All Stories

  1. Vitamin C Modulates the PI3K/AKT Pathway via Glutamate and Nitric Oxide in Developing Avian Retina Cells in Culture

    Article • Brain Sciences, April 2025, MDPI AG

    Roberto Paes-de-Carvalho

  2. The Healthy and Diseased Retina Seen through Neuron–Glia Interactions

    Article • International Journal of Molecular Sciences, January 2024, MDPI AG

    Roberto Paes-de-Carvalho

  3. The Healthy and Diseased Retina Seen through Neuron-Glia Interactions

    Article • January 2024, MDPI AG

    Roberto Paes-de-Carvalho

  4. Chemical signaling in the developing avian retina: Focus on cyclic AMP and AKT-dependent pathways

    Article • Frontiers in Cell and Developmental Biology, December 2022, Frontiers

    Roberto Paes-de-Carvalho

  5. Trace amine-associated receptor 1 modulates motor hyperactivity, cognition, and anxiety-like behavior in an animal model of ADHD

    Article • Progress in Neuro-Psychopharmacology and Biological Psychiatry, July 2022, Elsevier

    Roberto Paes-de-Carvalho

  6. Activation of adenosine A3 receptors regulates vitamin C transport and redox balance in neurons

    Article • Free Radical Biology and Medicine, February 2021, Elsevier

    Roberto Paes-de-Carvalho

  7. Astrocytes as a target for Nogo‐A and implications for synapse formation in vitro and in a model of acute demyelination

    Article • Glia, January 2021, Wiley

    Roberto Paes-de-Carvalho

  8. Role of Neuropeptide S on Behavioural and Neurochemical Changes of an Animal Model of Attention-Deficit/Hyperactivity Disorder

    Article • Neuroscience, November 2020, Elsevier

    Roberto Paes-de-Carvalho

  9. NMDA-induced nitric oxide generation and CREB activation in central nervous system is dependent on eukaryotic elongation factor 2 kinase

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, October 2020, Elsevier

    Roberto Paes-de-Carvalho

  10. Bicuculline regulated protein synthesis is dependent on Homer1 and promotes its interaction with eEF2K through mTORC1‐dependent phosphorylation

    Article • Journal of Neurochemistry, September 2020, Wiley

    Roberto Paes-de-Carvalho

  11. Protein synthesis inhibition promotes nitric oxide generation and activation of CGKII-dependent downstream signaling pathways in the retina

    Article • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research, August 2020, Elsevier

    Roberto Paes-de-Carvalho

  12. Microglia Dysfunction Caused by the Loss of Rhoa Disrupts Neuronal Physiology and Leads to Neurodegeneration

    Article • Cell Reports, June 2020, Elsevier

    Roberto Paes-de-Carvalho

  13. Caffeine exposure ameliorates acute ischemic cell death in avian developing retina

    Article • Purinergic Signalling, February 2020, Springer Science + Business Media

    Roberto Paes-de-Carvalho

  14. Dopamine-Induced Ascorbate Release From Retinal Neurons Involves Glutamate Release, Activation of AMPA/Kainate Receptors and Downstream Signaling Pathways

    Article • Frontiers in Neuroscience, May 2019, Frontiers

    Roberto Paes-de-Carvalho, Renato Socodato

  15. Repulsive Environment Attenuation during Adult Mouse Optic Nerve Regeneration

    Article • Neural Plasticity, September 2018, Hindawi Publishing Corporation

    Roberto Paes-de-Carvalho

  16. Chlorogenic acids inhibit glutamate dehydrogenase and decrease intracellular ATP levels in cultures of chick embryo retina cells

    Article • Biochemical Pharmacology, September 2018, Elsevier

    Roberto Paes-de-Carvalho

  17. Cannabinoid Receptor Type 1 Expression in the Developing Avian Retina: Morphological and Functional Correlation With the Dopaminergic System

