All Stories

  1. Diaminopyrimidines, diaminopyridines and diaminopyridazines as histamine H4 receptor modulators

    Article • Bioorganic & Medicinal Chemistry Letters, February 2015, Elsevier

    Dr Robin L Thurmond

  2. Phase 2a, randomized, double-blind, placebo-controlled, multicenter, parallel-group study of a H4R-antagonist (JNJ-39758979) in Japanese adults with moderate atopic dermatitis

    Article • The Journal of Dermatology, December 2014, Wiley

    Dr Robin L Thurmond

  3. The effect of pKa on pyrimidine/pyridine-derived histamine H4 ligands

    Article • Bioorganic & Medicinal Chemistry Letters, December 2014, Elsevier

    Dr Robin L Thurmond

  4. Discovery and SAR of 6-Alkyl-2,4-diaminopyrimidines as Histamine H 4 Receptor Antagonists

    Article • Journal of Medicinal Chemistry, March 2014, American Chemical Society (ACS)

    Dr Robin L Thurmond

  5. Effect Of A Novel, Oral Histamine H4R Antagonist On Histamine-Induced Pruritus In Healthy Subjects

    Article • Journal of Allergy and Clinical Immunology, February 2014, Elsevier

    Dr Robin L Thurmond

  6. Peripheral Neuronal Mechanism of Itch

    Article • January 2014, Taylor & Francis

    Dr Robin L Thurmond

  7. Histamine synthesis is required for granule maturation in murine mast cells

    Article • European Journal of Immunology, October 2013, Wiley

    Dr Robin L Thurmond

  8. Antagonism of the histamine H4 receptor reduces LPS-induced TNF production in vivo

    Article • Inflammation Research, March 2013, Springer Science + Business Media

    Dr Robin L Thurmond

  9. Alcaftadine, a new antihistamine with combined antagonist activity at histamine H1, H2, and H4 receptors

    Article • Journal of Receptor Ligand and Channel Research, December 2012, Taylor & Francis

    Dr Robin L Thurmond

  10. Tricyclic aminopyrimidine histamine H4 receptor antagonists

    Article • Bioorganic & Medicinal Chemistry Letters, November 2011, Elsevier

    Dr Robin L Thurmond

  11. Histamine H4 receptor activation enhances LPS-induced IL-6 production in mast cells via ERK and PI3K activation

    Article • European Journal of Immunology, May 2011, Wiley

    Dr Robin L Thurmond

  12. Triamino pyrimidines and pyridines as histamine H4 receptor modulators

    Article • Bioorganic & Medicinal Chemistry Letters, May 2011, Elsevier

    Dr Robin L Thurmond

  13. Basophils Contribute To Allergic Rhinitis Through Engagement Of The Histamine H4 Receptor

    Article • May 2011, American Thoracic Society

    Dr Robin L Thurmond

  14. Diazinones as P2 replacements for pyrazole-based cathepsin S inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, July 2010, Elsevier

    Dr Robin L Thurmond

  15. Histamine H4 receptor antagonism diminishes existing airway inflammation and dysfunction via modulation of Th2 cytokines

    Article • June 2010, Springer Science + Business Media

    Dr Robin L Thurmond

  16. Agonist/antagonist modulation in a series of 2-aryl benzimidazole H4 receptor ligands

    Article • Bioorganic & Medicinal Chemistry Letters, June 2010, Elsevier

    Dr Robin L Thurmond

  17. Recent Advances in the Design of Cathepsin S Inhibitors

    Article • Current Topics in Medicinal Chemistry, May 2010, Bentham Science Publishers

    Dr Robin L Thurmond

  18. The Histamine H4 Receptor Mediates Inflammation and Pruritus in Th2-Dependent Dermal Inflammation

    Article • Journal of Investigative Dermatology, April 2010, Elsevier

    Dr Robin L Thurmond

  19. Thioether acetamides as P3 binding elements for tetrahydropyrido-pyrazole cathepsin S inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2010, Elsevier

    Dr Robin L Thurmond

  20. Discovery and SAR of novel pyrazole-based thioethers as cathepsin S inhibitors: Part 1

    Article • Bioorganic & Medicinal Chemistry Letters, April 2010, Elsevier

    Dr Robin L Thurmond

  21. Histamine H4 receptor antagonists

    Article • January 2010, Karger Publishers

    Dr Robin L Thurmond

  22. Phosphoinositide 3-Kinase Gamma (PI3Kγ) Inhibitors for the Treatment of Inflammation and Autoimmune Disease

    Article • Recent Patents on Inflammation & Allergy Drug Discovery, January 2010, Bentham Science Publishers

    Dr Robin L Thurmond

  23. Pharmacological characterization of oxime agonists of the histamine H4 receptor

    Article • Journal of Receptor Ligand and Channel Research, December 2009, Taylor & Francis

