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  1. Fragmented mRNAs discovered in blood open new possibilities in disease biomarker research

    Article • The EMBO Journal, May 2019, EMBO

    Ryan M Spengler

  2. The long non-coding RNA NEAT1 is elevated in polyglutamine repeat expansion diseases and protects from disease gene-dependent toxicities

    Article • Human Molecular Genetics, September 2018, Oxford University Press (OUP)

    Ryan M Spengler

  3. Comprehensive multi-center assessment of small RNA-seq methods for quantitative miRNA profiling

    Article • Nature Biotechnology, July 2018, Springer Science + Business Media

    Ryan M Spengler

  4. Deconvolution of seed and RNA-binding protein crosstalk in RNAi-based functional genomics

    Article • Nature Genetics, April 2018, Springer Science + Business Media

    Ryan M Spengler

  5. Cis-acting single nucleotide polymorphisms alter MicroRNA-mediated regulation of human brain-expressed transcripts

    Article • Human Molecular Genetics, September 2016, Oxford University Press (OUP)

    Ryan M Spengler

  6. Elucidation of transcriptome-wide microRNA binding sites in human cardiac tissues by Ago2 HITS-CLIP

    Article • Nucleic Acids Research, July 2016, Oxford University Press (OUP)

    Ryan M Spengler

  7. Artificial miRNAs Targeting Mutant Huntingtin Show Preferential Silencing In Vitro and In Vivo

    Article • Molecular Therapy — Nucleic Acids, January 2015, Elsevier

    Ryan M Spengler

  8. Single nucleotide seed modification restores in vivo tolerability of a toxic artificial miRNA sequence in the mouse brain

    Article • Nucleic Acids Research, October 2014, Oxford University Press (OUP)

    Ryan M Spengler

  9. Transcriptome-wide Discovery of microRNA Binding Sites in Human Brain

    Article • Neuron, January 2014, Elsevier

    Ryan M Spengler

  10. Human-specific microRNA regulation of FOXO1: implications for microRNA recognition element evolution

    Article • Human Molecular Genetics, December 2013, Oxford University Press (OUP)

    Ryan M Spengler

  11. Gene regulation by microRNAs created from "junk" genomic elements

    Article • Human Molecular Genetics, November 2013, Oxford University Press (OUP)

    Ryan M Spengler

  12. siSPOTR: An RNAi gene silencing design tool that minimizes off-target side effects

    Article • Nucleic Acids Research, August 2012, Oxford University Press (OUP)

    Ryan M Spengler

  13. Rational Design of Therapeutic siRNAs: Minimizing Off-targeting Potential to Improve the Safety of RNAi Therapy for Huntington's Disease

    Article • Molecular Therapy, December 2011, Elsevier

    Ryan M Spengler

  14. Adenosine deamination in human transcripts generates novel microRNA binding sites

    Article • Human Molecular Genetics, September 2009, Oxford University Press (OUP)

    Ryan M Spengler

  15. Rational Design Leads to More Potent RNA Interference Against Hepatitis B Virus: Factors Effecting Silencing Efficiency

    Article • Molecular Therapy, March 2009, Elsevier

    Ryan M Spengler