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  1. Selection for Molecularly Complementary Modules (MCMs) Drives the Origins and Evolution of Pleiofunctional, Epistatic Interactomes (PEIs)

    Article • Life, January 2026, MDPI AG

    Professor Robert Root-Bernstein

  2. An art-science perspective on artificial intelligence creativity: From problem finding to materiality and embodied cognition

    Article • Journal of Creativity, August 2025, Elsevier

    Professor Robert Root-Bernstein

  3. Capsaicin (But Not Other Vanillins) Enhances Estrogen Binding to Its Receptor: Implications for Power Sports and Cancers

    Article • Life, January 2025, MDPI AG

    Professor Robert Root-Bernstein

  4. Risk of HIV infection and AIDS is dependent on the presence of other infections.

    Article • Academia Medicine, August 2024, Academia.edu

    Professor Robert Root-Bernstein

  5. Integrate chaos theory with Epoker and leave God out of it!

    Article • The Journal of Physiology, February 2024, Wiley

    Professor Robert Root-Bernstein

  6. T-Cell Receptor Sequences Identify Combined Coxsackievirus–Streptococci Infections as Triggers for Autoimmune Myocarditis and Coxsackievirus–Clostridia Infections for Type 1 Diabetes

    Article • International Journal of Molecular Sciences, February 2024, MDPI AG

    Professor Robert Root-Bernstein

  7. ‘Evolutionary poker’: an agent‐based model of interactome emergence and epistasis tested against Lenski's long‐term E. coli experiments

    Article • The Journal of Physiology, September 2023, Wiley

    Professor Robert Root-Bernstein

  8. SARS-CoV-2 and Its Bacterial Co- or Super-Infections Synergize to Trigger COVID-19 Autoimmune Cardiopathies

    Article • International Journal of Molecular Sciences, July 2023, MDPI AG

    Professor Robert Root-Bernstein

  9. Clostridia and Enteroviruses as Synergistic Triggers of Type 1 Diabetes Mellitus

    Article • International Journal of Molecular Sciences, May 2023, MDPI AG

    Professor Robert Root-Bernstein

  10. From Co-Infections to Autoimmune Disease via Hyperactivated Innate Immunity: COVID-19 Autoimmune Coagulopathies, Autoimmune Myocarditis and Multisystem Inflammatory Syndrome in Children

    Article • International Journal of Molecular Sciences, February 2023, MDPI AG

    Professor Robert Root-Bernstein

  11. “Sea Water” Supplemented with Calcium Phosphate and Magnesium Sulfate in a Long-Term Miller-Type Experiment Yields Sugars, Nucleic Acids Bases, Nucleosides, Lipids, Amino Acids, and Oligopeptides

    Article • Life, January 2023, MDPI AG

    Professor Robert Root-Bernstein

  12. T Cell Receptor Sequences Amplified during Severe COVID-19 and Multisystem Inflammatory Syndrome in Children Mimic SARS-CoV-2, Its Bacterial Co-Infections and Host Autoantigens

    Article • International Journal of Molecular Sciences, January 2023, MDPI AG

    Professor Robert Root-Bernstein

  13. Complementary Sets of Autoantibodies Induced by SARS-CoV-2, Adenovirus and Bacterial Antigens Cross-React with Human Blood Protein Antigens in COVID-19 Coagulopathies

    Article • International Journal of Molecular Sciences, September 2022, MDPI AG

    Professor Robert Root-Bernstein

  14. Novel Apparatuses for Incorporating Natural Selection Processes into Origins-of-Life Experiments to Produce Adaptively Evolving Chemical Ecosystems

    Article • Life, September 2022, MDPI AG

    Professor Robert Root-Bernstein

  15. Polymathy Among Nobel Laureates As a Creative Strategy— The Qualitative and Phenomenological Evidence

    Article • Creativity Research Journal, April 2022, Taylor & Francis

    Professor Robert Root-Bernstein

  16. Biased, Bitopic, Opioid–Adrenergic Tethered Compounds May Improve Specificity, Lower Dosage and Enhance Agonist or Antagonist Function with Reduced Risk of Tolerance and Addiction

