All Stories

  1. Modulating the Dehydration Conditions of Adefovir Dipivoxil Dihydrate to Obtain Different Physical Forms of Anhydrate

    Article • Journal of Pharmaceutical Sciences, March 2015, Elsevier

    Raj Suryanarayanan

  2. Mechanism of Amorphous Itraconazole Stabilization in Polymer Solid Dispersions: Role of Molecular Mobility

    Article • Molecular Pharmaceutics, October 2014, American Chemical Society (ACS)

    Raj Suryanarayanan

  3. Surface Acidity and Solid-State Compatibility of Excipients with an Acid-Sensitive API: Case Study of Atorvastatin Calcium

    Article • AAPS PharmSciTech, October 2014, American Association of Pharmaceutical Scientists (AAPS)

    Raj Suryanarayanan

  4. Azithromycin Hydrates—Implications of Processing‐Induced Phase Transformations

    Article • Journal of Pharmaceutical Sciences, October 2014, Elsevier

    Raj Suryanarayanan

  5. Dielectric Spectroscopy of Small Molecule Pharmaceuticals—Effect of Sample Configuration

    Article • Journal of Pharmaceutical Sciences, October 2014, Elsevier

    Raj Suryanarayanan

  6. Molecular Motions in Sucrose-PVP and Sucrose-Sorbitol Dispersions—II. Implications of Annealing on Secondary Relaxations

    Article • Pharmaceutical Research, May 2014, Springer Science + Business Media

    Raj Suryanarayanan

  7. Ultrasonication as a Potential Tool to Predict Solute Crystallization in Freeze-Concentrates

    Article • Pharmaceutical Research, January 2014, Springer Science + Business Media

    Raj Suryanarayanan

  8. Chlorine

    Article • January 2014, Elsevier

    Raj Suryanarayanan

  9. Controlling the physical form of mannitol in freeze-dried systems

    Article • European Journal of Pharmaceutics and Biopharmaceutics, October 2013, Elsevier

    Raj Suryanarayanan

  10. Quantification, Mechanism, and Mitigation of Active Ingredient Phase Transformation in Tablets

    Article • Molecular Pharmaceutics, July 2013, American Chemical Society (ACS)

    Raj Suryanarayanan

  11. Instability in Theophylline and Carbamazepine Hydrate Tablets: Cocrystal Formation Due to Release of Lattice Water

    Article • Pharmaceutical Research, April 2013, Springer Science + Business Media

    Raj Suryanarayanan

  12. Correlation between Molecular Mobility and Physical Stability of Amorphous Itraconazole

    Article • Molecular Pharmaceutics, January 2013, American Chemical Society (ACS)

    Raj Suryanarayanan

  13. Investigating Gabapentin Polymorphism Using Solid-State NMR Spectroscopy

    Article • AAPS PharmSciTech, November 2012, American Association of Pharmaceutical Scientists (AAPS)

    Raj Suryanarayanan

  14. Molecular Mobility as an Effective Predictor of the Physical Stability of Amorphous Trehalose

    Article • Molecular Pharmaceutics, October 2012, American Chemical Society (ACS)

    Raj Suryanarayanan

  15. Use of Dielectric Spectroscopy To Monitor Molecular Mobility in Glassy and Supercooled Trehalose

    Article • The Journal of Physical Chemistry B, September 2012, American Chemical Society (ACS)

    Raj Suryanarayanan

  16. Physical Characterization of Pentamidine Isethionate during Freeze-Drying—Relevance to development of Stable Lyophilized Product

    Article • Journal of Pharmaceutical Sciences, May 2012, Elsevier

    Raj Suryanarayanan

  17. Phase Transformation in Thiamine Hydrochloride Tablets: Influence on Tablet Microstructure, Physical Properties, and Performance

    Article • Journal of Pharmaceutical Sciences, April 2012, Elsevier

    Raj Suryanarayanan

  18. Calorimetry and complementary techniques to characterize frozen and freeze-dried systems

    Article • Advanced Drug Delivery Reviews, April 2012, Elsevier

    Raj Suryanarayanan

  19. Erratum to: The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin

    Article • AAPS PharmSciTech, September 2011, American Association of Pharmaceutical Scientists (AAPS)

    Raj Suryanarayanan

  20. Investigation of PEG Crystallization in Frozen and Freeze‐Dried PEGylated Recombinant Human Growth Hormone–Sucrose Systems: Implications on Storage Stability

    Article • Journal of Pharmaceutical Sciences, August 2011, Elsevier

    Raj Suryanarayanan

  21. The Stabilizing Effect of Moisture on the Solid-State Degradation of Gabapentin

    Article • AAPS PharmSciTech, July 2011, American Association of Pharmaceutical Scientists (AAPS)