    Dr Robin L Thurmond

  24. Pyrazole-based arylalkyne cathepsin S inhibitors. Part II: Optimization of cellular potency

    Article • Bioorganic & Medicinal Chemistry Letters, November 2009, Elsevier

    Dr Robin L Thurmond

  25. Pyrazole-based cathepsin S inhibitors with arylalkynes as P1 binding elements

    Article • Bioorganic & Medicinal Chemistry Letters, November 2009, Elsevier

    Dr Robin L Thurmond

  26. The Critical Role of Histamine H4 Receptor in the Development of Allergic Rhinitis in Mice

    Article • Journal of Allergy and Clinical Immunology, February 2009, Elsevier

    Dr Robin L Thurmond

  27. The histamine H4 receptor antagonist JNJ7777120 induces increases in the histamine content of the rat conjunctiva

    Article • Inflammation Research, January 2009, Springer Science + Business Media

    Dr Robin L Thurmond, Dr Ekaterini Tiligada

  28. Cloning and pharmacological characterization of the dog histamine H4 receptor

    Article • European Journal of Pharmacology, September 2008, Elsevier

    Dr Robin L Thurmond

  29. The role of histamine H1 and H4 receptors in allergic inflammation: the search for new antihistamines

    Article • Nature Reviews Drug Discovery, January 2008, Springer Science + Business Media

    Dr Robin L Thurmond

  30. The new biology of histamine receptors

    Article • Current Allergy and Asthma Reports, January 2008, Springer Science + Business Media

    Dr Robin L Thurmond

  31. TLR7/9 Antagonists as Therapeutics for Immune-Mediated Inflammatory Disorders

    Article • Inflammation & Allergy - Drug Targets, December 2007, Bentham Science Publishers

    Dr Robin L Thurmond

  32. Histamine H4 receptor expression is elevated in human nasal polyp tissue

    Article • Cell Biology International, November 2007, Wiley

    Dr Robin L Thurmond

  33. Pyrazole-based cathepsin S inhibitors with improved cellular potency

    Article • Bioorganic & Medicinal Chemistry Letters, October 2007, Elsevier

    Dr Robin L Thurmond

  34. The histamine H4 receptor: A novel modulator of inflammatory and immune disorders

    Article • Pharmacology & Therapeutics, March 2007, Elsevier

    Dr Robin L Thurmond

  35. Histamine H4 receptor antagonists are superior to traditional antihistamines in the attenuation of experimental pruritus

    Article • Journal of Allergy and Clinical Immunology, January 2007, Elsevier

    Dr Robin L Thurmond

  36. Histamine H4 Receptor Antagonists are Superior to H1R Antagonists in the Attenuation of Experimental Allergic Pruritus

    Article • Journal of Allergy and Clinical Immunology, January 2007, Elsevier

    Dr Robin L Thurmond

  37. Histamine 4 Receptor (H4R) Antagonism Reduces Edema In A Th2 And IgE Dependent Model Of Atopic Dermatitis

    Article • Journal of Allergy and Clinical Immunology, January 2007, Elsevier

    Dr Robin L Thurmond

  38. Identification of 2-arylbenzimidazoles as potent human histamine H4 receptor ligands

    Article • Bioorganic & Medicinal Chemistry Letters, December 2006, Elsevier

    Dr Robin L Thurmond

  39. The histamine H4 receptor in autoimmune disease

    Article • Expert Opinion on Investigational Drugs, October 2006, Informa Healthcare

    Dr Robin L Thurmond

  40. STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes

    Article • International Immunopharmacology, October 2006, Elsevier

    Dr Robin L Thurmond

  41. The Histamine H4 Receptor: Drug Discovery in the Post-genomic Era

    Article • May 2006, Wiley

    Dr Robin L Thurmond

  42. Antigen Presenting Cells as Drug Targets

    Article • April 2006, Wiley

    Dr Robin L Thurmond

  43. The SAR of 4-substituted (6,6-bicyclic) piperidine cathepsin S inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, April 2006, Elsevier

    Dr Robin L Thurmond

  44. Proteases as Drug Targets

    Article • January 2006, Taylor & Francis

    Dr Robin L Thurmond

  45. Preparation and Biological Evaluation of Indole, Benzimidazole, and Thienopyrrole Piperazine Carboxamides:  Potent Human Histamine H 4 Antagonists

    Article • Journal of Medicinal Chemistry, December 2005, American Chemical Society (ACS)

    Dr Robin L Thurmond

  46. Inhibitory effects of histamine H4 receptor antagonists on experimental colitis in the rat

    Article • European Journal of Pharmacology, October 2005, Elsevier

    Dr Robin L Thurmond

  47. Evaluation of Histamine H1-, H2-, and H3-Receptor Ligands at the Human Histamine H4 Receptor: Identification of 4-Methylhistamine as the First Potent and Selective H4 Receptor Agonist

    Article • Journal of Pharmacology and Experimental Therapeutics, June 2005, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Robin L Thurmond

  48. The Mechanism of Molecular Redundancy in Autoimmune Inflammation in the Context of CD44 Deficiency

    Article • Annals of the New York Academy of Sciences, June 2005, Wiley

    Dr Robin L Thurmond

  49. Discovery and SAR studies of a novel series of noncovalent cathepsin S inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, March 2005, Elsevier

