All Stories

  1. DPP4 inhibitors as a novel therapeutic strategy in colorectal cancer: Integrating network biology and experimental insights

    Article • PLOS One, October 2025, PLOS

    sanaa bardaweel, Prof. Reema Abu Khalaf

  2. Exploring the anticancer potential of nitrated N-substituted-4-hydroxy-2-quinolone-3-carboxamides: synthesis, biological assessment, and computational analysis

    Article • BMC Chemistry, August 2025, Springer Science + Business Media

    Prof. Reema Abu Khalaf

  3. Trifluorooxoacetamido Benzamides as Breakthrough CETP Inhibitors: A Synergistic Approach of Synthesis, Biological Assessment, and Molecular Modeling

    Article • Palestinian Medical and Pharmaceutical Journal, August 2025, An-Najah National University

    Prof. Reema Abu Khalaf

  4. Molecular Modeling, Cheminformatics Analysis, and Synthesis of Trifluoromethylated Aromatic Sulfonamides as Putative Inhibitors of Cholesteryl Ester Transfer Protein

    Article • ChemistrySelect, April 2025, Wiley

    Prof. Reema Abu Khalaf

  5. Fluorinated Diaryl Sulfonamides: Molecular Modeling, Synthesis, and In Vitro Validation as New CETP Inhibitors

    Article • Current Computer - Aided Drug Design, December 2024, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  6. Synthesis, Molecular Modeling and Biological Evaluation of Novel Trifluoromethyl Benzamides as Promising CETP Inhibitors

    Article • Current Computer - Aided Drug Design, October 2024, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  7. Synthesis, Molecular Modeling, and Evaluation of Novel Methylated Benzene Sulfonamide Derivatives as Cholesteryl Ester Transfer Protein (CETP) Inhibitors

    Article • ChemistrySelect, September 2024, Wiley

    Prof. Reema Abu Khalaf

  8. Synthesis and In-Silico Studies of Ortho-Fluorinated Benzenesulfonamides as Putative Anti-CETP Agents

    Article • Current Organic Chemistry, May 2024, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  9. Chemical Synthesis, Biological Evaluation, and Cheminformatics Analysis of a Group of Chlorinated Diaryl Sulfonamides: Promising Inhibitors of Cholesteryl Ester Transfer Protein

    Article • Current Computer - Aided Drug Design, February 2024, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  10. Lycopene as a Potential Bioactive Compound: Chemistry, Extraction, and Anticancer Prospective

    Article • Current Cancer Drug Targets, September 2023, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  11. Cholesteryl Ester Transfer Protein Inhibitory Activity of New 4-Bromophenethyl Benzamides

    Article • Jordan Journal of Pharmaceutical Sciences, July 2023, The University of Jordan

    Prof. Reema Abu Khalaf

  12. Trifluoromethylated Aryl Sulfonamides as Novel CETP Inhibitors: Synthesis, Induced Fit Docking, Pharmacophore Mapping and Subsequent In vitro Validation

    Article • Medicinal Chemistry, May 2023, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  13. Design, Synthesis, and Biological Examination of N‐ Phenyl‐6‐fluoro‐4‐hydroxy‐2‐quinolone‐3‐carboxamides as Anticancer Agents

    Article • ChemistrySelect, May 2022, Wiley

    Prof. Reema Abu Khalaf

  14. Synthesis and Molecular Modeling of Novel 3,5-Bis(trifluoromethyl) benzylamino Benzamides as Potential CETP Inhibitors

    Article • Medicinal Chemistry, May 2022, Bentham Science Publishers

    Prof. Reema Abu Khalaf, MSc Mohammad Awad

  15. Thiomethylphenyl Benzenesulfonamides as Potential Cholesteryl Ester Transfer Protein Inhibitors: Synthesis, Molecular Modeling and Biological Evaluation

    Article • Current Organic Chemistry, April 2022, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  16. Phenanthridine Sulfonamide Derivatives as Potential DPP-IV Inhibitors: Design, Synthesis and Biological Evaluation