    Raj Suryanarayanan

  22. Subtraction of DC Conductivity and Annealing: Approaches To Identify Johari–Goldstein Relaxation in Amorphous Trehalose

    Article • Molecular Pharmaceutics, June 2011, American Chemical Society (ACS)

    Raj Suryanarayanan

  23. Unintended Water Mediated Cocrystal Formation in Carbamazepine and Aspirin Tablets

    Article • Molecular Pharmaceutics, May 2011, American Chemical Society (ACS)

    Raj Suryanarayanan

  24. Thermophysical Properties of Carboxylic and Amino Acid Buffers at Subzero Temperatures: Relevance to Frozen State Stabilization

    Article • The Journal of Physical Chemistry B, May 2011, American Chemical Society (ACS)

    Raj Suryanarayanan

  25. Molecular Motions in Sucrose-PVP and Sucrose-Sorbitol Dispersions: I. Implications of Global and Local Mobility on Stability

    Article • Pharmaceutical Research, April 2011, Springer Science + Business Media

    Raj Suryanarayanan

  26. Spectroscopic Characterization of Molecular Aggregates in Solutions: Impact on Crystallization of Indomethacin Polymorphs from Acetonitrile and Ethanol

    Article • Crystal Growth & Design, April 2011, American Chemical Society (ACS)

    Raj Suryanarayanan

  27. Unusual Effect of Water Vapor Pressure on Dehydration of Dibasic Calcium Phosphate Dihydrate

    Article • Journal of Pharmaceutical Sciences, April 2011, Elsevier

    Raj Suryanarayanan

  28. Predicting the Crystallization Propensity of Carboxylic Acid Buffers in Frozen Systems—Relevance to Freeze-Drying

    Article • Journal of Pharmaceutical Sciences, April 2011, Elsevier

    Raj Suryanarayanan

  29. Investigation of PEG Crystallization in Frozen PEG–Sucrose–Water Solutions: II. Characterization of the Equilibrium Behavior During Freeze-Thawing

    Article • Journal of Pharmaceutical Sciences, November 2010, Elsevier

    Raj Suryanarayanan

  30. The Effect of Crystallizing and Non-crystallizing Cosolutes on Succinate Buffer Crystallization and the Consequent pH Shift in Frozen Solutions

    Article • Pharmaceutical Research, October 2010, Springer Science + Business Media

    Raj Suryanarayanan

  31. Characterization and Structure Analysis of Thiamine Hydrochloride Methanol Solvate

    Article • Crystal Growth & Design, September 2010, American Chemical Society (ACS)

    Raj Suryanarayanan

  32. Influence of Crystallizing and Non-crystallizing Cosolutes on Trehalose Crystallization During Freeze-Drying

    Article • Pharmaceutical Research, September 2010, Springer Science + Business Media

    Raj Suryanarayanan

  33. Crystallization of Trehalose in Frozen Solutions and its Phase Behavior during Drying

    Article • Pharmaceutical Research, September 2010, Springer Science + Business Media

    Raj Suryanarayanan

  34. Investigation of Solution and Vapor Phase Mediated Phase Transformation in Thiamine Hydrochloride

    Article • Journal of Pharmaceutical Sciences, September 2010, Elsevier

    Raj Suryanarayanan

  35. Water Sorption Induced Transformations in Crystalline Solid Surfaces: Characterization by Atomic Force Microscopy

    Article • Journal of Pharmaceutical Sciences, September 2010, Elsevier

    Raj Suryanarayanan

  36. Investigation of PEG Crystallization in Frozen PEG-Sucrose-Water Solutions. I. Characterization of the Nonequilibrium Behavior during Freeze-Thawing

    Article • Journal of Pharmaceutical Sciences, June 2010, Elsevier

    Raj Suryanarayanan

  37. Insights Into the Dehydration Behavior of Thiamine Hydrochloride (vitamin B1) Hydrates: Part II

    Article • Journal of Pharmaceutical Sciences, April 2010, Elsevier

    Raj Suryanarayanan

  38. Calorimetric and Diffractometric Evidence for the Sequential Crystallization of Buffer Components and the Consequential pH Swing in Frozen Solutions

    Article • The Journal of Physical Chemistry B, March 2010, American Chemical Society (ACS)

    Raj Suryanarayanan

  39. Non-destructive determination of the coating film thickness by X-ray powder diffractometry and correlation with the dissolution behavior of film-coated tablets

    Article • Journal of Pharmaceutical and Biomedical Analysis, March 2010, Elsevier