    Article • Pharmaceuticals, February 2022, MDPI AG

    Professor Robert Root-Bernstein

  17. Co-Evolution of Opioid and Adrenergic Ligands and Receptors: Shared, Complementary Modules Explain Evolution of Functional Interactions and Suggest Novel Engineering Possibilities

    Article • Life, November 2021, MDPI AG

    Professor Robert Root-Bernstein

  18. COVID‐19 coagulopathies: Human blood proteins mimic SARS‐CoV‐2 virus, vaccine proteins and bacterial co‐infections inducing autoimmunity

    Article • BioEssays, October 2021, Wiley

    Professor Robert Root-Bernstein

  19. Pneumococcal and Influenza Vaccination Rates and Pneumococcal Invasive Disease Rates Set Geographical and Ethnic Population Susceptibility to Serious COVID-19 Cases and Deaths

    Article • Vaccines, May 2021, MDPI AG

    Professor Robert Root-Bernstein

  20. Innate Receptor Activation Patterns Involving TLR and NLR Synergisms in COVID-19, ALI/ARDS and Sepsis Cytokine Storms: A Review and Model Making Novel Predictions and Therapeutic Suggestions

    Article • International Journal of Molecular Sciences, February 2021, MDPI AG

    Professor Robert Root-Bernstein

  21. Possible Cross-Reactivity between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death

    Article • Vaccines, September 2020, MDPI AG

    Professor Robert Root-Bernstein

  22. Possible Cross-Reactivity Between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death

    Article • September 2020, MDPI AG

    Professor Robert Root-Bernstein

  23. Age and Location in Severity of COVID‐19 Pathology: Do Lactoferrin and Pneumococcal Vaccination Explain Low Infant Mortality and Regional Differences?

    Article • BioEssays, August 2020, Wiley

    Professor Robert Root-Bernstein

  24. Glutathione and Glutathione-Like Sequences of Opioid and Aminergic Receptors Bind Ascorbic Acid, Adrenergic and Opioid Drugs Mediating Antioxidant Function: Relevance for Anesthesia and Abuse

    Article • International Journal of Molecular Sciences, August 2020, MDPI AG

    Professor Robert Root-Bernstein

  25. Possible Cross-Reactivity Between SARS-CoV-2 Proteins, CRM197 and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death

    Article • August 2020, MDPI AG

    Professor Robert Root-Bernstein

  26. Cross-Reactivity Between SARS-CoV-2 Proteins and Proteins in Pneumococcal Vaccines May Protect Against Symptomatic SARS-CoV-2 Disease and Death

    Article • July 2020, MDPI AG

    Professor Robert Root-Bernstein

  27. Synergistic Activation of Toll-Like and NOD Receptors by Complementary Antigens as Facilitators of Autoimmune Disease: Review, Model and Novel Predictions

    Article • International Journal of Molecular Sciences, June 2020, MDPI AG

    Professor Robert Root-Bernstein

  28. Why Infants Rarely Die of COVID-19 and Morbidity and Mortality Rates Vary by Location: Pneumococcal and Hib Vaccinations as Possible Means to Mitigate Future Pandemics

    Article • May 2020, MDPI AG

    Professor Robert Root-Bernstein

  29. Why Infants Rarely Die of COVID-19 and Morbidity and Mortality Rates Vary by Location: Pneumococcal and Hib Vaccinations as Possible Means to Mitigate Future Pandemics

    Article • April 2020, MDPI AG

    Professor Robert Root-Bernstein

  30. A Statistical Study of Intra-Domain and Trans-Domain Polymathy among Nobel Laureates

    Article • Creativity Research Journal, April 2020, Taylor & Francis

    Professor Robert Root-Bernstein

  31. Mutual Enhancement of Opioid and Adrenergic Receptors by Combinations of Opioids and Adrenergic Ligands Is Reflected in Molecular Complementarity of Ligands: Drug Development Possibilities

    Article • International Journal of Molecular Sciences, August 2019, MDPI AG

    Professor Robert Root-Bernstein

  32. <strong>A General Theory of Autoimmune Disease Causation: Integrating Innate and Adaptive Immunity, Altered Antigen Processing, Sex and Genetic Predispositions, and Microbiome Effects</strong>