    Article • Frontiers in Cellular Neuroscience, March 2018, Frontiers

    Roberto Paes-de-Carvalho

  18. Dopamine Promotes Ascorbate Release from Retinal Neurons: Role of D1 Receptors and the Exchange Protein Directly Activated by cAMP type 2 (EPAC2)

    Article • Molecular Neurobiology, February 2018, Springer Science + Business Media

    Renato Socodato, Roberto Paes-de-Carvalho

  19. Vitamin C decreases glutamate uptake and activates glutamate receptors in the nervous system

    Article • Journal of Neurochemistry, December 2017, Wiley

    Renato Socodato, Roberto Paes-de-Carvalho

  20. Genetic ablation of RhoA in adult microglia causes synapse and neuronal loss

    Article • November 2017, Cold Spring Harbor Laboratory Press

    Renato Socodato, Roberto Paes-de-Carvalho

  21. Caveolin-1–mediated internalization of the vitamin C transporter SVCT2 in microglia triggers an inflammatory phenotype

    Article • Science Signaling, March 2017, American Association for the Advancement of Science

    Renato Socodato, Roberto Paes-de-Carvalho

  22. Dopamine promotes NMDA receptor hypofunction in the retina through D1 receptor-mediated Csk activation, Src inhibition and decrease of GluN2B phosphorylation

    Article • Scientific Reports, January 2017, Springer Science + Business Media

    Roberto Paes-de-Carvalho, Renato Socodato

  23. Caffeine alters glutamate–aspartate transporter function and expression in rat retina

    Article • Neuroscience, November 2016, Elsevier

    Roberto Paes-de-Carvalho

  24. Caffeine exposure alters adenosine system and neurochemical markers during retinal development

    Article • Journal of Neurochemistry, June 2016, Wiley

    Renato Socodato, Roberto Paes-de-Carvalho

  25. Determination of ascorbic acid in the retina during chicken embryo development using high performance liquid chromatography and UV detection

    Article • Analytical Methods, January 2016, Royal Society of Chemistry

    Roberto Paes-de-Carvalho

  26. c-Src deactivation by the polyphenol 3-O-caffeoylquinic acid abrogates reactive oxygen species-mediated glutamate release from microglia and neuronal excitotoxicity

    Article • Free Radical Biology and Medicine, February 2015, Elsevier

    Renato Socodato, Roberto Paes-de-Carvalho

  27. Adenosine Transporters and Receptors

    Article • January 2015, Elsevier

    Roberto Paes-de-Carvalho

  28. c-Src function is necessary and sufficient for triggering microglial cell activation

    Article • Glia, November 2014, Wiley

    Renato Socodato, Roberto Paes-de-Carvalho

  29. IL-6, A1 and A2aR: A crosstalk that modulates BDNF and induces neuroprotection

    Article • Biochemical and Biophysical Research Communications, July 2014, Elsevier

    Roberto Paes-de-Carvalho

  30. The nitric oxide-cGKII system relays death and survival signals during embryonic retinal development via AKT-induced CREB1 activation

    Article • Cell Death and Differentiation, February 2014, Springer Science + Business Media

    Renato Socodato, Roberto Paes-de-Carvalho

  31. Nitric Oxide in the Nervous System

    Article • January 2014, Elsevier

    Roberto Paes-de-Carvalho, Renato Socodato

  32. Nitric oxide regulates AKT phosphorylation and nuclear translocation in cultured retinal cells

    Article • Cellular Signalling, December 2013, Elsevier

    Professor Marco A M Prado, Roberto Paes-de-Carvalho

  33. IL-6 treatment increases the survival of retinal ganglion cells in vitro: The role of adenosine A1 receptor

    Article • Biochemical and Biophysical Research Communications, January 2013, Elsevier

    Roberto Paes-de-Carvalho

  34. Molecular Modeling of a Phenyl‐Amidine Class of NMDA Receptor Antagonists and the Rational Design of New Triazolyl‐Amidine Derivatives

