All Stories

  1. Structures of trehalose-6-phosphate synthase, Tps1, from the fungal pathogen Cryptococcus neoformans : A target for antifungals

    Article • Proceedings of the National Academy of Sciences, July 2024, Proceedings of the National Academy of Sciences

    Professor Richard G Brennan

  2. Structural and In Vivo Studies on Trehalose-6-Phosphate Synthase from Pathogenic Fungi Provide Insights into Its Catalytic Mechanism, Biological Necessity, and Potential for Novel Antifungal Drug Design

    Article • mBio, July 2017, ASM Journals

    Professor Richard G Brennan

  3. Mutations within themepAOperator Affect Binding of the MepR Regulatory Protein and Its Induction by MepA Substrates in Staphylococcus aureus

    Article • Journal of Bacteriology, January 2015, ASM Journals

    Professor Richard G Brennan

  4. The Molecular Mechanisms of Allosteric Mutations Impairing MepR Repressor Function in Multidrug-Resistant Strains of Staphylococcus aureus

    Article • mBio, August 2013, ASM Journals

    Professor Richard G Brennan

  5. Functional Consequences of Substitution Mutations in MepR, a Repressor of the Staphylococcus aureus mepA Multidrug Efflux Pump Gene

    Article • Journal of Bacteriology, June 2013, ASM Journals

    Professor Richard G Brennan

  6. Crystal Structure of a MepR-DNA Complex Reveals the Mechanism of Transcription Repression of S. Aureus Multidrug Efflux Pump mepA

    Article • Biophysical Journal, January 2013, Elsevier

    Professor Richard G Brennan

  7. Structural and biochemical characterization of MepR, a multidrug binding transcription regulator of the Staphylococcus aureus multidrug efflux pump MepA

    Article • Nucleic Acids Research, December 2008, Oxford University Press (OUP)

    Professor Richard G Brennan