    Article • Current Computer - Aided Drug Design, February 2022, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  17. Cholesteryl ester transfer protein inhibitory oxoacetamido-benzamide derivatives: Glide docking, pharmacophore mapping, and synthesis

    Article • Brazilian Journal of Pharmaceutical Sciences, January 2022, FapUNIFESP (SciELO)

    Prof. Reema Abu Khalaf

  18. Synthesis, Biological Evaluation, and QPLD Studies of Piperazine Derivatives as Potential DPP-IV Inhibitors

    Article • Medicinal Chemistry, November 2021, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  19. Discovery, synthesis and in combo studies of Schiff’s bases as promising dipeptidyl peptidase-IV inhibitors

    Article • Molecular Diversity, September 2021, Springer Science + Business Media

    Prof. Reema Abu Khalaf

  20. Piperazine sulfonamides as DPP-IV inhibitors: Synthesis, induced-fit docking and in vitro biological evaluation

    Article • Acta Pharmaceutica, April 2021, De Gruyter

    Prof. Reema Abu Khalaf

  21. Molecular Modeling, Synthesis and Biological Evaluation of N-Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents

    Article • Molecules, November 2020, MDPI AG

    Prof. Reema Abu Khalaf

  22. DPP-IV Inhibitory Phenanthridines: Ligand, Structure-Based Design and Synthesis

    Article • Current Computer - Aided Drug Design, June 2020, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  23. Isolation and structure elucidation of bioactive polyphenols

    Article • January 2019, Elsevier

    Prof. Reema Abu Khalaf

  24. Ligand-Based Drug Design: Synthesis and Biological Evaluation of Substituted Benzoin Derivatives as Potential Antitumor Agents

    Article • Medicinal Chemistry, September 2018, Bentham Science Publishers

    Prof. Reema Abu Khalaf, Prof. Dima A. Sabbah, Wamidh Talib, sanaa bardaweel, Ghassan Abu Sheikha, Mohammad S. Mubarak

  25. Synthesis, Structural Characterization and Docking Studies of Sulfamoyl- Phenyl Acid Esters as Dipeptidyl Peptidase-IV Inhibitors

    Article • Current Computer - Aided Drug Design, May 2018, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  26. Structure-Based Design: Synthesis, X-ray Crystallography, and Biological Evaluation of N-Substituted-4-Hydroxy-2-Quinolone-3-Carboxamides as Potential Cytotoxic Agents

    Article • Anti-Cancer Agents in Medicinal Chemistry, April 2018, Bentham Science Publishers

    Prof. Dima A. Sabbah, kamal sweidan, Prof. Reema Abu Khalaf, Mohammad S. Mubarak, Ghassan Abu Sheikha, sanaa bardaweel

  27. Benzoin Schiff Bases: Design, Synthesis, and Biological Evaluation as Potential Antitumor Agents

    Article • Medicinal Chemistry, April 2018, Bentham Science Publishers

    Prof. Dima A. Sabbah, Ghassan Abu Sheikha, Prof. Reema Abu Khalaf, Mohammad S. Mubarak, sanaa bardaweel

  28. Synthesis of Novel Benzimidazole-2-carboxamide Derivatives and in Vivo Antihyperlipidemic Activity Evaluation

    Article • Chemical and Pharmaceutical Bulletin, January 2018, Pharmaceutical Society of Japan

    Prof. Reema Abu Khalaf

  29. Benzamides as CETP Inhibitors

    Article • Archiv der Pharmazie, November 2017, Wiley

    Prof. Reema Abu Khalaf, Ghassan Abu Sheikha

  30. CETP Inhibitory Activity of Chlorobenzyl Benzamides: QPLD Docking, Pharmacophore Mapping and Synthesis

    Article • Letters in Drug Design & Discovery, October 2017, Bentham Science Publishers

    Prof. Dima A. Sabbah, Prof. Reema Abu Khalaf, HAMADA ABDELAZIZ, Ghassan Abu Sheikha