    Raj Suryanarayanan

  40. Insights into the dehydration behavior of thiamine hydrochloride (Vitamin B1) hydrates: Part I

    Article • Journal of Pharmaceutical Sciences, February 2010, Elsevier

    Raj Suryanarayanan

  41. Trehalose Crystallization During Freeze-Drying: Implications On Lyoprotection

    Article • The Journal of Physical Chemistry Letters, December 2009, American Chemical Society (ACS)

    Raj Suryanarayanan

  42. “pH Swing” in Frozen Solutions—Consequence of Sequential Crystallization of Buffer Components

    Article • The Journal of Physical Chemistry Letters, November 2009, American Chemical Society (ACS)

    Raj Suryanarayanan

  43. Local Mobility in Amorphous Pharmaceuticals—Characterization and Implications on Stability

    Article • Journal of Pharmaceutical Sciences, September 2009, Elsevier

    Raj Suryanarayanan

  44. The Effect of Bulking Agents on the Chemical Stability of Acid-Sensitive Compounds in Freeze-Dried Formulations: Sucrose Inversion Study

    Article • Journal of Pharmaceutical Sciences, September 2009, Elsevier

    Raj Suryanarayanan

  45. Synchrotron X-ray Diffraction Investigation of the Anomalous Behavior of Ice During Freezing of Aqueous Systems

    Article • The Journal of Physical Chemistry B, April 2009, American Chemical Society (ACS)

    Raj Suryanarayanan

  46. Phase Transitions in Frozen Systems and During Freeze–Drying: Quantification Using Synchrotron X-Ray Diffractometry

    Article • Pharmaceutical Research, March 2009, Springer Science + Business Media

    Raj Suryanarayanan

  47. Physical Characterization of Dibasic Calcium Phosphate Dihydrate and Anhydrate

    Article • Journal of Pharmaceutical Sciences, March 2009, Elsevier

    Raj Suryanarayanan

  48. Implications of Global and Local Mobility in Amorphous Sucrose and Trehalose as Determined by Differential Scanning Calorimetry

    Article • Pharmaceutical Research, January 2009, Springer Science + Business Media

    Raj Suryanarayanan

  49. Coating Processes and Equipment

    Article • June 2008, Taylor & Francis

    Raj Suryanarayanan

  50. A rapid thermal method for cocrystal screening

    Article • CrystEngComm, January 2008, Royal Society of Chemistry

    Raj Suryanarayanan

  51. Correlation between Chemical Reactivity and the Hammett Acidity Function in Amorphous Solids Using Inversion of Sucrose as a Model Reaction

    Article • Journal of Pharmaceutical Sciences, January 2008, Elsevier

    Raj Suryanarayanan

  52. X-Ray Powder Diffractometry of Intact Film Coated Tablets—An Approach to Monitor the Physical Form of the Active Pharmaceutical Ingredient During Processing and Storage

    Article • Journal of Pharmaceutical Sciences, August 2007, Elsevier

    Raj Suryanarayanan

  53. David James William Grant, M. A., D. Phil., D. Sc. (1937–2005)

    Article • Journal of Pharmaceutical Sciences, May 2007, Elsevier

    Raj Suryanarayanan, Professor Albert H.L. Chow

  54. Processing-Induced Phase Transitions of Theophylline—Implications on the Dissolution of Theophylline Tablets

    Article • Journal of Pharmaceutical Sciences, May 2007, Elsevier

    Raj Suryanarayanan

  55. Glycine Crystallization in Frozen and Freeze-dried Systems: Effect of pH and Buffer Concentration

    Article • Pharmaceutical Research, January 2007, Springer Science + Business Media

    Raj Suryanarayanan

  56. Influence of Processing Conditions on the Physical State of Mannitol—Implications in Freeze-Drying

    Article • Pharmaceutical Research, December 2006, Springer Science + Business Media

    Raj Suryanarayanan

  57. Calculation of the Penetration Depth of X-rays in Intact Pharmaceutical Film-Coated Tablets by Microdiffractometry

    Article • Pharmaceutical Research, September 2006, Springer Science + Business Media

    Raj Suryanarayanan

  58. Investigation of the Multi-Step Dehydration Reaction of Theophylline Monohydrate Using 2-Dimensional Powder X-ray Diffractometry

    Article • Pharmaceutical Research, September 2006, Springer Science + Business Media

    Raj Suryanarayanan

  59. Ionization States in the Microenvironment of Solid Dosage Forms: Effect of Formulation Variables and Processing

    Article • Pharmaceutical Research, August 2006, Springer Science + Business Media

