All Stories

  1. Selection of Ribofuranose‐Isomer Among Pentoses by Phosphorylation with Diamidophosphate
  2. Selection of Ribofuranose‐Isomer Among Pentoses by Phosphorylation with Diamidophosphate
  3. Phosphorylation of nucleosides by P-N bond species generated from prebiotic reduced phosphorus sources
  4. Protocol for preparing cyclic-phospholipid decanoate and glyceryl-didecanoate-phosphate-containing vesicles
  5. A Magnesium Binding Site And The Anomeric Effect Regulate The Abiotic Redox Chemistry Of Nicotinamide Nucleotides
  6. Experimentally modeling the emergence of prebiotically plausible phospholipid vesicles
  7. Cyclophospholipids Enable a Protocellular Life Cycle
  8. Enhancing Prebiotic Phosphorylation and Modulating the Regioselectivity of Nucleosides with Diamidophosphate
  9. Carbonyl Migration in Uronates Affords a Potential Prebiotic Pathway for Pentose Production
  10. The potential of glyoxylate as a prebiotic source molecule and a reactant in protometabolic pathways—The glyoxylose reaction
  11. Prebiotic Chemistry of Phosphite: Mild Thermal Routes to Form Condensed-P Energy Currency Molecules Leading Up to the Formation of Organophosphorus Compounds
  12. A Plausible Prebiotic Path to Nucleosides: Ribosides and Related Aldosides Generated from Ribulose, Fructose, and Similar Abiotic Precursors
  13. Nucleobases in Meteorites to Nucleobases in RNA and DNA?
  14. Prebiotic synthesis of α-amino acids and orotate from α-ketoacids potentiates transition to extant metabolic pathways
  15. Cyanide as a primordial reductant enables a protometabolic reductive glyoxylate pathway
  16. A Plausible Prebiotic One‐Pot Synthesis of Orotate and Pyruvate Suggestive of Common Protometabolic Pathways
  17. One-pot chemical pyro- and tri-phosphorylation of peptides by using diamidophosphate in water
  18. Synthesis and hydrolytic stability of cyclic phosphatidic acids: implications for synthetic- and proto-cell studies
  19. Innenrücktitelbild: Concurrent Prebiotic Formation of Nucleoside‐Amidophosphates and Nucleoside‐Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization (Angew. Chem. 1/2022)
  20. Inside Back Cover: Concurrent Prebiotic Formation of Nucleoside‐Amidophosphates and Nucleoside‐Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization (Angew. Chem. Int. Ed. 1/2022)
  21. Concurrent Prebiotic Formation of Nucleoside‐Amidophosphates and Nucleoside‐Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization
  22. Concurrent Prebiotic Formation of Nucleoside‐Amidophosphates and Nucleoside‐Triphosphates Potentiates Transition from Abiotic to Biotic Polymerization
  23. Prebiotic Synthesis of α-Amino Acids and Orotate from α-Ketoacids Potentiates Transition to Extant Metabolic Pathways
  24. Cover Feature: Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3 (Chem. Eur. J. 56/2021)
  25. Towards an Understanding of the Molecular Mechanisms of Variable Unnatural Base‐Pair Behavior: A Biophysical Analysis of dNaM‐dTPT3
  26. Cover Feature: Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential? (ChemBioChem 21/2021)
  27. Depsipeptide Nucleic Acids: Prebiotic Formation, Oligomerization, and Self-Assembly of a New Proto-Nucleic Acid Candidate
