All Stories

  1. Avian Influenza Virus PB1 Gene in H3N2 Viruses Evolved in Humans To Reduce Interferon Inhibition by Skewing Codon Usage toward Interferon-Altered tRNA Pools

    Article • mBio, July 2018, ASM Journals

    Professor Robert M Krug

  2. Role of N Terminus-Truncated NS1 Proteins of Influenza A Virus in Inhibiting IRF3 Activation

    Article • Journal of Virology, February 2016, ASM Journals

    Professor Robert M Krug

  3. Functions of the influenza A virus NS1 protein in antiviral defense

    Article • Current Opinion in Virology, June 2015, Elsevier

    Professor Robert M Krug

  4. An RNA-synthesizing machine

    Article • Nature, December 2014, Springer Science + Business Media

    Professor Robert M Krug

  5. Cellular DDX21 RNA Helicase Inhibits Influenza A Virus Replication but Is Counteracted by the Viral NS1 Protein

    Article • Cell Host & Microbe, April 2014, Elsevier

    Professor Robert M Krug

  6. 19F NMR Reveals Multiple Conformations at the Dimer Interface of the Nonstructural Protein 1 Effector Domain from Influenza A Virus

    Article • Structure, April 2014, Elsevier

    Professor Robert M Krug

  7. Exploring naphthyl-carbohydrazides as inhibitors of influenza A viruses

    Article • European Journal of Medicinal Chemistry, January 2014, Elsevier

    Professor Robert M Krug

  8. The virus genome and its replication

    Article • August 2013, Wiley

    Professor Robert M Krug

  9. The NS1 protein: A master regulator of host and viral functions

    Article • August 2013, Wiley

    Professor Robert M Krug

  10. Interferon-induced ISG15 pathway: an ongoing virus–host battle

    Article • Trends in Microbiology, April 2013, Elsevier

    Professor Robert M Krug

  11. Biochemical and Structural Evidence in Support of a Coherent Model for the Formation of the Double-Helical Influenza A Virus Ribonucleoprotein

    Article • mBio, December 2012, ASM Journals

    Professor Robert M Krug

  12. Sequence in the Influenza A Virus Nucleoprotein Required for Viral Polymerase Binding and RNA Synthesis

    Article • Journal of Virology, April 2012, ASM Journals

    Professor Robert M Krug

  13. Identification of Influenza Virus Inhibitors Targeting NS1A Utilizing Fluorescence Polarization–Based High-Throughput Assay

    Article • April 2012, SAGE Publications

    Professor Robert M Krug

  14. Structural basis for the sequence-specific recognition of human ISG15 by the NS1 protein of influenza B virus

    Article • Proceedings of the National Academy of Sciences, August 2011, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  15. Crystal structure of human ISG15 in complex with NS1 N-terminal region from influenza virus B, Northeast Structural Genomics Consortium Target IDs HX6481, HR2873, and OR2

    Article • June 2011, Protein Data Bank, Rutgers University

    Professor Robert M Krug

  16. Dimer Interface of the Effector Domain of Non-structural Protein 1 from Influenza A Virus: AN INTERFACE WITH MULTIPLE FUNCTIONS

    Article • Journal of Biological Chemistry, May 2011, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Robert M Krug

  17. Synthesis and evaluation of quinoxaline derivatives as potential influenza NS1A protein inhibitors

    Article • Bioorganic & Medicinal Chemistry Letters, May 2011, Elsevier

    Professor Robert M Krug

  18. Influenza A virus strains that circulate in humans differ in the ability of their NS1 proteins to block the activation of IRF3 and interferon-β transcription

    Article • Virology, December 2010, Elsevier

    Professor Robert M Krug

  19. The ESEV PDZ-Binding Motif of the Avian Influenza A Virus NS1 Protein Protects Infected Cells from Apoptosis by Directly Targeting Scribble

    Article • Journal of Virology, August 2010, ASM Journals

    Professor Robert M Krug

  20. Structures of influenza A proteins and insights into antiviral drug targets

    Article • Nature Structural & Molecular Biology, April 2010, Springer Science + Business Media

    Professor Robert M Krug

  21. Species Specificity of the NS1 Protein of Influenza B Virus: NS1 BINDS ONLY HUMAN AND NON-HUMAN PRIMATE UBIQUITIN-LIKE ISG15 PROTEINS

    Article • Journal of Biological Chemistry, January 2010, American Society for Biochemistry & Molecular Biology (ASBMB)

    Professor Robert M Krug

  22. ISG15 conjugation system targets the viral NS1 protein in influenza A virus–infected cells

    Article • Proceedings of the National Academy of Sciences, January 2010, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  23. Emerging antiviral targets for influenza A virus