    Dr Robin L Thurmond

  50. The Histamine H4 Receptor and Potential Therapeutic Uses for H4 Ligands

    Article • Mini-Reviews in Medicinal Chemistry, November 2004, Bentham Science Publishers

    Dr Robin L Thurmond

  51. Nonpeptidic, Noncovalent Inhibitors of the Cysteine Protease Cathepsin S

    Article • Journal of Medicinal Chemistry, September 2004, American Chemical Society (ACS)

    Dr Robin L Thurmond

  52. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

    Article • British Journal of Pharmacology, July 2004, Wiley

    Dr Robin L Thurmond

  53. Histamine H4 receptor mediates eosinophil chemotaxis with cell shape change and adhesion molecule upregulation

    Article • British Journal of Pharmacology, May 2004, Wiley

    Dr Robin L Thurmond

  54. A Potent and Selective Histamine H4 Receptor Antagonist with Anti-Inflammatory Properties

    Article • Journal of Pharmacology and Experimental Therapeutics, January 2004, American Society for Pharmacology & Experimental Therapeutics (ASPET)

    Dr Robin L Thurmond

  55. The First Potent and Selective Non-Imidazole Human Histamine H 4 Receptor Antagonists

    Article • Journal of Medicinal Chemistry, September 2003, American Chemical Society (ACS)

    Dr Robin L Thurmond

  56. Cloning, expression, purification, and activity of dog (Canis familiaris) and monkey (Saimiri boliviensis) cathepsin S

    Article • Protein Expression and Purification, March 2003, Elsevier

    Dr Robin L Thurmond

  57. Elastic Deformation of Membrane Bilayers Probed by Deuterium NMR Relaxation

    Article • Journal of the American Chemical Society, July 2002, American Chemical Society (ACS)

    Dr Robin L Thurmond

  58. Subdomains in the F and G helices of bacteriorhodopsin regulate the conformational transitions of the reprotonation mechanism

    Article • Proteins Structure Function and Bioinformatics, June 2002, Wiley

    Dr Robin L Thurmond

  59. Conformational Energetics of Rhodopsin Modulated by Nonlamellar-Forming Lipids †

    Article • Biochemistry, May 2002, American Chemical Society (ACS)

    Dr Robin L Thurmond

  60. Gene-expression-based responses to drug treatment

    Article • Drug News & Perspectives, January 2002, Prous Science

    Dr Robin L Thurmond

  61. Kinetics of small molecule inhibitor binding to p38 kinase

    Article • European Journal of Biochemistry, November 2001, Wiley

    Dr Robin L Thurmond

  62. Composite membrane deformation on the mesoscopic length scale

    Article • June 2001, American Physical Society (APS)

    Dr Robin L Thurmond

  63. Chapter 3 NMR Studies of Membrane Lipid Properties

    Article • January 1997, Elsevier

    Dr Robin L Thurmond

  64. Membrane Thickness and Molecular Ordering in Acholeplasma laidlawii Strain A Studied by 2H NMR Spectroscopy

    Article • Biochemistry, November 1994, American Chemical Society (ACS)

    Dr Robin L Thurmond

  65. Structure and packing of phosphatidylcholines in lamellar and hexagonal liquid-crystalline mixtures with a nonionic detergent: a wide-line deuterium and phosphorus-31 NMR study

    Article • The Journal of Physical Chemistry, January 1994, American Chemical Society (ACS)

    Dr Robin L Thurmond

  66. Curvature, order, and dynamics of lipid hexagonal phases studied by deuterium NMR spectroscopy

    Article • Biochemistry, May 1993, American Chemical Society (ACS)

    Dr Robin L Thurmond

  67. Deuterium NMR study of intermolecular interactions in lamellar phases containing palmitoyllysophosphatidylcholine

    Article • The Journal of Physical Chemistry, November 1992, American Chemical Society (ACS)

    Dr Robin L Thurmond

  68. Effect of bile salts on monolayer curvature of a phosphatidylethanolamine/water model membrane system

    Article • Biophysical Journal, September 1991, Elsevier

    Dr Robin L Thurmond

  69. Molecular areas of phospholipids as determined by 2H NMR spectroscopy. Comparison of phosphatidylethanolamines and phosphatidylcholines

    Article • Biophysical Journal, January 1991, Elsevier

    Dr Robin L Thurmond

  70. Influences of membrane curvature in lipid hexagonal phases studied by deuterium NMR spectroscopy

    Article • Biochemical and Biophysical Research Communications, December 1990, Elsevier

    Dr Robin L Thurmond

  71. Magnetic alignment and orientational order of dipalmitoylphosphatidylcholine bilayers containing palmitoyllsyophosphatidylcholine

    Article • Chemistry and Physics of Lipids, June 1990, Elsevier

    Dr Robin L Thurmond

  72. Histamine Receptors and Signaling

    Article • Springer Science + Business Media

    Dr Robin L Thurmond