    Article • June 2019, MDPI AG

    Professor Robert Root-Bernstein

  33. The Mysterious, and Potentially Revolutionary, Immunological Properties of Transfer Factor: A Review

    Article • May 2019, MDPI AG

    Professor Robert Root-Bernstein

  34. Correlation between tools for thinking; arts, crafts, and design avocations; and scientific achievement among STEMM professionals

    Article • Proceedings of the National Academy of Sciences, February 2019, Proceedings of the National Academy of Sciences

    Professor Robert Root-Bernstein

  35. The Ribosome as a Missing Link in Prebiotic Evolution III: Over-Representation of tRNA- and rRNA-Like Sequences and Plieofunctionality of Ribosome-Related Molecules Argues for the Evolution of Primitive Genomes from Ribosomal RNA Modules

    Article • International Journal of Molecular Sciences, January 2019, MDPI AG

    Professor Robert Root-Bernstein

  36. Adrenergic Agonists Bind to Adrenergic-Receptor-Like Regions of the Mu Opioid Receptor, Enhancing Morphine and Methionine-Enkephalin Binding: A New Approach to “Biased Opioids”?

    Article • International Journal of Molecular Sciences, January 2018, MDPI AG

    Professor Robert Root-Bernstein

  37. Rapid Non-Enzymatic Glycation of the Insulin Receptor under Hyperglycemic Conditions Inhibits Insulin Binding In Vitro: Implications for Insulin Resistance

    Article • International Journal of Molecular Sciences, December 2017, MDPI AG

    Professor Robert Root-Bernstein

  38. Human Immunodeficiency Virus Proteins Mimic Human T Cell Receptors Inducing Cross-Reactive Antibodies

    Article • International Journal of Molecular Sciences, October 2017, MDPI AG

    Professor Robert Root-Bernstein

  39. The ribosome as a missing link in prebiotic evolution II: Ribosomes encode ribosomal proteins that bind to common regions of their own mRNAs and rRNAs

    Article • Journal of Theoretical Biology, May 2016, Elsevier

    Professor Robert Root-Bernstein

  40. How to Make a Non-Antigenic Protein (Auto) Antigenic: Molecular Complementarity Alters Antigen Processing and Activates Adaptive-Innate Immunity Synergy

    Article • Anti-Cancer Agents in Medicinal Chemistry, October 2015, Bentham Science Publishers

    Professor Robert Root-Bernstein

  41. Unresolved issues in theories of autoimmune disease using myocarditis as a framework

    Article • Journal of Theoretical Biology, June 2015, Elsevier

    Professor Robert Root-Bernstein

  42. The ribosome as a missing link in the evolution of life

    Article • Journal of Theoretical Biology, February 2015, Elsevier

    Professor Robert Root-Bernstein

  43. Compounds such as vitamin C and opiates that enhance receptors adrenalin-like drugs

    Article • Current Medicinal Chemistry, August 2014, Bentham Science Publishers

    Professor Robert Root-Bernstein

  44. Tools for thinking applied to nature: an inclusive pedagogical framework for environmental education

    Article • Oryx, March 2014, Cambridge University Press

    Professor Robert Root-Bernstein

  45. How peptide hormones that bind to each other co-evolved to build each other's cellular receptors

    Article • Journal of Receptor Ligand and Channel Research, July 2010, Taylor & Francis

    Professor Robert Root-Bernstein

  46. Experimental Test of L- and D-Amino Acid Binding to L- and D-Codons Suggests that Homochirality and Codon Directionality Emerged with the Genetic Code

    Article • Symmetry, June 2010, MDPI AG

    Professor Robert Root-Bernstein

  47. The Eukaryotic Cell Originated in the Integration and Redistribution of Hyperstructures from Communities of Prokaryotic Cells Based on Molecular Complementarity

    Article • International Journal of Molecular Sciences, June 2009, MDPI AG

    Pr Vic Norris, Professor Robert Root-Bernstein