    Article • Trends in Pharmacological Sciences, June 2009, Elsevier

    Professor Robert M Krug

  24. Interferon-Induced ISG15 Conjugation Inhibits Influenza A Virus Gene Expression and Replication in Human Cells

    Article • Journal of Virology, April 2009, ASM Journals

    Professor Robert M Krug

  25. Influenza A Virus Polymerase Is an Integral Component of the CPSF30-NS1A Protein Complex in Infected Cells

    Article • Journal of Virology, December 2008, ASM Journals

    Professor Robert M Krug

  26. Interaction of the Influenza A Virus Nucleocapsid Protein with the Viral RNA Polymerase Potentiates Unprimed Viral RNA Replication

    Article • Journal of Virology, October 2008, ASM Journals

    Professor Robert M Krug

  27. Structural basis for suppression of a host antiviral response by influenza A virus

    Article • Proceedings of the National Academy of Sciences, September 2008, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  28. Faculty Opinions recommendation of The structural basis for cap binding by influenza virus polymerase subunit PB2.

    Article • June 2008, F1000Research

    Professor Robert M Krug

  29. A site on the influenza A virus NS1 protein mediates both inhibition of PKR activation and temporal regulation of viral RNA synthesis

    Article • Virology, June 2007, Elsevier

    Professor Robert M Krug

  30. The H5N1 Influenza Virus NS Genes Selected after 1998 Enhance Virus Replication in Mammalian Cells

    Article • Journal of Virology, May 2007, ASM Journals

    Professor Robert M Krug

  31. Nuclear and Nucleolar Targeting of Influenza A Virus NS1 Protein: Striking Differences between Different Virus Subtypes

    Article • Journal of Virology, March 2007, ASM Journals

    Professor Robert M Krug

  32. Faculty Opinions recommendation of IFN-stimulated gene 15 functions as a critical antiviral molecule against influenza, herpes, and Sindbis viruses.

    Article • January 2007, F1000Research

    Professor Robert M Krug

  33. The mechanism by which influenza A virus nucleoprotein forms oligomers and binds RNA

    Article • Nature, December 2006, Springer Science + Business Media

    Professor Robert M Krug

  34. Retinoic acid inducible gene-I and mda-5 are involved in influenza A virus-induced expression of antiviral cytokines

    Article • Microbes and Infection, July 2006, Elsevier

    Professor Robert M Krug

  35. The primary function of RNA binding by the influenza A virus NS1 protein in infected cells: Inhibiting the 2′-5′ oligo (A) synthetase/RNase L pathway

    Article • Proceedings of the National Academy of Sciences, May 2006, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  36. Binding of the influenza A virus NS1 protein to PKR mediates the inhibition of its activation by either PACT or double-stranded RNA

    Article • Virology, May 2006, Elsevier

    Professor Robert M Krug

  37. The CPSF30 Binding Site on the NS1A Protein of Influenza A Virus Is a Potential Antiviral Target

    Article • Journal of Virology, April 2006, ASM Journals

    Professor Robert M Krug

  38. Influenza Virus Virulence and Its Molecular Determinants

    Article • January 2005, Elsevier

    Professor Robert M Krug

  39. Biophysical Characterization of the Complex between Double-Stranded RNA and the N-Terminal Domain of the NS1 Protein from Influenza A Virus:  Evidence for a Novel RNA-Binding Mode †

    Article • Biochemistry, February 2004, American Chemical Society (ACS)

    Professor Robert M Krug

  40. Intracellular warfare between human influenza viruses and human cells: the roles of the viral NS1 protein

    Article • Virology, May 2003, Elsevier

    Professor Robert M Krug

  41. Cellular antiviral responses against influenza A virus are countered at the posttranscriptional level by the viral NS1A protein via its binding to a cellular protein required for the 3′ end processing of cellular pre-mRNAS

    Article • Virology, March 2003, Elsevier

    Professor Robert M Krug

  42. The potential use of influenza virus as an agent for bioterrorism

    Article • Antiviral Research, January 2003, Elsevier

    Professor Robert M Krug

  43. Structural Basis for Ubiquitin-like ISG 15 Protein Binding to the NS1 Protein of Influenza B Virus: A Protein–Protein Interaction Function That Is Not Shared by the Corresponding N-terminal Domain of the NS1 Protein of Influenza A Virus

    Article • Virology, December 2002, Elsevier

    Professor Robert M Krug, Dr Weiming Yuan

  44. The award of the “Interbrew-Baillet Latour de la Santé — 2002” prize to Robert M. Krug for outstanding contributions to influenza virus research

