All Stories

  1. NOVA1 acts as an oncogenic RNA-binding protein to regulate cholesterol homeostasis in human glioblastoma cells

    Article • Proceedings of the National Academy of Sciences, February 2024, Proceedings of the National Academy of Sciences

    Dr Robert B Darnell

  2. DRUL for school: Opening Pre-K with safe, simple, sensitive saliva testing for SARS-CoV-2

    Article • PLoS ONE, June 2021, PLOS

    Dr Robert B Darnell

  3. Dendritic cell vaccines containing lymphocytes produce improved immunogenicity in patients with cancer

    Article • Journal of Translational Medicine, December 2014, Springer Science + Business Media

    Dr Robert B Darnell

  4. Loss of the multifunctional RNA-binding protein RBM47 as a source of selectable metastatic traits in breast cancer

    Article • eLife, June 2014, eLife

    Dr Christina B Marney, Dr Sakari Vanharanta, Dr Robert B Darnell

  5. Mapping Argonaute and conventional RNA-binding protein interactions with RNA at single-nucleotide resolution using HITS-CLIP and CIMS analysis

    Article • Nature Protocols, January 2014, Springer Science + Business Media

    Dr Robert B Darnell

  6. RNA Protein Interaction in Neurons

    Article • Annual Review of Neuroscience, July 2013, Annual Reviews

    Dr Robert B Darnell

  7. Ri/Nova gene-associated paraneoplastic subacute motor neuronopathy

    Article • Muscle & Nerve, March 2013, Wiley

    Dr Robert B Darnell

  8. Dendritic cells loaded with FK506 kill T cells in an antigen-specific manner and prevent autoimmunity in vivo

    Article • eLife, February 2013, eLife

    Dr Dana Orange, Suyan Tian, Dr Robert B Darnell

  9. NOVA-dependent regulation of cryptic NMD exons controls synaptic protein levels after seizure

    Article • eLife, January 2013, eLife

    Dr Robert B Darnell

  10. Paraneoplastic Syndromes (Contemporary Neurology Series)

    Article • Neuro-Ophthalmology, December 2012, Taylor & Francis

    Dr Robert B Darnell

  11. Cellular Immune Suppression in Paraneoplastic Neurologic Syndromes Targeting Intracellular Antigens

    Article • Archives of Neurology, September 2012, American Medical Association (AMA)

    Dr Robert B Darnell

  12. Neuronal Elav-like (Hu) Proteins Regulate RNA Splicing and Abundance to Control Glutamate Levels and Neuronal Excitability

    Article • Neuron, September 2012, Elsevier

    Dr Robert B Darnell

  13. The George C. Cotzias Lecturer: Robert B. Darnell, D, PhD: Neurology Collides with the RNA World – From Intellectual Disability to Motor Neuron Disease

    Article • Neurology Today, May 2012, Wolters Kluwer Health

    Dr Robert B Darnell

  14. De Novo Gene Disruptions in Children on the Autistic Spectrum

    Article • Neuron, April 2012, Elsevier

    Dr Robert B Darnell

  15. An alternative mode of microRNA target recognition

    Article • Nature Structural & Molecular Biology, February 2012, Springer Science + Business Media

    Dr Robert B Darnell

  16. The maintenance of Purkinje axons by an RNA-binding protein HuC in adult cerebellum

    Article • Neuroscience Research, September 2011, Elsevier

    Dr Robert B Darnell

  17. FMRP Stalls Ribosomal Translocation on mRNAs Linked to Synaptic Function and Autism

    Article • Cell, July 2011, Elsevier

    Dr Robert B Darnell

  18. Protein-RNA and Protein-Protein Recognition by Dual KH1/2 Domains of the Neuronal Splicing Factor Nova-1

    Article • Structure, July 2011, Elsevier

    Dr Robert B Darnell

  19. Structure-function studies of FMRP RGG peptide recognition of an RNA duplex-quadruplex junction

    Article • Nature Structural & Molecular Biology, June 2011, Springer Science + Business Media

    Dr Robert B Darnell

  20. Mapping in vivo protein-RNA interactions at single-nucleotide resolution from HITS-CLIP data

    Article • Nature Biotechnology, June 2011, Springer Science + Business Media

    Dr Robert B Darnell

  21. The neuronal splicing factor Nova controls alternative splicing in N-type and P-type CaV2 calcium channels

    Article • Channels, November 2010, Taylor & Francis

    Dr Robert B Darnell

  22. RNA regulation in Neurodegeneration and Cancer

    Article • November 2010, Springer Science + Business Media

    Dr Robert B Darnell

  23. Faculty Opinions recommendation of Transmembrane receptor DCC associates with protein synthesis machinery and regulates translation.