    Raj Suryanarayanan

  60. Structure in Dehydrated Trehalose Dihydrate—Evaluation of the Concept of Partial Crystallinity

    Article • Pharmaceutical Research, August 2006, Springer Science + Business Media

    Raj Suryanarayanan

  61. Solute Crystallization in Frozen Systems–Use of Synchrotron Radiation to Improve Sensitivity

    Article • Pharmaceutical Research, August 2006, Springer Science + Business Media

    Raj Suryanarayanan

  62. Calculation of the Penetration Depth of X-rays in Intact Pharmaceutical Film-Coated Tablets by Microdiffractometory

    Article • Pharmaceutical Research, August 2006, Springer Science + Business Media

    Raj Suryanarayanan

  63. Impact of Freeze-Drying on Ionization of Sulfonephthalein Probe Molecules in Trehalose–Citrate Systems

    Article • Journal of Pharmaceutical Sciences, July 2006, Elsevier

    Raj Suryanarayanan

  64. Processing‐induced Phase Transformations and Their Implications on Pharmaceutical Product Quality

    Article • February 2006, Wiley

    Raj Suryanarayanan

  65. Quantification of Crystallinity in Substantially Amorphous Materials by Synchrotron X-ray Powder Diffractometry

    Article • Pharmaceutical Research, August 2005, Springer Science + Business Media

    Raj Suryanarayanan

  66. Influence of the Active Pharmaceutical Ingredient Concentration on the Physical State of Mannitol—Implications in Freeze-Drying

    Article • Pharmaceutical Research, August 2005, Springer Science + Business Media

    Raj Suryanarayanan

  67. Measurement of enthalpic relaxation by differential scanning calorimetry—effect of experimental conditions

    Article • Thermochimica Acta, August 2005, Elsevier

    Raj Suryanarayanan

  68. Partially Crystalline Systems in Lyophilization: II. Withstanding Collapse at High Primary Drying Temperatures and Impact on Protein Activity Recovery

    Article • Journal of Pharmaceutical Sciences, April 2005, Elsevier

    Raj Suryanarayanan

  69. Partially Crystalline Systems in Lyophilization: I. Use of Ternary State Diagrams to Determine Extent of Crystallization of Bulking Agent

    Article • Journal of Pharmaceutical Sciences, April 2005, Elsevier

    Raj Suryanarayanan

  70. Raffinose Crystallization During Freeze-Drying and Its Impact on Recovery of Protein Activity

    Article • Pharmaceutical Research, February 2005, Springer Science + Business Media

    Raj Suryanarayanan

  71. Crystallization of Cephalothin Sodium During Lyophilization from tert-Butyl Alcohol?Water Cosolvent System

    Article • Pharmaceutical Research, January 2005, Springer Science + Business Media

    Raj Suryanarayanan

  72. Characterization and Crystal Structure of D‐Mannitol Hemihydrate

    Article • Journal of Pharmaceutical Sciences, November 2004, Elsevier

    Raj Suryanarayanan

  73. Quantification of glycine crystallinity by near-infrared (NIR) spectroscopy

    Article • Journal of Pharmaceutical Sciences, October 2004, Elsevier

    Raj Suryanarayanan

  74. Effect of Preparation Method on Physical Properties of Amorphous Trehalose

    Article • Pharmaceutical Research, July 2004, Springer Science + Business Media

    Raj Suryanarayanan

  75. Effect of Aging on the Physical Properties of Amorphous Trehalose

    Article • Pharmaceutical Research, May 2004, Springer Science + Business Media

    Raj Suryanarayanan

  76. Infrared spectroscopic studies of protein formulations containing glycine

    Article • Journal of Pharmaceutical Sciences, May 2004, Elsevier

    Raj Suryanarayanan

  77. Preformulation Studies to Meet the Challenges in the Manufacture of Betaine Solid Dosage Form

    Article • Journal of Pharmaceutical Sciences, January 2004, Elsevier

    Raj Suryanarayanan

  78. Use of Glancing Angle X-Ray Powder Diffractometry to Depth-Profile Phase Transformations During Dissolution of Indomethacin and Theophylline Tablets

    Article • Pharmaceutical Research, January 2004, Springer Science + Business Media

    Raj Suryanarayanan

  79. Crystallization of D-Mannitol in Binary Mixtures with NaCl: Phase Diagram and Polymorphism

    Article • Pharmaceutical Research, December 2003, Springer Science + Business Media

    Raj Suryanarayanan

  80. Solid-vapor interactions: Influence of environmental conditions on the dehydration of carbamazepine dihydrate

    Article • AAPS PharmSciTech, December 2003, American Association of Pharmaceutical Scientists (AAPS)