    Article • Archives of Virology, August 2002, Springer Science + Business Media

    Professor Robert M Krug, Dr Bertha C RAMIREZ

  45. Human influenza viruses activate an interferon-independent transcription of cellular antiviral genes: Outcome with influenza A virus is unique

    Article • Proceedings of the National Academy of Sciences, July 2002, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  46. Efficient Translation of mRNAs in Influenza A Virus-Infected Cells Is Independent of the Viral 5′ Untranslated Region

    Article • Virology, October 2001, Elsevier

    Professor Robert M Krug

  47. Selective nuclear export of viral mRNAs in influenza-virus-infected cells

    Article • Trends in Microbiology, August 2000, Elsevier

    Professor Robert M Krug

  48. RNA binding by the novel helical domain of the influenza virus NS1 protein requires its dimer structure and a small number of specific basic amino acids

    Article • RNA, February 1999, Cold Spring Harbor Laboratory Press

    Professor Robert M Krug

  49. Induction of Apoptosis by Influenza Virus

    Article • Seminars in Virology, August 1998, Elsevier

    Professor Robert M Krug

  50. Influenza Virus NS1 Protein Interacts with the Cellular 30 kDa Subunit of CPSF and Inhibits 3′ End Formation of Cellular Pre-mRNAs

    Article • Molecular Cell, June 1998, Elsevier

    Professor Robert M Krug

  51. Regulation of a nuclear export signal by an adjacent inhibitory sequence: The effector domain of the influenza virus NS1 protein

    Article • Proceedings of the National Academy of Sciences, April 1998, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  52. Chimeras Containing Influenza NS1 and HIV-1 Rev Protein Sequences: Mechanism of Their Inhibition of Nuclear Export of Rev Protein–RNA Complexes

    Article • Virology, February 1998, Elsevier

    Professor Robert M Krug

  53. A novel RNA-binding motif in influenza A virus non-structural protein 1

    Article • Nature Structural & Molecular Biology, November 1997, Springer Science + Business Media

    Professor Robert M Krug

  54. Crystal structure of the unique RNA-binding domain of the influenza virus NS1 protein

    Article • Nature Structural & Molecular Biology, November 1997, Springer Science + Business Media

    Professor Robert M Krug

  55. Surprising Function of the Three Influenza Viral Polymerase Proteins: Selective Protection of Viral mRNAs against the Cap-Snatching Reaction Catalyzed by the Same Polymerase Proteins

    Article • Virology, December 1996, Elsevier

    Professor Robert M Krug

  56. The RNA-Binding and Effector Domains of the Viral NS1 Protein Are Conserved to Different Extents among Influenza A and B Viruses

    Article • Virology, September 1996, Elsevier

    Professor Robert M Krug

  57. New approach for inhibiting Rev function and HIV-1 production using the influenza virus NS1 protein.

    Article • Proceedings of the National Academy of Sciences, August 1996, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  58. Binding of the Influenza Virus NS1 Protein to Double-Stranded RNA Inhibits the Activation of the Protein Kinase That Phosphorylates the eIF-2 Translation Initiation Factor

    Article • Virology, December 1995, Elsevier

    Professor Robert M Krug

  59. The Influenza Virus NS1 Protein Forms Multimers in Vitro and in Vivo

    Article • Virology, October 1995, Elsevier

    Professor Robert M Krug

  60. The choice of alternative 5' splice sites in influenza virus M1 mRNA is regulated by the viral polymerase complex.

    Article • Proceedings of the National Academy of Sciences, July 1995, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  61. The influenza virus NS1 protein: a novel inhibitor of pre-mRNA splicing.

    Article • Genes & Development, August 1994, Cold Spring Harbor Laboratory Press

    Professor Robert M Krug

  62. Nucleocytoplasmic transport: the influenza virus NS1 protein regulates the transport of spliced NS2 mRNA and its precursor NS1 mRNA.

    Article • Genes & Development, February 1992, Cold Spring Harbor Laboratory Press

    Professor Robert M Krug

  63. The Influenza Viruses

    Article • January 1989, Springer Science + Business Media

    Professor Robert M Krug

  64. Expression and Replication of the Influenza Virus Genome

    Article • January 1989, Springer Science + Business Media

    Professor Robert M Krug

  65. Regulation of splicing of influenza viral NS1 mRNA

    Article • Virus Research, September 1988, Elsevier

    Professor Robert M Krug

  66. Splicing of influenza viral NS1 mRNA

    Article • Virus Research, September 1985, Elsevier

    Professor Robert M Krug

  67. Synthesis of influenza viral genome templates

    Article • Virus Research, September 1985, Elsevier

    Professor Robert M Krug

  68. Translational control in influenza virus-infected cells

    Article • Virus Research, September 1985, Elsevier

    Professor Robert M Krug

  69. Expression of functional influenza viral cap-recognizing protein, the PB2 protein, using eukaryotic vectors

    Article • Virus Research, September 1985, Elsevier

    Professor Robert M Krug

  70. Expression of a functional influenza viral cap-recognizing protein by using a bovine papilloma virus vector.

    Article • Proceedings of the National Academy of Sciences, July 1985, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  71. Influenza Viral RNA Transcription