  31. Molecular Docking and Pharmacophore Modeling Studies of Fluorinated Benzamides as Potential CETP Inhibitors

    Article • Medicinal Chemistry, April 2017, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  32. Synthesis and in vivo anti-hyperlipidemic activity of novel n-benzoylphenyl-2-furamide derivatives in Wistar rats

    Article • Tropical Journal of Pharmaceutical Research, February 2017, African Journals Online (AJOL)

    Prof. Reema Abu Khalaf

  33. Exploring Natural Products as a Source for Antidiabetic Lead Compounds and Possible Lead Optimization

    Article • Current Topics in Medicinal Chemistry, July 2016, Bentham Science Publishers

    Prof. Reema Abu Khalaf

  34. Molecular modeling based approach, synthesis, and cytotoxic activity of novel benzoin derivatives targeting phosphoinostide 3-kinase (PI3Kα)

    Article • Bioorganic & Medicinal Chemistry Letters, August 2015, Elsevier

    Prof. Reema Abu Khalaf

  35. Pharmacophore modeling and molecular docking studies of acridines as potential DPP-IV inhibitors

    Article • Canadian Journal of Chemistry, July 2015, Canadian Science Publishing

    Prof. Reema Abu Khalaf

  36. Tryptophan and thiosemicarbazide derivatives: design, synthesis, and biological evaluation as potential β-d-galactosidase and β-d-glucosidase inhibitors

    Article • Medicinal Chemistry Research, December 2014, Springer Science + Business Media

    Prof. Reema Abu Khalaf, prof mutasem taha, Mohammad S. Mubarak

  37. Design, Synthesis and Biological Evaluation of N4-Sulfonamido- Succinamic, Phthalamic, Acrylic and Benzoyl Acetic Acid Derivatives as Potential DPP IV Inhibitors

    Article • The Open Medicinal Chemistry Journal, November 2013, Bentham Science Publishers

    Prof. Reema Abu Khalaf, Full Professor Mahmoud A Al-Sha'er, prof mutasem taha

  38. In Vivo Antihyperlipidemic Activity of a New Series of N-(Benzoylphenyl) and N-(Acetylphenyl)-1-benzofuran-2-carboxamides in Rats

    Article • Archiv der Pharmazie, January 2012, Wiley

    Dr Waseem El-huneidi, Prof. Reema Abu Khalaf

  39. Design, synthesis, and biological evaluation of sulfonic acid ester and benzenesulfonamide derivatives as potential CETP inhibitors

    Article • Medicinal Chemistry Research, November 2011, Springer Science + Business Media

    Prof. Reema Abu Khalaf, Full Professor Mahmoud A Al-Sha'er, prof mutasem taha

  40. Discovery of New Antifungal Leads via Pharmacophore Modeling and QSAR Analysis of Fungal N‐Myristoyl Transferase Inhibitors Followed by In Silico Screening

    Article • Chemical Biology & Drug Design, July 2011, Wiley

    Professor Amjad M. Qandil, Prof. Reema Abu Khalaf, prof mutasem taha

  41. Discovery of new β-D-galactosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening

    Article • Journal of Computational Chemistry, August 2010, Wiley

    Prof. Reema Abu Khalaf, prof mutasem taha

  42. Design, Synthesis, and Biological Evaluation of Benzylamino-Methanone Based Cholesteryl Ester Transfer Protein Inhibitors

    Article • Molecules, August 2010, MDPI AG

    Prof. Reema Abu Khalaf

  43. Discovery of new β-d-glucosidase inhibitors via pharmacophore modeling and QSAR analysis followed by in silico screening

    Article • Journal of Molecular Modeling, May 2010, Springer Science + Business Media

    Prof. Reema Abu Khalaf, prof mutasem taha

  44. Discovery of new cholesteryl ester transfer protein inhibitors via ligand-based pharmacophore modeling and QSAR analysis followed by synthetic exploration

    Article • European Journal of Medicinal Chemistry, April 2010, Elsevier

    Prof. Reema Abu Khalaf, prof mutasem taha