted long-chain acyl-Co...
Cardiovascular Research
September 2013
Peroxisomes contribute to the acylcarnitine production when the carnitine shuttle is de...
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
September 2013
Biochemical Competition Makes Fatty-Acid β-Oxidation Vulnerable to Substrate Overload
PLoS Computational Biology
August 2013
Impaired amino acid metabolism contributes to fasting-induced hypoglycemia in fatty aci...
Human Molecular Genetics
August 2013
Substrate specificity of human carnitine acetyltransferase: Implications for fatty acid...
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
June 2013
Prevention and reversal of hepatic steatosis with a high-protein diet in mice
Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease
May 2013
Carnitine supplementation attenuates myocardial lipid accumulation in long-chain acyl-C...
Journal of Inherited Metabolic Disease
April 2013
Overexpression of PLIN5 in skeletal muscle promotes oxidative gene expression and intra...
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
April 2013
Carnitine palmitoyltransferase 2 and carnitine/acylcarnitine translocase are involved i...
The FASEB Journal
January 2013
Genetic basis of hyperlysinemia
Orphanet Journal of Rare Diseases
January 2013
Acylcarnitines
Diabetes
December 2012
Adaptive reciprocity of lipid and glucose metabolism in human short-term starvation
AJP Endocrinology and Metabolism
December 2012
Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expe...
PLoS ONE
August 2012
Functional redundancy of mitochondrial enoyl-CoA isomerases in the oxidation of unsatur...
The FASEB Journal
July 2012
Characterization of D-3-hydroxybutyrylcarnitine (ketocarnitine): an identified ketosis-...
Metabolism
July 2012
Improving the description of metabolic networks: the TCA cycle as example
The FASEB Journal
June 2012
Muscle or liver-specific Sirt3 deficiency induces hyperacetylation of mitochondrial pro...
Scientific Reports
May 2012
A Diet Rich in Unsaturated Fatty Acids Prevents Progression Toward Heart Failure in a R...
Circulation Heart Failure
May 2012
Peroxisomal L-bifunctional enzyme (Ehhadh) is essential for the production of medium-ch...
Journal of Lipid Research
April 2012
Bezafibrate lowers very long-chain fatty acids in X-linked adrenoleukodystrophy fibrobl...
Journal of Inherited Metabolic Disease
March 2012
Treatment of genetically obese mice with the iminosugar N-(5-adamantane-1-yl-methoxy-pe...
Metabolism
January 2012
Role of Medium- and Short-Chain L-3-Hydroxyacyl-CoA Dehydrogenase in the Regulation of ...
Endocrinology
December 2011
New Driver for Lipid Synthesis
Cell
November 2011
The metabolic footprint of aging in mice
Scientific Reports
October 2011
Fasting-Induced Myocardial Lipid Accumulation in Long-Chain Acyl-CoA Dehydrogenase Knoc...
Circulation Cardiovascular Imaging
September 2011
Differential effects of short- and long-term high-fat diet feeding on hepatic fatty aci...
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
July 2011
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induce...
Journal of Biological Chemistry
June 2011
Post-natal myogenic and adipogenic developmental
Nucleus
May 2011
PARP-2 Regulates SIRT1 Expression and Whole-Body Energy Expenditure
Cell Metabolism
April 2011
Critical assessment of human metabolic pathway databases: a stepping stone for future i...
BMC Systems Biology
January 2011
Acyl-CoA Dehydrogenase 9 Is Required for the Biogenesis of Oxidative Phosphorylation Co...
Cell Metabolism
September 2010
The Effects of Long- or Medium-Chain Fat Diets on Glucose Tolerance and Myocellular Con...
Obesity
July 2010
The enzymology of mitochondrial fatty acid beta-oxidation and its application to follow...
Journal of Inherited Metabolic Disease
May 2010
A general introduction to the biochemistry of mitochondrial fatty acid β-oxidation
Journal of Inherited Metabolic Disease
March 2010
Effect of Statins on the Viability of Macrophages and Smooth Muscle Cells
Journal of Cardiovascular Pharmacology
March 2010
Glutamine Synthetase in Muscle Is Required for Glutamine Production during Fasting and ...
Journal of Biological Chemistry
January 2010
Increased mitochondrial content rescues in vivo muscle oxidative capacity in long-term ...
The FASEB Journal
December 2009
Mitochondrial long chain fatty acid β-oxidation in man and mouse
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
August 2009
Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution...