    Article • January 1985, Springer Science + Business Media

    Professor Robert M Krug

  72. Nuclear-cytoplasmic transport and VAI RNA-independent translation of influenza viral messenger RNAs in late adenovirus-infected cells

    Article • Cell, June 1984, Elsevier

    Professor Robert M Krug

  73. MOLECULAR TOPOGRAPHY OF THE INFLUENZA VIRUS P PROTEIN COMPLEX DURING CAPPED RNA-PRIMED MESSENGER RNA SYNTHESIS

    Article • January 1984, Elsevier

    Professor Robert M Krug

  74. Molecular model of a eucaryotic transcription complex: Functions and movements of influenza P proteins during capped RNA-primed transcription

    Article • Cell, September 1983, Elsevier

    Professor Robert M Krug

  75. Transcription and Replication of Influenza Viruses

    Article • January 1983, Springer Science + Business Media

    Professor Robert M Krug

  76. Studies on the helical nucleocapsid of influenza virus

    Article • Virology, April 1982, Elsevier

    Professor Robert M Krug

  77. Role of two of the influenza virus core P proteins in recognizing cap 1 structures (m 7 GpppNm) on RNAs and in initiating viral RNA transcription

    Article • Proceedings of the National Academy of Sciences, December 1981, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  78. Influenza virus, an RNA virus, synthesizes its messenger RNA in the nucleus of infected cells

    Article • Cell, November 1981, Elsevier

    Professor Robert M Krug

  79. A unique cap(m7GpppXm)-dependent influenza virion endonuclease cleaves capped RNAs to generate the primers that initiate viral RNA transcription

    Article • Cell, March 1981, Elsevier

    Professor Robert M Krug

  80. THE INITIATION OF INFLUENZA VIRAL RNA TRANSCRIPTION BY CAPPED RNA PRIMERS

    Article • January 1981, Elsevier

    Professor Robert M Krug

  81. The 5′ ends of influenza viral messenger RNAs are donated by capped cellular RNAs

    Article • Trends in Biochemical Sciences, January 1981, Elsevier

    Professor Robert M Krug

  82. Selected host cell capped RNA fragments prime influenza viral RNA transcription in vivo

    Article • Nucleic Acids Research, January 1981, Oxford University Press (OUP)

    Professor Robert M Krug

  83. Both the 7-methyl and the 2'-O-methyl groups in the cap of mRNA strongly influence its ability to act as primer for influenza virus RNA transcription.

    Article • Proceedings of the National Academy of Sciences, July 1980, Proceedings of the National Academy of Sciences

    Professor Robert M Krug

  84. CAPPED EUKARYOTIC MESSENGER RNAs ARE PRIMERS FOR INFLUENZA VIRAL RNA TRANSCRIPTION1

    Article • January 1980, Elsevier

    Professor Robert M Krug

  85. Identification of the RNA region transferred from a representative primer, β-globin mRNA, to influenza mRNA during in vitro transcription

    Article • Nucleic Acids Research, January 1980, Oxford University Press (OUP)

    Professor Robert M Krug

  86. Are the 5′ ends of influenza viral mrnas synthesized in vivo donated by host mRNAs?

    Article • Cell, October 1979, Elsevier

    Professor Robert M Krug

  87. INFLUENZA VIRAL RNA TRANSCRIPTS SYNTHESIZED IN VIVO AND IN VITRO

    Article • January 1976, Elsevier

    Professor Robert M Krug

  88. Studies on the intranuclear localization of influenza virus-specific proteins

    Article • Virology, April 1975, Elsevier

    Professor Robert M Krug

  89. Influenza viral messenger RNA

    Article • Virology, November 1974, Elsevier

    Professor Robert M Krug

  90. Cytoplasmic and nuclear virus-specific proteins in influenza virus-infected MDCK cells

    Article • Virology, November 1973, Elsevier

    Professor Robert M Krug

  91. Cytoplasmic and nucleoplasmic viral RNPs in influenza virus-infected MDCK cells

    Article • Virology, October 1972, Elsevier

    Professor Robert M Krug

  92. Influenza viral RNPs newly synthesized during the latent period of viral growth in MDCK cells

    Article • Virology, April 1971, Elsevier

    Professor Robert M Krug