All Stories

  1. Nitrous oxide modulates cortical activity, wake–sleep oscillations, and produces antidepressant-like effects in mice

    Article • February 2025, Cold Spring Harbor Laboratory Press

    Samuel Kohtala

  2. Ketamine’s Multifaceted Neuropharmacological and Neurobiological Actions

    Article • January 2025, Springer Science + Business Media

    Samuel Kohtala

  3. Nitrous oxide induces hypothermia and TrkB activation: Maintenance of body temperature abolishes antidepressant-like effects in mice

    Article • Neuropharmacology, December 2024, Elsevier

    Samuel Kohtala

  4. Linking Hypothermia and Altered Metabolism with TrkB Activation

    Article • ACS Chemical Neuroscience, August 2023, American Chemical Society (ACS)

    Samuel Kohtala

  5. Ketamine reduces electrophysiological network activity in cortical neuron cultures already at sub-micromolar concentrations – Impact on TrkB-ERK1/2 signaling

    Article • Neuropharmacology, May 2023, Elsevier

    Samuel Kohtala

  6. A wake-up call: Sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants

    Article • Progress in Neurobiology, November 2021, Elsevier

    Samuel Kohtala

  7. Physiological basis underlying antidepressant-induced activation of TrkB receptors

    Article • August 2021, Cold Spring Harbor Laboratory Press

    Samuel Kohtala

  8. Rapid‐acting antidepressants and the regulation of TrkB neurotrophic signalling—Insights from ketamine, nitrous oxide, seizures and anaesthesia

    Article • Basic & Clinical Pharmacology & Toxicology, May 2021, Wiley

    Samuel Kohtala

  9. Time is of the essence: Coupling sleep-wake and circadian neurobiology to the antidepressant effects of ketamine

    Article • Pharmacology & Therapeutics, May 2021, Elsevier

    Samuel Kohtala

  10. Ketamine—50 years in use: from anesthesia to rapid antidepressant effects and neurobiological mechanisms

    Article • Pharmacological Reports, February 2021, Springer Science + Business Media

    Samuel Kohtala

  11. A wake-up call - revealing the oversight of sleep physiology and related translational discrepancies in studies of rapid-acting antidepressants

    Article • September 2020, Cold Spring Harbor Laboratory Press

    Samuel Kohtala

  12. Rapid-acting antidepressants and ENCORE-D

    Article • Pharmacological Reviews, March 2020, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Tomi Rantamäki, Samuel Kohtala

  13. Ketamine-induced regulation of TrkB-GSK3β signaling is accompanied by slow EEG oscillations and sedation but is independent of hydroxynorketamine metabolites

    Article • Neuropharmacology, October 2019, Elsevier

    Samuel Kohtala

  14. Commentary: Commonly Used Anesthesia/Euthanasia Methods for Brain Collection Differentially Impact MAPK Activity in Male and Female C57BL/6 Mice

    Article • Frontiers in Cellular Neuroscience, May 2019, Frontiers

    Samuel Kohtala

  15. P.1.17 Brain metabolome during anesthesia – similarities and differences between post-ictal state

    Article • European Neuropsychopharmacology, January 2019, Elsevier

    Samuel Kohtala

  16. Dyskinesia and brain-derived neurotrophic factor levels after long-term levodopa and nicotinic receptor agonist treatments in female mice with near-total unilateral dopaminergic denervation

    Article • BMC Neuroscience, November 2018, Springer Science + Business Media

    Samuel Kohtala

  17. Cortical Excitability and Activation of TrkB Signaling During Rebound Slow Oscillations Are Critical for Rapid Antidepressant Responses

    Article • Molecular Neurobiology, October 2018, Springer Science + Business Media

    Samuel Kohtala

  18. Putative rapid-acting antidepressant nitrous oxide (“laughing gas”) evokes rebound emergence of slow EEG oscillations during which TrkB signaling is induced

    Article • March 2018, Cold Spring Harbor Laboratory Press

    Samuel Kohtala

  19. Isoflurane produces antidepressant effects and induces TrkB signaling in rodents

    Article • Scientific Reports, August 2017, Springer Science + Business Media

    Samuel Kohtala

  20. Brief isoflurane anesthesia regulates striatal AKT-GSK3β signaling and ameliorates motor deficits in a rat model of early-stage Parkinson′s disease

    Article • Journal of Neurochemistry, June 2017, Wiley

    Tomi Rantamäki, Samuel Kohtala

  21. Brief Isoflurane Anesthesia Produces Prominent Phosphoproteomic Changes in the Adult Mouse Hippocampus

    Article • ACS Chemical Neuroscience, April 2016, American Chemical Society (ACS)

    Samuel Kohtala