  28. Diamidophosphate (DAP): A Plausible Prebiotic Phosphorylating Reagent with a Chem to BioChem Potential?
  29. Separations of Carbohydrates with Noncovalent Shift Reagents by Frequency-Modulated Ion Mobility-Orbitrap Mass Spectrometry
  30. Cyanide as a Primordial Reductant enables a Protometabolic Reductive Glyoxylate Pathway
  31. Transcriptional processing of an unnatural base pair by eukaryotic RNA polymerase II
  32. Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA
  33. Prebiotic Phosphorylation and Concomitant Oligomerization of Deoxynucleosides to form DNA
  34. Frontispiece: The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
  35. Noncovalent Helicene Structure between Nucleic Acids and Cyanuric Acid
  36. The Unexpected Base‐Pairing Behavior of Cyanuric Acid in RNA and Ribose versus Cyanuric Acid Induced Helicene Assembly of Nucleic Acids: Implications for the Pre‐RNA Paradigm
  37. Prebiotically Plausible RNA Activation Compatible with Ribozyme‐Catalyzed Ligation
  38. Präbiotisch plausible RNA‐Aktivierung kompatibel mit ribozymkatalysierter Ligation
  39. A plausible metal-free ancestral analogue of the Krebs cycle composed entirely of α-ketoacids
  40. A sensitive quantitative analysis of abiotically synthesized short homopeptides using ultraperformance liquid chromatography and time-of-flight mass spectrometry
  41. Depsipeptide nucleic acids: prebiotic formation, oligomerization, and self-assembly of a new candidate proto-nucleic acid
  42. Mutually stabilizing interactions between proto-peptides and RNA
  43. Introduction: Chemical Evolution and the Origins of Life
  44. Chemical Origins of Life: Its Engagement with Society
  45. New codons for efficient production of unnatural proteins in a semisynthetic organism
  46. Nanopore Sequencing of an Expanded Genetic Alphabet Reveals High-Fidelity Replication of a Predominantly Hydrophobic Unnatural Base Pair
  47. Chemistry of Abiotic Nucleotide Synthesis
  48. Organic acid shift reagents for the discrimination of carbohydrate isobars by ion mobility-mass spectrometry
  49. The Oligomerization of Glucose Under Plausible Prebiotic Conditions
  50. Synthesis of 2-Thioorotidine and Comparison of Its Unusual Instability with Its Canonical Pyrimidine Counterparts
  51. Prebiotic Phosphorylation of Uridine using Diamidophosphate in Aerosols
  52. The role of sugar-backbone heterogeneity and chimeras in the simultaneous emergence of RNA and DNA
  53. Cyclophospholipids Increase Protocellular Stability to Metal Ions
  54. Bis(dimethylamino)phosphorodiamidate: A Reagent for the Regioselective Cyclophosphorylation of cis-Diols Enabling One-Step Access to High-Value Target Cyclophosphates
  55. Selective incorporation of proteinaceous over nonproteinaceous cationic amino acids in model prebiotic oligomerization reactions
  56. Optimization of Replication, Transcription, and Translation in a Semi-Synthetic Organism
  57. Cyclophospholipids Increase Protocellular Stability to Metal Ions
  58. Cyclophospholipids Increase Protocellular Stability to Metal Ions
  59. Geochemical Sources and Availability of Amidophosphates on the Early Earth
  60. Geochemical Sources and Availability of Amidophosphates on the Early Earth
  61. Prebiotic phosphorylation of 2-thiouridine provides either nucleotides or DNA building blocks via photoreduction
  62. Carbohydrate isomer resolutionviamulti-site derivatization cyclic ion mobility-mass spectrometry
  63. Experimentally investigating the origin of DNA/RNA on early Earth
  64. Frontispiece: Life's Biological Chemistry: A Destiny or Destination Starting from Prebiotic Chemistry?
  65. Base-Mediated Cascade Aldol Addition and Fragmentation Reactions of Dihydroxyfumaric Acid and Aromatic Aldehydes: Controlling Chemodivergence via Choice of Base, Solvent, and Substituents
  66. Frontispiece: Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems
  67. Effect of temperature modulations on TEMPO-mediated regioselective oxidation of unprotected carbohydrates and nucleosides
