All Stories

  1. Unequal Absorption of Radiolabeled and Nonradiolabeled Drug from the Oral Dose Leads to Incorrect Estimates of Drug Absorption and Circulating Metabolites in a Mass Balance Study

    Article • Drug Metabolism Letters, April 2019, Bentham Science Publishers

    Ryan Takahashi

  2. Mixed Matrix Method Provides A Reliable Metabolite Exposure Comparison for Assessment of Metabolites in Safety Testing (MIST)

    Article • Drug Metabolism Letters, November 2017, Bentham Science Publishers

    Ryan Takahashi

  3. CYP1A1-Mediated Intramolecular Rearrangement of Aminoazepane in GDC-0339

    Article • Drug Metabolism and Disposition, August 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  4. Applying Stable Isotope Labeled Amino Acids in Micropatterned Hepatocyte Coculture to Directly Determine the Degradation Rate Constant for CYP3A4

    Article • Drug Metabolism and Disposition, March 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  5. Novel Mechanism of Decyanation of GDC-0425 by Cytochrome P450

    Article • Drug Metabolism and Disposition, February 2017, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  6. Absorption, Metabolism, Excretion, and the Contribution of Intestinal Metabolism to the Oral Disposition of [14C]Cobimetinib, a MEK Inhibitor, in Humans

    Article • Drug Metabolism and Disposition, October 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  7. Elucidating the Mechanisms of Formation for Two Unusual Cytochrome P450–Mediated Fused Ring Metabolites of GDC-0623, a MAPK/ERK Kinase Inhibitor

    Article • Drug Metabolism and Disposition, October 2015, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  8. Elucidating the Mechanism of Cytochrome P450–Mediated Pyrimidine Ring Conversion to Pyrazole Metabolites with the BACE1 Inhibitor GNE-892 in Rats

    Article • Drug Metabolism and Disposition, March 2014, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  9. The Effect of Allelic Variation in Aldo-Keto Reductase 1C2 on the in Vitro Metabolism of Dihydrotestosterone

    Article • Journal of Pharmacology and Experimental Therapeutics, March 2009, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  10. Aldo-Keto Reductase 1C2 Fails to Metabolize Doxorubicin and Daunorubicin in Vitro

    Article • Drug Metabolism and Disposition, March 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi

  11. Two Allelic Variants of Aldo-Keto Reductase 1A1 Exhibit Reduced in Vitro Metabolism of Daunorubicin

    Article • Drug Metabolism and Disposition, February 2008, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Ryan Takahashi