    Raj Suryanarayanan

  81. Enthalpic relaxation in frozen aqueous trehalose solutions

    Article • Thermochimica Acta, November 2003, Elsevier

    Raj Suryanarayanan

  82. Solute Crystallization in Mannitol–Glycine Systems—Implications on Protein Stabilization in Freeze‐Dried Formulations

    Article • Journal of Pharmaceutical Sciences, November 2003, Elsevier

    Raj Suryanarayanan

  83. Racemic species of sodium ibuprofen: Characterization and polymorphic relationships

    Article • Journal of Pharmaceutical Sciences, July 2003, Elsevier

    Raj Suryanarayanan

  84. Quantitative analyses of complex pharmaceutical mixtures by the Rietveld method

    Article • Powder Diffraction, March 2001, Cambridge University Press

    Raj Suryanarayanan

  85. Quantitation of crystallinity in substantially amorphous pharmaceuticals and study of crystallization kinetics by X-ray powder diffractometry

    Article • Powder Diffraction, March 2000, Cambridge University Press

    Raj Suryanarayanan

  86. In Situ Dehydration of Carbamazepine Dihydrate: A Novel Technique to Prepare Amorphous Anhydrous Carbamazepine

    Article • Pharmaceutical Development and Technology, January 2000, Taylor & Francis

    Raj Suryanarayanan

  87. A method for the rapid evaluation of the physical stability of pharmaceutical hydrates

    Article • Thermochimica Acta, April 1999, Elsevier

    Raj Suryanarayanan

  88. Solid-State Phase Transitions of AG337, an Antitumor Agent

    Article • Pharmaceutical Development and Technology, January 1999, Taylor & Francis

    Raj Suryanarayanan

  89. Applications of pressure differential scanning calorimetry in the study of pharmaceutical hydrates. II. Ampicillin trihydrate

    Article • International Journal of Pharmaceutics, August 1998, Elsevier

    Raj Suryanarayanan

  90. Characterization of Phase Transitions During Freeze-Drying by In Situ X-ray Powder Diffractometry

    Article • Pharmaceutical Development and Technology, January 1998, Taylor & Francis

    Raj Suryanarayanan

  91. Influence of Environmental Conditions on the Kinetics and Mechanism of Dehydration of Carbamazepine Dihydrate

    Article • Pharmaceutical Development and Technology, January 1998, Taylor & Francis

    Raj Suryanarayanan

  92. Polymorphism in Anhydrous Theophylline—Implications on the Dissolution Rate of Theophylline Tablets

    Article • Journal of Pharmaceutical Sciences, November 1997, American Geophysical Union (AGU)

    Raj Suryanarayanan

  93. Applications of pressure differential scanning calorimetry in the study of pharmaceutical hydrates

    Article • International Journal of Pharmaceutics, November 1997, Elsevier

    Raj Suryanarayanan

  94. Identification of drugs in pharmaceutical dosage forms by X-ray powder diffractometry

    Article • Journal of Pharmaceutical and Biomedical Analysis, April 1997, Elsevier

    Raj Suryanarayanan

  95. A Novel X-ray Powder Diffractometric Method for Studying the Reaction between Pseudoephedrine Enantiomers

    Article • Journal of Pharmaceutical Sciences, March 1997, American Geophysical Union (AGU)

    Raj Suryanarayanan

  96. X-Ray Powder Diffractometry

    Article • July 1995, Taylor & Francis

    Raj Suryanarayanan

  97. Sustained Intracerebral Delivery of Nerve Growth Factor with Biodegradable Polymer Microspheres

    Article • January 1994, Elsevier

    Raj Suryanarayanan

  98. Plasma Spraying: Theory and Applications

    Article • June 1993, World Scientific Pub Co Pte Lt

    Raj Suryanarayanan

  99. Sustained Release of Nerve Growth Factor from Biodegradable Polymer Microspheres

    Article • Neurosurgery, March 1992, Wolters Kluwer Health

    Raj Suryanarayanan

  100. Sustained Release of Nerve Growth Factor from Biodegradable Polymer Microspheres

    Article • Neurosurgery, March 1992, Wolters Kluwer Health

    Raj Suryanarayanan

  101. Kinetics of Transition of Anhydrous Carbamazepine to Carbamazepine Dihydrate in Aqueous Suspensions

    Article • Journal of Pharmaceutical Sciences, May 1991, Elsevier

    Raj Suryanarayanan

  102. Determination of the Relative Amounts of α-carbamazepine and β-carbamazepine in a Mixture by Powder X-Ray Diffractometry

    Article • Powder Diffraction, September 1990, Cambridge University Press

    Raj Suryanarayanan