    Article • October 2010, F1000Research

    Dr Robert B Darnell

  24. HITS‐CLIP: panoramic views of protein–RNA regulation in living cells

    Article • Wiley Interdisciplinary Reviews - RNA, August 2010, Wiley

    Dr Robert B Darnell

  25. Nova2 Regulates Neuronal Migration through an RNA Switch in Disabled-1 Signaling

    Article • Neuron, June 2010, Elsevier

    Dr Robert B Darnell

  26. The Onconeural Antigen cdr2 Is a Novel APC/C Target that Acts in Mitosis to Regulate C-Myc Target Genes in Mammalian Tumor Cells

    Article • PLoS ONE, April 2010, PLOS

    Dr Robert B Darnell

  27. Paraneoplastic Syndromes

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  28. Pathogenesis

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  29. Paraneoplastic Antinuclear and Antinucleolar Antibodies

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  30. Synaptic and Channel Antibodies

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  31. Cytoplasmic Antibodies

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  32. Cerebral Hemisphere Syndromes

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  33. Brainstem and Cerebellum

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  34. Spinal Cord Syndromes

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  35. Neuromuscular Junction and Muscle

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  36. Clinical Findings, Diagnosis, Treatment, and Prognosis

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  37. Anti-Retinal and Optic Nerve Antibodies

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  38. Hematologic Malignancies and Miscellaneous Solid Tumors

    Article • April 2010, Oxford University Press (OUP)

    Dr Robert B Darnell

  39. Faculty Opinions recommendation of Aberrant alternative splicing and extracellular matrix gene expression in mouse models of myotonic dystrophy.

    Article • March 2010, F1000Research

    Dr Robert B Darnell

  40. RNA processing and its regulation: global insights into biological networks

    Article • Nature Reviews Genetics, January 2010, Springer Science + Business Media

    Dr Robert B Darnell

  41. RNA Regulation in Neurologic Disease and Cancer

    Article • Cancer Research and Treatment, January 2010, Korean Cancer Association

    Dr Robert B Darnell

  42. The maintenance of Purkinje axons by HuC in adult cerebellum

    Article • Neuroscience Research, January 2010, Elsevier

    Dr Robert B Darnell

  43. A Mouse Model of the Human Fragile X Syndrome I304N Mutation

    Article • PLoS Genetics, December 2009, PLOS

    Dr Robert B Darnell

  44. Autoimmune encephalopathy: The spectrum widens

    Article • Annals of Neurology, July 2009, Wiley

    Dr Robert B Darnell

  45. Argonaute HITS-CLIP decodes microRNA–mRNA interaction maps

    Article • Nature, June 2009, Springer Science + Business Media

    Dr Robert B Darnell

  46. Tolerance to the Neuron-Specific Paraneoplastic HuD Antigen

    Article • PLoS ONE, June 2009, PLOS

    Dr Robert B Darnell

  47. HITS-CLIP yields genome-wide insights into brain alternative RNA processing

    Article • Nature, November 2008, Springer Science + Business Media

    Dr Robert B Darnell

  48. F.16. Identification of HuD-specific CD8+ T Cells in Paraneoplastic Neurologic Degeneration Patients with Tumor Immunity and Autoimmunity

    Article • Clinical Immunology, January 2008, Elsevier

    Dr Robert B Darnell

  49. CLIP: Crosslinking and ImmunoPrecipitation of In Vivo RNA Targets of RNA-Binding Proteins

    Article • January 2008, Springer Science + Business Media

    Dr Robert B Darnell

  50. Evolution of Nova-Dependent Splicing Regulation in the Brain

    Article • PLoS Genetics, January 2007, PLOS

    Dr Robert B Darnell

  51. NMDA receptor as a target in paraneoplastic encephalitis

    Article • Annals of Neurology, January 2007, Wiley

    Dr Robert B Darnell

  52. Functional and Mechanistic Insights From Genome-Wide Studies of Splicing Regulation in the Brain

    Article • January 2007, Springer Science + Business Media

    Dr Robert B Darnell

  53. An RNA map predicting Nova-dependent splicing regulation

    Article • Nature, October 2006, Springer Science + Business Media

    Dr Robert B Darnell

  54. Paraneoplastic Syndromes Affecting the Nervous System

    Article • Seminars in Oncology, June 2006, Elsevier

    Dr Robert B Darnell

  55. RNA binding proteins and the regulation of neuronal synaptic plasticity

    Article • Current Opinion in Neurobiology, February 2006, Elsevier

    Dr Robert B Darnell

  56. CLIP: A method for identifying protein–RNA interaction sites in living cells

    Article • Methods, December 2005, Elsevier

    Dr Robert B Darnell

  57. Common Molecular Pathways Mediate Long-Term Potentiation of Synaptic Excitation and Slow Synaptic Inhibition

    Article • Cell, October 2005, Elsevier

    Lily Jan, Dr Robert B Darnell

  58. A new cause of limbic encephalopathy

    Article • Brain, August 2005, Oxford University Press (OUP)