  68. Life's Biological Chemistry: A Destiny or Destination Starting from Prebiotic Chemistry?
  69. Chimeric XNA: An Unconventional Design for Orthogonal Informational Systems
  70. Heterogeneous Pyrophosphate‐Linked DNA–Oligonucleotides: Aversion to DNA but Affinity for RNA
  71. Linked cycles of oxidative decarboxylation of glyoxylate as protometabolic analogs of the citric acid cycle
  72. Glycosylation of a model proto-RNA nucleobase with non-ribose sugars: implications for the prebiotic synthesis of nucleosides
  73. Rapid resolution of carbohydrate isomers via multi-site derivatization ion mobility-mass spectrometry
  74. Elongation of Model Prebiotic Proto-Peptides by Continuous Monomer Feeding
  75. Phosphorylation, oligomerization and self-assembly in water under potential prebiotic conditions
  76. Surveying the sequence diversity of model prebiotic peptides by mass spectrometry
  77. Orotidine‐Containing RNA: Implications for the Hierarchical Selection (Systems Chemistry Emergence) of RNA
  78. Nitrogenous Derivatives of Phosphorus and the Origins of Life: Plausible Prebiotic Phosphorylating Agents in Water
  79. Anchimeric‐Assisted Spontaneous Hydrolysis of Cyanohydrins Under Ambient Conditions: Implications for Cyanide‐Initiated Selective Transformations
  80. Reaction of glycine with glyoxylate: Competing transaminations, aldol reactions, and decarboxylations
  81. Giving Rise to Life: Transition from Prebiotic Chemistry to Protobiology
  82. Investigations towards the Synthesis of 5-Amino-l-lyxofuranosides and 4-Amino-lyxopyranosides and NMR Analysis
  83. Prebiotic Organic Chemistry and Chemical pre-Biology: Speaking to the Synthetic Organic Chemists
  84. Nucleobase modification by an RNA enzyme
  85. A Plausible Prebiotic Origin of Glyoxylate: Nonenzymatic Transamination Reactions of Glycine with Formaldehyde
  86. Mineral-Induced Enantioenrichment of Tartaric Acid
  87. The Abiotic Oxidation of Organic Acids to Malonate
  88. RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World
  89. RNA–DNA Chimeras in the Context of an RNA World Transition to an RNA/DNA World
  90. Spontaneous formation and base pairing of plausible prebiotic nucleotides in water
  91. pH‐controlled reaction divergence of decarboxylation versus fragmentation in reactions of dihydroxyfumarate with glyoxylate and formaldehyde: parallels to biological pathways
  92. Kinetics of prebiotic depsipeptide formation from the ester–amide exchange reaction
  93. Small molecule-mediated duplex formation of nucleic acids with ‘incompatible’ backbones
  94. ChemInform Abstract: On the Emergence of RNA
  95. Cover Picture: On the Emergence of RNA (Isr. J. Chem. 8/2015)
  96. Ester‐Mediated Amide Bond Formation Driven by Wet–Dry Cycles: A Possible Path to Polypeptides on the Prebiotic Earth
  97. Hydrogen-Bonding Complexes of 5-Azauracil and Uracil Derivatives in Organic Medium
  98. Microwave‐Assisted Phosphitylation of DNA and RNA Nucleosides and Their Analogs
  99. On the Emergence of RNA
  100. Synthesis of orotidine by intramolecular nucleosidation
  101. Furanose
  102. p-RNA
  103. Synthesis of phosphoramidites of isoGNA, an isomer of glycerol nucleic acid
  104. Correction to “Production of Tartrates by Cyanide-Mediated Dimerization of Glyoxylate: A Potential Abiotic Pathway to the Citric Acid Cycle”
  105. A Plausible Simultaneous Synthesis of Amino Acids and Simple Peptides on the Primordial Earth
  106. Spontaneous Prebiotic Formation of a β-Ribofuranoside That Self-Assembles with a Complementary Heterocycle
  107. RNA as an Emergent Entity: An Understanding Gained Through Studying its Nonfunctional Alternatives
  108. Microwave-assisted preparation of nucleoside-phosphoramidites
  109. Furanose
  110. p-RNA
  111. Chemical Etiology of Nucleic Acid Structure: The Pentulofuranosyl Oligonucleotide Systems: The (1′→3′)‐β‐L‐Ribulo, (4′→3′)‐α‐L‐Xylulo, and (1′→3′)‐α‐L‐Xylulo Nucleic Acids