Obesity
April 2009
Muscle acylcarnitines during short-term fasting in lean healthy men
Clinical Science
April 2009
Effects of Insulin on Ketogenesis Following Fasting in Lean and Obese Men
Obesity
February 2009
Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated ...
Cellular and Molecular Life Sciences
February 2009
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Me...
Cell Metabolism
February 2009
A key role for the peroxisomal ABCD2 transporter in fatty acid homeostasis
AJP Endocrinology and Metabolism
January 2009
Metabolomics: Unraveling the chemical individuality of common human diseases
Annals of Medicine
January 2009
Specific SIRT1 Activation Mimics Low Energy Levels and Protects against Diet-Induced Me...
Cell Metabolism
November 2008
Increased intramyocellular lipid content but normal skeletal muscle mitochondrial oxida...
The FASEB Journal
July 2008
The Glucosylceramide Synthase InhibitorN-(5-Adamantane-1-yl-methoxy-pentyl)-deoxynojiri...
Journal of Pharmacology and Experimental Therapeutics
June 2008
A cholesterol-free, high-fat diet suppresses gene expression of cholesterol transporter...
AJP Gastrointestinal and Liver Physiology
May 2008
Characterization of l-aminocarnitine, an inhibitor of fatty acid oxidation
Molecular Genetics and Metabolism
April 2008
Peroxisome Proliferator-activated Receptor (PPAR)-2 Controls Adipocyte Differentiation ...
Journal of Biological Chemistry
October 2007
Compromised Intestinal Lipid Absorption in Mice with a Liver-Specific Deficiency of Liv...
Molecular and Cellular Biology
October 2007
In VivoImaging of Farnesoid X Receptor Activity Reveals the Ileum as the Primary Bile A...
Molecular Endocrinology
June 2007
A liver revival featuring bile acids
Journal of Hepatology
March 2007
The small heterodimer partner is a gonadal gatekeeper of sexual maturation in male mice
Genes & Development
February 2007
Homing in on bile acid physiology
Cell Metabolism
December 2006
Peroxisomes and bile acid biosynthesis
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research
December 2006
Endocrine functions of bile acids
The EMBO Journal
March 2006
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
Nature
January 2006
Manipulation of isoprenoid biosynthesis as a possible therapeutic option in mevalonate ...
Arthritis & Rheumatism
January 2006
PGC-1α
Cell
October 2004
Bile acids lower triglyceride levels via a pathway involving FXR, SHP, and SREBP-1c
Journal of Clinical Investigation
May 2004
Peroxisome proliferator-activated receptor-γ: too much of a good thing causes harm
EMBO Reports
February 2004
The enterohepatic nuclear receptors are major regulators of the enterohepatic circulati...
Annals of Medicine
January 2004
Compensation by the muscle limits the metabolic consequences of lipodystrophy in PPARγ ...
Proceedings of the National Academy of Sciences
November 2003
Carrier frequency of the V377I (1129G>A) MVK mutation, associated with Hyper-IgD and pe...
European Journal of Human Genetics
February 2003
Regulation of Isoprenoid/Cholesterol Biosynthesis in Cells from Mevalonate Kinase-defic...
Journal of Biological Chemistry
December 2002
Hyper IgD syndrome (HIDS) associated with in vitro evidence of defective monocyte TNFRS...
Clinical & Experimental Immunology
December 2002
Lack of isoprenoid products raises ex vivo interleukin-1? secretion in hyperimmunoglobu...
Arthritis & Rheumatism
October 2002
Erratum: Organization of the mevalonate kinase (MVK) gene and identification of novel m...
European Journal of Human Genetics
August 2001
Organization of the mevalonate kinase (MVK) gene and identification of novel mutations ...
European Journal of Human Genetics
April 2001
Nonorthologous Gene Displacement of Phosphomevalonate Kinase
Molecular Genetics and Metabolism
March 2001
Biochemical and genetic aspects of mevalonate kinase and its deficiency
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids
December 2000
Journal of Inherited Metabolic Disease
January 2000
Journal of Inherited Metabolic Disease
January 2000
Identification and Characterization of Three Novel Missense Mutations in Mevalonate Kin...
Human Molecular Genetics
August 1999
Mutations in MVK, encoding mevalonate kinase, cause hyperimmunoglobulinaemiaD and perio...
Nature Genetics
June 1999