    Dr Robert B Darnell

  59. Apoptotic Cells Deliver Processed Antigen to Dendritic Cells for Cross-Presentation

    Article • PLoS Biology, April 2005, PLOS

    Dr Robert B Darnell

  60. Nova autoregulation reveals dual functions in neuronal splicing

    Article • The EMBO Journal, March 2005, Wiley

    Dr Robert B Darnell

  61. Neuroimmunology of the paraneoplastic neurological degenerations

    Article • Current Opinion in Immunology, October 2004, Elsevier

    Dr Robert B Darnell

  62. Sox21 is a repressor of neuronal differentiation and is antagonized by YB-1

    Article • Neuroscience Letters, April 2004, Elsevier

    Dr Robert B Darnell, Masanori Sakaguchi

  63. The fragile X mental retardation protein, FMRP, recognizes G-quartets

    Article • Mental Retardation and Developmental Disabilities Research Reviews, January 2004, Wiley

    Dr Robert B Darnell

  64. Paraneoplastic neurological degenerations: keys to tumour immunity

    Article • Nature Reviews Cancer, January 2004, Springer Science + Business Media

    Dr Robert B Darnell

  65. Paraneoplastic Neurologic Disorders

    Article • Archives of Neurology, January 2004, American Medical Association (AMA)

    Dr Robert B Darnell

  66. Memory, Synaptic Translation, and…Prions?

    Article • Cell, December 2003, Elsevier

    Dr Robert B Darnell

  67. Paraneoplastic Syndromes Involving the Nervous System

    Article • New England Journal of Medicine, October 2003, New England Journal of Medicine (NEJM/MMS)

    Dr Robert B Darnell

  68. Observing the invisible: successful tumor immunity in humans

    Article • Nature Immunology, March 2003, Springer Science + Business Media

    Dr Robert B Darnell

  69. RNA Logic in Time and Space

    Article • Cell, September 2002, Elsevier

    Dr Robert B Darnell

  70. Fragile X Mental Retardation Protein Targets G Quartet mRNAs Important for Neuronal Function

    Article • Cell, November 2001, Elsevier

    Dr Robert B Darnell

  71. Microarray Identification of FMRP-Associated Brain mRNAs and Altered mRNA Translational Profiles in Fragile X Syndrome

    Article • Cell, November 2001, Elsevier

    Dr Robert B Darnell

  72. PARANEOPLASTICNEUROLOGICDISEASEANTIGENS: RNA-Binding Proteins and Signaling Proteins in Neuronal Degeneration

    Article • Annual Review of Neuroscience, March 2001, Annual Reviews

    Dr Robert B Darnell

  73. The splice of life: Alternative splicing and neurological disease

    Article • Nature Reviews Neuroscience, January 2001, Springer Science + Business Media

    Dr Robert B Darnell

  74. cdr2-Specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed

    Article • Annals of Neurology, August 2000, Wiley

    Dr Robert B Darnell

  75. cdr2‐Specific CTLs are detected in the blood of all patients with paraneoplastic cerebellar degeneration analyzed

    Article • Annals of Neurology, August 2000, Wiley

    Dr Robert B Darnell

  76. Involvement of the TRAP220 Component of the TRAP/SMCC Coactivator Complex in Embryonic Development and Thyroid Hormone Action

    Article • Molecular Cell, April 2000, Elsevier

    Dr Robert B Darnell

  77. Sequence-Specific RNA Binding by a Nova KH Domain

    Article • Cell, February 2000, Elsevier

    Dr Robert B Darnell

  78. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration

    Article • Annals of Neurology, January 2000, Wiley

    Dr Robert B Darnell

  79. Detection and treatment of activated T cells in the cerebrospinal fluid of patients with paraneoplastic cerebellar degeneration

    Article • Annals of Neurology, January 2000, Wiley

    Dr Robert B Darnell

  80. The Importance of Defining the Paraneoplastic Neurologic Disorders

    Article • New England Journal of Medicine, June 1999, New England Journal of Medicine (NEJM/MMS)

    Dr Robert B Darnell

  81. Immunologic Complexity in Neurons

    Article • Neuron, November 1998, Elsevier

    Dr Robert B Darnell

  82. Tumor-specific killer cells in paraneoplastic cerebellar degeneration

    Article • Nature Reports Stem Cells, November 1998, Springer Science + Business Media

    Dr Robert B Darnell

  83. β-NAP, a cerebellar degeneration antigen, is a neuron-specific vesicle coat protein

    Article • Cell, September 1995, Elsevier

    Dr Robert B Darnell

  84. The polymerase chain reaction: Application to nervous system disease

    Article • Annals of Neurology, October 1993, Wiley

    Dr Robert B Darnell

  85. Nova, the paraneoplastic Ri antigen, is homologous to an RNA-binding protein and is specifically expressed in the developing motor system

    Article • Neuron, October 1993, Elsevier

    Dr Robert B Darnell

  86. The neuronal nuclear antigen recognized by the human anti-Ri autoantibody is expressed in central but not peripheral nervous system neurons

    Article • Neuroscience Letters, February 1993, Elsevier

    Dr Robert B Darnell