    Article • Chemical Biology & Drug Design, December 2012, Wiley

    Professor Magaly G Albuquerque, Roberto Paes-de-Carvalho

  35. Leishmania Metacyclogenesis Is Promoted in the Absence of Purines

    Article • PLoS Neglected Tropical Diseases, September 2012, PLOS

    Roberto Paes-de-Carvalho

  36. Calcium-permeable α-Amino-3-hydroxy-5-methyl-4-isoxazolepropionic Acid Receptors Trigger Neuronal Nitric-oxide Synthase Activation to Promote Nerve Cell Death in an Src Kinase-dependent Fashion

    Article • Journal of Biological Chemistry, September 2012, American Society for Biochemistry & Molecular Biology (ASBMB)

    Renato Socodato, Roberto Paes-de-Carvalho

  37. Expression of A1 adenosine receptors in the developing avian retina: in vivo modulation by A2Areceptors and endogenous adenosine

    Article • Journal of Neurochemistry, September 2012, Wiley

    Roberto Paes-de-Carvalho

  38. Nitric Oxide Modulates Sodium Vitamin C Transporter 2 (SVCT-2) Protein Expression via Protein Kinase G (PKG) and Nuclear Factor-κB (NF-κB)

    Article • Journal of Biological Chemistry, October 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Roberto Paes-de-Carvalho, Renato Socodato

  39. Differential adenosine uptake in mixed neuronal/glial or purified glial cultures of avian retinal cells: Modulation by adenosine metabolism and the ERK cascade

    Article • Biochemical and Biophysical Research Communications, October 2011, Elsevier

    Roberto Paes-de-Carvalho

  40. Developmental regulation of neuronal survival by adenosine in the in vitro and in vivo avian retina depends on a shift of signaling pathways leading to CREB phosphorylation or dephosphorylation

    Article • Journal of Neurochemistry, December 2010, Wiley

    Roberto Paes-de-Carvalho, Renato Socodato

  41. Modulation of A1 adenosine receptor expression by cell aggregation and long-term activation of A2a receptors in cultures of avian retinal cells: involvement of the cyclic AMP/PKA pathway

    Article • Journal of Neurochemistry, May 2010, Wiley

    Roberto Paes-de-Carvalho

  42. Purinergic modulation in the development of the rat uncrossed retinotectal pathway

    Article • Neuroscience, November 2009, Elsevier

    Roberto Paes-de-Carvalho

  43. Modulation of GABA release by nitric oxide in the chick retina: Different effects of nitric oxide depending on the cell population

    Article • Vision Research, October 2009, Elsevier

    Roberto Paes-de-Carvalho

  44. Adenosine deamination to inosine in isolated basolateral membrane from kidney proximal tubule: Implications for modulation of the membrane-associated protein kinase A

    Article • Archives of Biochemistry and Biophysics, June 2009, Elsevier

    Roberto Paes-de-Carvalho

  45. Glutamate and nitric oxide modulate ERK and CREB phosphorylation in the avian retina: evidence for direct signaling from neurons to Müller glial cells

    Article • Journal of Neurochemistry, January 2009, Wiley

    Roberto Paes-de-Carvalho, Renato Socodato

  46. Glutamate receptors modulate sodium-dependent and calcium-independent vitamin C bidirectional transport in cultured avian retinal cells

    Article • Journal of Neurochemistry, January 2009, Wiley

    Roberto Paes-de-Carvalho

  47. L-Arginine Uptake and Release by Cultured Avian Retinal Cells

    Article • Journal of Neurochemistry, July 2008, Wiley

    Roberto Paes-de-Carvalho

  48. Nitric oxide regulates cell survival in purified cultures of avian retinal neurons: involvement of multiple transduction pathways

    Article • Journal of Neurochemistry, January 2007, Wiley

    Roberto Paes-de-Carvalho

  49. Homology Model of NR2B Subunit of NMDA receptor in complex with glutamate

    Article • October 2006, Protein Data Bank, Rutgers University

    Roberto Paes-de-Carvalho

  50. Inhibition of protein synthesis by activation of NMDA receptors in cultured retinal cells: a new mechanism for the regulation of nitric oxide production