  112. Production of Tartrates by Cyanide-Mediated Dimerization of Glyoxylate: A Potential Abiotic Pathway to the Citric Acid Cycle
  113. Correction to Role of pKa of Nucleobases in the Origins of Chemical Evolution
  114. Base‐Pairing Properties of a Structural Isomer of Glycerol Nucleic Acid
  115. The Origin of RNA and “My Grandfather’s Axe”
  116. Role of pKa of Nucleobases in the Origins of Chemical Evolution
  117. A Unified Mechanism for Abiotic Adenine and Purine Synthesis in Formamide
  118. Exploratory Experiments on the Chemistry of the “Glyoxylate Scenario”: Formation of Ketosugars from Dihydroxyfumarate
  119. Diastereoselective Self‐Condensation of Dihydroxyfumaric Acid in Water: Potential Route to Sugars
  120. An expedient synthesis of l-ribulose and derivatives
  121. Mapping the Landscape of Potentially Primordial Informational Oligomers: (3′→2′)‐D‐Phosphoglyceric Acid Linked Acyclic Oligonucleotides Tagged with 2,4‐Disubstituted 5‐Aminopyrimidines as Recognition Elements
  122. p-RNA
  123. Furanose
  124. Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligo‐dipeptides Tagged with Orotic Acid Derivatives as Recognition Elements
  125. The Structure of a TNA−TNA Complex in Solution: NMR Study of the Octamer Duplex Derived from α-(l)-Threofuranosyl-(3′-2′)-CGAATTCG
  126. Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides and Oligodipeptoids Tagged with Triazines as Recognition Elements
  127. Mapping the Landscape of Potentially Primordial Informational Oligomers: Oligodipeptides Tagged with 2,4‐Disubstituted 5‐Aminopyrimidines as Recognition Elements
  128. Tautomerism in 5,8‐Diaza‐7,9‐dicarbaguanine (‘Alloguanine’)
  129. Mannich-Type C-Nucleosidations with 7-Carba-purines and 4-Aminopyrimidines
  130. Mannich-Type C-Nucleosidations in the 5,8-Diaza-7,9-dicarba-purine Family1
  131. Base‐Pairing Systems Related to TNA Containing Phosphoramidate Linkages: Synthesis of Building Blocks and Pairing Properties
  132. Why Does TNA Cross‐Pair More Strongly with RNA Than with DNA? An Answer From X‐ray Analysis
  133. Pentopyranosyl Oligonucleotide Systems. 9th Communication
  134. 2,6-Diamino-5,8-diaza-7,9-dicarba-purine1
  135. C-Nucleosidations with 2,6-Diamino-5,8-diaza-7,9-dicarba-purine1
  136. Pentopyranosyl Oligonucleotide Systems. Communication No. 13
  137. The α‐L‐Threofuranosyl‐(3′→2′)‐oligonucleotide System (‘TNA'): Synthesis and Pairing Properties
  138. Crystal Structure of a B-Form DNA Duplex Containing (l)-α-Threofuranosyl (3‘→2‘) Nucleosides:  A Four-Carbon Sugar Is Easily Accommodated into the Backbone of DNA
  139. 2,6-Diaminopurine in TNA:  Effect on Duplex Stabilities and on the Efficiency of Template-Controlled Ligations1
  140. Base-Pairing Systems Related to TNA:  α-Threofuranosyl Oligonucleotides Containing Phosphoramidate Linkages1
  141. Pentopyranosyl oligonucleotide systems. Part 11: systems with shortened backbones: (?)-β-ribopyranosyl-(4′→3′)- and (?)-α-lyxopyranosyl-(4′→3′)-oligonucleotides
  142. Chemical Etiology of Nucleic Acid Structure: The α-Threofuranosyl-(3'→2') Oligonucleotide System
  143. Regioselective -Phosphorylation of Aldoses in Aqueous Solution
  144. Regioselectiveα-Phosphorylation of Aldoses in Aqueous Solution
  145. Regioselektive α-Phosphorylierung von Aldosen in wässriger Lösung
  146. Chemical Etiology of Nucleic Acid Structure: Comparing Pentopyranosyl-(2'→4') Oligonucleotides with RNA
  147. Pyranosyl‐RNA (‘p‐RNA’): Base‐pairing selectivity and potential to replicate. Preliminary communication
  148. Bis(tri-n-butylstannyl)benzopinacolate: Preparation and use as a mediator of intermolecular free radical reactions
  149. Investigation of a model for 1,2-asymmetric induction in reactions of .alpha.-carbalkoxy radicals: a stereochemical comparison of reactions of .alpha.-carbalkoxy radicals and ester enolates
  150. Synthesis of 6H-dibenzo[b,d]pyran-6-ones via dienone-phenol rearrangements of spiro[2,5-cyclohexadiene-1,1′(3′H)-isobenzofuran]-3′-ones
  151. Stereoselective Free Radical Reactions at C(20) of Steroid Side Chains