    Article • Journal of Neurochemistry, June 2006, Wiley

    Roberto Paes-de-Carvalho

  51. Nitric oxide regulates the proliferation of chick embryo retina cells by a cyclic GMP-independent mechanism

    Article • International Journal of Developmental Neuroscience, February 2006, Elsevier

    Roberto Paes-de-Carvalho, Renato Socodato

  52. Activation of glutamate receptors promotes a calcium-dependent and transporter-mediated release of purines in cultured avian retinal cells: possible involvement of calcium/calmodulin-dependent protein kinase II

    Article • Neurochemistry International, May 2005, Elsevier

    Roberto Paes-de-Carvalho

  53. Stimulation of the proximal tubule Na+-ATPase activity by adenosine A2A receptor

    Article • The International Journal of Biochemistry & Cell Biology, January 2005, Elsevier

    Roberto Paes-de-Carvalho

  54. Article • Neurochemical Research, January 2003, Springer Science + Business Media

    Roberto Paes-de-Carvalho

  55. Adenosine as a signaling molecule in the retina: biochemical and developmental aspects

    Article • Anais da Academia Brasileira de Ciências, September 2002, FapUNIFESP (SciELO)

    Roberto Paes-de-Carvalho

  56. Inhibition of vaccinia virus replication by adenosine in BSC-40 cells: involvement of A2 receptor-mediated PKA activation

    Article • Archives of Virology, July 2002, Springer Science + Business Media

    Roberto Paes-de-Carvalho

  57. Long-term activation of adenosine A2a receptors blocks glutamate excitotoxicity in cultures of avian retinal neurons

    Article • Brain Research, May 2001, Elsevier

    Roberto Paes-de-Carvalho

  58. Antagonistic and synergistic effects of combined treatment with interleukin-2 and interleukin-4 on mixed retinal cell cultures

    Article • Journal of Neuroimmunology, February 2001, Elsevier

    Roberto Paes-de-Carvalho

  59. Long-term activation of adenosine receptors regulates the survival and blocks glutamate-mediated neurotoxicity in cultures of retinal neurons

    Article • Anais da Academia Brasileira de Ciências, September 2000, FapUNIFESP (SciELO)

    Roberto Paes-de-Carvalho

  60. Effect of Spleen-Cell-Conditioned Medium on [3H]-Choline Uptake by Retinal Cells in vitro Is Mediated by IL-2

    Article • NeuroImmunoModulation, January 2000, Karger Publishers

    Roberto Paes-de-Carvalho

  61. Developmental regulation of group iii metabotropic glutamate receptors modulating adenylate cyclase activity in the avian retina

    Article • Neurochemistry International, October 1998, Elsevier

    Roberto Paes-de-Carvalho

  62. Veratridine- and glutamate-induced release of [3H]-GABA from cultured chick retina cells: possible involvement of a GAT-1-like subtype of GABA transporter

    Article • Brain Research, July 1998, Elsevier

    Roberto Paes-de-Carvalho

  63. Developmental regulation of adenosine A1 receptors, uptake sites and endogenous adenosine in the chick retina

    Article • Developmental Brain Research, November 1992, Elsevier

    Roberto Paes-de-Carvalho

  64. Development of A1 adenosine receptors in the chick embryo retina

    Article • Journal of Neuroscience Research, February 1990, Wiley

    Roberto Paes-de-Carvalho

  65. Development of adenosine-dependent cyclic AMP accumulation in the avian optic tectum

    Article • Developmental Brain Research, September 1987, Elsevier

    Roberto Paes-de-Carvalho

  66. Purinergic modulation of T-lymphocyte activation: Differential susceptibility of distinct activation steps and correlation with intracellular 3′,5′-cyclic adenosine monophosphate accumulation

    Article • Cellular Immunology, August 1986, Elsevier

    Roberto Paes-de-Carvalho